{"id":"https://openalex.org/W2099313339","doi":"https://doi.org/10.1186/s12885-015-1732-9","title":"Expression of Oct3/4 and Nanog in the head and neck squamous carcinoma cells and its clinical implications for delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma","display_name":"Expression of Oct3/4 and Nanog in the head and neck squamous carcinoma cells and its clinical implications for delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma","publication_year":2015,"publication_date":"2015-10-19","ids":{"openalex":"https://openalex.org/W2099313339","doi":"https://doi.org/10.1186/s12885-015-1732-9","mag":"2099313339","pmid":"https://pubmed.ncbi.nlm.nih.gov/26483189","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4610045"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-015-1732-9","doi":"https://doi.org/10.1186/s12885-015-1732-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-015-1732-9","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-015-1732-9","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-015-1732-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028084797","display_name":"Noboru Habu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210143233","display_name":"Tachikawa Hospital","ror":"https://ror.org/03q7hxz75","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210143233"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noboru Habu","raw_affiliation_strings":["Department of Otorhinolaryngology, Tachikawa Hospital, Tokyo, Japan. habunoboru@gmail.com","Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. habunoboru@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Tachikawa Hospital, Tokyo, Japan. habunoboru@gmail.com","institution_ids":["https://openalex.org/I4210143233"]},{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. habunoboru@gmail.com","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027926421","display_name":"Yorihisa Imanishi","orcid":"https://orcid.org/0000-0003-0047-7987","observed_orcids":["https://orcid.org/0000-0003-0047-7987"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yorihisa Imanishi","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. yorihisa@ja2.so-net.ne.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. yorihisa@ja2.so-net.ne.jp","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084143917","display_name":"Kaori Kameyama","orcid":"https://orcid.org/0000-0003-2069-3249","observed_orcids":["https://orcid.org/0000-0003-2069-3249"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaori Kameyama","raw_affiliation_strings":["Department of Pathology, Keio University School of Medicine, Tokyo, Japan. kameyama@a5.keio.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keio University School of Medicine, Tokyo, Japan. kameyama@a5.keio.jp","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063135751","display_name":"Masayuki Shimoda","orcid":"https://orcid.org/0000-0003-4929-6546","observed_orcids":["https://orcid.org/0000-0003-4929-6546"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Shimoda","raw_affiliation_strings":["Department of Pathology, Keio University School of Medicine, Tokyo, Japan. shimoda@a2.keio.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keio University School of Medicine, Tokyo, Japan. shimoda@a2.keio.jp","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022974609","display_name":"Yutaka Tokumaru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094747","display_name":"Tokyo Medical Center","ror":"https://ror.org/005xkwy83","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094747","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaka Tokumaru","raw_affiliation_strings":["Department of Otorhinolaryngology, National Tokyo Medical Center, Tokyo, Japan. toku@sb4.so-net.ne.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, National Tokyo Medical Center, Tokyo, Japan. toku@sb4.so-net.ne.jp","institution_ids":["https://openalex.org/I4210094747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000765342","display_name":"Koji Sakamoto","orcid":"https://orcid.org/0000-0002-1794-576X","observed_orcids":["https://orcid.org/0000-0002-1794-576X"]},"institutions":[{"id":"https://openalex.org/I4210123464","display_name":"Saiseikai Utsunomiya hospital","ror":"https://ror.org/03a2szg51","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123464"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Sakamoto","raw_affiliation_strings":["Department of Otorhinolaryngology, Saiseikai Utsunomiya Hospital, Utsunomiya, Japan. kojisakamoto355@yahoo.co.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Saiseikai Utsunomiya Hospital, Utsunomiya, Japan. kojisakamoto355@yahoo.co.jp","institution_ids":["https://openalex.org/I4210123464"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ryoichi Fujii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405283826","display_name":"Saiseikai Yokohama-shi Nanbu Hospital","ror":"https://ror.org/02bgn2p26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210120601","https://openalex.org/I4405283826"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryoichi Fujii","raw_affiliation_strings":["Department of Otorhinolaryngology, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan. ryoichi421@nifty.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan. ryoichi421@nifty.com","institution_ids":["https://openalex.org/I4405283826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079519796","display_name":"Seiji Shigetomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136279","display_name":"Yokohama Municipal Citizen's Hospital","ror":"https://ror.org/034s1fw96","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210136279"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiji Shigetomi","raw_affiliation_strings":["Department of Otorhinolaryngology, Yokohama Municipal Citizen's Hospital, Yokohama, Japan. shigetomi@mva.biglobe.ne.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Yokohama Municipal Citizen's Hospital, Yokohama, Japan. shigetomi@mva.biglobe.ne.jp","institution_ids":["https://openalex.org/I4210136279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113917922","display_name":"Kuninori Otsuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kuninori Otsuka","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. rynonic@jt9.so-net.ne.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. rynonic@jt9.so-net.ne.jp","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114777965","display_name":"Yoichiro Sato","orcid":"https://orcid.org/0000-0001-7772-0645","observed_orcids":["https://orcid.org/0000-0001-7772-0645"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichiro Sato","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. y-ichiro-orlhns@hotmail.co.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. y-ichiro-orlhns@hotmail.co.jp","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026392622","display_name":"Yoshihiro Watanabe","orcid":"https://orcid.org/0000-0002-5756-0530","observed_orcids":["https://orcid.org/0000-0002-5756-0530"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Watanabe","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. ywatanabefhu@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. ywatanabefhu@gmail.com","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031107859","display_name":"Hiroyuki Ozawa","orcid":"https://orcid.org/0000-0002-0990-831X","observed_orcids":["https://orcid.org/0000-0002-0990-831X"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Ozawa","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. ozakkyy123@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. ozakkyy123@gmail.com","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110415720","display_name":"Toshiki Tomita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiki Tomita","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. tomitamt@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. tomitamt@gmail.com","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110738588","display_name":"Masato Fujii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094747","display_name":"Tokyo Medical Center","ror":"https://ror.org/005xkwy83","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094747","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Fujii","raw_affiliation_strings":["National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan. fujiimasato@kankakuki.go.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan. fujiimasato@kankakuki.go.jp","institution_ids":["https://openalex.org/I4210094747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054057203","display_name":"Kaoru Ogawa","orcid":"https://orcid.org/0000-0002-2461-4125","observed_orcids":["https://orcid.org/0000-0002-2461-4125","https://orcid.org/0009-0003-1630-5757"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaoru Ogawa","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. ogawak@a5.keio.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan. ogawak@a5.keio.jp","institution_ids":["https://openalex.org/I203951103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5027926421"],"corresponding_institution_ids":["https://openalex.org/I203951103"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":2.0173,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.88076625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"730","last_page":"730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5497999787330627,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5497999787330627,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.4431000053882599,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.8510000109672546},{"id":"https://openalex.org/keywords/nanog","display_name":"Nanog","score":0.9990000128746033},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tongue-squamous-cell-carcinoma","display_name":"tongue squamous cell carcinoma","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8289999961853027},{"id":"https://openalex.org/keywords/side-population","display_name":"side population cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/vascular-invasion","display_name":"vascular invasion","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.7570000290870667},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7820000052452087},{"id":"https://openalex.org/keywords/glossectomy","display_name":"glossectomy","score":0.699999988079071},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.4169999957084656},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.4050000011920929},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.835143506526947},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6516640186309814},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5798990726470947},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5299835205078125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.520248293876648},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5145718455314636},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4647625684738159},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.46006906032562256},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44994795322418213},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4372968375682831},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4194493889808655},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.41478264331817627},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4116821885108948},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35603004693984985},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.33427634835243225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3194698691368103},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.1125878393650055},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.10627463459968567},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014062","descriptor_name":"Tongue Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014062","descriptor_name":"Tongue Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058985","descriptor_name":"Side-Population Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12885-015-1732-9","doi":"https://doi.org/10.1186/s12885-015-1732-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-015-1732-9","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-015-1732-9","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3583140","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4610045","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26483189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26483189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4610045","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4610045/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12885-015-1732-9","doi":"https://doi.org/10.1186/s12885-015-1732-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-015-1732-9","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-015-1732-9","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G171969381","display_name":"Expression of stem cell markers Oct3/4 and Nanog and its clinical significance in oral tongue squamous cell carcinoma","funder_award_id":"25861587","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2882695102","display_name":"Study to control metastasis of HNSCC by targeting molecular mechanisms leading to epithelial-mesenchymal transition (EMT)","funder_award_id":"22591917","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5032522881","display_name":"HPV infection and cancer stem-cell in EGFR target therapy for head and neck cancer","funder_award_id":"24592614","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5707836406","display_name":"Control of metastasis and cancer stem-like cell property by inducing MET (mesenchymal-epithelial transition) in head and neck cancer","funder_award_id":"25462692","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5930542953","display_name":"Association with epithelial-mesenchymal trasition andcancer stem cell in Head and Neck cancer","funder_award_id":"23791933","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320909","display_name":"Keio University","ror":"https://ror.org/02kn6nx58"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2099313339.pdf","grobid_xml":"https://content.openalex.org/works/W2099313339.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W1480706413","https://openalex.org/W1483167997","https://openalex.org/W1491965179","https://openalex.org/W1578859370","https://openalex.org/W1608762409","https://openalex.org/W1838354729","https://openalex.org/W1970572671","https://openalex.org/W1976741685","https://openalex.org/W1980591417","https://openalex.org/W1982580620","https://openalex.org/W1985335182","https://openalex.org/W1986311875","https://openalex.org/W1987803647","https://openalex.org/W1990099538","https://openalex.org/W1992514491","https://openalex.org/W1992676863","https://openalex.org/W1996591010","https://openalex.org/W1997880930","https://openalex.org/W1998864452","https://openalex.org/W1999356404","https://openalex.org/W2002101428","https://openalex.org/W2003554910","https://openalex.org/W2005145657","https://openalex.org/W2009886857","https://openalex.org/W2010620134","https://openalex.org/W2013614359","https://openalex.org/W2014363686","https://openalex.org/W2014562331","https://openalex.org/W2014691022","https://openalex.org/W2023316892","https://openalex.org/W2023427658","https://openalex.org/W2025567248","https://openalex.org/W2028593825","https://openalex.org/W2032072974","https://openalex.org/W2032080388","https://openalex.org/W2032571174","https://openalex.org/W2038249969","https://openalex.org/W2039767026","https://openalex.org/W2040190863","https://openalex.org/W2041013784","https://openalex.org/W2043746859","https://openalex.org/W2050877098","https://openalex.org/W2051055358","https://openalex.org/W2051875932","https://openalex.org/W2053911973","https://openalex.org/W2056422677","https://openalex.org/W2057880610","https://openalex.org/W2064437405","https://openalex.org/W2068416436","https://openalex.org/W2069557445","https://openalex.org/W2070156193","https://openalex.org/W2076174476","https://openalex.org/W2076583198","https://openalex.org/W2076971256","https://openalex.org/W2078448971","https://openalex.org/W2079830144","https://openalex.org/W2080533553","https://openalex.org/W2080987888","https://openalex.org/W2085265737","https://openalex.org/W2089666373","https://openalex.org/W2097308038","https://openalex.org/W2101632685","https://openalex.org/W2102085111","https://openalex.org/W2106078700","https://openalex.org/W2112595718","https://openalex.org/W2113218395","https://openalex.org/W2115356458","https://openalex.org/W2122147062","https://openalex.org/W2122245635","https://openalex.org/W2126851387","https://openalex.org/W2129686681","https://openalex.org/W2133703873","https://openalex.org/W2134959033","https://openalex.org/W2134987819","https://openalex.org/W2137956382","https://openalex.org/W2142046859","https://openalex.org/W2144108148","https://openalex.org/W2145961505","https://openalex.org/W2146052797","https://openalex.org/W2146362101","https://openalex.org/W2150163104","https://openalex.org/W2150485214","https://openalex.org/W2153101406","https://openalex.org/W2154589460","https://openalex.org/W2157600729","https://openalex.org/W2164658851","https://openalex.org/W2167650288","https://openalex.org/W2167960944","https://openalex.org/W2793841049"],"related_works":["https://openalex.org/W2476619897","https://openalex.org/W7144829117","https://openalex.org/W7146063690","https://openalex.org/W2796269560","https://openalex.org/W7139540687","https://openalex.org/W3039316772","https://openalex.org/W7145295869","https://openalex.org/W2590762061","https://openalex.org/W1982580620","https://openalex.org/W2099090234"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,120],"side":[2],"population":[3,115],"(SP)":[4],"of":[5,23,31,61,85,100,122,151,179,217,227,261,275,293,319,335,349],"cancer":[6,12],"cells":[7,14,38,87,187,201],"is":[8],"reportedly":[9],"enriched":[10],"with":[11,45,89,103,163,232,331],"stem":[13],"(CSCs),":[15],"however,":[16,59],"the":[17,29,72,79,83,98,123,264,269,288,317],"functional":[18],"role":[19],"and":[20,33,95,131,137,148,153,181,194,219,222,225,248,273,280,291,296,306,327],"clinical":[21,46],"relevance":[22],"CSC":[24,80,124,310],"marker":[25],"molecules":[26],"upregulated":[27],"in":[28,82,92,117,171,185,199,210,312,321],"SP":[30,84,112,186,200],"head":[32],"neck":[34,63],"squamous":[35,51],"carcinoma":[36,53],"(HNSCC)":[37],"are":[39],"yet":[40],"to":[41,67,77,96,110,142,316],"be":[42,338],"elucidated.":[43],"Patients":[44],"stage":[47,164],"I/II":[48,165],"(T1-2N0M0)":[49],"tongue":[50],"cell":[52,174,192,325],"(TSCC)":[54],"typically":[55],"undergo":[56],"partial":[57],"glossectomy;":[58],"development":[60,318],"delayed":[62],"metastasis":[64],"(DNM)":[65],"tends":[66],"reduce":[68],"their":[69,90],"survival.":[70],"In":[71,133],"present":[73],"study,":[74],"we":[75],"aimed":[76],"determine":[78],"markers":[81,102,125,311],"HNSCC":[86,118],"along":[88,330],"functions":[91],"cellular":[93,144],"behaviors,":[94],"clarify":[97],"association":[99],"these":[101],"DNM.":[104,233,262,351],"METHODS:":[105],"Flow":[106],"cytometry":[107],"was":[108,126,207],"applied":[109],"isolate":[111],"from":[113,160],"main":[114],"(MP)":[116],"cells.":[119,190],"expression":[121,216,240,334],"examined":[127],"by":[128,323],"semi-quantitative":[129],"RT-PCR":[130],"immunocytochemistry.":[132],"vitro":[134],"proliferation,":[135],"migration,":[136],"invasion":[138,195,228,250,286],"assays":[139],"were":[140,155,169,183,197,229,258],"performed":[141],"assess":[143],"behaviors.":[145],"Clinicopathological":[146],"factors":[147],"immunohistochemical":[149],"expressions":[150],"Oct3/4":[152,180,218,239,267,305,336],"Nanog":[154,182,307],"evaluated":[156],"using":[157],"surgical":[158],"specimens":[159],"50":[161],"patients":[162,345],"TSCC.":[166],"RESULTS:":[167],"SPs":[168],"isolated":[170],"all":[172],"three":[173],"lines":[175],"examined.":[176],"Expression":[177],"levels":[178],"higher":[184,198],"than":[188,202],"MP":[189,203],"Additionally,":[191],"migration":[193],"abilities":[196],"cells,":[204],"whereas":[205],"there":[206],"no":[208],"difference":[209],"proliferation.":[211],"Univariate":[212],"analysis":[213],"showed":[214,268,287],"that":[215,238,304],"Nanog,":[220],"vascular":[221,249,285,332],"muscular":[223],"invasion,":[224,333],"mode":[226],"significantly":[230],"correlated":[231],"Multivariate":[234],"logistic":[235],"regression":[236],"revealed":[237],"(risk":[241,251],"ratio":[242,252],"=":[243,246,253,256],"14.78,":[244],"p":[245,255],"0.002)":[247],"12.93,":[254],"0.017)":[257],"independently":[259],"predictive":[260],"Regarding":[263],"diagnostic":[265],"performance,":[266],"highest":[270,289],"accuracy,":[271],"sensitivity,":[272],"NPV":[274],"82.0":[276],"%,":[277,279,282,298],"61.5":[278],"86.8":[281],"respectively,":[283],"while":[284],"specificity":[290],"PPV":[292],"94.6":[294],"%":[295],"71.4":[297],"respectively.":[299],"CONCLUSION:":[300],"These":[301],"results":[302],"suggest":[303],"represent":[308],"probable":[309],"HNSCC,":[313],"which":[314],"contribute":[315],"DNM":[320],"part":[322],"enhancing":[324],"motility":[326],"invasiveness.":[328],"Moreover,":[329],"can":[337],"considered":[339],"a":[340],"potential":[341],"predictor":[342],"for":[343],"selecting":[344],"at":[346],"high":[347],"risk":[348],"developing":[350]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
