{"id":"https://openalex.org/W2099310472","doi":"https://doi.org/10.1016/j.virusres.2015.10.006","title":"Identification of two amino acids within E2 important for the pathogenicity of chimeric classical swine fever virus","display_name":"Identification of two amino acids within E2 important for the pathogenicity of chimeric classical swine fever virus","publication_year":2015,"publication_date":"2015-10-26","ids":{"openalex":"https://openalex.org/W2099310472","doi":"https://doi.org/10.1016/j.virusres.2015.10.006","mag":"2099310472","pmid":"https://pubmed.ncbi.nlm.nih.gov/26454191"},"language":"en","primary_location":{"id":"doi:10.1016/j.virusres.2015.10.006","doi":"https://doi.org/10.1016/j.virusres.2015.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.virusres.2015.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S114911520","display_name":"Virus Research","issn_l":"0168-1702","issn":["0168-1702","1872-7492"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virus Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032870549","display_name":"Rui Wu","orcid":"https://orcid.org/0000-0002-9170-0517","observed_orcids":["https://orcid.org/0000-0002-9170-0517"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Wu","raw_affiliation_strings":["State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4391768268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435374","display_name":"Ling Li","orcid":"https://orcid.org/0000-0003-2938-4303","observed_orcids":["https://orcid.org/0000-0003-2938-4303"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Li","raw_affiliation_strings":["State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4391768268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103940043","display_name":"Yu Zhao","orcid":"https://orcid.org/0009-0008-0727-5994","observed_orcids":["https://orcid.org/0009-0008-0727-5994"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zhao","raw_affiliation_strings":["State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4391768268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101665103","display_name":"Jun Tu","orcid":"https://orcid.org/0000-0003-0867-1522","observed_orcids":["https://orcid.org/0000-0003-0867-1522"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Tu","raw_affiliation_strings":["Wuhan Chopper Biology Co., LTD, Wuhan 430070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Chopper Biology Co., LTD, Wuhan 430070, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062218864","display_name":"Zishu Pan","orcid":"https://orcid.org/0000-0002-5326-3264","observed_orcids":["https://orcid.org/0000-0002-5326-3264"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zishu Pan","raw_affiliation_strings":["State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China. Electronic address: zspan@whu.edu.cn","State key laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China. Electronic address: zspan@whu.edu.cn","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4391768268"]},{"raw_affiliation_string":"State key laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4391768268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062218864"],"corresponding_institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4391768268"],"apc_list":{"value":3010,"currency":"USD","value_usd":3010},"apc_paid":null,"fwci":2.7044,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.87223933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"211","issue":null,"first_page":"79","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.2232999950647354,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/classical-swine-fever-virus","display_name":"classical swine fever virus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/e2-glycoprotein","display_name":"E2 glycoprotein","score":0.9190000295639038},{"id":"https://openalex.org/keywords/chimeric-viruses","display_name":"chimeric viruses","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pathogenicity","display_name":"pathogenicity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/amino-acid-mutations","display_name":"amino acid mutations","score":0.6769999861717224},{"id":"https://openalex.org/keywords/shimen-strain","display_name":"Shimen strain","score":0.6520000100135803},{"id":"https://openalex.org/keywords/virus-attenuation","display_name":"viral attenuation","score":0.5090000033378601},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.5540000200271606},{"id":"https://openalex.org/keywords/reverse-genetics","display_name":"reverse genetics","score":0.5559999942779541},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8798581957817078},{"id":"https://openalex.org/C2779005923","wikidata":"https://www.wikidata.org/wiki/Q683770","display_name":"Classical swine fever","level":3,"score":0.8579623103141785},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.740364134311676},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7320491075515747},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6940080523490906},{"id":"https://openalex.org/C25365240","wikidata":"https://www.wikidata.org/wiki/Q1897151","display_name":"Reverse genetics","level":4,"score":0.6016737818717957},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49622660875320435},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.491190642118454},{"id":"https://openalex.org/C64502627","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogenicity","level":2,"score":0.49076589941978455},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43932634592056274},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.42363405227661133},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.34584906697273254},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3244624137878418},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.28384536504745483}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006691","descriptor_name":"Classical Swine Fever","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006692","descriptor_name":"Classical Swine Fever Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006692","descriptor_name":"Classical Swine Fever Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006692","descriptor_name":"Classical Swine Fever Virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D006692","descriptor_name":"Classical Swine Fever Virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.virusres.2015.10.006","doi":"https://doi.org/10.1016/j.virusres.2015.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.virusres.2015.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S114911520","display_name":"Virus Research","issn_l":"0168-1702","issn":["0168-1702","1872-7492"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virus Research","raw_type":"journal-article"},{"id":"pmid:26454191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26454191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virus research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W580141916","https://openalex.org/W1040741532","https://openalex.org/W1521322505","https://openalex.org/W1538173922","https://openalex.org/W1861104203","https://openalex.org/W2007997330","https://openalex.org/W2010133928","https://openalex.org/W2018996246","https://openalex.org/W2027560652","https://openalex.org/W2035948945","https://openalex.org/W2039277389","https://openalex.org/W2039774355","https://openalex.org/W2046887653","https://openalex.org/W2051553690","https://openalex.org/W2054667493","https://openalex.org/W2072576519","https://openalex.org/W2092916490","https://openalex.org/W2105988008","https://openalex.org/W2108827586","https://openalex.org/W2110639041","https://openalex.org/W2129770092","https://openalex.org/W2136238132","https://openalex.org/W2159527899","https://openalex.org/W2159776316","https://openalex.org/W2160972243","https://openalex.org/W2172085583","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2159527899","https://openalex.org/W2039277389","https://openalex.org/W4220943513","https://openalex.org/W2160972243","https://openalex.org/W2727121778","https://openalex.org/W2508320949","https://openalex.org/W2010133928","https://openalex.org/W2106218159","https://openalex.org/W2146795482","https://openalex.org/W2621349231"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}