{"id":"https://openalex.org/W2099263276","doi":"https://doi.org/10.1161/01.res.77.4.651","title":"Ligation of Endothelial \u03b1 v \u03b2 3 Integrin Increases Capillary Hydraulic Conductivity of Rat Lung","display_name":"Ligation of Endothelial \u03b1 v \u03b2 3 Integrin Increases Capillary Hydraulic Conductivity of Rat Lung","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W2099263276","doi":"https://doi.org/10.1161/01.res.77.4.651","mag":"2099263276","pmid":"https://pubmed.ncbi.nlm.nih.gov/7554109"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.77.4.651","doi":"https://doi.org/10.1161/01.res.77.4.651","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.77.4.651","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079597293","display_name":"Hiroshi Tsukada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroshi Tsukada","raw_affiliation_strings":["From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Physiology (P.M.-L.), Albany (NY) Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I1321572752","https://openalex.org/I78577930","https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Physiology (P.M.-L.), Albany (NY) Medical College","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109591535","display_name":"Xiaoyou Ying","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyou Ying","raw_affiliation_strings":["From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Physiology (P.M.-L.), Albany (NY) Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I1321572752","https://openalex.org/I78577930","https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Physiology (P.M.-L.), Albany (NY) Medical College","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042830767","display_name":"Chenzhong Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenzhong Fu","raw_affiliation_strings":["From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Physiology (P.M.-L.), Albany (NY) Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I1321572752","https://openalex.org/I78577930","https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Physiology (P.M.-L.), Albany (NY) Medical College","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085901337","display_name":"Shigemi Ishikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shigemi Ishikawa","raw_affiliation_strings":["From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Physiology (P.M.-L.), Albany (NY) Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I1321572752","https://openalex.org/I78577930","https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Physiology (P.M.-L.), Albany (NY) Medical College","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038879605","display_name":"Paula J. McKeown\u2010Longo","orcid":"https://orcid.org/0000-0001-8945-5762","observed_orcids":["https://orcid.org/0000-0001-8945-5762"]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula McKeown-Longo","raw_affiliation_strings":["From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Physiology (P.M.-L.), Albany (NY) Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I1321572752","https://openalex.org/I78577930","https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Physiology (P.M.-L.), Albany (NY) Medical College","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005953721","display_name":"Steven \u039c. Albelda","orcid":"https://orcid.org/0000-0002-6598-3752","observed_orcids":["https://orcid.org/0000-0002-6598-3752"]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Albelda","raw_affiliation_strings":["From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Physiology (P.M.-L.), Albany (NY) Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I1321572752","https://openalex.org/I78577930","https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Physiology (P.M.-L.), Albany (NY) Medical College","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089054248","display_name":"Sunita Bhattacharya","orcid":"https://orcid.org/0000-0002-2476-1280","observed_orcids":["https://orcid.org/0000-0002-2476-1280"]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunita Bhattacharya","raw_affiliation_strings":["From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Physiology (P.M.-L.), Albany (NY) Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I1321572752","https://openalex.org/I78577930","https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Physiology (P.M.-L.), Albany (NY) Medical College","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031817279","display_name":"Bonnie Anderson Bray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonnie Anderson Bray","raw_affiliation_strings":["From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Physiology (P.M.-L.), Albany (NY) Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I1321572752","https://openalex.org/I78577930","https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Physiology (P.M.-L.), Albany (NY) Medical College","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076054649","display_name":"Jahar Bhattacharya","orcid":"https://orcid.org/0000-0002-5588-6211","observed_orcids":["https://orcid.org/0000-0002-5588-6211"]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jahar Bhattacharya","raw_affiliation_strings":["From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","the Department of Physiology (P.M.-L.), Albany (NY) Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (H.T., X.Y., C.F., S.I., B.A.B., J.B.), Physiology & Cellular Biophysics (J.B.), and Pediatrics (S.B.), College of Physicians & Surgeons, Columbia University, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY; the Department of Physiology (P.M.-L.), Albany (NY) Medical College; and the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I1321572752","https://openalex.org/I78577930","https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Medicine (S.A.), University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Physiology (P.M.-L.), Albany (NY) Medical College","institution_ids":["https://openalex.org/I4405260259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9588,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.75208513,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"77","issue":"4","first_page":"651","last_page":"659"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-v-beta3-integrin","display_name":"alpha v beta 3 integrin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/vitronectin","display_name":"vitronectin","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tyrosine-kinase-signaling","display_name":"tyrosine kinase signaling","score":0.9010000228881836},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.8500000238418579},{"id":"https://openalex.org/keywords/zymosan-activated-serum","display_name":"zymosan-activated serum","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.7787383794784546},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5809432864189148},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5033764243125916},{"id":"https://openalex.org/C2780245509","wikidata":"https://www.wikidata.org/wiki/Q5023913","display_name":"Calphostin C","level":4,"score":0.4991185665130615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45187681913375854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3444064259529114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32602056860923767},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3204272389411926},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3172696828842163},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24040743708610535},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.2185111939907074},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19445070624351501},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15956813097000122}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015938","descriptor_name":"Complement Membrane Attack Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019030","descriptor_name":"Receptors, Vitronectin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.res.77.4.651","doi":"https://doi.org/10.1161/01.res.77.4.651","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.77.4.651","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:7554109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7554109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G382402740","display_name":null,"funder_award_id":"HL-36024","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G557961099","display_name":null,"funder_award_id":"CA-58626","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W121092139","https://openalex.org/W1494049520","https://openalex.org/W1494832268","https://openalex.org/W1522673104","https://openalex.org/W1559044733","https://openalex.org/W1565477787","https://openalex.org/W1581836002","https://openalex.org/W1583092524","https://openalex.org/W1656644300","https://openalex.org/W1965050416","https://openalex.org/W1970539529","https://openalex.org/W1989002893","https://openalex.org/W1991011809","https://openalex.org/W2001753204","https://openalex.org/W2014414465","https://openalex.org/W2018732312","https://openalex.org/W2026327508","https://openalex.org/W2029773366","https://openalex.org/W2033393629","https://openalex.org/W2038750138","https://openalex.org/W2041875613","https://openalex.org/W2053001031","https://openalex.org/W2062810137","https://openalex.org/W2066279385","https://openalex.org/W2070564979","https://openalex.org/W2079476443","https://openalex.org/W2082929638","https://openalex.org/W2084162464","https://openalex.org/W2087192520","https://openalex.org/W2104069909","https://openalex.org/W2110810854","https://openalex.org/W2142714350","https://openalex.org/W2145247599","https://openalex.org/W2148849095","https://openalex.org/W2152133730","https://openalex.org/W2155010287","https://openalex.org/W2156411608","https://openalex.org/W2169654353","https://openalex.org/W2177719047","https://openalex.org/W2224334460","https://openalex.org/W2281459428","https://openalex.org/W2286744586","https://openalex.org/W2327150539","https://openalex.org/W2336469222","https://openalex.org/W2339721493","https://openalex.org/W2399064038","https://openalex.org/W6844766922"],"related_works":["https://openalex.org/W2264105930","https://openalex.org/W2049725813","https://openalex.org/W7019857053","https://openalex.org/W1965050416","https://openalex.org/W2460792408","https://openalex.org/W122617136","https://openalex.org/W2133701478","https://openalex.org/W7097154811","https://openalex.org/W1797781559","https://openalex.org/W2065433187"],"abstract_inverted_index":{"Complement-mediated":[0],"pulmonary":[1],"edema":[2],"results":[3],"from":[4],"increases":[5,62,128,167],"in":[6,53],"lung":[7,55,164],"capillary":[8,165],"hydraulic":[9],"conductivity":[10],"(Lp),":[11],"possibly":[12],"by":[13,49,65,83,92,104],"receptor-mediated":[14],"mechanisms.":[15],"We":[16,148],"considered":[17],"the":[18,24,31,50,75,97,137,155,173],"Lp":[19,61,127],"effects":[20],"of":[21,57,126,154,163],"vitronectin":[22,131],"and":[23,39,69,119,132,171],"vitronectin-containing":[25],"complement":[26],"complex":[27],"SC5b-9,":[28,38],"which":[29],"ligate":[30],"integrin":[32,80,162],"alpha":[33,76,98,158],"v":[34,77,99,159],"beta":[35,78,100,160],"3.":[36],"Vitronectin,":[37],"SC5b-9-enriched":[40],"zymosan-activated":[41,133],"serum":[42],"all":[43],"rapidly":[44],"increased":[45],"Lp,":[46],"as":[47],"determined":[48],"split-drop":[51],"technique":[52],"single":[54],"capillaries":[56],"rat":[58],"lung.":[59],"The":[60,114],"were":[63],"inhibited":[64],"a":[66,70,93],"monospecific":[67],"(LM609)":[68],"polyclonal":[71],"(R838)":[72],"antibody":[73,87,95],"against":[74,96],"3":[79,161],"but":[81],"not":[82],"an":[84],"irrelevant":[85],"monoclonal":[86,94],"isotype":[88],"matched":[89],"with":[90],"LM609,":[91],"5":[101],"integrin,":[102],"or":[103],"preimmune":[105],"rabbit":[106],"serum.":[107,134],"Vitronectin":[108],"monomers":[109],"failed":[110],"to":[111,130],"increase":[112],"Lp.":[113],"tyrosine":[115,183],"kinase":[116,139,184],"blockers":[117],"genistein":[118],"methyl":[120],"2,5-dihydroxycinnamate":[121],"caused":[122],"significant":[123],"concentration-dependent":[124],"inhibitions":[125],"due":[129],"By":[135],"contrast,":[136],"protein":[138],"C":[140,143],"blocker":[141],"calphostin":[142],"had":[144],"no":[145],"major":[146],"effect.":[147],"conclude":[149],"that":[150],"(1)":[151],"multivalent":[152],"ligation":[153],"luminally":[156],"located":[157],"endothelium":[166],"transcapillary":[168],"liquid":[169],"flux,":[170],"(2)":[172],"dominant":[174],"signal":[175],"transduction":[176],"pathway":[177],"for":[178],"this":[179],"effect":[180],"occurs":[181],"through":[182],"activation.":[185]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}