{"id":"https://openalex.org/W2099175348","doi":null,"title":"Pivotal role of the nuclear receptor PPARgamma in colon epithelial cells","display_name":"Pivotal role of the nuclear receptor PPARgamma in colon epithelial cells","publication_year":2004,"publication_date":"2004-02-27","ids":{"openalex":"https://openalex.org/W2099175348","mag":"2099175348"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26895772","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Pivotal_role_of_the_nuclear_receptor_PPARgamma_in_colon_epithelial_cells/26895772","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/38487","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109878932","display_name":"Emmelie \u00c5. Jansson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emmelie \u00c5. Jansson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109878932"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/colonic-epithelial-cells","display_name":"colonic epithelial cells","score":0.8579999804496765},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/commensal-bacteria","display_name":"commensal bacteria","score":0.7879999876022339},{"id":"https://openalex.org/keywords/bacteroides-thetaiotaomicron","display_name":"Bacteroides thetaiotaomicron","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tlr4-signaling","display_name":"TLR4 signaling","score":0.9390000104904175},{"id":"https://openalex.org/keywords/germ-free-mice","display_name":"germ-free mice","score":0.9269999861717224},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.5759999752044678},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.42100000381469727},{"id":"https://openalex.org/keywords/anti-inflammatory-mechanism","display_name":"anti-inflammatory mechanism","score":0.3970000147819519},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.7210000157356262},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.6605426073074341},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6370188593864441},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5812406539916992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5515888333320618},{"id":"https://openalex.org/C2908934157","wikidata":"https://www.wikidata.org/wiki/Q798597","display_name":"Bacteroides thetaiotaomicron","level":4,"score":0.5504353046417236},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.5341208577156067},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.491884708404541},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.4860127866268158},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.46602579951286316},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.42855218052864075},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4223301410675049},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3975628614425659},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34136635065078735},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.23467731475830078},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22920465469360352},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21526756882667542},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.20604249835014343},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1998271346092224},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19159075617790222},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07991063594818115},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26895772","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Pivotal_role_of_the_nuclear_receptor_PPARgamma_in_colon_epithelial_cells/26895772","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/38487","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38487","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2099175348","doi":null,"is_oa":false,"landing_page_url":"http://openarchive.ki.se/xmlui/bitstream/10616/38487/1/thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/38487","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38487","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":175,"referenced_works":["https://openalex.org/W91098912","https://openalex.org/W166805679","https://openalex.org/W1483162601","https://openalex.org/W1485161311","https://openalex.org/W1494611500","https://openalex.org/W1505047300","https://openalex.org/W1507061074","https://openalex.org/W1511823445","https://openalex.org/W1527649416","https://openalex.org/W1547109494","https://openalex.org/W1551951780","https://openalex.org/W1570767394","https://openalex.org/W1621684029","https://openalex.org/W1633340712","https://openalex.org/W1639924204","https://openalex.org/W1789825216","https://openalex.org/W1812573520","https://openalex.org/W1843523988","https://openalex.org/W1856169132","https://openalex.org/W1857766814","https://openalex.org/W1897551156","https://openalex.org/W1911224311","https://openalex.org/W1945510071","https://openalex.org/W1965553518","https://openalex.org/W1967251205","https://openalex.org/W1968134126","https://openalex.org/W1968703258","https://openalex.org/W1969161886","https://openalex.org/W1969437387","https://openalex.org/W1969839676","https://openalex.org/W1969941746","https://openalex.org/W1971432398","https://openalex.org/W1973557663","https://openalex.org/W1977480736","https://openalex.org/W1977508482","https://openalex.org/W1978125779","https://openalex.org/W1979618971","https://openalex.org/W1979993283","https://openalex.org/W1985118687","https://openalex.org/W1985689886","https://openalex.org/W1986242902","https://openalex.org/W1989800047","https://openalex.org/W1990120674","https://openalex.org/W1990606472","https://openalex.org/W1991293484","https://openalex.org/W1994964287","https://openalex.org/W1995398218","https://openalex.org/W1995558575","https://openalex.org/W1995975692","https://openalex.org/W1999855196","https://openalex.org/W2001018199","https://openalex.org/W2002375694","https://openalex.org/W2002404925","https://openalex.org/W2002519246","https://openalex.org/W2003115027","https://openalex.org/W2005674716","https://openalex.org/W2006959379","https://openalex.org/W2008632158","https://openalex.org/W2010184221","https://openalex.org/W2010438605","https://openalex.org/W2011778539","https://openalex.org/W2011843272","https://openalex.org/W2016153572","https://openalex.org/W2016443141","https://openalex.org/W2016754754","https://openalex.org/W2017443683","https://openalex.org/W2018884883","https://openalex.org/W2021285446","https://openalex.org/W2021758696","https://openalex.org/W2022048961","https://openalex.org/W2025631499","https://openalex.org/W2029157767","https://openalex.org/W2030693139","https://openalex.org/W2033728702","https://openalex.org/W2036541245","https://openalex.org/W2036999913","https://openalex.org/W2037153840","https://openalex.org/W2039661491","https://openalex.org/W2040266493","https://openalex.org/W2046833545","https://openalex.org/W2047591801","https://openalex.org/W2049643877","https://openalex.org/W2050318141","https://openalex.org/W2051188589","https://openalex.org/W2053567111","https://openalex.org/W2057618822","https://openalex.org/W2057830803","https://openalex.org/W2058118313","https://openalex.org/W2059813946","https://openalex.org/W2059895383","https://openalex.org/W2060110412","https://openalex.org/W2061440069","https://openalex.org/W2063726851","https://openalex.org/W2065667627","https://openalex.org/W2066092624","https://openalex.org/W2067526109","https://openalex.org/W2068947460","https://openalex.org/W2071343795","https://openalex.org/W2074058488","https://openalex.org/W2077012773","https://openalex.org/W2078535741","https://openalex.org/W2078591745","https://openalex.org/W2079968415","https://openalex.org/W2080801828","https://openalex.org/W2080988481","https://openalex.org/W2081572587","https://openalex.org/W2081846665","https://openalex.org/W2084708456","https://openalex.org/W2085385977","https://openalex.org/W2086320165","https://openalex.org/W2087647782","https://openalex.org/W2088404163","https://openalex.org/W2090553336","https://openalex.org/W2091321756","https://openalex.org/W2091695331","https://openalex.org/W2092040814","https://openalex.org/W2093797523","https://openalex.org/W2095833996","https://openalex.org/W2096215604","https://openalex.org/W2098588381","https://openalex.org/W2099376515","https://openalex.org/W2099939845","https://openalex.org/W2101463611","https://openalex.org/W2103314962","https://openalex.org/W2106787323","https://openalex.org/W2106877484","https://openalex.org/W2108345134","https://openalex.org/W2108727531","https://openalex.org/W2109069210","https://openalex.org/W2110223162","https://openalex.org/W2112558428","https://openalex.org/W2112832648","https://openalex.org/W2113456624","https://openalex.org/W2114786602","https://openalex.org/W2114864434","https://openalex.org/W2115518955","https://openalex.org/W2116101489","https://openalex.org/W2120459847","https://openalex.org/W2123927174","https://openalex.org/W2127230663","https://openalex.org/W2134567873","https://openalex.org/W2136419595","https://openalex.org/W2141175150","https://openalex.org/W2145717531","https://openalex.org/W2146597835","https://openalex.org/W2149022033","https://openalex.org/W2149351690","https://openalex.org/W2151807579","https://openalex.org/W2152123530","https://openalex.org/W2156575042","https://openalex.org/W2156896745","https://openalex.org/W2157393124","https://openalex.org/W2158569397","https://openalex.org/W2159980792","https://openalex.org/W2161174158","https://openalex.org/W2161276143","https://openalex.org/W2165655699","https://openalex.org/W2165989770","https://openalex.org/W2166027111","https://openalex.org/W2166254889","https://openalex.org/W2167215692","https://openalex.org/W2169224393","https://openalex.org/W2170932034","https://openalex.org/W2171685880","https://openalex.org/W2171996338","https://openalex.org/W2174491121","https://openalex.org/W2189490860","https://openalex.org/W2258483157","https://openalex.org/W2333284976","https://openalex.org/W2335925695","https://openalex.org/W2398863832","https://openalex.org/W2411951155","https://openalex.org/W2505983032","https://openalex.org/W2619645383","https://openalex.org/W7097257549"],"related_works":["https://openalex.org/W2148649000","https://openalex.org/W2009938323","https://openalex.org/W2085843498","https://openalex.org/W2011690287","https://openalex.org/W2412736801","https://openalex.org/W2003115027","https://openalex.org/W2136054045","https://openalex.org/W2313360377","https://openalex.org/W2057099241","https://openalex.org/W7164133969"],"abstract_inverted_index":{"When":[0],"symbiosis":[1],"between":[2,259,280,333,387,687],"the":[3,8,12,31,45,88,100,154,181,186,199,208,229,235,238,241,246,269,293,308,374,379,384,413,454,460,472,690],"residential":[4],"intestinal":[5,282],"flora":[6],"and":[7,38,56,177,217,252,264,286,336,389,412,496,526,534,550,622,669,689],"epithelial":[9,32,170],"cells":[10,171,206,366],"of":[11,30,36,40,47,51,77,90,112,126,153,158,166,190,198,262,272,284,292,360,405,417,440,463,467,494,514,532,542,554,579,620,649,667],"gastrointestinal":[13,200],"tract":[14],"is":[15,71,256,313,373,442,449],"broken":[16],"one":[17,152,251,540],"endpoint":[18],"may":[19,331,458,485,500],"be":[20,353,486,501,518],"chronic":[21,326],"inflammation,":[22],"e.g.":[23,444],"Inflammatory":[24],"Bowel":[25],"Disease":[26],"(IBD).":[27],"The":[28,511,528],"disruption":[29],"lining":[33],"elicits":[34],"activation":[35],"NF-kappaB":[37,52,66,98,263,288,650],"secretion":[39],"potent":[41],"inflammatory":[42,544,656],"mediators.":[43],"In":[44,114,180,240,303,378,470],"case":[46],"IBD,":[48,159],"elevated":[49,287,402,661],"levels":[50,125,165,261,267,283,296,317,404,439,457,666],"have":[53,61],"been":[54,62,368],"observed":[55,279,302],"interestingly":[57],"several":[58],"nuclear":[59,110],"receptors":[60],"reported":[63],"to":[64,96,173,225,231,237,325,346,451,482,504],"attenuate":[65,614],"activity.":[67],"One":[68,370],"such":[69,349,523],"receptor":[70,582],"PPARgamma.":[72,127,406],"My":[73],"thesis":[74],"presents":[75],"evidence":[76],"a":[78,106,161,193,257,337,350,424,430,490],"possible":[79,187,371,385],"molecular":[80],"mechanism":[81],"whereby":[82],"commensal":[83,196],"bacteria":[84,142,197,613],"not":[85,137],"only":[86],"regulate":[87,144],"expression":[89,124,578],"PPARgamma,":[91,533],"but":[92],"also":[93,130],"its":[94,145,361,535],"ability":[95,230],"export":[97,111],"from":[99,234,655],"nucleus,":[101],"independently":[102],"Of":[103],"IkappaB,":[104],"suggesting":[105],"novel":[107],"pathway":[108],"for":[109,355],"NF-kappaB.":[113],"paper":[115,250],"I":[116],"we":[117,129,184,244,305,382],"show":[118,131,306,393,409],"that":[119,132,141,221,307,394,410,453,497,546],"TLR4":[120],"signalling":[121,419],"can":[122,143,422,517],"increase":[123],"Moreover":[128],"germ":[133],"free":[134],"mice":[135],"do":[136],"express":[138],"PPARgamma":[139,167,222,266,285,356,388,398,425,464,668],"indicating":[140],"expression.":[146],"Interestingly,":[147],"patients":[148,176,299,659],"with":[149,207,215,397,664],"ulcerative":[150,585],"colitis,":[151],"two":[155],"main":[156],"forms":[157],"display":[160],"defect":[162],"in":[163,168,204,213,249,268,318,363,401,429,445,465,475,584,651,662],"protein":[164,330,403],"colonic":[169,270,364,653],"compared":[172],"Crohn's":[174],"disease":[175,658],"healthy":[178],"controls.":[179],"second":[182],"paper,":[183],"assess":[185,253,347],"anti-inflammatory":[188],"effects":[189,359],"Bacteroides":[191],"thetaiotaomicron,":[192,227],"common":[194],"anaerobic":[195,611],"tract,":[201],"upon":[202,223],"co-infection":[203],"CaCo-2":[205],"pathogenic":[209],"Salmonella":[210],"enterica.":[211],"Immunohistochemistry":[212],"combination":[214],"biochemical":[216],"functional":[218,685],"experiments":[219],"revealed":[220],"exposure":[224],"B.":[226],"possess":[228],"shuttle":[232],"NFkappaB":[233,295],"nucleus":[236],"cytosol.":[239],"third":[242],"manuscript":[243,381],"extend":[245],"observations":[247],"presented":[248,474],"whether":[254,348],"there":[255],"relationship":[258],"high":[260],"low":[265,281,665],"epithelium":[271],"IBD":[273,298],"patients.":[274],"No":[275],"strict":[276],"correlation":[277],"was":[278],"levels.":[289],"Individual":[290],"variations":[291],"absolute":[294],"among":[297],"were":[300],"however":[301],"addition,":[304],"apoptosis":[309],"inducing":[310],"ligand,":[311],"TRAIL,":[312],"expressed":[314],"at":[315],"lower":[316],"inflamed":[319,652],"colon":[320,446],"mucosa,":[321],"thereby":[322],"linking":[323],"it":[324,448],"inflammation.":[327],"A":[328],"DNA-binding":[329],"switch":[332],"an":[334,543],"activator":[335],"repressor,":[338],"depending":[339],"on":[340],"cofactor":[341],"assembly.":[342],"This":[343],"prompted":[344],"us":[345],"factor":[351,372],"could":[352],"identified":[354],"since":[357],"opposing":[358],"function":[362,462],"tumor":[365],"had":[367],"reported.":[369],"transcriptional":[375],"co-factor":[376],"beta-catenin.":[377,390],"final":[380],"examine":[383],"interplay":[386],"Biochemical":[391],"data":[392,408,473],"beta-catenin":[395,411,441,456],"interacts":[396],"which":[399],"results":[400],"Functional":[407],"known":[414],"chemical":[415],"agonist":[416],"Writ":[418],"Lithium":[420],"chloride,":[421],"activate":[423],"dependent":[426,432],"reporter":[427],"gene":[428],"dose":[431],"manner.":[433],"Hence,":[434],"under":[435,508],"conditions":[436],"where":[437],"abnormal":[438],"observed,":[443],"cancer,":[447],"tempting":[450],"speculate":[452],"altered":[455],"change":[459],"net":[461],"favour":[466],"cell":[468],"growth.":[469],"summary,":[471],"this":[476],"thesis,":[477],"provide":[478],"some":[479],"aspects":[480],"as":[481,524,539],"how":[483],"homeostasis":[484,549],"tightly":[487],"regulated":[488],"by":[489,520,616],"very":[491],"limited":[492],"set":[493],"factors":[495,499],"these":[498,515],"intimately":[502],"connected":[503],"execute":[505],"multiple":[506],"functions":[507,516,537],"stringent":[509],"control.":[510,552],"fine":[512],"tuning":[513],"guided":[519],"epigenetic":[521],"factors,":[522],"microbes":[525],"nutrients.":[527],"strategic":[529],"tissue":[530],"distribution":[531],"pleiotropic":[536],"serve":[538],"example":[541],"gatekeeper":[545],"integrates":[547],"gut":[548,612],"metabolic":[551],"List":[553],"scientific":[555],"papers":[556],"I.":[557],"Dubuquoy":[558],"L,":[559],"Jansson":[560,601,635,673],"EA,":[561,602,636,674],"Deeb":[562],"S,":[563,565,573,606],"Rakotobe":[564],"Karoui":[566],"M,":[567],"Colombel":[568],"JF,":[569],"Auwerx":[570],"J,":[571],"Pettersson":[572,605,645,681],"Desreumaux":[574],"P":[575],"(2003).":[576],"\"Impaired":[577],"peroxisome":[580,691],"proliferator-activated":[581],"gamma":[583],"colitis.":[586],"\"":[587,624],"Gastroenterology":[588],"124(5):":[589],"1265-76":[590],"https://pubmed.ncbi.nlm.nih.gov/12730867":[591],"II.":[592],"Kelly":[593,677],"D,":[594,678],"Campbell":[595],"JI,":[596],"King":[597],"TP,":[598],"Grant":[599],"G,":[600],"Coutts":[603],"AG,":[604],"Conway":[607],"S":[608,646,682],"(2004).":[609,647,683],"\"Commensal":[610],"inflammation":[615],"regulating":[617],"nuclear-cytoplasmic":[618],"shuttling":[619],"PPAR-gamma":[621],"RelA.":[623],"Nat":[625],"Immunol":[626],"5(1):":[627],"104-12.":[628],"Epub":[629],"2003":[630],"Dec":[631],"21":[632],"https://pubmed.ncbi.nlm.nih.gov/14691478":[633],"III.":[634],"Spiik":[637],"A-K,":[638],"Axelsson":[639],"L-G,":[640],"Bresso":[641],"F,":[642],"Lofberg":[643],"R,":[644],"\"Levels":[648],"mucosa":[654],"bowel":[657],"are":[660],"parallel":[663],"TRAIL.\"":[670],"(Manuscript)":[671],"IV.":[672],"Are":[675],"A,":[676],"Arulampalam":[679],"V,":[680],"\"A":[684],"link":[686],"WNT-signalling/beta-catenin":[688],"proliferator":[692],"activated":[693],"receptor-gamma.\"":[694],"(Submitted)":[695]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
