{"id":"https://openalex.org/W2099096563","doi":"https://doi.org/10.1186/1758-5996-6-83","title":"CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models","display_name":"CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models","publication_year":2014,"publication_date":"2014-08-12","ids":{"openalex":"https://openalex.org/W2099096563","doi":"https://doi.org/10.1186/1758-5996-6-83","mag":"2099096563","pmid":"https://pubmed.ncbi.nlm.nih.gov/25143786","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4138375"},"language":"en","primary_location":{"id":"doi:10.1186/1758-5996-6-83","doi":"https://doi.org/10.1186/1758-5996-6-83","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-5996-6-83","pdf_url":"https://dmsjournal.biomedcentral.com/counter/pdf/10.1186/1758-5996-6-83","source":{"id":"https://openalex.org/S52792101","display_name":"Diabetology & Metabolic Syndrome","issn_l":"1758-5996","issn":["1758-5996"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetology &amp; Metabolic Syndrome","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dmsjournal.biomedcentral.com/counter/pdf/10.1186/1758-5996-6-83","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018898843","display_name":"Manoj Kumar Sadasivuni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manoj Kumar Sadasivuni","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056667323","display_name":"Bobbili Madhusudhan Reddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bobbili Madhusudhan Reddy","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000842580","display_name":"Jaideep K. Singh","orcid":"https://orcid.org/0000-0003-4422-392X","observed_orcids":["https://orcid.org/0000-0003-4422-392X"]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jaideep Singh","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084588976","display_name":"Anup Mammen Oommen","orcid":"https://orcid.org/0000-0001-7653-5106","observed_orcids":["https://orcid.org/0000-0001-7653-5106"]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mammen O Anup","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073773928","display_name":"Sunil Venkategowda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Venkategowda Sunil","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026720227","display_name":"Mudigere N Lakshmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mudigere N Lakshmi","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028856477","display_name":"Sivakumaran Yogeshwari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sivakumaran Yogeshwari","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025699495","display_name":"Suni K. Chacko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suni K Chacko","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054407420","display_name":"Talanki Lokesh Pooja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Talanki Lokesh Pooja","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049898297","display_name":"Anilkumar Dandu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anilkumar Dandu","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049291059","display_name":"Chandrashekaran Harish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chandrashekaran Harish","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021709046","display_name":"Aralakuppe S Gopala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aralakuppe S Gopala","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014270843","display_name":"Shivakumar Pratibha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shivakumar Pratibha","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071264623","display_name":"Baisani S Naveenkumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Baisani S Naveenkumar","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044826208","display_name":"Puttrevana M Pallavi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Puttrevana M Pallavi","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102077770","display_name":"Mahesh Kumar Verma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mahesh Kumar Verma","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026501238","display_name":"Yoganand Moolemath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yoganand Moolemath","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040052186","display_name":"Baggavalli P Somesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Baggavalli P Somesh","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084229216","display_name":"Marikunte Venkatanarasappa Venkataranganna","orcid":"https://orcid.org/0000-0002-0188-7243","observed_orcids":["https://orcid.org/0000-0002-0188-7243"]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Marikunte V Venkataranganna","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113692534","display_name":"Madanahalli R Jagannath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105948","display_name":"Connexios (India)","ror":"https://ror.org/01smpy304","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210105948"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Madanahalli R Jagannath","raw_affiliation_strings":["Connexios Life Sciences Pvt Ltd, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connexios Life Sciences Pvt Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210105948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113692534"],"corresponding_institution_ids":["https://openalex.org/I4210105948"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.2203,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.4982099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"6","issue":"1","first_page":"83","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.03629999980330467,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rexinoids","display_name":"rexinoids","score":0.8989999890327454},{"id":"https://openalex.org/keywords/retinoid-x-receptor","display_name":"retinoid X receptor","score":0.8709999918937683},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9570000171661377},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.781000018119812},{"id":"https://openalex.org/keywords/ppar-activation","display_name":"PPAR activation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/liver-x-receptor","display_name":"liver X receptor","score":0.7070000171661377},{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.6470000147819519},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor","display_name":"thyroid hormone receptor","score":0.7549999952316284},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.6959999799728394},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.781000018119812},{"id":"https://openalex.org/keywords/hepatomegaly","display_name":"hepatomegaly","score":0.8809999823570251},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.8009999990463257},{"id":"https://openalex.org/keywords/non-shivering-thermogenesis","display_name":"non-shivering thermogenesis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cold-tolerance","display_name":"cold tolerance","score":0.3700000047683716},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.3529999852180481},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8742321133613586},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.7805646657943726},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6090848445892334},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.5776440501213074},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5268139839172363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4274485409259796},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.420790433883667},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.366136372089386},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.20253869891166687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09209209680557251},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.06502524018287659}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1758-5996-6-83","doi":"https://doi.org/10.1186/1758-5996-6-83","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-5996-6-83","pdf_url":"https://dmsjournal.biomedcentral.com/counter/pdf/10.1186/1758-5996-6-83","source":{"id":"https://openalex.org/S52792101","display_name":"Diabetology & Metabolic Syndrome","issn_l":"1758-5996","issn":["1758-5996"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetology &amp; Metabolic Syndrome","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4138375","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4138375","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetol Metab Syndr","raw_type":"Text"},{"id":"pmid:25143786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25143786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetology & metabolic syndrome","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/1758-5996-6-83","doi":"https://doi.org/10.1186/1758-5996-6-83","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-5996-6-83","pdf_url":"https://dmsjournal.biomedcentral.com/counter/pdf/10.1186/1758-5996-6-83","source":{"id":"https://openalex.org/S52792101","display_name":"Diabetology & Metabolic Syndrome","issn_l":"1758-5996","issn":["1758-5996"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetology &amp; Metabolic Syndrome","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2099096563.pdf","grobid_xml":"https://content.openalex.org/works/W2099096563.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W15429299","https://openalex.org/W222706872","https://openalex.org/W1946563447","https://openalex.org/W1963769572","https://openalex.org/W1968173997","https://openalex.org/W1970825376","https://openalex.org/W1975982666","https://openalex.org/W1976450615","https://openalex.org/W1982920909","https://openalex.org/W1983128420","https://openalex.org/W1987052134","https://openalex.org/W1987601141","https://openalex.org/W1991893150","https://openalex.org/W1992958610","https://openalex.org/W1996263427","https://openalex.org/W1996499493","https://openalex.org/W1996885736","https://openalex.org/W1999669689","https://openalex.org/W2000054651","https://openalex.org/W2002536749","https://openalex.org/W2007667022","https://openalex.org/W2021207793","https://openalex.org/W2022420894","https://openalex.org/W2023229796","https://openalex.org/W2037917220","https://openalex.org/W2044763374","https://openalex.org/W2049481764","https://openalex.org/W2052013968","https://openalex.org/W2052516365","https://openalex.org/W2053951015","https://openalex.org/W2054462517","https://openalex.org/W2057443869","https://openalex.org/W2064326876","https://openalex.org/W2064535286","https://openalex.org/W2075858435","https://openalex.org/W2087613795","https://openalex.org/W2087822238","https://openalex.org/W2089714144","https://openalex.org/W2091544680","https://openalex.org/W2096639035","https://openalex.org/W2096842458","https://openalex.org/W2096876054","https://openalex.org/W2098596035","https://openalex.org/W2100448400","https://openalex.org/W2104320483","https://openalex.org/W2107054031","https://openalex.org/W2108911915","https://openalex.org/W2111291230","https://openalex.org/W2112448671","https://openalex.org/W2112546342","https://openalex.org/W2115248104","https://openalex.org/W2115520841","https://openalex.org/W2116613046","https://openalex.org/W2116623091","https://openalex.org/W2120116378","https://openalex.org/W2122660225","https://openalex.org/W2123289485","https://openalex.org/W2123336893","https://openalex.org/W2123936150","https://openalex.org/W2125656045","https://openalex.org/W2130092916","https://openalex.org/W2131483137","https://openalex.org/W2135009079","https://openalex.org/W2139692118","https://openalex.org/W2144829836","https://openalex.org/W2147312818","https://openalex.org/W2152216243","https://openalex.org/W2153673003","https://openalex.org/W2160222676","https://openalex.org/W2162463137","https://openalex.org/W2166012863","https://openalex.org/W2172203327","https://openalex.org/W2316751250"],"related_works":["https://openalex.org/W7095350384","https://openalex.org/W7098673630","https://openalex.org/W2087822238","https://openalex.org/W1972589661","https://openalex.org/W3031464481","https://openalex.org/W3038463830","https://openalex.org/W1992432475","https://openalex.org/W1990489419","https://openalex.org/W2120161339","https://openalex.org/W2261279697"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,236],"addition":[2],"to":[3,82,94,112,129,349],"their":[4],"role":[5],"in":[6,22,62,107,244,257,267,270,281,285,309],"growth,":[7],"cellular":[8],"differentiation":[9],"and":[10,19,29,35,43,69,87,144,167,190,226,228,234,261,269,291,306],"homeostasis":[11],"Retinoid":[12],"X":[13],"Receptors":[14],"(RXR)":[15],"regulate":[16],"multiple":[17,96,335],"physiological":[18],"metabolic":[20,54,101,340],"pathways":[21],"various":[23],"organs":[24],"that":[25,40,115,323],"have":[26],"beneficial":[27],"glucose":[28,188,246],"lipid":[30],"(cholesterol)":[31],"lowering,":[32],"insulin":[33,131,301],"sensitizing":[34],"anti-obesity":[36],"effects.":[37],"Rexinoids,":[38],"compounds":[39,114],"specifically":[41],"binds":[42],"activate":[44],"RXR,":[45],"are":[46],"therefore":[47],"considered":[48],"as":[49,204,327],"potential":[50,93],"therapeutics":[51],"for":[52,91,164,332],"treating":[53],"syndrome.":[55,102],"Apparently":[56],"many":[57],"of":[58,78,99,122,125,127,172,231,242,275,334,338,345],"the":[59,63,72,100,339,343],"rexinoids":[60],"developed":[61],"past":[64],"increased":[65],"triglycerides,":[66],"caused":[67],"hepatomegaly":[68],"also":[70],"suppressed":[71],"thyroid":[73],"hormone":[74],"axis.":[75],"The":[76],"aim":[77],"this":[79],"study":[80,200],"is":[81,316],"evaluate":[83],"CNX-013-B2,":[84],"a":[85,108,119,239,251,273,328],"potent":[86],"highly":[88],"selective":[89,321],"rexinoid,":[90],"its":[92],"treat":[95,130],"risk":[97,336,344],"factors":[98,337],"METHODS:":[103],"CNX-013-B2":[104,157,220,315],"was":[105],"selected":[106,196],"screening":[109],"system":[110],"designed":[111],"identify":[113],"selectively":[116,221],"activated":[117],"only":[118],"chosen":[120],"sub-set":[121],"heterodimer":[123],"partners":[124],"RXR":[126],"importance":[128],"resistance.":[132],"Male":[133],"C57BL/6j":[134],"mice":[135,149,238,272],"(n":[136,150],"=":[137,151],"10)":[138],"on":[139],"high":[140],"fat":[141],"diet":[142],"(HFD)":[143],"16":[145],"week":[146],"old":[147],"ob/ob":[148,237],"8)":[152],"were":[153,193,217,312],"treated":[154],"orally":[155,318],"with":[156,214,299,352],"(10":[158],"mg/kg":[159],"twice":[160],"daily)":[161],"or":[162],"vehicle":[163],"10":[165],"weeks":[166,169],"4":[168],"respectively.":[170],"Measurement":[171],"plasma":[173],"glucose,":[174,283],"triglyceride,":[175],"cholesterol":[176,260,293],"including":[177],"LDL-C,":[178],"glycerol,":[179],"free":[180],"fatty":[181],"acids,":[182],"feed":[183],"intake,":[184],"body":[185,310],"weight,":[186,206],"oral":[187],"tolerance":[189],"non-shivering":[191],"thermogenesis":[192,305],"performed":[194],"at":[195],"time":[197],"points.":[198],"After":[199],"termination":[201],"such":[202],"measurements":[203],"organ":[205],"triglyceride":[207,287],"content,":[208],"mRNA":[209],"levels,":[210,297],"protein":[211],"phosphorylation":[212],"along":[213],"histological":[215],"analysis":[216],"performed.":[218],"RESULTS:":[219],"activates":[222],"PPARs-":[223],"\u03b1,":[224],"\u03b2/\u03b4":[225],"\u03b3":[227],"modulates":[229],"activity":[230],"LXR,":[232],"THR":[233],"FXR.":[235],"significant":[240],"reduction":[241,256,274,308],"25%":[243],"fed":[245,286],"(p":[247,253,264,277,288,294],"<":[248,254,265,278,289,295],"0.001":[249],"),":[250],"14%":[252],"0.05)":[255],"serum":[258],"total":[259,292],"18%":[262],"decrease":[263],"0.01)":[266,290],"LDL-C":[268],"DIO":[271],"12%":[276],"0.01":[279],")":[280],"fasting":[282],"20%":[284],"0.001)":[296],"coupled":[298],"enhanced":[300],"sensitivity,":[302],"cold":[303],"induced":[304],"7%":[307],"weight":[311],"observed.":[313],"CONCLUSION:":[314],"an":[317],"bio":[319],"available":[320],"rexinoid":[322],"can":[324],"be":[325,350],"used":[326],"novel":[329],"therapeutic":[330],"agent":[331],"management":[333],"syndrome":[341],"without":[342],"side":[346],"effects":[347],"reported":[348],"associated":[351],"rexinoids.":[353]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
