{"id":"https://openalex.org/W2098914716","doi":null,"title":"Cell lineage tracing in the human pancreas","display_name":"Cell lineage tracing in the human pancreas","publication_year":2008,"publication_date":"2008-02-07","ids":{"openalex":"https://openalex.org/W2098914716","mag":"2098914716"},"language":"en","primary_location":{"id":"pmh:oai:stud.epsilon.slu.se:11410","doi":null,"is_oa":true,"landing_page_url":"https://stud.epsilon.slu.se/11410/","pdf_url":"https://stud.epsilon.slu.se/11410/","source":{"id":"https://openalex.org/S4306401562","display_name":"Epsilon Archive for Student Projects (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"L3"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://stud.epsilon.slu.se/11410/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085536352","display_name":"Julia Engqvist","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Julia Engqvist","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5085536352"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lineage-tracing","display_name":"lineage tracing","score":0.9240000247955322},{"id":"https://openalex.org/keywords/human-pancreas","display_name":"human pancreas","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mtdna-mutations","display_name":"mitochondrial DNA mutations","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.8230000138282776},{"id":"https://openalex.org/keywords/pancreatic-stem-cells","display_name":"pancreatic stem cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/pancreatic-regeneration","display_name":"pancreatic regeneration","score":0.8320000171661377},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.6990000009536743},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.4429999887943268},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.756371259689331},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6110855340957642},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.5994956493377686},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.558285117149353},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5260234475135803},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4621591866016388},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.4411608576774597},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4261522889137268},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3753873407840729},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3599589169025421},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20671150088310242},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10023090243339539}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:stud.epsilon.slu.se:11410","doi":null,"is_oa":true,"landing_page_url":"https://stud.epsilon.slu.se/11410/","pdf_url":"https://stud.epsilon.slu.se/11410/","source":{"id":"https://openalex.org/S4306401562","display_name":"Epsilon Archive for Student Projects (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"L3"},{"id":"mag:2098914716","doi":null,"is_oa":false,"landing_page_url":"http://epsilon.slu.se/10670570.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:stud.epsilon.slu.se:11410","doi":null,"is_oa":true,"landing_page_url":"https://stud.epsilon.slu.se/11410/","pdf_url":"https://stud.epsilon.slu.se/11410/","source":{"id":"https://openalex.org/S4306401562","display_name":"Epsilon Archive for Student Projects (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"L3"},"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2098914716.pdf","grobid_xml":"https://content.openalex.org/works/W2098914716.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W596882846","https://openalex.org/W1482760469","https://openalex.org/W1579015840","https://openalex.org/W1584701201","https://openalex.org/W1599875969","https://openalex.org/W1887455807","https://openalex.org/W1894632965","https://openalex.org/W1983411076","https://openalex.org/W1986815130","https://openalex.org/W1995812738","https://openalex.org/W1996262633","https://openalex.org/W2008008845","https://openalex.org/W2008477650","https://openalex.org/W2010377736","https://openalex.org/W2013978682","https://openalex.org/W2016886090","https://openalex.org/W2017435512","https://openalex.org/W2018185503","https://openalex.org/W2019264784","https://openalex.org/W2023427658","https://openalex.org/W2027670788","https://openalex.org/W2034772726","https://openalex.org/W2037029587","https://openalex.org/W2037896667","https://openalex.org/W2041739600","https://openalex.org/W2054554935","https://openalex.org/W2059297052","https://openalex.org/W2068687762","https://openalex.org/W2072400505","https://openalex.org/W2073615128","https://openalex.org/W2074725580","https://openalex.org/W2081673126","https://openalex.org/W2102085111","https://openalex.org/W2103794486","https://openalex.org/W2107748367","https://openalex.org/W2109291482","https://openalex.org/W2114898676","https://openalex.org/W2122439512","https://openalex.org/W2126792448","https://openalex.org/W2137103099","https://openalex.org/W2139739577","https://openalex.org/W2141586642","https://openalex.org/W2146383332","https://openalex.org/W2149487482","https://openalex.org/W2150043543","https://openalex.org/W2153382986","https://openalex.org/W2158615962","https://openalex.org/W2164468396","https://openalex.org/W2167304816","https://openalex.org/W2167650288","https://openalex.org/W2313066166","https://openalex.org/W2318413400"],"related_works":["https://openalex.org/W1907891130","https://openalex.org/W2059019019","https://openalex.org/W810675949","https://openalex.org/W2770472205","https://openalex.org/W2919632356","https://openalex.org/W2801622833","https://openalex.org/W3088138123","https://openalex.org/W2051949269","https://openalex.org/W1580120869","https://openalex.org/W2156524968"],"abstract_inverted_index":{"Background":[0],"and":[1,32,89,135,153,207,245,257,263],"aims:":[2],"The":[3,26],"human":[4,69,248,261],"pancreas":[5],"is":[6,30,63,78,250],"normally":[7],"proliferatively":[8],"quiescent;":[9],"however":[10],"loss":[11],"of":[12,92,111,127,170,177,180,231,239,242],"cells":[13,54,91,102,107,186,202,218,255],"gives":[14],"a":[15,21,40,79,83,112,121,143,158,193,272],"rapid":[16],"regenerative":[17],"response":[18],"to":[19,33,38,81,86,130,198],"restore":[20],"functionally":[22],"healthy":[23],"tissue":[24],"mass.":[25],"mechanism":[27],"for":[28,252,274],"this":[29,62,128,211,225],"unclear":[31],"date":[34],"research":[35],"has":[36],"failed":[37],"identify":[39,90],"definitive":[41],"pancreatic":[42,185],"stem":[43,73,113],"cell.":[44],"Cell":[45],"lineage":[46],"analyses":[47],"are":[48,190,203],"possible":[49],"in":[50,66,142,145,205,247,259],"animals":[51],"by":[52,109,166],"labelling":[53],"with":[55,264],"radioactive":[56],"tags":[57],"or":[58],"genetic":[59],"markers,":[60,75],"but":[61],"not":[64,227],"feasible":[65],"humans.":[67],"Current":[68],"studies":[70],"rely":[71],"on":[72],"cell":[74,114,129,243],"thus":[76],"there":[77],"need":[80],"develop":[82],"better":[84],"technique":[85],"track,":[87],"isolate":[88],"related":[93],"origin.":[94],"Mitochondrial":[95,137],"DNA":[96,118,138,216],"mutations":[97,139],"amass":[98],"naturally":[99],"within":[100,187],"our":[101,229],"as":[103,271],"we":[104],"age.":[105],"Therefore,":[106],"formed":[108],"division":[110,244],"carrying":[115],"mutated":[116,217],"mitochondrial":[117,147,215],"should,":[119],"given":[120],"qualitative":[122],"assay,":[123],"permit":[124],"the":[125,146,175,214,260],"progeny":[126],"be":[131,155,269],"traced.":[132],"\\n":[133,234],"\\nMethods":[134],"results:":[136],"often":[140],"result":[141],"defect":[144],"DNA-encoded":[148],"protein":[149],"cytochrome":[150],"c":[151],"oxidase,":[152],"can":[154],"identified":[156],"using":[157],"histochemical":[159],"stain.":[160],"Individual":[161],"mutant":[162],"patches":[163],"were":[164],"studied":[165],"staining":[167],"serial":[168],"sections":[169],"normal":[171,204,221],"pancreas.":[172],"This":[173,236],"revealed":[174],"presence":[176],"clonal":[178,232],"units":[179],"cells,":[181],"strong":[182],"evidence":[183,230],"that":[184,200,213],"each":[188],"patch":[189],"derived":[191],"from":[192],"common":[194],"progenitor.":[195],"We":[196],"tried":[197],"show":[199],"these":[201],"synthetic":[206,222],"proliferative":[208],"function,":[209],"although":[210],"showed":[212],"didn't":[219],"have":[220],"function.":[223],"However":[224],"did":[226],"negate":[228],"proliferation.":[233],"\\nConclusion:":[235],"novel":[237],"means":[238],"tracing":[240],"patterns":[241],"migration":[246],"tissues":[249],"suitable":[251],"finding":[253],"how":[254],"proliferate":[256],"move":[258],"pancreas,":[262],"continued":[265],"work":[266],"it":[267],"might":[268],"useful":[270],"marker":[273],"other":[275],"changes":[276],"e.g.":[277],"pre-cancerous":[278],"lesions.":[279]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}