{"id":"https://openalex.org/W2098730441","doi":"https://doi.org/10.1128/jvi.75.24.12308-12318.2001","title":"Clustered Charge-to-Alanine Mutagenesis of the Vaccinia Virus A20 Gene: Temperature-Sensitive Mutants Have a DNA-Minus Phenotype and Are Defective in the Production of Processive DNA Polymerase Activity","display_name":"Clustered Charge-to-Alanine Mutagenesis of the Vaccinia Virus A20 Gene: Temperature-Sensitive Mutants Have a DNA-Minus Phenotype and Are Defective in the Production of Processive DNA Polymerase Activity","publication_year":2001,"publication_date":"2001-12-15","ids":{"openalex":"https://openalex.org/W2098730441","doi":"https://doi.org/10.1128/jvi.75.24.12308-12318.2001","mag":"2098730441","pmid":"https://pubmed.ncbi.nlm.nih.gov/11711621","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/116127"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.75.24.12308-12318.2001","doi":"https://doi.org/10.1128/jvi.75.24.12308-12318.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.75.24.12308-12318.2001","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/116127","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065053025","display_name":"Almira S. Punjabi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Almira Punjabi","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035665075","display_name":"Kathleen Boyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Boyle","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080295278","display_name":"Joseph DeMasi","orcid":"https://orcid.org/0000-0002-7755-7427","observed_orcids":["https://orcid.org/0000-0002-7755-7427"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph DeMasi","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003061968","display_name":"Olivera Grubisha","orcid":"https://orcid.org/0000-0003-1067-1230","observed_orcids":["https://orcid.org/0000-0003-1067-1230"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivera Grubisha","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086864231","display_name":"Beth Unger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth Unger","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050347793","display_name":"Marilyn Khanna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marilyn Khanna","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028086587","display_name":"Paula Traktman","orcid":"https://orcid.org/0000-0002-6517-0225","observed_orcids":["https://orcid.org/0000-0002-6517-0225"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula Traktman","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":null,"apc_paid":null,"fwci":1.0445,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.71945551,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"75","issue":"24","first_page":"12308","last_page":"12318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vaccinia-virus","display_name":"vaccinia virus","score":0.984000027179718},{"id":"https://openalex.org/keywords/temperature-sensitive-mutants","display_name":"temperature-sensitive mutants","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dna-polymerase-processivity","display_name":"DNA polymerase processivity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.7080000042915344},{"id":"https://openalex.org/keywords/viral-life-cycle","display_name":"viral life cycle","score":0.5569999814033508},{"id":"https://openalex.org/keywords/viral-dna-accumulation","display_name":"viral DNA accumulation","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8556100130081177},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.7051907777786255},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.6636753082275391},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.5827654004096985},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5503869652748108},{"id":"https://openalex.org/C2781356689","wikidata":"https://www.wikidata.org/wiki/Q1986297","display_name":"Vaccinia","level":4,"score":0.5272611379623413},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5133020281791687},{"id":"https://openalex.org/C76535049","wikidata":"https://www.wikidata.org/wiki/Q3487941","display_name":"DNA polymerase delta","level":5,"score":0.4955805540084839},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45475566387176514},{"id":"https://openalex.org/C88354546","wikidata":"https://www.wikidata.org/wiki/Q3502973","display_name":"DNA polymerase II","level":5,"score":0.44130170345306396},{"id":"https://openalex.org/C31254050","wikidata":"https://www.wikidata.org/wiki/Q22328799","display_name":"DNA clamp","level":5,"score":0.43932002782821655},{"id":"https://openalex.org/C131140672","wikidata":"https://www.wikidata.org/wiki/Q2031164","display_name":"Processivity","level":4,"score":0.4385858178138733},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4285372197628021},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.41452986001968384},{"id":"https://openalex.org/C164965036","wikidata":"https://www.wikidata.org/wiki/Q2529148","display_name":"DNA polymerase I","level":5,"score":0.41019782423973083},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33622124791145325},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2504645884037018},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.18228048086166382},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.16523632407188416},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.1617727279663086}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014616","descriptor_name":"Vaccinia virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.75.24.12308-12318.2001","doi":"https://doi.org/10.1128/jvi.75.24.12308-12318.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.75.24.12308-12318.2001","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:116127","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/116127","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:11711621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11711621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:113893","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/113893/1/Clustered%20charge-to-alanine%20mutagenesis%20of%20the%20vaccinia%20virus%20A20%20gene.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/113893/1/Clustered%20charge-to-alanine%20mutagenesis%20of%20the%20vaccinia%20virus%20A20%20gene.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:116127","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/116127","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1629157557","display_name":null,"funder_award_id":"AI-21758","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5309024306","display_name":null,"funder_award_id":"AI 10428","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5920244797","display_name":"A NOVEL FAMILY OF VACCINIA VIRUS B1 RELATED KINASES","funder_award_id":"F32AI010428","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8208949493","display_name":"Vaccinia DNA Replication","funder_award_id":"R01AI021758","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W89499173","https://openalex.org/W274064933","https://openalex.org/W1484966744","https://openalex.org/W1495643895","https://openalex.org/W1507178827","https://openalex.org/W1536941941","https://openalex.org/W1539942373","https://openalex.org/W1557849078","https://openalex.org/W1558478065","https://openalex.org/W1625224420","https://openalex.org/W1672229312","https://openalex.org/W1709546832","https://openalex.org/W1781090922","https://openalex.org/W1841206673","https://openalex.org/W1878541330","https://openalex.org/W1892311206","https://openalex.org/W1905159235","https://openalex.org/W1957143406","https://openalex.org/W1965936005","https://openalex.org/W1979354418","https://openalex.org/W1998696660","https://openalex.org/W2001294226","https://openalex.org/W2009282271","https://openalex.org/W2020904650","https://openalex.org/W2063723654","https://openalex.org/W2066297924","https://openalex.org/W2068180515","https://openalex.org/W2078289436","https://openalex.org/W2085936072","https://openalex.org/W2087317842","https://openalex.org/W2089324363","https://openalex.org/W2095730364","https://openalex.org/W2106130068","https://openalex.org/W2117564816","https://openalex.org/W2120465550","https://openalex.org/W2138430170","https://openalex.org/W2143308044","https://openalex.org/W2146140682","https://openalex.org/W2146841503","https://openalex.org/W2149630164","https://openalex.org/W2161616221","https://openalex.org/W4211040323"],"related_works":["https://openalex.org/W1998696660","https://openalex.org/W2162158835","https://openalex.org/W1989718073","https://openalex.org/W2120465550","https://openalex.org/W6996296448","https://openalex.org/W2585862023","https://openalex.org/W2085936072","https://openalex.org/W1519414959","https://openalex.org/W2141161993","https://openalex.org/W1625224420"],"abstract_inverted_index":{"Although":[0],"the":[1,14,18,35,40,43,52,82,85,90,96,103,129,138,149,159,165,170,187,202,219,227,268],"vaccinia":[2,256,281],"virus":[3,133,142,257,282],"DNA":[4,163,174,283],"polymerase":[5,54,175,195,249],"is":[6,143,242],"inherently":[7],"distributive,":[8],"a":[9,48,78,155,191,208,238,245,264],"highly":[10],"processive":[11,53,194,248],"form":[12],"of":[13,20,42,51,84,89,98,102,119,140,145,161,204,267,270],"enzyme":[15],"exists":[16],"within":[17],"cytoplasm":[19],"infected":[21,185],"cells":[22,184],"(W.":[23],"F.":[24],"McDonald,":[25,59],"N.":[26],"Klemperer,":[27,57],"and":[28,64,87,122,137,173,231,275],"P.":[29,65],"Traktman,":[30,66],"Virology":[31],"234:168-175,":[32],"1997).":[33],"In":[34,213],"accompanying":[36],"report":[37,95],"we":[38,76,94],"outline":[39],"purification":[41],"49-kDa":[44],"A20":[45,91,104,111,171,220,235,258],"protein":[46,172,221,259],"as":[47,251],"stoichiometric":[49],"component":[50],"complex":[55],"(N.":[56],"W.":[58],"K.":[60],"Boyle,":[61],"B.":[62],"Unger,":[63],"J.":[67],"Virol.":[68],"75:12298-12307,":[69],"2001).":[70],"To":[71],"complement":[72],"this":[73,116],"biochemical":[74],"analysis,":[75],"undertook":[77],"genetic":[79],"approach":[80],"to":[81,177,200],"analysis":[83],"structure":[86],"function":[88],"protein.":[92],"Here":[93],"application":[97],"clustered":[99],"charge-to-alanine":[100],"mutagenesis":[101],"gene.":[105],"Eight":[106],"mutant":[107],"viruses":[108,153,189,233],"containing":[109],"altered":[110],"alleles":[112],"were":[113],"isolated":[114],"using":[115,207],"approach;":[117],"two":[118],"these,":[120],"tsA20-6":[121],"tsA20-ER5,":[123],"have":[124],"tight":[125],"temperature-sensitive":[126],"phenotypes.":[127],"At":[128],"nonpermissive":[130,166],"temperature,":[131,167],"neither":[132],"forms":[134],"macroscopic":[135],"plaques":[136],"yield":[139],"infectious":[141],"<1%":[144],"that":[146,218,232,241],"obtained":[147],"at":[148,164],"permissive":[150],"temperature.":[151],"Both":[152],"show":[154,190],"profound":[156],"defect":[157,192],"in":[158,193,226,247,253,280],"accumulation":[160],"viral":[162,228],"although":[168],"both":[169],"accumulate":[176],"wild-type":[178],"levels.":[179],"Cytoplasmic":[180],"extracts":[181],"prepared":[182],"from":[183],"with":[186,234,244,277],"tsA20":[188],"activity;":[196],"they":[197],"are":[198],"unable":[199],"direct":[201],"formation":[203],"RFII":[205],"product":[206],"singly":[209],"primed":[210],"M13":[211],"template.":[212],"sum,":[214],"these":[215],"data":[216],"indicate":[217],"plays":[222],"an":[223],"essential":[224,278],"role":[225],"life":[229],"cycle":[230],"lesions":[236],"exhibit":[237],"DNA(-)":[239],"phenotype":[240],"correlated":[243],"loss":[246],"activity":[250],"assayed":[252],"vitro.":[254],"The":[255],"can,":[260],"therefore,":[261],"be":[262],"considered":[263],"new":[265],"member":[266],"family":[269],"proteins":[271],"(E9,":[272],"B1,":[273],"D4,":[274],"D5)":[276],"roles":[279],"replication.":[284]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
