{"id":"https://openalex.org/W2098724902","doi":"https://doi.org/10.1002/cncr.26070","title":"Rising incidence of second cancers in patients with low\u2010risk (T1N0) thyroid cancer who receive radioactive iodine therapy","display_name":"Rising incidence of second cancers in patients with low\u2010risk (T1N0) thyroid cancer who receive radioactive iodine therapy","publication_year":2011,"publication_date":"2011-03-22","ids":{"openalex":"https://openalex.org/W2098724902","doi":"https://doi.org/10.1002/cncr.26070","mag":"2098724902","pmid":"https://pubmed.ncbi.nlm.nih.gov/21432843","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3155861"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.26070","doi":"https://doi.org/10.1002/cncr.26070","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cncr.26070","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3155861","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013033278","display_name":"Narayanan Gopalakrishna Iyer","orcid":"https://orcid.org/0000-0002-8812-6219","observed_orcids":["https://orcid.org/0000-0002-8812-6219","https://orcid.org/0000-0002-3138-4882"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Gopalakrishna Iyer","raw_affiliation_strings":["Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084443648","display_name":"Luc G.T. Morris","orcid":"https://orcid.org/0000-0002-4417-2280","observed_orcids":["https://orcid.org/0000-0002-4417-2280"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luc G. T. Morris","raw_affiliation_strings":["Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York","The first 2 authors contributed equally to this article. N.G.I., L.G.T.M., and I.G. conceived hypotheses, data acquisition, and analysis and prepared the article; A.R.S. and R.M.T. critically reviewed the data and the article. N.G.I. and L.G.T.M. had full access to all data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis","A.R.S. and R.M.T. critically reviewed the data and the article. N.G.I. and L.G.T.M. had full access to all data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis","The first 2 authors contributed equally to this article. N.G.I., L.G.T.M., and I.G. conceived hypotheses, data acquisition, and analysis and prepared the article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"The first 2 authors contributed equally to this article. N.G.I., L.G.T.M., and I.G. conceived hypotheses, data acquisition, and analysis and prepared the article; A.R.S. and R.M.T. critically reviewed the data and the article. N.G.I. and L.G.T.M. had full access to all data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis","institution_ids":[]},{"raw_affiliation_string":"A.R.S. and R.M.T. critically reviewed the data and the article. N.G.I. and L.G.T.M. had full access to all data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis","institution_ids":[]},{"raw_affiliation_string":"The first 2 authors contributed equally to this article. N.G.I., L.G.T.M., and I.G. conceived hypotheses, data acquisition, and analysis and prepared the article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009898984","display_name":"Robert Michael Tuttle","orcid":"https://orcid.org/0000-0001-9899-9702","observed_orcids":["https://orcid.org/0000-0001-9899-9702"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Michael Tuttle","raw_affiliation_strings":["Endocrinology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042607297","display_name":"Ashok R. Shaha","orcid":"https://orcid.org/0000-0001-7478-9436","observed_orcids":["https://orcid.org/0000-0001-7478-9436"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashok R. Shaha","raw_affiliation_strings":["Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075136197","display_name":"Ian Ganly","orcid":"https://orcid.org/0000-0001-7636-5426","observed_orcids":["https://orcid.org/0000-0001-7636-5426"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ian Ganly","raw_affiliation_strings":["","Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York","Fax: (212) 396-5560"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Fax: (212) 396-5560","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075136197"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":22.788,"has_fulltext":false,"cited_by_count":321,"citation_normalized_percentile":{"value":0.99708995,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"117","issue":"19","first_page":"4439","last_page":"4446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.2904999852180481,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/second-primary-malignancy","display_name":"second primary malignancy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/radioactive-iodine-therapy","display_name":"radioiodine therapy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/low-risk-thyroid-cancer","display_name":"low-risk thyroid cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/differentiated-thyroid-cancer","display_name":"differentiated thyroid cancer","score":0.8650000095367432},{"id":"https://openalex.org/keywords/malignant-salivary-gland-tumors","display_name":"malignant salivary gland tumors","score":0.8679999709129333},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.859000027179718},{"id":"https://openalex.org/keywords/radiation-induced-cancer-risk","display_name":"radiation-induced cancer risk","score":0.7379999756813049},{"id":"https://openalex.org/keywords/thyroid-ablation","display_name":"thyroid ablation","score":0.42899999022483826},{"id":"https://openalex.org/keywords/seer","display_name":"SEER","score":0.4429999887943268},{"id":"https://openalex.org/keywords/standardized-incidence-ratio","display_name":"standardized incidence ratio","score":0.8090000152587891},{"id":"https://openalex.org/keywords/excess-absolute-risk","display_name":"excess absolute risk","score":0.9629999995231628},{"id":"https://openalex.org/keywords/age-specific-risk","display_name":"age-specific risk","score":0.39399999380111694},{"id":"https://openalex.org/keywords/treatment-trends","display_name":"treatment trends","score":0.5009999871253967},{"id":"https://openalex.org/keywords/american-thyroid-association-guidelines","display_name":"American Thyroid Association guidelines","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9259844422340393},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.7079184055328369},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6349470615386963},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5489606261253357},{"id":"https://openalex.org/C120195587","wikidata":"https://www.wikidata.org/wiki/Q2138790","display_name":"Absolute risk reduction","level":3,"score":0.5269280672073364},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5204832553863525},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.4891505539417267},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46319928765296936},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.44190749526023865},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.413303941488266},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002291","descriptor_name":"Carcinoma, Papillary","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D018263","descriptor_name":"Adenocarcinoma, Follicular","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D018426","descriptor_name":"SEER Program","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/cncr.26070","doi":"https://doi.org/10.1002/cncr.26070","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cncr.26070","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:21432843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21432843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3155861","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3155861","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3155861","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3155861","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6130476866","display_name":"Head and Neck Training Program in Surgical Oncology","funder_award_id":"T32CA009685","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W44067190","https://openalex.org/W303557043","https://openalex.org/W1970781169","https://openalex.org/W1981822569","https://openalex.org/W1988823481","https://openalex.org/W1993224622","https://openalex.org/W2003224875","https://openalex.org/W2019835932","https://openalex.org/W2028080080","https://openalex.org/W2029563033","https://openalex.org/W2033297297","https://openalex.org/W2033882181","https://openalex.org/W2034709690","https://openalex.org/W2039796662","https://openalex.org/W2048672164","https://openalex.org/W2055689052","https://openalex.org/W2075008733","https://openalex.org/W2079394734","https://openalex.org/W2088828338","https://openalex.org/W2106438455","https://openalex.org/W2116542352","https://openalex.org/W2117971741","https://openalex.org/W2121348024","https://openalex.org/W2158180864","https://openalex.org/W2167719032","https://openalex.org/W2168133848","https://openalex.org/W2170614078","https://openalex.org/W2268494163","https://openalex.org/W2323016503","https://openalex.org/W2341110239","https://openalex.org/W2616027747","https://openalex.org/W4250935076"],"related_works":["https://openalex.org/W4286630682","https://openalex.org/W2252695361","https://openalex.org/W2033297297","https://openalex.org/W3127519359","https://openalex.org/W1971927636","https://openalex.org/W7214901084","https://openalex.org/W4321611052","https://openalex.org/W4415398964","https://openalex.org/W2026706132","https://openalex.org/W2626408702"],"abstract_inverted_index":{"BACKGROUND:":[0],"American":[1],"Thyroid":[2],"Association":[3],"guidelines":[4],"currently":[5],"recommend":[6],"the":[7,35,44,94,99,104,120,134,159,162,181,193,249,295],"selective":[8],"use":[9,59,90,166,296],"of":[10,50,57,63,102,114,164,183,208,231,265,278,293,297],"radioactive":[11],"iodine":[12],"(RAI)":[13],"therapy":[14],"in":[15,32,68,88,93,119,133,154,167,236,252,268,291,299],"patients":[16,39,69,128,147,168,237,254,269],"with":[17,40,70,129,169,203,248,270,275,284],"well":[18],"differentiated":[19],"thyroid":[20,41],"cancer":[21,42],"(WDTC).":[22],"Despite":[23],"these":[24],"guidelines,":[25],"RAI":[26,58,89,165,209,298],"ablation":[27],"has":[28],"been":[29],"used":[30,84],"routinely":[31],"all":[33],"but":[34],"very":[36],"lowest":[37],"risk":[38,62,101,112,142,206,230,251,264],"over":[43,91],"last":[45],"30":[46],"years.":[47],"The":[48,75,228,262],"objective":[49],"this":[51,300],"study":[52,160],"was":[53,83,185,195,233],"to":[54,85,138,176],"evaluate":[55],"patterns":[56],"and":[60,78,109,125,150,192,220],"elevated":[61,205],"secondary":[64],"primary":[65],"malignancies":[66,213],"(SPM)":[67],"low-risk":[71,170,179,271],"(T1N0)":[72,171,272],"WDTC.":[73],"METHODS:":[74],"Surveillance,":[76],"Epidemiology,":[77],"End":[79],"Results":[80],"(SEER)":[81],"database":[82],"analyze":[86],"trends":[87],"time":[92],"United":[95],"States.":[96],"To":[97],"determine":[98],"excess":[100,110,197,229,250],"SPM,":[103],"standardized":[105],"incidence":[106],"ratio":[107],"(SIR)":[108],"absolute":[111],"(EAR)":[113],"various":[115],"cancers":[116],"were":[117,131,152,210],"calculated":[118],"2":[121],"cohorts.":[122],"Between":[123],"1973":[124],"2007,":[126],"37,176":[127],"WDTC":[130,172],"followed":[132],"SEER":[135],"Program,":[136],"equating":[137],"408,750":[139],"person-years":[140],"at":[141],"(PYR).":[143],"In":[144],"total,":[145],"14,589":[146],"received":[148],"RAI,":[149,286],"SPMs":[151],"observed":[153],"3223":[155],"patients.":[156],"RESULTS:":[157],"During":[158],"period,":[161],"rate":[163],"increased":[173,263],"from":[174],"3.3%":[175],"38.1%.":[177],"For":[178],"patients,":[180],"SIR":[182],"SPM":[184,202,267],"1.21":[186],"(95%":[187],"confidence":[188],"interval":[189],"[CI],":[190],"0.93-1.54),":[191],"EAR":[194],"4.6":[196],"cases":[198],"per":[199],"10,000":[200],"PYR.":[201],"significantly":[204,234],"because":[207],"salivary":[211],"gland":[212],"(SIR":[214,222,241,255],"=":[215,223,242,256],"11.13;":[216],"95%":[217,225,244,258],"CI,":[218,226,245,259],"1.35-40.2)":[219],"leukemia":[221,232],"5.68;":[224],"2.09-12.37).":[227],"greater":[235],"aged":[238],"<45":[239],"years":[240],"5.32;":[243],"2.75-9.30)":[246],"compared":[247],"older":[253],"2.26;":[257],"1.43-3.39).":[260],"CONCLUSIONS:":[261],"a":[266,276,288],"WDTC,":[273],"along":[274],"lack":[277],"data":[279],"demonstrating":[280],"improved":[281],"survival":[282],"outcomes":[283],"adjuvant":[285],"provide":[287],"compelling":[289],"argument":[290],"favor":[292],"rationing":[294],"patient":[301],"population.":[302]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":30},{"year":2016,"cited_by_count":33},{"year":2015,"cited_by_count":39},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":32},{"year":2012,"cited_by_count":26}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
