{"id":"https://openalex.org/W2098717226","doi":null,"title":"Relating Heart Rate Variability, Urinary Catecholamines, and Baseline Fitness to Respiratory Distress Index and Severity of Disease in Obstructive Sleep Apnea Patients","display_name":"Relating Heart Rate Variability, Urinary Catecholamines, and Baseline Fitness to Respiratory Distress Index and Severity of Disease in Obstructive Sleep Apnea Patients","publication_year":2001,"publication_date":"2001-08-17","ids":{"openalex":"https://openalex.org/W2098717226","mag":"2098717226"},"language":"en","primary_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/34651","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/34651","pdf_url":"http://hdl.handle.net/10919/34651","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10919/34651","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022262966","display_name":"Howard Monroe Ballentine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Howard Monroe Ballentine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022262966"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.19900000095367432,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.9819999933242798},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.996999979019165},{"id":"https://openalex.org/keywords/urinary-catecholamines","display_name":"urinary catecholamines","score":0.9300000071525574},{"id":"https://openalex.org/keywords/autonomic-function","display_name":"autonomic function","score":0.7020000219345093},{"id":"https://openalex.org/keywords/parasympathetic-activity","display_name":"parasympathetic activity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/sympathetic-nerve-activity","display_name":"sympathetic activity","score":0.4480000138282776},{"id":"https://openalex.org/keywords/physical-fitness","display_name":"physical fitness","score":0.5600000023841858},{"id":"https://openalex.org/keywords/vo2max","display_name":"VO2max","score":0.8349999785423279},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9810000061988831},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.5630000233650208},{"id":"https://openalex.org/keywords/rem-sleep","display_name":"REM sleep","score":0.8019999861717224},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.5519999861717224},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.6539999842643738},{"id":"https://openalex.org/keywords/neck-circumference","display_name":"neck circumference","score":0.9229999780654907},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"risk assessment","score":0.5239999890327454},{"id":"https://openalex.org/keywords/cycle-ergometry","display_name":"cycle ergometry","score":0.6240000128746033},{"id":"https://openalex.org/keywords/polysomnography","display_name":"polysomnography","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.7353342175483704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6702896952629089},{"id":"https://openalex.org/C71635504","wikidata":"https://www.wikidata.org/wiki/Q933954","display_name":"Heart rate variability","level":4,"score":0.6550651788711548},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5552300810813904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5096263885498047},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.49468085169792175},{"id":"https://openalex.org/C139265228","wikidata":"https://www.wikidata.org/wiki/Q5283089","display_name":"Distress","level":2,"score":0.4601500630378723},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.45147716999053955},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.44752633571624756},{"id":"https://openalex.org/C2777935920","wikidata":"https://www.wikidata.org/wiki/Q213600","display_name":"Sleep apnea","level":2,"score":0.4452531933784485},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.426803320646286},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.425345778465271},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.36339712142944336},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.36004990339279175},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.3425453305244446},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.29571494460105896},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.10982868075370789},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.10752591490745544},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/34651","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/34651","pdf_url":"http://hdl.handle.net/10919/34651","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2098717226","doi":null,"is_oa":false,"landing_page_url":"https://scholar.lib.vt.edu/theses/available/etd-08202001-091016/unrestricted/Howard_Ballentine_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/34651","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/34651","pdf_url":"http://hdl.handle.net/10919/34651","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2098717226.pdf","grobid_xml":"https://content.openalex.org/works/W2098717226.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W11469709","https://openalex.org/W63340880","https://openalex.org/W109061776","https://openalex.org/W1526735853","https://openalex.org/W1551170900","https://openalex.org/W1592920100","https://openalex.org/W1969950653","https://openalex.org/W1988816021","https://openalex.org/W1995849187","https://openalex.org/W1996617418","https://openalex.org/W2007072345","https://openalex.org/W2008049691","https://openalex.org/W2015162362","https://openalex.org/W2016340323","https://openalex.org/W2017661070","https://openalex.org/W2019046584","https://openalex.org/W2019905170","https://openalex.org/W2062324314","https://openalex.org/W2063255044","https://openalex.org/W2063851257","https://openalex.org/W2073148126","https://openalex.org/W2078259015","https://openalex.org/W2083274334","https://openalex.org/W2084181053","https://openalex.org/W2091732895","https://openalex.org/W2093581528","https://openalex.org/W2094566254","https://openalex.org/W2115958342","https://openalex.org/W2123473674","https://openalex.org/W2125069744","https://openalex.org/W2136769393","https://openalex.org/W2139434612","https://openalex.org/W2149262511","https://openalex.org/W2151969637","https://openalex.org/W2160939467","https://openalex.org/W2169789234","https://openalex.org/W2172549965","https://openalex.org/W2179422083","https://openalex.org/W2188309943","https://openalex.org/W2300678488","https://openalex.org/W2335449614","https://openalex.org/W2402529590","https://openalex.org/W2419666760"],"related_works":["https://openalex.org/W7095508852","https://openalex.org/W2140648060","https://openalex.org/W1976877720","https://openalex.org/W2736989971","https://openalex.org/W2896544527","https://openalex.org/W4312520247","https://openalex.org/W4225294344","https://openalex.org/W7161570960","https://openalex.org/W2606396787","https://openalex.org/W4400474222"],"abstract_inverted_index":{"Heart":[0],"Rate":[1],"Variability":[2],"(HRV)":[3],"currently":[4],"is":[5,323,336],"utilized":[6],"when":[7,99],"assessing":[8],"the":[9,52,71,88,136,215,237,248,274,282,293,310,347],"risk":[10,91,360],"of":[11,55,73,75,90,106,114,126,173,217,221,250,285,312,316,333,349],"mortality":[12],"in":[13,37,44,51,58,77,92,365],"individuals":[14],"suffering":[15],"from":[16],"coronary":[17],"heart":[18,239],"disease":[19],"or":[20],"diabetic":[21],"neuropathy.":[22],"Research":[23],"has":[24],"shown":[25],"that":[26,308,338,352],"patients":[27,79],"with":[28,60,156,200],"Obstructive":[29],"Sleep":[30],"Apnea":[31],"(OSA)":[32],"also":[33,324],"show":[34],"a":[35,65,121,359],"decrease":[36],"HRV,":[38,57,139,286],"as":[39,41,128,212,265,309],"well":[40],"an":[42,49,84,325],"increase":[43,50],"sympathetic":[45],"drive":[46],"characterized":[47],"by":[48,130,158,180],"low-frequency":[53],"component":[54,220],"HRV.":[56],"conjunction":[59],"other":[61],"indicators,":[62],"may":[63,82,355],"represent":[64,83],"non-invasive,":[66],"low":[67],"cost":[68],"method":[69],"for":[70,87,363],"confirmation":[72],"severity":[74,125,311,332,348],"OSA":[76,127,157,313,366],"some":[78],"and":[80,104,135,142,149,163,194,204,257,289,319,331,340,351],"therefore":[81],"additional":[85],"tool":[86,362],"assessment":[89,109,361],"these":[93,353],"individuals.":[94],"This":[95],"becomes":[96],"especially":[97],"true":[98],"urinary":[100],"catecholamines,":[101],"fitness":[102,341],"level,":[103],"quality":[105],"life":[107],"(QOL)":[108],"are":[110,343],"included.":[111],"The":[112,268,305],"purpose":[113],"this":[115],"study":[116],"was":[117,166,233,271],"to":[118,236,273,295,346],"determine":[119],"if":[120],"correlation":[122],"exists":[123],"between":[124,328],"assessed":[129],"respiratory":[131],"distress":[132,230],"index":[133,231],"(RDI)":[134,232],"selected":[137],"measures":[138,354],"fitness,":[140,287,317],"QOL,":[141,288,318],"catecholamine":[143],"output.":[144],"Subjects":[145,199],"were":[146,153,178,188,291],"6":[147],"men":[148],"5":[150],"women":[151],"who":[152],"recently":[154],"diagnosed":[155],"polysomnographic":[159],"(PSG)":[160],"study.":[161],"HRV":[162,222,339],"blood":[164],"pressure":[165],"measured":[167],"during":[168],"two":[169],"consecutive":[170],"trials":[171],"consisting":[172],"512":[174],"heartbeats.":[175],"Catecholamine":[176],"levels":[177,187,342],"determined":[179],"HPLC":[181],"following":[182,190,196],"24-hour":[183],"urine":[184],"collection.":[185],"Fitness":[186],"established":[189],"cycle":[191],"ergometer":[192],"testing":[193],"QOL":[195],"questionnaire":[197],"completion.":[198],"lower":[201],"weight,":[202],"BMI,":[203],"neck":[205],"circumference":[206],"had":[207],"significantly":[208],"higher":[209],"parasympathetic":[210],"influence":[211],"analyzed":[213],"through":[214],"amount":[216,249],"high":[218],"frequency":[219,283],"(r":[223,253,260,277,299],"=.738,":[224],".726,":[225],".789,":[226],"respectively;":[227],"p<0.05).":[228,280],"Respiratory":[229],"negatively":[234],"related":[235,345],"average":[238,269],"rate":[240],"(HR=RR":[241],"average,":[242],"r":[243],"=":[244,254,261,278,300,303],"-.610,":[245],"p<0.05),":[246],"while":[247],"total":[251],"sleep":[252,259,320],".657,":[255],"p<0.05)":[256],"REM":[258],".739,":[262],"p<0.01)":[263],"increased":[264,297],"HR":[266,270],"increased.":[267],"correlated":[272],"predicted":[275],"VO2max":[276],".677,":[279],"When":[281],"components":[284],"catecholamines":[290],"combined,":[292],"association":[294],"RDI":[296],"dramatically":[298],".984,":[301],"p":[302],".02).":[304],"results":[306],"indicate":[307],"increases,":[314],"markers":[315],"decrease.":[321],"There":[322],"inverse":[326],"relationship":[327],"autonomic":[329],"function":[330],"OSA.":[334],"It":[335],"concluded":[337],"inversely":[344],"OSA,":[350],"be":[356],"developed":[357],"into":[358],"use":[364],"patient":[367],"evaluatio":[368]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}