{"id":"https://openalex.org/W2098697213","doi":"https://doi.org/10.1128/jcm.01057-10","title":"pfmdr1 Amplification Associated with Clinical Resistance to Mefloquine in West Africa: Implications for Efficacy of Artemisinin Combination Therapies","display_name":"pfmdr1 Amplification Associated with Clinical Resistance to Mefloquine in West Africa: Implications for Efficacy of Artemisinin Combination Therapies","publication_year":2010,"publication_date":"2010-07-29","ids":{"openalex":"https://openalex.org/W2098697213","doi":"https://doi.org/10.1128/jcm.01057-10","mag":"2098697213","pmid":"https://pubmed.ncbi.nlm.nih.gov/20668121","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2953132"},"language":"en","primary_location":{"id":"doi:10.1128/jcm.01057-10","doi":"https://doi.org/10.1128/jcm.01057-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jcm.01057-10","pdf_url":null,"source":{"id":"https://openalex.org/S53087977","display_name":"Journal of Clinical Microbiology","issn_l":"0095-1137","issn":["0095-1137","1070-633X","1098-660X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2953132/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089661257","display_name":"Beno\u00eet Witkowski","orcid":"https://orcid.org/0000-0002-8599-6382","observed_orcids":["https://orcid.org/0000-0002-8599-6382"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210119060","display_name":"Laboratoire de Chimie de Coordination","ror":"https://ror.org/01rtzw447","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I4210119060","https://openalex.org/I4210128300","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210123497","display_name":"H\u00f4pital Rangueil","ror":"https://ror.org/034zn5b34","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210123497"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benoit Witkowski","raw_affiliation_strings":["CNRS, Laboratoire de Chimie de Coordination, UPR8241, Toulouse, France, and Universite\u0301 de Toulouse III, Toulouse, France","Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Universite\u0301 de Toulouse, and Faculte\u0301 de Me\u0301decine de Rangueil, Universite\u0301 de Toulouse III, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, Laboratoire de Chimie de Coordination, UPR8241, Toulouse, France, and Universite\u0301 de Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I4210119060","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Universite\u0301 de Toulouse, and Faculte\u0301 de Me\u0301decine de Rangueil, Universite\u0301 de Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I3019448017","https://openalex.org/I4210123497","https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069862680","display_name":"Xavier Iriart","orcid":"https://orcid.org/0000-0002-0998-8962","observed_orcids":["https://orcid.org/0000-0002-0998-8962"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210123497","display_name":"H\u00f4pital Rangueil","ror":"https://ror.org/034zn5b34","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210123497"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Xavier Iriart","raw_affiliation_strings":["Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Universite\u0301 de Toulouse, and Faculte\u0301 de Me\u0301decine de Rangueil, Universite\u0301 de Toulouse III, Toulouse, France","UMR3 MD-UM-UPS, Universite\u0301 Paul Sabatier Toulouse III, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Universite\u0301 de Toulouse, and Faculte\u0301 de Me\u0301decine de Rangueil, Universite\u0301 de Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I3019448017","https://openalex.org/I4210123497","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"UMR3 MD-UM-UPS, Universite\u0301 Paul Sabatier Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049602195","display_name":"Patrice Njomnang Soh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210119060","display_name":"Laboratoire de Chimie de Coordination","ror":"https://ror.org/01rtzw447","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I4210119060","https://openalex.org/I4210128300","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210123497","display_name":"H\u00f4pital Rangueil","ror":"https://ror.org/034zn5b34","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210123497"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrice Njomnang Soh","raw_affiliation_strings":["CNRS, Laboratoire de Chimie de Coordination, UPR8241, Toulouse, France, and Universite\u0301 de Toulouse III, Toulouse, France","Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Universite\u0301 de Toulouse, and Faculte\u0301 de Me\u0301decine de Rangueil, Universite\u0301 de Toulouse III, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, Laboratoire de Chimie de Coordination, UPR8241, Toulouse, France, and Universite\u0301 de Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I4210119060","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Universite\u0301 de Toulouse, and Faculte\u0301 de Me\u0301decine de Rangueil, Universite\u0301 de Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I3019448017","https://openalex.org/I4210123497","https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012951448","display_name":"Sandie M\u00e9nard","orcid":"https://orcid.org/0000-0001-6972-3598","observed_orcids":["https://orcid.org/0000-0001-6972-3598"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210123497","display_name":"H\u00f4pital Rangueil","ror":"https://ror.org/034zn5b34","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210123497"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandie Menard","raw_affiliation_strings":["Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Universite\u0301 de Toulouse, and Faculte\u0301 de Me\u0301decine de Rangueil, Universite\u0301 de Toulouse III, Toulouse, France","UMR3 MD-UM-UPS, Universite\u0301 Paul Sabatier Toulouse III, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Universite\u0301 de Toulouse, and Faculte\u0301 de Me\u0301decine de Rangueil, Universite\u0301 de Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I3019448017","https://openalex.org/I4210123497","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"UMR3 MD-UM-UPS, Universite\u0301 Paul Sabatier Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111608634","display_name":"Muriel Alvarez","orcid":"https://orcid.org/0000-0001-5230-0134","observed_orcids":["https://orcid.org/0000-0001-5230-0134"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Muriel Alvarez","raw_affiliation_strings":["Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040132761","display_name":"V\u00e9ronique Naneix-Laroche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Veronique Naneix-Laroche","raw_affiliation_strings":["Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043909607","display_name":"Bruno Marchou","orcid":"https://orcid.org/0000-0002-0673-2945","observed_orcids":["https://orcid.org/0000-0002-0673-2945"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Marchou","raw_affiliation_strings":["Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032112646","display_name":"Jean\u2010Fran\u00e7ois Magnaval","orcid":"https://orcid.org/0000-0002-7759-894X","observed_orcids":["https://orcid.org/0000-0002-7759-894X","https://orcid.org/0000-0003-0423-7948"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Franc\u0327ois Magnaval","raw_affiliation_strings":["UMR3 MD-UM-UPS, Universite\u0301 Paul Sabatier Toulouse III, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR3 MD-UM-UPS, Universite\u0301 Paul Sabatier Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011423966","display_name":"Fran\u00e7oise Benoit\u2010Vical","orcid":"https://orcid.org/0000-0002-9468-4823","observed_orcids":["https://orcid.org/0000-0002-9468-4823"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210119060","display_name":"Laboratoire de Chimie de Coordination","ror":"https://ror.org/01rtzw447","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I4210119060","https://openalex.org/I4210128300","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210123497","display_name":"H\u00f4pital Rangueil","ror":"https://ror.org/034zn5b34","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210123497"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franc\u0327oise Benoit-Vical","raw_affiliation_strings":["CNRS, Laboratoire de Chimie de Coordination, UPR8241, Toulouse, France, and Universite\u0301 de Toulouse III, Toulouse, France","Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Universite\u0301 de Toulouse, and Faculte\u0301 de Me\u0301decine de Rangueil, Universite\u0301 de Toulouse III, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, Laboratoire de Chimie de Coordination, UPR8241, Toulouse, France, and Universite\u0301 de Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I4210119060","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Universite\u0301 de Toulouse, and Faculte\u0301 de Me\u0301decine de Rangueil, Universite\u0301 de Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I3019448017","https://openalex.org/I4210123497","https://openalex.org/I4405258862"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050142232","display_name":"Antoine Berry","orcid":"https://orcid.org/0000-0002-6626-7766","observed_orcids":["https://orcid.org/0000-0002-6626-7766"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210123497","display_name":"H\u00f4pital Rangueil","ror":"https://ror.org/034zn5b34","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210123497"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Antoine Berry","raw_affiliation_strings":["Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Universite\u0301 de Toulouse, and Faculte\u0301 de Me\u0301decine de Rangueil, Universite\u0301 de Toulouse III, Toulouse, France","UMR3 MD-UM-UPS, Universite\u0301 Paul Sabatier Toulouse III, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Universite\u0301 de Toulouse, and Faculte\u0301 de Me\u0301decine de Rangueil, Universite\u0301 de Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I3019448017","https://openalex.org/I4210123497","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"UMR3 MD-UM-UPS, Universite\u0301 Paul Sabatier Toulouse III, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5050142232"],"corresponding_institution_ids":["https://openalex.org/I134560555","https://openalex.org/I3019448017","https://openalex.org/I4210123497","https://openalex.org/I4405258862"],"apc_list":null,"apc_paid":null,"fwci":3.1726,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.91218068,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"48","issue":"10","first_page":"3797","last_page":"3799"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pfmdr1","display_name":"pfmdr1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/mefloquine-resistance","display_name":"mefloquine resistance","score":0.9309999942779541},{"id":"https://openalex.org/keywords/falciparum-malaria","display_name":"falciparum malaria","score":0.8489999771118164},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9549999833106995},{"id":"https://openalex.org/keywords/copy-number-amplification","display_name":"copy number amplification","score":0.847000002861023},{"id":"https://openalex.org/keywords/artemisinin-based-combination-therapy","display_name":"artemisinin-based combination therapy","score":0.9470000267028809},{"id":"https://openalex.org/keywords/antimalarial-drug-resistance","display_name":"antimalarial drug resistance","score":0.8349999785423279},{"id":"https://openalex.org/keywords/west-africa","display_name":"West Africa","score":0.9300000071525574}],"concepts":[{"id":"https://openalex.org/C2777199930","wikidata":"https://www.wikidata.org/wiki/Q736270","display_name":"Mefloquine","level":4,"score":0.993741512298584},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.8999261856079102},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.7204450964927673},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.684450626373291},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.5551497936248779},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5270412564277649},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4735754430294037},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43148452043533325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4160096049308777},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3921836018562317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3880141079425812},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22520622611045837},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.18376636505126953},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.171736478805542},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11129581928253174}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000354","descriptor_name":"Africa, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015767","descriptor_name":"Mefloquine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015767","descriptor_name":"Mefloquine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/jcm.01057-10","doi":"https://doi.org/10.1128/jcm.01057-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jcm.01057-10","pdf_url":null,"source":{"id":"https://openalex.org/S53087977","display_name":"Journal of Clinical Microbiology","issn_l":"0095-1137","issn":["0095-1137","1070-633X","1098-660X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Microbiology","raw_type":"journal-article"},{"id":"pmid:20668121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20668121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical microbiology","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:2953132","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2953132/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Microbiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2953132","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2953132/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Microbiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1865107143","https://openalex.org/W1970137783","https://openalex.org/W1986212668","https://openalex.org/W1994981343","https://openalex.org/W2002448488","https://openalex.org/W2008166606","https://openalex.org/W2010357659","https://openalex.org/W2021704622","https://openalex.org/W2038490127","https://openalex.org/W2040574032","https://openalex.org/W2041422568","https://openalex.org/W2048404226","https://openalex.org/W2051633841","https://openalex.org/W2057204208","https://openalex.org/W2082804385","https://openalex.org/W2094313233","https://openalex.org/W2097263871","https://openalex.org/W2112261944","https://openalex.org/W2113516463","https://openalex.org/W2118266103","https://openalex.org/W2132831164","https://openalex.org/W2137636253","https://openalex.org/W2144616253","https://openalex.org/W2163765308","https://openalex.org/W2170412790"],"related_works":["https://openalex.org/W7095424839","https://openalex.org/W2102940694","https://openalex.org/W2048404226","https://openalex.org/W7095069481","https://openalex.org/W2097263871","https://openalex.org/W2138754677","https://openalex.org/W2144616253","https://openalex.org/W2095918221","https://openalex.org/W2113516463","https://openalex.org/W7098744154"],"abstract_inverted_index":{"We":[0],"describe":[1],"here":[2],"a":[3],"clinical":[4],"failure":[5],"in":[6,16,21,44],"the":[7,33,36,39,52],"treatment":[8],"with":[9,20],"mefloquine":[10,23],"of":[11,35,41],"acute":[12],"falciparum":[13],"malaria":[14],"contracted":[15],"Africa":[17],"and":[18,25,38],"associated":[19],"vitro":[22],"resistance":[24],"pfmdr1":[26],"copy":[27],"number":[28],"amplification.":[29],"This":[30],"case":[31],"raises":[32],"question":[34],"presence":[37],"evolution":[40],"this":[42],"genotype":[43],"Africa,":[45],"which":[46],"is":[47],"also":[48],"known":[49],"to":[50,54],"alter":[51],"susceptibility":[53],"artemisinin":[55],"combination":[56],"therapy":[57],"(ACT).":[58]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}