{"id":"https://openalex.org/W2098644652","doi":"https://doi.org/10.1172/jci117277","title":"Effects of chronic beta-adrenergic blockade on the left ventricular and cardiocyte abnormalities of chronic canine mitral regurgitation.","display_name":"Effects of chronic beta-adrenergic blockade on the left ventricular and cardiocyte abnormalities of chronic canine mitral regurgitation.","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W2098644652","doi":"https://doi.org/10.1172/jci117277","mag":"2098644652","pmid":"https://pubmed.ncbi.nlm.nih.gov/7911128","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/294505"},"language":"en","primary_location":{"id":"doi:10.1172/jci117277","doi":"https://doi.org/10.1172/jci117277","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci117277","pdf_url":"http://www.jci.org/articles/view/117277/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/117277/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091849037","display_name":"Hiroyuki Tsutsui","orcid":"https://orcid.org/0000-0002-5291-2875","observed_orcids":["https://orcid.org/0000-0002-5291-2875"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Tsutsui","raw_affiliation_strings":["Department of Medicine, Gazes Cardiac Research Institute, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Gazes Cardiac Research Institute, Charleston, South Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041498326","display_name":"Francis G. Spinale","orcid":"https://orcid.org/0000-0003-0529-5605","observed_orcids":["https://orcid.org/0000-0003-0529-5605"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210135841","display_name":"Iowa City VA Medical Center","ror":"https://ror.org/03r9k1585","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210132647","https://openalex.org/I4210135841","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F G Spinale","raw_affiliation_strings":["I Veterans Affairs Medical Center Department ofInternal Medicine , University ofIowa , Iowa City , Iowa , 52246","Medical University of South Carolina;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I Veterans Affairs Medical Center Department ofInternal Medicine , University ofIowa , Iowa City , Iowa , 52246","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210135841"]},{"raw_affiliation_string":"Medical University of South Carolina;","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044152667","display_name":"M Nagatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Nagatsu","raw_affiliation_strings":["Cardiology Division , Department ofMedicine , Gazes Cardiac Research Institute, and tCardiothoracic Division , Department ofSurgery , Medical University ofSouth Carolina , Charleston , South Carolina , 29425 ;","Medical University of South Carolina;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division , Department ofMedicine , Gazes Cardiac Research Institute, and tCardiothoracic Division , Department ofSurgery , Medical University ofSouth Carolina , Charleston , South Carolina , 29425 ;","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Medical University of South Carolina;","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042014179","display_name":"Phillip G. Schmid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P G Schmid","raw_affiliation_strings":["lRalph H. Johnson Department of Veterans Affairs Medical Center , Charleston , South Carolina , 29403 ;","University of Iowa, "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"lRalph H. Johnson Department of Veterans Affairs Medical Center , Charleston , South Carolina , 29403 ;","institution_ids":["https://openalex.org/I4210132004"]},{"raw_affiliation_string":"University of Iowa, ","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K Ishihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Ishihara","raw_affiliation_strings":["Medical University of South Carolina;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina;","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058364754","display_name":"Gilberto DeFreyte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G DeFreyte","raw_affiliation_strings":["Cardiology Division , Department ofMedicine , Gazes Cardiac Research Institute, and tCardiothoracic Division , Department ofSurgery , Medical University ofSouth Carolina , Charleston , South Carolina , 29425 ;","Medical University of South Carolina;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division , Department ofMedicine , Gazes Cardiac Research Institute, and tCardiothoracic Division , Department ofSurgery , Medical University ofSouth Carolina , Charleston , South Carolina , 29425 ;","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Medical University of South Carolina;","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070334765","display_name":"George Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210135841","display_name":"Iowa City VA Medical Center","ror":"https://ror.org/03r9k1585","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210132647","https://openalex.org/I4210135841","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Cooper","raw_affiliation_strings":["I Veterans Affairs Medical Center Department ofInternal Medicine , University ofIowa , Iowa City , Iowa , 52246","Department of Veterans Affairs","Medical University of South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I Veterans Affairs Medical Center Department ofInternal Medicine , University ofIowa , Iowa City , Iowa , 52246","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210135841"]},{"raw_affiliation_string":"Department of Veterans Affairs","institution_ids":["https://openalex.org/I1322918889"]},{"raw_affiliation_string":"Medical University of South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013881418","display_name":"Blase Anthony Carabello","orcid":"https://orcid.org/0000-0002-2423-1730","observed_orcids":["https://orcid.org/0000-0002-2423-1730"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B A Carabello","raw_affiliation_strings":["Cardiology Division , Department ofMedicine , Gazes Cardiac Research Institute, and tCardiothoracic Division , Department ofSurgery , Medical University ofSouth Carolina , Charleston , South Carolina , 29425 ;","Department ofMed- icine , Medical University ofSouth Carolina , 171 Ashley Avenue , Char- leston , SC 29425 ","Department of Veterans Affairs","Medical University of South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division , Department ofMedicine , Gazes Cardiac Research Institute, and tCardiothoracic Division , Department ofSurgery , Medical University ofSouth Carolina , Charleston , South Carolina , 29425 ;","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department ofMed- icine , Medical University ofSouth Carolina , 171 Ashley Avenue , Char- leston , SC 29425 ","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Veterans Affairs","institution_ids":["https://openalex.org/I1322918889"]},{"raw_affiliation_string":"Medical University of South Carolina","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":5.1307,"has_fulltext":true,"cited_by_count":188,"citation_normalized_percentile":{"value":0.95922201,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"93","issue":"6","first_page":"2639","last_page":"2648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.15690000355243683,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.14900000393390656,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-blockade","display_name":"beta-adrenergic blockade","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mitral-regurgitation","display_name":"mitral regurgitation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/left-ventricular-dysfunction","display_name":"left ventricular dysfunction","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cardiomyocyte-contractility","display_name":"cardiomyocyte contractility","score":0.9399999976158142},{"id":"https://openalex.org/keywords/beta-adrenergic-responsiveness","display_name":"beta-adrenergic responsiveness","score":0.8180000185966492},{"id":"https://openalex.org/keywords/canine-model","display_name":"canine model","score":0.6830000281333923},{"id":"https://openalex.org/keywords/cardiac-contractile-function","display_name":"cardiac contractile function","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.820070743560791},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6717444062232971},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6407245397567749},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6056457757949829},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5720720291137695},{"id":"https://openalex.org/C2993373945","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Mitral regurgitation","level":2,"score":0.5381572842597961},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.517946183681488},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3760465383529663},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16869637370109558},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008944","descriptor_name":"Mitral Valve Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci117277","doi":"https://doi.org/10.1172/jci117277","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci117277","pdf_url":"http://www.jci.org/articles/view/117277/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:294505","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/294505","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:7911128","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7911128","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.429.8168","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.429.8168","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jci.org/articles/view/117277/version/1/pdf/render/","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1172/jci117277","doi":"https://doi.org/10.1172/jci117277","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci117277","pdf_url":"http://www.jci.org/articles/view/117277/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5245594494","display_name":"BETA BLOCKADE IN MITRAL REGURGITATION","funder_award_id":"R01HL038185","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2098644652.pdf","grobid_xml":"https://content.openalex.org/works/W2098644652.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W87739557","https://openalex.org/W1746209417","https://openalex.org/W1852249741","https://openalex.org/W1963989474","https://openalex.org/W1964770392","https://openalex.org/W1967543356","https://openalex.org/W1970301730","https://openalex.org/W1975452026","https://openalex.org/W1976882108","https://openalex.org/W1981850993","https://openalex.org/W1985313243","https://openalex.org/W1989021471","https://openalex.org/W1989282030","https://openalex.org/W1999868720","https://openalex.org/W2003541384","https://openalex.org/W2008823580","https://openalex.org/W2014523487","https://openalex.org/W2020216791","https://openalex.org/W2027899199","https://openalex.org/W2028327365","https://openalex.org/W2031107219","https://openalex.org/W2033404807","https://openalex.org/W2038677584","https://openalex.org/W2044110796","https://openalex.org/W2053829803","https://openalex.org/W2058279355","https://openalex.org/W2058441408","https://openalex.org/W2060463116","https://openalex.org/W2062304838","https://openalex.org/W2062673133","https://openalex.org/W2063106685","https://openalex.org/W2065724905","https://openalex.org/W2066034228","https://openalex.org/W2066920501","https://openalex.org/W2071833353","https://openalex.org/W2075908462","https://openalex.org/W2080293692","https://openalex.org/W2083637909","https://openalex.org/W2083762419","https://openalex.org/W2097166266","https://openalex.org/W2098636377","https://openalex.org/W2102967129","https://openalex.org/W2104475665","https://openalex.org/W2109713069","https://openalex.org/W2110889457","https://openalex.org/W2112140701","https://openalex.org/W2120530986","https://openalex.org/W2131598032","https://openalex.org/W2164188631","https://openalex.org/W2165415846","https://openalex.org/W2170237197","https://openalex.org/W2225473590","https://openalex.org/W2267952155","https://openalex.org/W2281888096","https://openalex.org/W2339250602","https://openalex.org/W2395056800","https://openalex.org/W2401744707","https://openalex.org/W2410502502","https://openalex.org/W2460259036","https://openalex.org/W2474069627","https://openalex.org/W2593366827","https://openalex.org/W4235171205"],"related_works":["https://openalex.org/W7097474128","https://openalex.org/W2058279355","https://openalex.org/W2049634353","https://openalex.org/W2288206460","https://openalex.org/W2034086174","https://openalex.org/W2128136949","https://openalex.org/W2052956743","https://openalex.org/W2098636377","https://openalex.org/W1975245626","https://openalex.org/W2021608109"],"abstract_inverted_index":{"The":[0,134],"mechanism":[1,56],"by":[2],"which":[3,46,238],"beta":[4,38,128,150,212],"blockade":[5,39,213],"improves":[6,214],"left":[7,43,91,215],"ventricular":[8,44,92,216],"dysfunction":[9,45],"in":[10,48,122,146,180,191,204,218,230,239,246],"various":[11],"cardiomyopathies":[12],"has":[13],"been":[14],"ascribed":[15],"to":[16,24,105,201],"improved":[17,25,62,132],"contractile":[18,64,117,130,199,233,250],"function":[19,65,118,131,217,234],"of":[20,57,66,71,136,149,158,235,249],"the":[21,42,67,101,112,123,140,147,162,181,192,205,231,247],"myocardium":[22],"or":[23],"beta-adrenergic":[26],"responsiveness.":[27],"In":[28,111],"this":[29,58],"study":[30],"we":[31],"tested":[32],"two":[33],"hypotheses:":[34],"(a)":[35],"that":[36,53,114,125,210],"chronic":[37,75,127,211,219],"would":[40,60],"improve":[41],"develops":[47],"mitral":[49,77,221],"regurgitation,":[50],"and":[51,89,143],"(b)":[52],"an":[54,228,244],"important":[55],"effect":[59],"be":[61,106],"innate":[63,232],"myocardium.":[68],"Two":[69],"groups":[70,85],"six":[72],"dogs":[73],"with":[74,169,227,243],"severe":[76],"regurgitation":[78],"were":[79,197],"studied.":[80],"After":[81],"3":[82],"mo":[83],"both":[84],"had":[86],"developed":[87],"similar":[88],"significant":[90],"dysfunction.":[93],"One":[94],"group":[95,103,113,124,183],"was":[96,153,165,174,225],"then":[97,144],"gradually":[98],"beta-blocked":[99,163,182,206],"while":[100],"second":[102],"continued":[104],"observed":[107],"without":[108],"further":[109],"intervention.":[110],"remained":[115,119],"unblocked,":[116],"depressed.":[120,155],"However,":[121,156],"received":[126],"blockade,":[129],"substantially.":[133],"contractility":[135,157],"cardiocytes":[137,159],"isolated":[138,160,236],"from":[139,161],"unblocked":[141,193],"hearts":[142],"studied":[145],"absence":[148],"receptor":[151],"stimulation":[152],"extremely":[154],"ventricles":[164],"virtually":[166],"normal.":[167],"Consistent":[168],"these":[170],"data,":[171],"myofibrillar":[172],"density":[173],"much":[175],"higher,":[176],"55":[177],"+/-":[178,186],"4%":[179],"vs.":[184],"39":[185],"2%":[187],"(P":[188],"<":[189],"0.01)":[190],"group;":[194],"thus,":[195],"there":[196],"more":[198],"elements":[200],"generate":[202],"force":[203],"group.":[207],"We":[208],"conclude":[209],"experimental":[220],"regurgitation.":[222],"This":[223],"improvement":[224,229],"associated":[226,242],"cardiocytes,":[237],"turn":[240],"is":[241],"increase":[245],"number":[248],"elements.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}