{"id":"https://openalex.org/W2098560717","doi":"https://doi.org/10.1186/1897-4287-4-2-81","title":"Childhood Adrenocortical Tumours: a Review","display_name":"Childhood Adrenocortical Tumours: a Review","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2098560717","doi":"https://doi.org/10.1186/1897-4287-4-2-81","mag":"2098560717","pmid":"https://pubmed.ncbi.nlm.nih.gov/20223012","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2837290"},"language":"en","primary_location":{"id":"doi:10.1186/1897-4287-4-2-81","doi":"https://doi.org/10.1186/1897-4287-4-2-81","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1897-4287-4-2-81","pdf_url":"https://hccpjournal.biomedcentral.com/track/pdf/10.1186/1897-4287-4-2-81","source":{"id":"https://openalex.org/S160800418","display_name":"Hereditary Cancer in Clinical Practice","issn_l":"1731-2302","issn":["1731-2302","1897-4287"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hereditary Cancer in Clinical Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://hccpjournal.biomedcentral.com/track/pdf/10.1186/1897-4287-4-2-81","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086139439","display_name":"Rosana Marques Pereira","orcid":"https://orcid.org/0000-0002-0270-1519","observed_orcids":["https://orcid.org/0000-0002-0270-1519"]},"institutions":[{"id":"https://openalex.org/I4210134516","display_name":"Hospital de Cl\u00ednicas Universidade Federal do Paran\u00e1","ror":"https://ror.org/03ej9xm26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210134516"]},{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rosana Marques-Pereira","raw_affiliation_strings":["Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana; Curitiba PR, Brazil. sandrini@ufpr.br","Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, Curitiba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana; Curitiba PR, Brazil. sandrini@ufpr.br","institution_ids":["https://openalex.org/I4210134516","https://openalex.org/I52418104"]},{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, Curitiba, Brazil","institution_ids":["https://openalex.org/I4210134516","https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048397624","display_name":"Luiz DeLacerda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134516","display_name":"Hospital de Cl\u00ednicas Universidade Federal do Paran\u00e1","ror":"https://ror.org/03ej9xm26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210134516"]},{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luiz DeLacerda","raw_affiliation_strings":["Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, R. Padre Camargo, 250, Curitiba, PR, 80060-240, Brazil","Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, Curitiba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, R. Padre Camargo, 250, Curitiba, PR, 80060-240, Brazil","institution_ids":["https://openalex.org/I4210134516","https://openalex.org/I52418104"]},{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, Curitiba, Brazil","institution_ids":["https://openalex.org/I4210134516","https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015776887","display_name":"Hadriano M. Lacerda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134516","display_name":"Hospital de Cl\u00ednicas Universidade Federal do Paran\u00e1","ror":"https://ror.org/03ej9xm26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210134516"]},{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Hadriano M Lacerda","raw_affiliation_strings":["Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, R. Padre Camargo, 250, Curitiba, PR, 80060-240, Brazil","Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, Curitiba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, R. Padre Camargo, 250, Curitiba, PR, 80060-240, Brazil","institution_ids":["https://openalex.org/I4210134516","https://openalex.org/I52418104"]},{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, Curitiba, Brazil","institution_ids":["https://openalex.org/I4210134516","https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043443450","display_name":"Edson Michalkiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134516","display_name":"Hospital de Cl\u00ednicas Universidade Federal do Paran\u00e1","ror":"https://ror.org/03ej9xm26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210134516"]},{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Edson Michalkiewicz","raw_affiliation_strings":["Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, R. Padre Camargo, 250, Curitiba, PR, 80060-240, Brazil","Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, Curitiba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, R. Padre Camargo, 250, Curitiba, PR, 80060-240, Brazil","institution_ids":["https://openalex.org/I4210134516","https://openalex.org/I52418104"]},{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, Curitiba, Brazil","institution_ids":["https://openalex.org/I4210134516","https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075389872","display_name":"Fabiano Sandrini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134516","display_name":"Hospital de Cl\u00ednicas Universidade Federal do Paran\u00e1","ror":"https://ror.org/03ej9xm26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210134516"]},{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fabiano Sandrini","raw_affiliation_strings":["Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, R. Padre Camargo, 250, Curitiba, PR, 80060-240, Brazil","Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, Curitiba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, R. Padre Camargo, 250, Curitiba, PR, 80060-240, Brazil","institution_ids":["https://openalex.org/I4210134516","https://openalex.org/I52418104"]},{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, Curitiba, Brazil","institution_ids":["https://openalex.org/I4210134516","https://openalex.org/I52418104"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111756338","display_name":"Romolo Sandrini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134516","display_name":"Hospital de Cl\u00ednicas Universidade Federal do Paran\u00e1","ror":"https://ror.org/03ej9xm26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210134516"]},{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Romolo Sandrini","raw_affiliation_strings":["Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, R. Padre Camargo, 250, Curitiba, PR, 80060-240, Brazil","Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, Curitiba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, R. Padre Camargo, 250, Curitiba, PR, 80060-240, Brazil","institution_ids":["https://openalex.org/I4210134516","https://openalex.org/I52418104"]},{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Pediatrics, Clinical Hospital, Federal University of Parana, Curitiba, Brazil","institution_ids":["https://openalex.org/I4210134516","https://openalex.org/I52418104"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111756338"],"corresponding_institution_ids":["https://openalex.org/I4210134516","https://openalex.org/I52418104"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.21015043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"2","first_page":"81","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/masculinization","display_name":"masculinization","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cushing-s-syndrome","display_name":"Cushing's syndrome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.5860000252723694},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.765999972820282},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5920000076293945},{"id":"https://openalex.org/keywords/penetrance","display_name":"penetrance","score":0.906000018119812},{"id":"https://openalex.org/keywords/hereditary-cancer-susceptibility","display_name":"hereditary cancer predisposition","score":0.6679999828338623},{"id":"https://openalex.org/keywords/southern-brazil","display_name":"southern Brazil","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8707149028778076},{"id":"https://openalex.org/C200544954","wikidata":"https://www.wikidata.org/wiki/Q516389","display_name":"Penetrance","level":4,"score":0.693266749382019},{"id":"https://openalex.org/C2781399356","wikidata":"https://www.wikidata.org/wiki/Q918285","display_name":"Adrenocortical carcinoma","level":2,"score":0.57257080078125},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5711105465888977},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5221096277236938},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.5179537534713745},{"id":"https://openalex.org/C2776631543","wikidata":"https://www.wikidata.org/wiki/Q1433654","display_name":"Virilization","level":4,"score":0.47462761402130127},{"id":"https://openalex.org/C2776735609","wikidata":"https://www.wikidata.org/wiki/Q417465","display_name":"Mitotane","level":3,"score":0.46895235776901245},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.4550403952598572},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4319442808628082},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4099283516407013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4095477759838104},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3564210832118988},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13434463739395142},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.12576642632484436},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.09632441401481628},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08260568976402283},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/1897-4287-4-2-81","doi":"https://doi.org/10.1186/1897-4287-4-2-81","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1897-4287-4-2-81","pdf_url":"https://hccpjournal.biomedcentral.com/track/pdf/10.1186/1897-4287-4-2-81","source":{"id":"https://openalex.org/S160800418","display_name":"Hereditary Cancer in Clinical Practice","issn_l":"1731-2302","issn":["1731-2302","1897-4287"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hereditary Cancer in Clinical Practice","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2837290","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2837290","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hered Cancer Clin Pract","raw_type":"Text"},{"id":"pmid:20223012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20223012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hereditary cancer in clinical practice","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.333.131","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.131","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.biomedcentral.com/content/pdf/1897-4287-4-2-81.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:66ec68f7f0894207a0c0296625cbe42f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/66ec68f7f0894207a0c0296625cbe42f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hereditary Cancer in Clinical Practice, Vol 4, Iss 2, Pp 81-89 (2006)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1897-4287-4-2-81","doi":"https://doi.org/10.1186/1897-4287-4-2-81","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1897-4287-4-2-81","pdf_url":"https://hccpjournal.biomedcentral.com/track/pdf/10.1186/1897-4287-4-2-81","source":{"id":"https://openalex.org/S160800418","display_name":"Hereditary Cancer in Clinical Practice","issn_l":"1731-2302","issn":["1731-2302","1897-4287"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hereditary Cancer in Clinical Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2098560717.pdf","grobid_xml":"https://content.openalex.org/works/W2098560717.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W63968789","https://openalex.org/W65178870","https://openalex.org/W1481956726","https://openalex.org/W1514348119","https://openalex.org/W1568658568","https://openalex.org/W1596222665","https://openalex.org/W1753185091","https://openalex.org/W1885316483","https://openalex.org/W1969330589","https://openalex.org/W1969633940","https://openalex.org/W1970258636","https://openalex.org/W1970399383","https://openalex.org/W1977052152","https://openalex.org/W1980250255","https://openalex.org/W1982343420","https://openalex.org/W1982808025","https://openalex.org/W1984648882","https://openalex.org/W1986058952","https://openalex.org/W1988623266","https://openalex.org/W1988892614","https://openalex.org/W1991079897","https://openalex.org/W1991494214","https://openalex.org/W1991711911","https://openalex.org/W2003238497","https://openalex.org/W2005542290","https://openalex.org/W2008887283","https://openalex.org/W2009148495","https://openalex.org/W2010094229","https://openalex.org/W2010321638","https://openalex.org/W2016160656","https://openalex.org/W2019268752","https://openalex.org/W2023531352","https://openalex.org/W2025619838","https://openalex.org/W2026435298","https://openalex.org/W2029987737","https://openalex.org/W2036931457","https://openalex.org/W2039634774","https://openalex.org/W2040642687","https://openalex.org/W2044046815","https://openalex.org/W2047661097","https://openalex.org/W2050992919","https://openalex.org/W2051972371","https://openalex.org/W2059880490","https://openalex.org/W2062637564","https://openalex.org/W2065310043","https://openalex.org/W2065554335","https://openalex.org/W2068048784","https://openalex.org/W2072241987","https://openalex.org/W2072800171","https://openalex.org/W2080125477","https://openalex.org/W2087908369","https://openalex.org/W2088545698","https://openalex.org/W2090492363","https://openalex.org/W2090940786","https://openalex.org/W2091480567","https://openalex.org/W2092675326","https://openalex.org/W2093865758","https://openalex.org/W2098165008","https://openalex.org/W2106396959","https://openalex.org/W2108158811","https://openalex.org/W2120218419","https://openalex.org/W2120961400","https://openalex.org/W2125426277","https://openalex.org/W2135277264","https://openalex.org/W2150110700","https://openalex.org/W2150561419","https://openalex.org/W2157388849","https://openalex.org/W2157455826","https://openalex.org/W2158106539","https://openalex.org/W2163679869","https://openalex.org/W2171162119","https://openalex.org/W2300747666","https://openalex.org/W2313193910","https://openalex.org/W2317722348","https://openalex.org/W2336089418","https://openalex.org/W2468053804","https://openalex.org/W3021616971","https://openalex.org/W4247033917","https://openalex.org/W4296412345","https://openalex.org/W6654590336"],"related_works":["https://openalex.org/W7100143857","https://openalex.org/W1987416125","https://openalex.org/W2254423082","https://openalex.org/W2013170178","https://openalex.org/W2059773232","https://openalex.org/W4226128851","https://openalex.org/W2108158811","https://openalex.org/W3038951562","https://openalex.org/W1986058952","https://openalex.org/W2017996475"],"abstract_inverted_index":{"Childhood":[0],"adrenocortical":[1],"tumour":[2,148,215],"(ACT)":[3],"is":[4,15,114,139,144,173,219],"not":[5],"a":[6,50,119,214],"common":[7],"disease,":[8],"but":[9],"in":[10,20,55,77,95,163],"southern":[11,96],"Brazil":[12],"the":[13,24,40,72,115,178,206,210,238,254,263],"prevalence":[14],"15":[16],"times":[17],"higher":[18],"than":[19,175],"other":[21],"parts":[22],"of":[23,53,60,180,187,208,212,231,234,237,247,257,262],"world.":[25],"One":[26],"hundred":[27],"and":[28,34,118,197,221,244,259],"thirty-seven":[29],"patients":[30,56,150,165,181],"have":[31,156,189],"been":[32],"identified":[33],"followed":[35],"by":[36],"our":[37,101],"group":[38,179],"over":[39],"past":[41],"four":[42],"decades.":[43],"Affected":[44],"children":[45],"are":[46,81],"predominantly":[47],"girls,":[48],"with":[49,67,151,166,182],"female-to-male":[51],"ratio":[52],"3.5:1":[54],"below":[57],"4":[58],"years":[59],"age.":[61],"Virilization":[62],"alone":[63],"(51.6%)":[64],"or":[65],"mixed":[66],"Cushing's":[68],"syndrome":[69],"(42.0%)":[70],"was":[71],"predominant":[73],"clinical":[74],"picture":[75],"observed":[76],"these":[78],"patients.":[79],"Tumours":[80],"unilateral,":[82],"affecting":[83],"both":[84],"glands":[85],"equally.":[86],"TP53":[87,217,239],"R337H":[88,218,240],"germline":[89],"mutations":[90],"underlie":[91],"most":[92],"childhood":[93],"ACTs":[94,258],"Brazil.":[97],"Epidemiological":[98],"data":[99],"from":[100],"casuistic":[102],"studies":[103],"revealed":[104],"that":[105],"this":[106],"mutation":[107,241],"has":[108,129],"~10%":[109],"penetrance":[110],"for":[111],"ACT.":[112],"Surgery":[113],"definitive":[116],"treatment,":[117],"complete":[120],"resection":[121],"should":[122],"always":[123],"be":[124],"attempted.":[125],"Although":[126],"adjuvant":[127],"chemotherapy":[128],"shown":[130],"some":[131],"encouraging":[132],"results,":[133],"its":[134,224],"influence":[135],"on":[136],"overall":[137],"outcome":[138],"small.":[140],"The":[141],"survival":[142,157],"rate":[143],"directly":[145],"correlated":[146],"to":[147,160,203,222],"size;":[149],"small,":[152],"completely":[153],"excised":[154],"tumours":[155,168],"rates":[158],"close":[159,232],"90%,":[161],"whereas":[162],"those":[164],"inoperable":[167],"and/or":[169],"metastatic":[170],"disease":[171],"it":[172],"less":[174],"10%.":[176],"In":[177],"large,":[183],"excisable":[184],"tumours,":[185],"half":[186],"them":[188],"an":[190,260],"intermediate":[191],"outcome.":[192,225],"Recent":[193],"molecular":[194],"biology":[195],"techniques":[196],"genomic":[198],"approaches":[199],"may":[200],"help":[201],"us":[202],"better":[204],"understand":[205],"pathogenesis":[207],"ACT,":[209],"risk":[211],"developing":[213],"when":[216],"present,":[220],"predict":[223],"An":[226],"ongoing":[227],"pilot":[228],"study":[229],"consisting":[230],"monitoring":[233],"healthy":[235],"carriers":[236],"-":[242,251],"siblings":[243],"first-degree":[245],"relatives":[246],"known":[248],"affected":[249],"cases":[250],"aims":[252],"at":[253],"early":[255],"detection":[256],"improvement":[261],"cure":[264],"rate.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}