{"id":"https://openalex.org/W2098547439","doi":"https://doi.org/10.1093/carcin/15.10.2245","title":"Promotion by polychlorinated biphenyls of lung and liver tumors in mice","display_name":"Promotion by polychlorinated biphenyls of lung and liver tumors in mice","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2098547439","doi":"https://doi.org/10.1093/carcin/15.10.2245","mag":"2098547439","pmid":"https://pubmed.ncbi.nlm.nih.gov/7955061"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/15.10.2245","doi":"https://doi.org/10.1093/carcin/15.10.2245","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/15.10.2245","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103390138","display_name":"Lucy M. Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"Lucy M. Anderson","raw_affiliation_strings":["Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Ft Detrick, MD 21702-1201","Laboratory of Comparative Carcinogenesis, National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Ft Detrick, MD 21702-1201","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Laboratory of Comparative Carcinogenesis, National Cancer Institute","institution_ids":["https://openalex.org/I4210123359","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090333923","display_name":"Daniel L. Logsdon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Logsdon","raw_affiliation_strings":["Program Resources, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program Resources, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045385145","display_name":"Stasia Ruskie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stasia Ruskie","raw_affiliation_strings":["Program Resources, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program Resources, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044376869","display_name":"Stephen D. Fox","orcid":"https://orcid.org/0000-0003-0664-9970","observed_orcids":["https://orcid.org/0000-0003-0664-9970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen D. Fox","raw_affiliation_strings":["Program Resources, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program Resources, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111561637","display_name":"Haleem J. Issaq","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haleem J. Issaq","raw_affiliation_strings":["Program Resources, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program Resources, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060084329","display_name":"Robert M. Kovatch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert M. Kovatch","raw_affiliation_strings":["Pathology Associates, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Associates, Inc","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111690459","display_name":"Charles W. Riggs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148012","display_name":"Data Management Services (United States)","ror":"https://ror.org/04jqjkn20","country_code":"US","type":"company","lineage":["https://openalex.org/I4210148012"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles M. Riggs","raw_affiliation_strings":["Data Management Services, Inc., Frederick Cancer Research and Development Center Ft Detnck, Frederick, MD 21702\u20131201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Management Services, Inc., Frederick Cancer Research and Development Center Ft Detnck, Frederick, MD 21702\u20131201, USA","institution_ids":["https://openalex.org/I4210148012"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":2.337,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.86021348,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"15","issue":"10","first_page":"2245","last_page":"2248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.3334999978542328,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":1.0},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.9020000100135803},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7789999842643738},{"id":"https://openalex.org/keywords/liver-tumors","display_name":"liver tumors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/aroclor-1254","display_name":"Aroclor 1254","score":0.9449999928474426},{"id":"https://openalex.org/keywords/n-nitrosodimethylamine","display_name":"N-nitrosodimethylamine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tumor-latency","display_name":"tumor latency","score":0.7099999785423279},{"id":"https://openalex.org/keywords/tumor-multiplicity","display_name":"tumor multiplicity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/pcb-congeners","display_name":"PCB congeners","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.5090741515159607},{"id":"https://openalex.org/C98147612","wikidata":"https://www.wikidata.org/wiki/Q215599","display_name":"Promotion (chess)","level":3,"score":0.4696497321128845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41028088331222534},{"id":"https://openalex.org/C74916050","wikidata":"https://www.wikidata.org/wiki/Q841090","display_name":"Classics","level":1,"score":0.32072824239730835},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.31872305274009705},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.1805267333984375},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12002459168434143},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.11026453971862793},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.09991997480392456}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001822","descriptor_name":"Body Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004128","descriptor_name":"Dimethylnitrosamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011078","descriptor_name":"Polychlorinated Biphenyls","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/15.10.2245","doi":"https://doi.org/10.1093/carcin/15.10.2245","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/15.10.2245","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:7955061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7955061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1963918993","https://openalex.org/W1967376028","https://openalex.org/W4300672261","https://openalex.org/W2092748712","https://openalex.org/W2257485227","https://openalex.org/W2263674171","https://openalex.org/W1999523634","https://openalex.org/W2428116146","https://openalex.org/W246632755","https://openalex.org/W1934843559"],"abstract_inverted_index":{"Polychlorinated":[0],"biphenyls":[1],"(PCB),":[2],"which":[3],"are":[4],"tumor":[5,36,56,119,189,258],"promoters,":[6],"have":[7,40],"been":[8,41,61],"found":[9],"in":[10,64,70,80,88,152,193,203,211,229,295],"human":[11,29],"tissues":[12,65],"for":[13,219],"decades.":[14],"Their":[15],"contribution":[16],"to":[17,24,27,109],"cancer":[18,30,50],"risk":[19],"may":[20],"only":[21,210],"now":[22],"start":[23],"appear,":[25],"due":[26],"long":[28],"latency":[31],"and":[32,49,83,111,123,135,143,183,196,209,216,233,239,263],"the":[33,91,113,153,194,220,225,231,286],"nature":[34],"of":[35,115,156,165,173,237,266,289],"promotion.":[37],"Epidemiological":[38],"associations":[39],"seen":[42],"between":[43,256],"PCB":[44,148,247],"exposure":[45,76],"or":[46],"tissue":[47],"content":[48],"at":[51,145,162,181,206,222,260],"several":[52],"sites.":[53],"In":[54],"rodents,":[55],"promotion":[57],"by":[58,90,98,170,179,246,284],"PCBs":[59,78,180,276],"has":[60],"little":[62],"studied":[63],"other":[66,270],"than":[67],"liver.":[68],"Previously,":[69],"an":[71],"experiment":[72],"modeling":[73],"infant":[74],"carcinogen":[75],"following":[77],"received":[79],"milk,":[81],"lung":[82,160,174,257,278],"liver":[84,240,282],"tumors,":[85,283],"initiated":[86,291],"neonatally":[87],"mice":[89,127,157,212],"environmental":[92],"nitrosamine":[93],"N-nitrosodimethylamine":[94],"(NDMA),":[95],"were":[96,128,150,167,176,191,243],"promoted":[97],"later":[99],"treatment":[100],"with":[101,158,268],"Aroclor":[102,116,136],"1254.":[103],"The":[104,272],"present":[105],"study":[106],"was":[107,227],"undertaken":[108],"confirm":[110,274],"characterize":[112],"effects":[114],"1254":[117,137],"on":[118,131,140],"number,":[120],"latency,":[121],"size":[122],"malignancy.":[124],"Male":[125],"Swiss":[126],"given":[129],"NDMA":[130,215],"postnatal":[132],"day":[133,141],"4":[134],"(250":[138],"mg/kg)":[139],"8,":[142],"killed":[144],"intervals.":[146],"Eight":[147],"congeners":[149],"quantified":[151],"carcasses.":[154],"Incidences":[155],"NDMA-initiated":[159],"tumors":[161,175,200,238,292],"28":[163,182,261],"weeks":[164,188,208,224,262],"age":[166],"increased":[168],"2.5-fold":[169],"PCBs.":[171,217],"Multiplicities":[172],"enhanced":[177],"four-fold":[178],"52":[184,207],"weeks.":[185],"By":[186],"72":[187,223],"numbers":[190,205,259],"similar":[192],"NDMA-only":[195,232],"NDMA-PCB":[197,234],"groups.":[198,235],"Liver":[199],"first":[201],"occurred":[202],"significant":[204,253],"receiving":[213],"both":[214,230],"As":[218],"lung,":[221],"incidence":[226,242],"high":[228],"Sizes":[236],"carcinoma":[241],"not":[244],"altered":[245],"treatment.":[248],"Carcass":[249],"analysis":[250],"revealed":[251],"a":[252],"positive":[254],"association":[255],"relative":[264],"percentage":[265],"2,2',4,4',5-pentachlorobiphenyl,":[267],"no":[269],"correlations.":[271],"results":[273],"that":[275],"promote":[277],"as":[279,281],"well":[280],"triggering":[285],"early":[287],"appearance":[288],"latent":[290],"otherwise":[293],"presenting":[294],"old":[296],"age.":[297]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
