{"id":"https://openalex.org/W2098528610","doi":"https://doi.org/10.1093/chromsci/bms171","title":"Validated Chromatographic Methods for Determination of Perindopril and Amlodipine in Pharmaceutical Formulation in the Presence of their Degradation Products","display_name":"Validated Chromatographic Methods for Determination of Perindopril and Amlodipine in Pharmaceutical Formulation in the Presence of their Degradation Products","publication_year":2012,"publication_date":"2012-10-30","ids":{"openalex":"https://openalex.org/W2098528610","doi":"https://doi.org/10.1093/chromsci/bms171","mag":"2098528610","pmid":"https://pubmed.ncbi.nlm.nih.gov/23112269"},"language":"en","primary_location":{"id":"doi:10.1093/chromsci/bms171","doi":"https://doi.org/10.1093/chromsci/bms171","is_oa":false,"landing_page_url":"https://doi.org/10.1093/chromsci/bms171","pdf_url":null,"source":{"id":"https://openalex.org/S144192255","display_name":"Journal of Chromatographic Science","issn_l":"0021-9665","issn":["0021-9665","1945-239X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatographic Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060351897","display_name":"Hala E. Zaazaa","orcid":"https://orcid.org/0000-0002-0173-1011","observed_orcids":["https://orcid.org/0000-0002-0173-1011"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"H. E. Zaazaa","raw_affiliation_strings":["Analytical Chemistry Department, Faculty of Pharmacy-Cairo University, Kasr El-Aini Street,11562 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Chemistry Department, Faculty of Pharmacy-Cairo University, Kasr El-Aini Street,11562 Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102749369","display_name":"Samah Sayed Abbas","orcid":"https://orcid.org/0000-0002-9089-9114","observed_orcids":["https://orcid.org/0000-0002-9089-9114","https://orcid.org/0000-0003-4801-1705"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"S. S. Abbas","raw_affiliation_strings":["Analytical Chemistry Department, Faculty of Pharmacy-Cairo University, Kasr El-Aini Street,11562 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Chemistry Department, Faculty of Pharmacy-Cairo University, Kasr El-Aini Street,11562 Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111703829","display_name":"Hebat Allah M Essam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"H. A. M. Essam","raw_affiliation_strings":["Analytical Chemistry Department, Faculty of Pharmacy-Cairo University, Kasr El-Aini Street,11562 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Chemistry Department, Faculty of Pharmacy-Cairo University, Kasr El-Aini Street,11562 Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110529255","display_name":"Mohammad Galal El-BARDICY","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"M. G. El-Bardicy","raw_affiliation_strings":["Analytical Chemistry Department, Faculty of Pharmacy-Cairo University, Kasr El-Aini Street,11562 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Chemistry Department, Faculty of Pharmacy-Cairo University, Kasr El-Aini Street,11562 Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111703829"],"corresponding_institution_ids":["https://openalex.org/I145487455"],"apc_list":{"value":4822,"currency":"USD","value_usd":4822},"apc_paid":null,"fwci":2.8117,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.88939517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"51","issue":"6","first_page":"533","last_page":"543"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12878","display_name":"Pharmaceutical Quality and Counterfeiting","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perindopril-arginine","display_name":"perindopril arginine","score":0.9369999766349792},{"id":"https://openalex.org/keywords/amlodipine","display_name":"amlodipine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stability-indicating-method","display_name":"stability-indicating assay","score":0.8769999742507935},{"id":"https://openalex.org/keywords/degradation-products","display_name":"degradation products","score":0.8130000233650208},{"id":"https://openalex.org/keywords/thin-layer-chromatography","display_name":"thin-layer chromatography","score":0.7549999952316284},{"id":"https://openalex.org/keywords/densitometry","display_name":"densitometry","score":0.8420000076293945},{"id":"https://openalex.org/keywords/high-performance-liquid-chromatography","display_name":"HPLC","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tablets","display_name":"tablets","score":0.6959999799728394},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/ich-guidelines","display_name":"ICH guidelines","score":0.6259999871253967},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.9015991687774658},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8962706327438354},{"id":"https://openalex.org/C2779532046","wikidata":"https://www.wikidata.org/wiki/Q308976","display_name":"Silica gel","level":2,"score":0.6510849595069885},{"id":"https://openalex.org/C2779646130","wikidata":"https://www.wikidata.org/wiki/Q411347","display_name":"Amlodipine","level":3,"score":0.5424012541770935},{"id":"https://openalex.org/C2777682752","wikidata":"https://www.wikidata.org/wiki/Q8564473","display_name":"Forced degradation","level":4,"score":0.4930846393108368},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.482711523771286},{"id":"https://openalex.org/C108454664","wikidata":"https://www.wikidata.org/wiki/Q853894","display_name":"High performance thin layer chromatography","level":3,"score":0.46131157875061035},{"id":"https://openalex.org/C2779200603","wikidata":"https://www.wikidata.org/wiki/Q277785","display_name":"Perindopril","level":3,"score":0.4401947557926178},{"id":"https://openalex.org/C190196608","wikidata":"https://www.wikidata.org/wiki/Q746133","display_name":"Thin-layer chromatography","level":2,"score":0.3884034752845764},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.3745024800300598},{"id":"https://openalex.org/C2780782300","wikidata":"https://www.wikidata.org/wiki/Q410156","display_name":"Ammonium acetate","level":3,"score":0.3203049302101135},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002855","descriptor_name":"Chromatography, Thin Layer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003720","descriptor_name":"Densitometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020913","descriptor_name":"Perindopril","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D020913","descriptor_name":"Perindopril","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/chromsci/bms171","doi":"https://doi.org/10.1093/chromsci/bms171","is_oa":false,"landing_page_url":"https://doi.org/10.1093/chromsci/bms171","pdf_url":null,"source":{"id":"https://openalex.org/S144192255","display_name":"Journal of Chromatographic Science","issn_l":"0021-9665","issn":["0021-9665","1945-239X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatographic Science","raw_type":"journal-article"},{"id":"pmid:23112269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23112269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatographic science","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.822.3676","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.822.3676","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://chromsci.oxfordjournals.org/content/51/6/533.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.822.785","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.822.785","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://chromsci.oxfordjournals.org/content/early/2012/10/30/chromsci.bms171.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1682768769","https://openalex.org/W1968961179","https://openalex.org/W1972540349","https://openalex.org/W1974464491","https://openalex.org/W1975714885","https://openalex.org/W1976140298","https://openalex.org/W1978748265","https://openalex.org/W1979455819","https://openalex.org/W1983697677","https://openalex.org/W1990748219","https://openalex.org/W1993664474","https://openalex.org/W1997248869","https://openalex.org/W2001888662","https://openalex.org/W2009555738","https://openalex.org/W2013595609","https://openalex.org/W2015044038","https://openalex.org/W2022271744","https://openalex.org/W2022890275","https://openalex.org/W2035685754","https://openalex.org/W2044536783","https://openalex.org/W2051654787","https://openalex.org/W2054553388","https://openalex.org/W2065130163","https://openalex.org/W2066193575","https://openalex.org/W2068398934","https://openalex.org/W2068634322","https://openalex.org/W2073296119","https://openalex.org/W2077808686","https://openalex.org/W2077901891","https://openalex.org/W2080787312","https://openalex.org/W2084884748","https://openalex.org/W2087299535","https://openalex.org/W2088643249","https://openalex.org/W2092003325","https://openalex.org/W2095145245","https://openalex.org/W2120383587","https://openalex.org/W2151512469","https://openalex.org/W2160465676","https://openalex.org/W2442923484","https://openalex.org/W2486528993","https://openalex.org/W2617002364","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3035803836","https://openalex.org/W2921173319","https://openalex.org/W2158766247","https://openalex.org/W1504679382","https://openalex.org/W2587566178","https://openalex.org/W3043332015","https://openalex.org/W4310034981","https://openalex.org/W4414424062","https://openalex.org/W2580185263","https://openalex.org/W1756653387"],"abstract_inverted_index":{"Two":[0],"specific,":[1],"sensitive,":[2],"and":[3,12,20,27,63,155,164,179],"precise":[4],"stability-indicating":[5],"chromatographic":[6],"methods":[7,123,140,146,171,183],"have":[8],"been":[9],"developed,":[10],"optimized":[11,125],"validated":[13,148],"for":[14,126,159],"determination":[15,47],"of":[16,31,48,102,129,136,162],"perindopril":[17],"arginin":[18],"(PER)":[19],"amlodipine":[21],"besylate":[22],"(AML)":[23],"in":[24,28,149,166,188],"their":[25,32,167],"mixtures":[26],"the":[29,49,86,121,130,137,152,160,181],"presence":[30],"degradation":[33],"products.":[34],"The":[35,75,144],"first":[36],"method":[37,77],"was":[38,54,78],"based":[39,79],"on":[40,80,91],"thin-layer":[41],"chromatography":[42],"(TLC)":[43],"combined":[44],"with":[45,112,151,184],"densitometric":[46],"separated":[50,90],"bands.":[51],"Adequate":[52],"separation":[53,128],"achieved":[55],"using":[56,97],"silica":[57],"gel":[58],"60":[59],"F254":[60],"TLC":[61],"plates":[62],"ethyl":[64],"acetate-methanol-toluene-ammonia":[65],"solution,":[66],"33%":[67],"(6.5:2:1:0.5":[68],"by":[69,84,110],"volume),":[70],"as":[71],"a":[72,92,98],"developing":[73],"system.":[74],"second":[76],"high-performance":[81],"liquid":[82],"chromatography,":[83],"which":[85],"proposed":[87],"components":[88],"were":[89,124,141,147,156,172],"reversed-phase":[93],"C18":[94],"analytical":[95],"column":[96],"mobile":[99],"phase":[100],"consisting":[101],"phosphate":[103],"buffer":[104],"(pH":[105],"2.5,":[106],"0.01":[107],"M)-acetonitrile-tetrahydrofuran":[108],"(60:40:0.1%":[109],"volume)":[111],"ultraviolet":[113],"detection":[114],"at":[115],"218":[116],"nm.":[117],"Different":[118],"parameters":[119,135],"affecting":[120],"suggested":[122,145],"maximum":[127],"cited":[131],"components.":[132],"System":[133],"suitability":[134],"two":[138],"developed":[139],"also":[142,173],"tested.":[143],"compliance":[150],"ICH":[153],"guidelines":[154],"successfully":[157],"applied":[158],"quantification":[161],"PER":[163],"AML":[165],"commercial":[168],"tablets.":[169],"Both":[170],"statistically":[174],"compared":[175],"to":[176,180],"each":[177],"other":[178],"reference":[182],"no":[185],"significant":[186],"differences":[187],"performance.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
