{"id":"https://openalex.org/W2098518995","doi":"https://doi.org/10.1091/mbc.e05-02-0109","title":"Calcium-induced Human Keratinocyte Differentiation Requiressrc- andfyn-mediated Phosphatidylinositol 3-Kinase\u2013dependent Activation of Phospholipase C-\u03b31","display_name":"Calcium-induced Human Keratinocyte Differentiation Requiressrc- andfyn-mediated Phosphatidylinositol 3-Kinase\u2013dependent Activation of Phospholipase C-\u03b31","publication_year":2005,"publication_date":"2005-05-05","ids":{"openalex":"https://openalex.org/W2098518995","doi":"https://doi.org/10.1091/mbc.e05-02-0109","mag":"2098518995","pmid":"https://pubmed.ncbi.nlm.nih.gov/15872086","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1165407"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.e05-02-0109","doi":"https://doi.org/10.1091/mbc.e05-02-0109","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e05-02-0109","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1165407","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083570335","display_name":"Zhongjian Xie","orcid":"https://orcid.org/0000-0002-1601-1156","observed_orcids":["https://orcid.org/0000-0002-1601-1156"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210166254","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210166254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhongjian Xie","raw_affiliation_strings":["Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California\u2013San Francisco, San Francisco, CA 94121","Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California-San Francisco, San Francisco, CA 94121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California\u2013San Francisco, San Francisco, CA 94121","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191","https://openalex.org/I4210166254"]},{"raw_affiliation_string":"Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California-San Francisco, San Francisco, CA 94121, USA","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191","https://openalex.org/I4210166254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017109928","display_name":"Patrick A. Singleton","orcid":"https://orcid.org/0000-0002-9319-2333","observed_orcids":["https://orcid.org/0000-0002-9319-2333"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210166254","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210166254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick A. Singleton","raw_affiliation_strings":["Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California\u2013San Francisco, San Francisco, CA 94121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California\u2013San Francisco, San Francisco, CA 94121","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191","https://openalex.org/I4210166254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069496915","display_name":"Lilly Bourguignon","orcid":"https://orcid.org/0000-0003-3172-9251","observed_orcids":["https://orcid.org/0000-0003-3172-9251"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210166254","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210166254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lilly Y.W. Bourguignon","raw_affiliation_strings":["Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California\u2013San Francisco, San Francisco, CA 94121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California\u2013San Francisco, San Francisco, CA 94121","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191","https://openalex.org/I4210166254"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032781101","display_name":"Daniel D. Bikle","orcid":"https://orcid.org/0000-0002-1040-475X","observed_orcids":["https://orcid.org/0000-0002-1040-475X"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210166254","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210166254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel D. Bikle","raw_affiliation_strings":["Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California\u2013San Francisco, San Francisco, CA 94121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California\u2013San Francisco, San Francisco, CA 94121","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191","https://openalex.org/I4210166254"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5486,"has_fulltext":true,"cited_by_count":97,"citation_normalized_percentile":{"value":0.80674119,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"16","issue":"7","first_page":"3236","last_page":"3246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8500000238418579},{"id":"https://openalex.org/keywords/phospholipase-c-gamma1","display_name":"phospholipase C-gamma1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.6200000047683716},{"id":"https://openalex.org/keywords/fyn","display_name":"Fyn","score":0.9950000047683716},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-4-5-trisphosphate","display_name":"phosphatidylinositol 3,4,5-trisphosphate","score":0.9729999899864197},{"id":"https://openalex.org/keywords/involucrin","display_name":"involucrin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/transglutaminase","display_name":"transglutaminase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dominant-negative-mutant","display_name":"dominant-negative mutant","score":0.5299999713897705},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C37686147","wikidata":"https://www.wikidata.org/wiki/Q423628","display_name":"FYN","level":4,"score":0.8607368469238281},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.7270272970199585},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6679863929748535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6541086435317993},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.651093602180481},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.5809330344200134},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5092970132827759},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.4792501926422119},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.4761336147785187},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.38310879468917847},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3713821768760681},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2861486077308655},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011503","descriptor_name":"Transglutaminases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018129","descriptor_name":"Phosphatidylinositol Phosphates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1091/mbc.e05-02-0109","doi":"https://doi.org/10.1091/mbc.e05-02-0109","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e05-02-0109","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:155295","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1165407","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1165407","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1165407","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"pmid:15872086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15872086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt7t44b6zq","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7t44b6zq","pdf_url":"https://escholarship.org/uc/item/7t44b6zq","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Biology of the Cell, vol 16, iss 7","raw_type":"article"},{"id":"pmh:qt7t44b6zq","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/7t44b6zq","pdf_url":"http://www.escholarship.org/uc/item/7t44b6zq","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Xie, Zhongjian J; Singleton, P A; Bourguignon, LYW; & Bikle, D D. (2005). Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma 1. Molecular Biology of the Cell, 16(7), 3236 - 3246. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7t44b6zq","raw_type":"article"},{"id":"mag:2336715334","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7t44b6zq.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:155295","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1165407","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.40149998664855957}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2098518995.pdf","grobid_xml":"https://content.openalex.org/works/W2098518995.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1491383374","https://openalex.org/W1536337406","https://openalex.org/W1568605582","https://openalex.org/W1587627449","https://openalex.org/W1804979462","https://openalex.org/W1829376516","https://openalex.org/W1958742527","https://openalex.org/W1966018982","https://openalex.org/W1981182586","https://openalex.org/W1984453879","https://openalex.org/W1986021138","https://openalex.org/W1989044922","https://openalex.org/W2004360930","https://openalex.org/W2013727892","https://openalex.org/W2017100096","https://openalex.org/W2023246298","https://openalex.org/W2024630630","https://openalex.org/W2031975110","https://openalex.org/W2036145275","https://openalex.org/W2049246519","https://openalex.org/W2050923205","https://openalex.org/W2054443936","https://openalex.org/W2059072734","https://openalex.org/W2060719924","https://openalex.org/W2062748780","https://openalex.org/W2064983363","https://openalex.org/W2068877244","https://openalex.org/W2075047779","https://openalex.org/W2077547402","https://openalex.org/W2078411762","https://openalex.org/W2086955015","https://openalex.org/W2088603460","https://openalex.org/W2089101401","https://openalex.org/W2091179088","https://openalex.org/W2093265249","https://openalex.org/W2103043702","https://openalex.org/W2110789444","https://openalex.org/W2119486893","https://openalex.org/W2132148332","https://openalex.org/W2135776211","https://openalex.org/W2145261791","https://openalex.org/W2152701998","https://openalex.org/W2153695113","https://openalex.org/W2169007182"],"related_works":["https://openalex.org/W2336715334","https://openalex.org/W653128423","https://openalex.org/W2007374663","https://openalex.org/W2130425664","https://openalex.org/W2415474540","https://openalex.org/W2013727892","https://openalex.org/W2004360930","https://openalex.org/W2086955015","https://openalex.org/W7217027711","https://openalex.org/W1969078249"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"demonstrated":[3],"that":[4,44,165],"phospholipase":[5],"C":[6],"(PLC)-gamma1":[7],"is":[8,181],"required":[9,182],"for":[10,183],"calcium-induced":[11,77,124,184],"human":[12,58,185],"keratinocyte":[13,59,156,186],"differentiation.":[14,187],"In":[15],"the":[16,22,45,69,128,135,138,153],"present":[17],"study,":[18],"we":[19,90],"investigated":[20],"whether":[21],"activation":[23,70,78,147,180],"of":[24,47,71,79,85,104,117,127,131,137,141,148,155],"PLC-gamma1":[25,55,72,80,149,168],"by":[26,73,174],"nonreceptor":[27],"kinases":[28],"such":[29],"as":[30,101,150,152],"src":[31,50,120],"and":[32,51,57,112,121,134,160,176],"fyn":[33,52,122],"plays":[34],"a":[35,83,102],"role":[36],"in":[37,95],"mediating":[38],"this":[39],"process.":[40],"Our":[41],"results":[42],"showed":[43],"combination":[46,116],"dominant":[48,118],"negative":[49,119],"blocked":[53,123,145],"calcium-stimulated":[54],"activity":[56,136],"differentiation,":[60],"whereas":[61],"each":[62],"separately":[63],"has":[64],"little":[65],"effect.":[66],"However,":[67],"unlike":[68],"epidermal":[74],"growth":[75],"factor,":[76],"was":[81],"not":[82],"result":[84],"direct":[86],"tyrosine":[87,125],"phosphorylation.":[88],"Therefore,":[89],"examined":[91],"an":[92],"alternative":[93],"mechanism,":[94],"particular":[96],"phosphatidylinositol":[97,105],"3,4,5-triphosphate":[98],"(PIP3)":[99],"formed":[100],"product":[103],"3-kinase":[106],"(PI3K)":[107],"activity.":[108],"PIP3":[109,171],"binds":[110],"to":[111],"activates":[113,167],"PLC-gamma1.":[114],"The":[115],"phosphorylation":[126],"regulatory":[129],"subunit":[130,140],"PI3K,":[132],"p85alpha,":[133],"catalytic":[139],"PI3K.":[142,178],"PI3K":[143],"inhibitors":[144],"calcium":[146,166],"well":[151],"induction":[154],"differentiation":[157],"markers":[158],"involucrin":[159],"transglutaminase.":[161],"These":[162],"data":[163],"indicate":[164],"via":[169],"increased":[170],"formation":[172],"mediated":[173],"c-src-":[175],"fyn-activated":[177],"This":[179]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}