{"id":"https://openalex.org/W2098518710","doi":"https://doi.org/10.1152/ajpgi.00554.2006","title":"Regulation of Triglyceride Metabolism.IV. Hormonal regulation of lipolysis in adipose tissue","display_name":"Regulation of Triglyceride Metabolism.IV. Hormonal regulation of lipolysis in adipose tissue","publication_year":2007,"publication_date":"2007-01-11","ids":{"openalex":"https://openalex.org/W2098518710","doi":"https://doi.org/10.1152/ajpgi.00554.2006","mag":"2098518710","pmid":"https://pubmed.ncbi.nlm.nih.gov/17218471","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2887286"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00554.2006","doi":"https://doi.org/10.1152/ajpgi.00554.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00554.2006","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2887286","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017939890","display_name":"Kathy Jaworski","orcid":"https://orcid.org/0000-0001-6014-5066","observed_orcids":["https://orcid.org/0000-0001-6014-5066"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathy Jaworski","raw_affiliation_strings":["Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA","Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA, 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA, 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036039665","display_name":"Eszter Sarkadi\u2010Nagy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eszter Sarkadi-Nagy","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057486939","display_name":"Robin E. Duncan","orcid":"https://orcid.org/0000-0002-3926-2740","observed_orcids":["https://orcid.org/0000-0002-3926-2740"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin E. Duncan","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103512536","display_name":"Maryam Ahmadian","orcid":"https://orcid.org/0000-0002-8326-8752","observed_orcids":["https://orcid.org/0000-0002-8326-8752"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maryam Ahmadian","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038863786","display_name":"Hei Sook Sul","orcid":"https://orcid.org/0000-0002-3372-5097","observed_orcids":["https://orcid.org/0000-0002-3372-5097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hei Sook Sul","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.9184,"has_fulltext":false,"cited_by_count":300,"citation_normalized_percentile":{"value":0.98029094,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"293","issue":"1","first_page":"G1","last_page":"G4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.04179999977350235,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.8980000019073486},{"id":"https://openalex.org/keywords/triglyceride-metabolism","display_name":"triglyceride metabolism","score":0.8450000286102295},{"id":"https://openalex.org/keywords/hormone-sensitive-lipase","display_name":"hormone-sensitive lipase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/adipose-triglyceride-lipase","display_name":"adipose triglyceride lipase","score":0.8479999899864197},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.4480000138282776},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":1.0},{"id":"https://openalex.org/keywords/autocrine-and-paracrine-regulation","display_name":"autocrine and paracrine regulation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/fatty-acid-mobilization","display_name":"fatty acid mobilization","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.9326802492141724},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7925236225128174},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.6854917407035828},{"id":"https://openalex.org/C2777062983","wikidata":"https://www.wikidata.org/wiki/Q21126841","display_name":"Adipose triglyceride lipase","level":4,"score":0.6678435802459717},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6225942373275757},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.5968361496925354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5937937498092651},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.5597443580627441},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4570382833480835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.436326265335083},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42709892988204956},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.4183706045150757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2115914523601532},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14121004939079285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07927200198173523},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002787","descriptor_name":"Sterol Esterase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008066","descriptor_name":"Lipolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008066","descriptor_name":"Lipolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpgi.00554.2006","doi":"https://doi.org/10.1152/ajpgi.00554.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00554.2006","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:17218471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17218471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2887286","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2887286","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Physiol Gastrointest Liver Physiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2887286","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2887286","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Physiol Gastrointest Liver Physiol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2916178663","display_name":"ENZYMES IN PHOSPHATIDIC ACID BIOSYNTHESIS","funder_award_id":"R01DK052806","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7824278941","display_name":"Role of desnutrin/ATGL in maintenance and function of brown adipose tissue","funder_award_id":"R01DK093928","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1966705420","https://openalex.org/W1966723744","https://openalex.org/W1983050178","https://openalex.org/W1987146541","https://openalex.org/W2001944628","https://openalex.org/W2015286298","https://openalex.org/W2017650269","https://openalex.org/W2027492954","https://openalex.org/W2030170677","https://openalex.org/W2046658782","https://openalex.org/W2062793520","https://openalex.org/W2077991483","https://openalex.org/W2090946848","https://openalex.org/W2105170604","https://openalex.org/W2110079579","https://openalex.org/W2110839026","https://openalex.org/W2121278592","https://openalex.org/W2122035650","https://openalex.org/W2127694087","https://openalex.org/W2129444657","https://openalex.org/W2131256997","https://openalex.org/W2142142781","https://openalex.org/W2155722642","https://openalex.org/W2170345337","https://openalex.org/W4248635034","https://openalex.org/W4254579053"],"related_works":["https://openalex.org/W7098698064","https://openalex.org/W2147821881","https://openalex.org/W2071635152","https://openalex.org/W2074742267","https://openalex.org/W2049299597","https://openalex.org/W2006251119","https://openalex.org/W2110839026","https://openalex.org/W1838722718","https://openalex.org/W2161204617","https://openalex.org/W338846998"],"abstract_inverted_index":{"Triacylglycerol":[0],"(TAG)":[1],"stored":[2],"in":[3,42,47,63,109,111,124,139,157,174],"adipose":[4,43,64,125],"tissue":[5,44,126],"can":[6],"be":[7,73],"rapidly":[8],"mobilized":[9],"by":[10,26,127],"the":[11,17,74,170,175],"hydrolytic":[12],"action":[13],"of":[14,19,31,36,58,122,144,155,177],"lipases,":[15],"with":[16],"release":[18],"fatty":[20],"acids":[21],"(FA)":[22],"that":[23],"are":[24],"used":[25],"other":[27,48],"tissues":[28,49],"during":[29],"times":[30],"energy":[32,161],"deprivation.":[33],"Unlike":[34],"synthesis":[35],"TAG,":[37,59],"which":[38],"occurs":[39,62],"not":[40],"only":[41],"but":[45],"also":[46,137],"such":[50,92],"as":[51],"liver":[52],"for":[53,79,160],"very-low-density":[54],"lipoprotein":[55],"formation,":[56],"hydrolysis":[57],"lipolysis,":[60],"predominantly":[61],"tissue.":[65],"Until":[66],"recently,":[67],"hormone-sensitive":[68,87],"lipase":[69,97],"was":[70],"considered":[71],"to":[72,104,151],"key":[75,107],"rate-limiting":[76],"enzyme":[77],"responsible":[78],"regulating":[80],"TAG":[81],"mobilization.":[82],"However,":[83],"recent":[84,171],"studies":[85],"on":[86],"lipase-null":[88],"mice":[89],"have":[90],"challenged":[91],"a":[93,106,152],"concept.":[94],"A":[95],"novel":[96],"named":[98],"desnutrin/ATGL":[99],"has":[100],"been":[101],"recently":[102],"discovered":[103],"play":[105],"role":[108],"lipolysis":[110,123,156],"adipocytes.":[112],"Lipolysis":[113],"is":[114,131],"under":[115],"tight":[116],"hormonal":[117],"regulation.":[118,141],"Although":[119],"opposing":[120],"regulation":[121,154,176],"insulin":[128],"and":[129,147,168],"catecholamines":[130],"well":[132],"understood,":[133],"autocrine/paracrine":[134,148],"factors":[135,149],"may":[136],"participate":[138],"its":[140],"Intricate":[142],"cooperation":[143],"these":[145],"endocrine":[146],"leads":[150],"fine":[153],"adipocytes,":[158],"needed":[159],"homeostasis.":[162],"In":[163],"this":[164],"review,":[165],"we":[166],"summarize":[167],"discuss":[169],"progress":[172],"made":[173],"adipocyte":[178],"lipolysis.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":26},{"year":2012,"cited_by_count":24}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}