{"id":"https://openalex.org/W2098505104","doi":"https://doi.org/10.2174/1574884711308020006","title":"The Discovery and Development of Selective Estrogen Receptor Modulators (SERMs) for Clinical Practice","display_name":"The Discovery and Development of Selective Estrogen Receptor Modulators (SERMs) for Clinical Practice","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W2098505104","doi":"https://doi.org/10.2174/1574884711308020006","mag":"2098505104","pmid":"https://pubmed.ncbi.nlm.nih.gov/23062036","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3624793"},"language":"en","primary_location":{"id":"doi:10.2174/1574884711308020006","doi":"https://doi.org/10.2174/1574884711308020006","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1574884711308020006","pdf_url":"http://www.eurekaselect.net/article/50311","source":{"id":"https://openalex.org/S165219199","display_name":"Current Clinical Pharmacology","issn_l":"1574-8847","issn":["1574-8847","2212-3938","2772-4328","2772-4336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.eurekaselect.net/article/50311","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024072230","display_name":"Philipp Y. Maximov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philipp Y. Maximov","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064850568","display_name":"Theresa M. Lee","orcid":"https://orcid.org/0000-0002-9508-6382","observed_orcids":["https://orcid.org/0000-0002-9508-6382"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa M. Lee","raw_affiliation_strings":["Division of Hematology and Oncology , Georgetown University Medical Center , 3970 Reservoir Rd NW , Washington , DC 20057 , USA","GEORGETOWN UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Oncology , Georgetown University Medical Center , 3970 Reservoir Rd NW , Washington , DC 20057 , USA","institution_ids":["https://openalex.org/I2799903593"]},{"raw_affiliation_string":"GEORGETOWN UNIVERSITY","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005756055","display_name":"Virgil Craig Jordan","orcid":"https://orcid.org/0000-0002-5818-037X","observed_orcids":["https://orcid.org/0000-0002-5818-037X"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"V. Craig Jordan","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3970 Reservoir Rd NW, Research Building, Suite E204A, Washington, DC 20057, USA","Breast Medical Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3970 Reservoir Rd NW, Research Building, Suite E204A, Washington, DC 20057, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4390039356"]},{"raw_affiliation_string":"Breast Medical Oncology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005756055"],"corresponding_institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4390039356"],"apc_list":null,"apc_paid":null,"fwci":14.8806,"has_fulltext":true,"cited_by_count":387,"citation_normalized_percentile":{"value":0.99801686,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"8","issue":"2","first_page":"135","last_page":"155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":1.0},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.9049999713897705},{"id":"https://openalex.org/keywords/raloxifene","display_name":"raloxifene","score":1.0},{"id":"https://openalex.org/keywords/ospemifene","display_name":"ospemifene","score":0.9020000100135803},{"id":"https://openalex.org/keywords/lasofoxifene","display_name":"lasofoxifene","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bazedoxifene","display_name":"bazedoxifene","score":0.9980000257492065},{"id":"https://openalex.org/keywords/arzoxifene","display_name":"arzoxifene","score":0.996999979019165},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7400000095367432},{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.6639999747276306},{"id":"https://openalex.org/keywords/uterine-cancer","display_name":"uterine cancer","score":0.7409999966621399},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.7950000166893005},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.8090000152587891},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.4390000104904175},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2777944059","wikidata":"https://www.wikidata.org/wiki/Q903917","display_name":"Selective estrogen receptor modulator","level":5,"score":0.9333410263061523},{"id":"https://openalex.org/C2779889926","wikidata":"https://www.wikidata.org/wiki/Q425223","display_name":"Raloxifene","level":5,"score":0.9105044007301331},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.8525068759918213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8399653434753418},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7368257641792297},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6391408443450928},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5005288124084473},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46362829208374023},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45320630073547363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4273143410682678},{"id":"https://openalex.org/C2780159708","wikidata":"https://www.wikidata.org/wiki/Q17003363","display_name":"Hormone replacement therapy (female-to-male)","level":3,"score":0.42483559250831604},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4194280207157135},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.41706258058547974},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4114558696746826},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3555556833744049},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2174/1574884711308020006","doi":"https://doi.org/10.2174/1574884711308020006","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1574884711308020006","pdf_url":"http://www.eurekaselect.net/article/50311","source":{"id":"https://openalex.org/S165219199","display_name":"Current Clinical Pharmacology","issn_l":"1574-8847","issn":["1574-8847","2212-3938","2772-4328","2772-4336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2625523","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3624793","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3624793","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3624793","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Clin Pharmacol","raw_type":"Text"},{"id":"pmid:23062036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23062036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current clinical pharmacology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.2174/1574884711308020006","doi":"https://doi.org/10.2174/1574884711308020006","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1574884711308020006","pdf_url":"http://www.eurekaselect.net/article/50311","source":{"id":"https://openalex.org/S165219199","display_name":"Current Clinical Pharmacology","issn_l":"1574-8847","issn":["1574-8847","2212-3938","2772-4328","2772-4336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2754843297","display_name":"A NEW THERAPEUTIC PARADIGM FOR BREAST CANCER EXPLOITING LOW DOSE ESTROGEN-INDUCED APOPTOSIS","funder_award_id":"W81XWH0610590","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4345334871","display_name":null,"funder_award_id":"SAC100009","funder_id":"https://openalex.org/F4320311413","funder_display_name":"Susan G. Komen"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8546021785","display_name":null,"funder_award_id":"SU2C-AACR-DT0409","funder_id":"https://openalex.org/F4320332898","funder_display_name":"Stand Up To Cancer"},{"id":"https://openalex.org/G9000862544","display_name":"Georgetown University Lombardi Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA051008","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320310223","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60"},{"id":"https://openalex.org/F4320311413","display_name":"Susan G. Komen","ror":"https://ror.org/02nadbe75"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332898","display_name":"Stand Up To Cancer","ror":"https://ror.org/01dmpb598"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2098505104.pdf","grobid_xml":"https://content.openalex.org/works/W2098505104.grobid-xml"},"referenced_works_count":238,"referenced_works":["https://openalex.org/W69014308","https://openalex.org/W94818953","https://openalex.org/W136586436","https://openalex.org/W167038568","https://openalex.org/W175672528","https://openalex.org/W1500505511","https://openalex.org/W1506399025","https://openalex.org/W1514642917","https://openalex.org/W1520764408","https://openalex.org/W1539763820","https://openalex.org/W1563890385","https://openalex.org/W1593442063","https://openalex.org/W1595283237","https://openalex.org/W1803004351","https://openalex.org/W1835906678","https://openalex.org/W1866375741","https://openalex.org/W1878298203","https://openalex.org/W1906888631","https://openalex.org/W1918705397","https://openalex.org/W1925049844","https://openalex.org/W1951021898","https://openalex.org/W1963570942","https://openalex.org/W1965325692","https://openalex.org/W1966216790","https://openalex.org/W1968820967","https://openalex.org/W1970052659","https://openalex.org/W1972493104","https://openalex.org/W1975740303","https://openalex.org/W1976389084","https://openalex.org/W1979408605","https://openalex.org/W1980557732","https://openalex.org/W1981125500","https://openalex.org/W1981476886","https://openalex.org/W1982866474","https://openalex.org/W1983625180","https://openalex.org/W1984670037","https://openalex.org/W1984873736","https://openalex.org/W1987557987","https://openalex.org/W1988203609","https://openalex.org/W1988337347","https://openalex.org/W1988567074","https://openalex.org/W1988672923","https://openalex.org/W1991455388","https://openalex.org/W1993035292","https://openalex.org/W1993193232","https://openalex.org/W1993430370","https://openalex.org/W1994453737","https://openalex.org/W1995360221","https://openalex.org/W1995584214","https://openalex.org/W1996044518","https://openalex.org/W1997279492","https://openalex.org/W1998525632","https://openalex.org/W1999003511","https://openalex.org/W2000565352","https://openalex.org/W2001507203","https://openalex.org/W2003010455","https://openalex.org/W2003019536","https://openalex.org/W2003491545","https://openalex.org/W2003863147","https://openalex.org/W2003996771","https://openalex.org/W2004163761","https://openalex.org/W2006624602","https://openalex.org/W2007165008","https://openalex.org/W2008039212","https://openalex.org/W2008549740","https://openalex.org/W2009249344","https://openalex.org/W2010440101","https://openalex.org/W2011306206","https://openalex.org/W2012537034","https://openalex.org/W2013323189","https://openalex.org/W2013809140","https://openalex.org/W2014324176","https://openalex.org/W2015473392","https://openalex.org/W2019994840","https://openalex.org/W2020725121","https://openalex.org/W2024541964","https://openalex.org/W2024606555","https://openalex.org/W2025587651","https://openalex.org/W2026579016","https://openalex.org/W2026809533","https://openalex.org/W2029406824","https://openalex.org/W2030525320","https://openalex.org/W2032346244","https://openalex.org/W2032497885","https://openalex.org/W2032654223","https://openalex.org/W2032958881","https://openalex.org/W2034238658","https://openalex.org/W2035138654","https://openalex.org/W2036222013","https://openalex.org/W2037460676","https://openalex.org/W2037965527","https://openalex.org/W2039576757","https://openalex.org/W2039629869","https://openalex.org/W2039871782","https://openalex.org/W2040379425","https://openalex.org/W2040887597","https://openalex.org/W2041938813","https://openalex.org/W2042162210","https://openalex.org/W2042457503","https://openalex.org/W2043180355","https://openalex.org/W2044702943","https://openalex.org/W2045204082","https://openalex.org/W2046776608","https://openalex.org/W2047172236","https://openalex.org/W2047246104","https://openalex.org/W2047875164","https://openalex.org/W2048257551","https://openalex.org/W2051676088","https://openalex.org/W2053775194","https://openalex.org/W2054372078","https://openalex.org/W2054376446","https://openalex.org/W2054783972","https://openalex.org/W2055421714","https://openalex.org/W2056475405","https://openalex.org/W2057442792","https://openalex.org/W2058430085","https://openalex.org/W2058617193","https://openalex.org/W2060011282","https://openalex.org/W2061023819","https://openalex.org/W2062798076","https://openalex.org/W2064707298","https://openalex.org/W2065562551","https://openalex.org/W2065785294","https://openalex.org/W2066591855","https://openalex.org/W2068113812","https://openalex.org/W2068435339","https://openalex.org/W2068611177","https://openalex.org/W2073353512","https://openalex.org/W2073487130","https://openalex.org/W2073883348","https://openalex.org/W2074335085","https://openalex.org/W2074480078","https://openalex.org/W2074769389","https://openalex.org/W2076741971","https://openalex.org/W2077239860","https://openalex.org/W2078885070","https://openalex.org/W2078922516","https://openalex.org/W2079081624","https://openalex.org/W2081838542","https://openalex.org/W2087135060","https://openalex.org/W2088585390","https://openalex.org/W2090507834","https://openalex.org/W2092626640","https://openalex.org/W2094378820","https://openalex.org/W2094438226","https://openalex.org/W2098010773","https://openalex.org/W2101738855","https://openalex.org/W2102477226","https://openalex.org/W2103829266","https://openalex.org/W2104775804","https://openalex.org/W2105153202","https://openalex.org/W2106536809","https://openalex.org/W2107114875","https://openalex.org/W2107859602","https://openalex.org/W2109388713","https://openalex.org/W2111144249","https://openalex.org/W2111650618","https://openalex.org/W2112577860","https://openalex.org/W2112629831","https://openalex.org/W2114108429","https://openalex.org/W2115103771","https://openalex.org/W2118136050","https://openalex.org/W2118728607","https://openalex.org/W2119399704","https://openalex.org/W2122767035","https://openalex.org/W2123973543","https://openalex.org/W2124527463","https://openalex.org/W2128366117","https://openalex.org/W2130377362","https://openalex.org/W2130868107","https://openalex.org/W2131394541","https://openalex.org/W2133010239","https://openalex.org/W2133813353","https://openalex.org/W2134062048","https://openalex.org/W2134627266","https://openalex.org/W2134716006","https://openalex.org/W2135686539","https://openalex.org/W2136020634","https://openalex.org/W2136673273","https://openalex.org/W2138545949","https://openalex.org/W2139434007","https://openalex.org/W2139582552","https://openalex.org/W2140636685","https://openalex.org/W2141232624","https://openalex.org/W2141349182","https://openalex.org/W2141647078","https://openalex.org/W2142686295","https://openalex.org/W2144013834","https://openalex.org/W2148979187","https://openalex.org/W2149636926","https://openalex.org/W2151227939","https://openalex.org/W2152780305","https://openalex.org/W2153009489","https://openalex.org/W2153867652","https://openalex.org/W2153956706","https://openalex.org/W2155481621","https://openalex.org/W2156455256","https://openalex.org/W2156857720","https://openalex.org/W2157462636","https://openalex.org/W2160618408","https://openalex.org/W2163126741","https://openalex.org/W2163459122","https://openalex.org/W2165198403","https://openalex.org/W2166026840","https://openalex.org/W2166297054","https://openalex.org/W2166760402","https://openalex.org/W2166969772","https://openalex.org/W2167072194","https://openalex.org/W2167515838","https://openalex.org/W2169449395","https://openalex.org/W2171632104","https://openalex.org/W2172157728","https://openalex.org/W2172185687","https://openalex.org/W2187452737","https://openalex.org/W2313313525","https://openalex.org/W2314799568","https://openalex.org/W2319274316","https://openalex.org/W2319555128","https://openalex.org/W2320446229","https://openalex.org/W2322034679","https://openalex.org/W2323152369","https://openalex.org/W2334214544","https://openalex.org/W2952009971","https://openalex.org/W4206075545","https://openalex.org/W4212936275","https://openalex.org/W4236552905","https://openalex.org/W4238509329","https://openalex.org/W4240373784","https://openalex.org/W4244342114","https://openalex.org/W4244519136","https://openalex.org/W4250999139","https://openalex.org/W4254906302","https://openalex.org/W4300899280","https://openalex.org/W4301361440","https://openalex.org/W6632407380","https://openalex.org/W6666453832","https://openalex.org/W6667569220","https://openalex.org/W7074153396"],"related_works":["https://openalex.org/W2048813529","https://openalex.org/W4230114496","https://openalex.org/W2385256533","https://openalex.org/W1984873736","https://openalex.org/W2131184855","https://openalex.org/W2419238605","https://openalex.org/W4388831704","https://openalex.org/W1982828828","https://openalex.org/W2327579772","https://openalex.org/W2326246052"],"abstract_inverted_index":{"Selective":[0],"estrogen":[1,13,19],"receptor":[2,20],"modulators":[3],"(SERMs)":[4],"are":[5,217,275,278,323,325],"structurally":[6],"different":[7,47],"compounds":[8,294],"that":[9,156,284],"interact":[10],"with":[11,50,204,221,259],"intracellular":[12],"receptors":[14],"in":[15,75,95,141,235,256,317,327],"target":[16],"organs":[17],"as":[18,137],"agonists":[21],"or":[22,164,277],"antagonists.":[23],"These":[24,148,242],"drugs":[25,243],"have":[26,35,125,130,178,230,244],"been":[27,231,245],"intensively":[28],"studied":[29],"over":[30],"the":[31,44,105,111,142,173,189,200,236,289,303,308],"past":[32],"decade":[33],"and":[34,58,83,92,113,118,166,183,191,214,225,238,305],"proven":[36],"to":[37,67,161,247,251],"be":[38,248,296],"a":[39,61,99,152,285],"highly":[40],"versatile":[41],"group":[42,309],"for":[43,80,110,172,233,262,280],"treatment":[45,114,237],"of":[46,71,115,144,199,240,288,292,307,310],"conditions":[48],"associated":[49,203],"postmenopausal":[51,96,116],"women's":[52],"health,":[53],"including":[54],"hormone":[55,253],"responsive":[56],"cancer":[57,82,102],"osteoporosis.":[59,241],"Tamoxifen,":[60],"failed":[62,100],"contraceptive":[63],"is":[64,104,159,207],"currently":[65,208],"used":[66],"treat":[68,167],"all":[69],"stages":[70],"breast":[72,81,101,168,195],"cancer,":[73],"chemoprevention":[74],"women":[76],"at":[77],"high":[78],"risk":[79],"also":[84,129],"has":[85],"beneficial":[86],"effects":[87,150,180,187,193,202],"on":[88,181,188,194],"bone":[89,182],"mineral":[90],"density":[91],"serum":[93,184],"lipids":[94],"women.":[97],"Raloxifene,":[98],"drug,":[103],"only":[106],"SERM":[107,219,282],"approved":[108],"internationally":[109],"prevention":[112,239],"osteoporosis":[117,163],"vertebral":[119],"fractures.":[120],"However,":[121],"although":[122],"these":[123,293],"SERMs":[124,316],"many":[126],"benefits,":[127],"they":[128],"some":[131],"potentially":[132,222],"serious":[133],"adverse":[134,149,201],"effects,":[135],"such":[136],"thromboembolic":[138],"disorders":[139],"and,":[140],"case":[143],"tamoxifen,":[145],"uterine":[146],"cancer.":[147,169],"represent":[151],"major":[153],"concern":[154],"given":[155],"long-term":[157],"therapy":[158,255],"required":[160],"prevent":[162,165],"The":[170,314],"search":[171],"'ideal'":[174],"SERM,":[175],"which":[176,216],"would":[177],"estrogenic":[179],"lipids,":[185],"neutral":[186],"uterus,":[190],"antiestrogenic":[192],"tissue,":[196],"but":[197],"none":[198],"current":[205],"therapies,":[206],"under":[209],"way.":[210],"Ospemifene,":[211],"lasofoxifene,":[212,321],"bazedoxifene":[213],"arzoxifene,":[215],"new":[218],"molecules":[220],"greater":[223],"efficacy":[224,268],"potency":[226],"than":[227],"previous":[228],"SERMs,":[229],"investigated":[232],"use":[234],"shown":[246],"comparably":[249],"effective":[250],"conventional":[252],"replacement":[254],"animal":[257],"models,":[258],"potential":[260,291],"indications":[261],"an":[263],"improved":[264],"safety":[265],"profile.":[266],"Clinical":[267],"data":[269],"from":[270],"ongoing":[271],"phase":[272],"III":[273],"trials":[274],"available":[276],"awaited":[279],"each":[281],"so":[283],"true":[286],"understanding":[287],"therapeutic":[290],"can":[295],"obtained.":[297],"In":[298],"this":[299],"article,":[300],"we":[301],"describe":[302],"discovery":[304],"development":[306],"medicines":[311],"called":[312],"SERMs.":[313],"newer":[315],"late":[318],"development:":[319],"ospemifene,":[320],"bazedoxifene,":[322],"arzoxifene":[324],"described":[326],"detail.":[328]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":40},{"year":2021,"cited_by_count":32},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":37},{"year":2018,"cited_by_count":34},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":39},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
