{"id":"https://openalex.org/W2098433299","doi":"https://doi.org/10.1002/sim.1668","title":"A breast cancer prediction model incorporating familial and personal risk factors","display_name":"A breast cancer prediction model incorporating familial and personal risk factors","publication_year":2004,"publication_date":"2004-03-23","ids":{"openalex":"https://openalex.org/W2098433299","doi":"https://doi.org/10.1002/sim.1668","mag":"2098433299","pmid":"https://pubmed.ncbi.nlm.nih.gov/15057881"},"language":"en","primary_location":{"id":"doi:10.1002/sim.1668","doi":"https://doi.org/10.1002/sim.1668","is_oa":false,"landing_page_url":"https://doi.org/10.1002/sim.1668","pdf_url":null,"source":{"id":"https://openalex.org/S55189604","display_name":"Statistics in Medicine","issn_l":"0277-6715","issn":["0277-6715","1097-0258"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012404195","display_name":"Jonathan P. Tyrer","orcid":"https://orcid.org/0000-0003-3724-4757","observed_orcids":["https://orcid.org/0000-0003-3724-4757"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan Tyrer","raw_affiliation_strings":["Department of Epidemiology, Mathematics and Statistics, Cancer Research UK. jonathan.tyrer@cancer.org.uk","Department of Epidemiology, Mathematics and Statistics, Cancer Research U.K., Wolfson Institute of Preventive Medicine Charterhouse Square, London EC1M 6BQ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Mathematics and Statistics, Cancer Research UK. jonathan.tyrer@cancer.org.uk","institution_ids":["https://openalex.org/I2801316944"]},{"raw_affiliation_string":"Department of Epidemiology, Mathematics and Statistics, Cancer Research U.K., Wolfson Institute of Preventive Medicine Charterhouse Square, London EC1M 6BQ, U.K","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074904688","display_name":"S.W. Duffy","orcid":"https://orcid.org/0000-0003-4901-7922","observed_orcids":["https://orcid.org/0000-0003-4901-7922"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen W. Duffy","raw_affiliation_strings":["Department of Epidemiology, Mathematics and Statistics, Cancer Research U.K., Wolfson Institute of Preventive Medicine Charterhouse Square, London EC1M 6BQ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Mathematics and Statistics, Cancer Research U.K., Wolfson Institute of Preventive Medicine Charterhouse Square, London EC1M 6BQ, U.K","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022237789","display_name":"Jack M. Cuzick","orcid":"https://orcid.org/0000-0001-7420-7512","observed_orcids":["https://orcid.org/0000-0001-7420-7512"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jack Cuzick","raw_affiliation_strings":["Department of Epidemiology, Mathematics and Statistics, Cancer Research U.K., Wolfson Institute of Preventive Medicine Charterhouse Square, London EC1M 6BQ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Mathematics and Statistics, Cancer Research U.K., Wolfson Institute of Preventive Medicine Charterhouse Square, London EC1M 6BQ, U.K","institution_ids":["https://openalex.org/I2801316944"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022237789"],"corresponding_institution_ids":["https://openalex.org/I2801316944"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":10.2018,"has_fulltext":false,"cited_by_count":1364,"citation_normalized_percentile":{"value":0.98992047,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"23","issue":"7","first_page":"1111","last_page":"1130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-risk-prediction","display_name":"breast cancer risk prediction","score":0.9200000166893005},{"id":"https://openalex.org/keywords/familial-risk-factors","display_name":"family risk factors","score":0.7720000147819519},{"id":"https://openalex.org/keywords/individual-risk-factors","display_name":"individual risk factors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/low-penetrance-genes","display_name":"low-penetrance genes","score":0.8700000047683716},{"id":"https://openalex.org/keywords/family-history-medicine","display_name":"family history (medicine)","score":0.8119999766349792},{"id":"https://openalex.org/keywords/reproductive-history","display_name":"reproductive history","score":0.7990000247955322},{"id":"https://openalex.org/keywords/bayesian-risk-estimation","display_name":"Bayesian risk estimation","score":0.578000009059906},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.7733168601989746},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7530286312103271},{"id":"https://openalex.org/C200544954","wikidata":"https://www.wikidata.org/wiki/Q516389","display_name":"Penetrance","level":4,"score":0.6695860028266907},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.5244593620300293},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4268728494644165},{"id":"https://openalex.org/C206179267","wikidata":"https://www.wikidata.org/wiki/Q188952","display_name":"Medical history","level":2,"score":0.418517529964447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3534563183784485},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.27708178758621216},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2751544713973999},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2704263925552368},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24024206399917603},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17242631316184998},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.13620451092720032},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11097052693367004},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019398","descriptor_name":"Genes, BRCA1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024522","descriptor_name":"Genes, BRCA2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/sim.1668","doi":"https://doi.org/10.1002/sim.1668","is_oa":false,"landing_page_url":"https://doi.org/10.1002/sim.1668","pdf_url":null,"source":{"id":"https://openalex.org/S55189604","display_name":"Statistics in Medicine","issn_l":"0277-6715","issn":["0277-6715","1097-0258"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in Medicine","raw_type":"journal-article"},{"id":"pmid:15057881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15057881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W156316974","https://openalex.org/W1536810585","https://openalex.org/W1550117782","https://openalex.org/W1643869946","https://openalex.org/W1980540383","https://openalex.org/W1991311566","https://openalex.org/W2002119787","https://openalex.org/W2004604530","https://openalex.org/W2004834796","https://openalex.org/W2005351661","https://openalex.org/W2015565457","https://openalex.org/W2038517636","https://openalex.org/W2079775784","https://openalex.org/W2088314358","https://openalex.org/W2096916467","https://openalex.org/W2097026108","https://openalex.org/W2103970959","https://openalex.org/W2110114459","https://openalex.org/W2124661897","https://openalex.org/W2141504335","https://openalex.org/W2149597080","https://openalex.org/W2163215770","https://openalex.org/W2165664908","https://openalex.org/W2182492050","https://openalex.org/W2328105863","https://openalex.org/W2432517183","https://openalex.org/W2469416225","https://openalex.org/W4294554434"],"related_works":["https://openalex.org/W4385724542","https://openalex.org/W2045400996","https://openalex.org/W3183302134","https://openalex.org/W7096025248","https://openalex.org/W2116975947","https://openalex.org/W2117298495","https://openalex.org/W7214615401","https://openalex.org/W4232474969","https://openalex.org/W1480061914","https://openalex.org/W3032696148"],"abstract_inverted_index":{"Abstract":[0],"An":[1],"Erratum":[2],"has":[3,23,116,210],"been":[4,211],"published":[5],"for":[6],"this":[7],"article":[8],"in":[9,11,168,188],"Statistics":[10],"Medicine":[12],"2005;":[13],"24(1):156.":[14],"Please":[15],"note":[16],"that":[17,217],"the":[18,32,111,120,136,148,176,204],"corresponding":[19],"author's":[20],"e\u2010mail":[21],"address":[22],"now":[24],"changed.":[25],"For":[26,159],"further":[27,200],"details":[28],"please":[29],"click":[30],"on":[31,59,74,203],"link":[33],"below.":[34],"DOI:":[35],"10.1002/sim.1913.":[36],"Many":[37],"factors":[38,61,86,99],"determine":[39],"a":[40,88,94,102,145,151,214,219],"woman's":[41,205],"risk":[42,78,85,157,198,221],"of":[43,47,76,106,110,119,123,135,139,178,193],"breast":[44,124,140,185,195],"cancer.":[45,141,196],"Some":[46],"them":[48],"are":[49,57],"genetic":[50,90,121],"and":[51,66,113,155],"relate":[52],"to":[53,96,100,173,184],"family":[54,164],"history,":[55],"others":[56],"based":[58,202],"personal":[60,84,156,206],"such":[62],"as":[63],"reproductive":[64],"history":[65,165],"medical":[67],"history.":[68,207],"While":[69],"many":[70],"papers":[71,81],"have":[72,82,143],"concentrated":[73],"subsets":[75],"these":[77,98,128],"factors,":[79],"no":[80],"incorporated":[83,212],"with":[87,170],"detailed":[89],"analysis.":[91],"There":[92],"is":[93,166],"need":[95],"combine":[97],"provide":[101],"better":[103],"overall":[104],"determinant":[105],"risk.":[107],"The":[108,208],"discovery":[109],"BRCA1":[112],"BRCA2":[114],"genes":[115,129,182],"explained":[117],"some":[118],"determinants":[122],"cancer":[125],"risk,":[126],"but":[127],"alone":[130],"do":[131],"not":[132],"explain":[133],"all":[134],"familial":[137],"aggregation":[138],"We":[142],"developed":[144],"model":[146,209],"incorporating":[147],"BRCA":[149],"genes,":[150],"low":[152],"penetrance":[153],"gene":[154],"factors.":[158],"an":[160],"individual":[161],"woman":[162],"her":[163,179,191],"used":[167],"conjuction":[169],"Bayes":[171],"theorem":[172],"iteratively":[174],"produce":[175],"likelihood":[177,192],"carrying":[180],"any":[181],"predisposing":[183],"cancer,":[186],"which":[187],"turn":[189],"affects":[190],"developing":[194],"This":[197],"was":[199],"refined":[201],"into":[213],"computer":[215],"program":[216],"gives":[218],"personalised":[220],"estimate.":[222],"Copyright":[223],"\u00a9":[224],"2004":[225],"John":[226],"Wiley":[227],"&":[228],"Sons,":[229],"Ltd.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":75},{"year":2025,"cited_by_count":70},{"year":2024,"cited_by_count":91},{"year":2023,"cited_by_count":102},{"year":2022,"cited_by_count":89},{"year":2021,"cited_by_count":81},{"year":2020,"cited_by_count":92},{"year":2019,"cited_by_count":98},{"year":2018,"cited_by_count":69},{"year":2017,"cited_by_count":75},{"year":2016,"cited_by_count":64},{"year":2015,"cited_by_count":67},{"year":2014,"cited_by_count":56},{"year":2013,"cited_by_count":65},{"year":2012,"cited_by_count":43}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}