{"id":"https://openalex.org/W2098417372","doi":"https://doi.org/10.1186/1743-8977-11-14","title":"Low-solubility particles and a Trojan-horse type mechanism of toxicity: the case of cobalt oxide on human lung cells","display_name":"Low-solubility particles and a Trojan-horse type mechanism of toxicity: the case of cobalt oxide on human lung cells","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2098417372","doi":"https://doi.org/10.1186/1743-8977-11-14","mag":"2098417372","pmid":"https://pubmed.ncbi.nlm.nih.gov/24669904","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3994290"},"language":"en","primary_location":{"id":"doi:10.1186/1743-8977-11-14","doi":"https://doi.org/10.1186/1743-8977-11-14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1743-8977-11-14","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/1743-8977-11-14","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/1743-8977-11-14","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054143636","display_name":"Richard Ortega","orcid":"https://orcid.org/0000-0003-1692-5406","observed_orcids":["https://orcid.org/0000-0003-1692-5406"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210125595","display_name":"Laboratoire de Physique des deux infinis Bordeaux","ror":"https://ror.org/034a4bk84","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210125595","https://openalex.org/I4210133362"]},{"id":"https://openalex.org/I4210133362","display_name":"Institut National de Physique Nucl\u00e9aire et de Physique des Particules","ror":"https://ror.org/03fd77x13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210133362"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Richard Ortega","raw_affiliation_strings":["Univ, Bordeaux, CENBG, UMR 5797, Gradignan F-33170, France. ortega@cenbg.in2p3.fr","Univ. Bordeaux, CENBG, UMR 5797, Gradignan, F-33170, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ, Bordeaux, CENBG, UMR 5797, Gradignan F-33170, France. ortega@cenbg.in2p3.fr","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210125595","https://openalex.org/I4210133362"]},{"raw_affiliation_string":"Univ. Bordeaux, CENBG, UMR 5797, Gradignan, F-33170, France","institution_ids":["https://openalex.org/I4210125595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009895673","display_name":"Carole Bresson","orcid":"https://orcid.org/0000-0002-0835-9371","observed_orcids":["https://orcid.org/0000-0002-0835-9371"]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210127723","display_name":"Direction des Energies","ror":"https://ror.org/03cwzta72","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I4210127723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carole Bresson","raw_affiliation_strings":["Laboratoire de d\u00e9veloppement Analytique Nucl\u00e9aire, Isotopique et El\u00e9mentaire, CEA, DEN, DPC, SEARS, Gif-sur-Yvette, France","Laboratoire de d\u00e9veloppement Analytique Nucl\u00e9aire, Isotopique et El\u00e9mentaire, CEA, DEN, DPC, SEARS, Gif-sur-Yvette, F-91191, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de d\u00e9veloppement Analytique Nucl\u00e9aire, Isotopique et El\u00e9mentaire, CEA, DEN, DPC, SEARS, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210127723"]},{"raw_affiliation_string":"Laboratoire de d\u00e9veloppement Analytique Nucl\u00e9aire, Isotopique et El\u00e9mentaire, CEA, DEN, DPC, SEARS, Gif-sur-Yvette, F-91191, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210127723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055844433","display_name":"Carine Darolles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210092902","display_name":"Institute of Environmental Biology and Biotechnology","ror":"https://ror.org/00jhh5t96","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092902"]},{"id":"https://openalex.org/I4210143636","display_name":"CEA Marcoule","ror":"https://ror.org/04140y156","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I4210143636"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carine Darolles","raw_affiliation_strings":["Lab Biochim System Perturb, CEA, DSV, IBEB, Bagnols-sur-C\u00e8ze, France","Lab Biochim System Perturb, CEA, DSV, IBEB, Bagnols-sur-C\u00e8ze, F-30207, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab Biochim System Perturb, CEA, DSV, IBEB, Bagnols-sur-C\u00e8ze, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210092902","https://openalex.org/I4210143636"]},{"raw_affiliation_string":"Lab Biochim System Perturb, CEA, DSV, IBEB, Bagnols-sur-C\u00e8ze, F-30207, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210092902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089264945","display_name":"C\u00e9line Gautier","orcid":"https://orcid.org/0000-0001-8657-9161","observed_orcids":["https://orcid.org/0000-0001-8657-9161"]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210127723","display_name":"Direction des Energies","ror":"https://ror.org/03cwzta72","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I4210127723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9line Gautier","raw_affiliation_strings":["Laboratoire d\u2019Analyse en Soutien aux Exploitants, CEA, DEN, DPC, SEARS, Gif-sur-Yvette, France","Laboratoire d'Analyse en Soutien aux Exploitants, CEA, DEN, DPC, SEARS, Gif-sur-Yvette, F-91191, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Analyse en Soutien aux Exploitants, CEA, DEN, DPC, SEARS, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210127723"]},{"raw_affiliation_string":"Laboratoire d'Analyse en Soutien aux Exploitants, CEA, DEN, DPC, SEARS, Gif-sur-Yvette, F-91191, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210127723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070170703","display_name":"St\u00e9phane Roudeau","orcid":"https://orcid.org/0000-0002-4539-9380","observed_orcids":["https://orcid.org/0000-0002-4539-9380"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210125595","display_name":"Laboratoire de Physique des deux infinis Bordeaux","ror":"https://ror.org/034a4bk84","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210125595","https://openalex.org/I4210133362"]},{"id":"https://openalex.org/I4210133362","display_name":"Institut National de Physique Nucl\u00e9aire et de Physique des Particules","ror":"https://ror.org/03fd77x13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210133362"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Roudeau","raw_affiliation_strings":["CNRS, IN2P3, CENBG, UMR 5797, Gradignan, France","Univ. Bordeaux, CENBG, UMR 5797, Gradignan, France","CNRS, IN2P3, CENBG, UMR 5797, Gradignan, F-33170, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, IN2P3, CENBG, UMR 5797, Gradignan, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210125595","https://openalex.org/I4210133362"]},{"raw_affiliation_string":"Univ. Bordeaux, CENBG, UMR 5797, Gradignan, France","institution_ids":["https://openalex.org/I4210125595"]},{"raw_affiliation_string":"CNRS, IN2P3, CENBG, UMR 5797, Gradignan, F-33170, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210125595","https://openalex.org/I4210133362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082448876","display_name":"Laura Perrin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210125595","display_name":"Laboratoire de Physique des deux infinis Bordeaux","ror":"https://ror.org/034a4bk84","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210125595","https://openalex.org/I4210133362"]},{"id":"https://openalex.org/I4210133362","display_name":"Institut National de Physique Nucl\u00e9aire et de Physique des Particules","ror":"https://ror.org/03fd77x13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210133362"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laura Perrin","raw_affiliation_strings":["CNRS, IN2P3, CENBG, UMR 5797, Gradignan, France","Univ. Bordeaux, CENBG, UMR 5797, Gradignan, France","CNRS, IN2P3, CENBG, UMR 5797, Gradignan, F-33170, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, IN2P3, CENBG, UMR 5797, Gradignan, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210125595","https://openalex.org/I4210133362"]},{"raw_affiliation_string":"Univ. Bordeaux, CENBG, UMR 5797, Gradignan, France","institution_ids":["https://openalex.org/I4210125595"]},{"raw_affiliation_string":"CNRS, IN2P3, CENBG, UMR 5797, Gradignan, F-33170, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210125595","https://openalex.org/I4210133362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108723601","display_name":"Myriam Janin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210127723","display_name":"Direction des Energies","ror":"https://ror.org/03cwzta72","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I4210127723"]},{"id":"https://openalex.org/I66456633","display_name":"Universit\u00e9 de N\u00eemes","ror":"https://ror.org/044t4x544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405261603","https://openalex.org/I66456633"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Myriam Janin","raw_affiliation_strings":["Laboratoire de d\u00e9veloppement Analytique Nucl\u00e9aire, Isotopique et El\u00e9mentaire, CEA, DEN, DPC, SEARS, Gif-sur-Yvette, France","Univ. N\u00eemes, Lab. G\u00e9ochimie Isotopique Environnementale, N\u00eemes, France","Laboratoire de d\u00e9veloppement Analytique Nucl\u00e9aire, Isotopique et El\u00e9mentaire, CEA, DEN, DPC, SEARS, Gif-sur-Yvette, F-91191, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de d\u00e9veloppement Analytique Nucl\u00e9aire, Isotopique et El\u00e9mentaire, CEA, DEN, DPC, SEARS, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210127723"]},{"raw_affiliation_string":"Univ. N\u00eemes, Lab. G\u00e9ochimie Isotopique Environnementale, N\u00eemes, France","institution_ids":["https://openalex.org/I66456633"]},{"raw_affiliation_string":"Laboratoire de d\u00e9veloppement Analytique Nucl\u00e9aire, Isotopique et El\u00e9mentaire, CEA, DEN, DPC, SEARS, Gif-sur-Yvette, F-91191, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210127723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083597092","display_name":"Magali Floriani","orcid":"https://orcid.org/0000-0001-5461-0486","observed_orcids":["https://orcid.org/0000-0001-5461-0486"]},"institutions":[{"id":"https://openalex.org/I1293448361","display_name":"Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire","ror":"https://ror.org/01ha22c77","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I1293448361","https://openalex.org/I4405256652"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Magali Floriani","raw_affiliation_strings":["Laboratoire d\u2019Ecotoxicologie des Radionucl\u00e9ides, IRSN, Institut de Radioprotection et S\u00fbret\u00e9 Nucl\u00e9aire, PRP-ENV/SERIS/LECO, Saint-Paul-Lez-Durance Cedex, France","Laboratoire d'Ecotoxicologie des Radionucl\u00e9ides, IRSN, Institut de Radioprotection et S\u00fbret\u00e9 Nucl\u00e9aire, PRP-ENV/SERIS/LECO, Saint-Paul-Lez-Durance Cedex, 13115, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Ecotoxicologie des Radionucl\u00e9ides, IRSN, Institut de Radioprotection et S\u00fbret\u00e9 Nucl\u00e9aire, PRP-ENV/SERIS/LECO, Saint-Paul-Lez-Durance Cedex, France","institution_ids":["https://openalex.org/I1293448361"]},{"raw_affiliation_string":"Laboratoire d'Ecotoxicologie des Radionucl\u00e9ides, IRSN, Institut de Radioprotection et S\u00fbret\u00e9 Nucl\u00e9aire, PRP-ENV/SERIS/LECO, Saint-Paul-Lez-Durance Cedex, 13115, France","institution_ids":["https://openalex.org/I1293448361"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032530017","display_name":"Val\u00e9rie Aloin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210092902","display_name":"Institute of Environmental Biology and Biotechnology","ror":"https://ror.org/00jhh5t96","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092902"]},{"id":"https://openalex.org/I4210143636","display_name":"CEA Marcoule","ror":"https://ror.org/04140y156","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I4210143636"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Aloin","raw_affiliation_strings":["Lab Biochim System Perturb, CEA, DSV, IBEB, Bagnols-sur-C\u00e8ze, France","Lab Biochim System Perturb, CEA, DSV, IBEB, Bagnols-sur-C\u00e8ze, F-30207, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab Biochim System Perturb, CEA, DSV, IBEB, Bagnols-sur-C\u00e8ze, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210092902","https://openalex.org/I4210143636"]},{"raw_affiliation_string":"Lab Biochim System Perturb, CEA, DSV, IBEB, Bagnols-sur-C\u00e8ze, F-30207, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210092902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088610050","display_name":"Asunci\u00f3n Carmona","orcid":"https://orcid.org/0000-0002-9253-4581","observed_orcids":["https://orcid.org/0000-0002-9253-4581"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210125595","display_name":"Laboratoire de Physique des deux infinis Bordeaux","ror":"https://ror.org/034a4bk84","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210125595","https://openalex.org/I4210133362"]},{"id":"https://openalex.org/I4210133362","display_name":"Institut National de Physique Nucl\u00e9aire et de Physique des Particules","ror":"https://ror.org/03fd77x13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210133362"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Asuncion Carmona","raw_affiliation_strings":["CNRS, IN2P3, CENBG, UMR 5797, Gradignan, France","Univ. Bordeaux, CENBG, UMR 5797, Gradignan, France","CNRS, IN2P3, CENBG, UMR 5797, Gradignan, F-33170, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, IN2P3, CENBG, UMR 5797, Gradignan, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210125595","https://openalex.org/I4210133362"]},{"raw_affiliation_string":"Univ. Bordeaux, CENBG, UMR 5797, Gradignan, France","institution_ids":["https://openalex.org/I4210125595"]},{"raw_affiliation_string":"CNRS, IN2P3, CENBG, UMR 5797, Gradignan, F-33170, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210125595","https://openalex.org/I4210133362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009516555","display_name":"V\u00e9ronique Malard","orcid":"https://orcid.org/0000-0002-0020-0518","observed_orcids":["https://orcid.org/0000-0002-0020-0518"]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210092902","display_name":"Institute of Environmental Biology and Biotechnology","ror":"https://ror.org/00jhh5t96","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092902"]},{"id":"https://openalex.org/I4210143636","display_name":"CEA Marcoule","ror":"https://ror.org/04140y156","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I4210143636"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V\u00e9ronique Malard","raw_affiliation_strings":["Lab Biochim System Perturb, CEA, DSV, IBEB, Bagnols-sur-C\u00e8ze, France","Lab Biochim System Perturb, CEA, DSV, IBEB, Bagnols-sur-C\u00e8ze, F-30207, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab Biochim System Perturb, CEA, DSV, IBEB, Bagnols-sur-C\u00e8ze, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210092902","https://openalex.org/I4210143636"]},{"raw_affiliation_string":"Lab Biochim System Perturb, CEA, DSV, IBEB, Bagnols-sur-C\u00e8ze, F-30207, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210092902"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5054143636"],"corresponding_institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210125595","https://openalex.org/I4210133362"],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":{"value":4090,"currency":"USD","value_usd":4090},"fwci":4.9839,"has_fulltext":true,"cited_by_count":111,"citation_normalized_percentile":{"value":0.96606088,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"14","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.4196999967098236,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.4196999967098236,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.31029999256134033,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.2020999938249588,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cobalt-oxide","display_name":"cobalt oxide","score":0.7979999780654907},{"id":"https://openalex.org/keywords/co3o4","display_name":"Co3O4","score":0.8050000071525574},{"id":"https://openalex.org/keywords/metal-oxide-nanoparticles","display_name":"metal oxide nanoparticles","score":0.7760000228881836},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.7990000247955322},{"id":"https://openalex.org/keywords/trojan-horse-mechanism","display_name":"Trojan horse mechanism","score":0.9020000100135803},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/lysosomal-acidification","display_name":"lysosomal acidification","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cobalt-ion-release","display_name":"cobalt ion release","score":0.7649999856948853},{"id":"https://openalex.org/keywords/endolysosomal-pathway","display_name":"endolysosomal pathway","score":0.8050000071525574},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"single-cell analysis","score":0.4390000104904175},{"id":"https://openalex.org/keywords/ion-beam-microanalysis","display_name":"ion beam microanalysis","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C515602321","wikidata":"https://www.wikidata.org/wiki/Q740","display_name":"Cobalt","level":2,"score":0.7894165515899658},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.7011396884918213},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6643723249435425},{"id":"https://openalex.org/C127445965","wikidata":"https://www.wikidata.org/wiki/Q2518429","display_name":"Nanotoxicology","level":3,"score":0.6305991411209106},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6098752021789551},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5510485768318176},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5005905628204346},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.45161038637161255},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4126625955104828},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.324210524559021},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.25889357924461365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14629900455474854},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12478592991828918},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.09996017813682556}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003035","descriptor_name":"Cobalt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003035","descriptor_name":"Cobalt","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1186/1743-8977-11-14","doi":"https://doi.org/10.1186/1743-8977-11-14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1743-8977-11-14","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/1743-8977-11-14","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2972641","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3994290","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24669904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24669904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and fibre toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3994290","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3994290/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Part Fibre Toxicol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.788.1561","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.788.1561","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8e/95/1743-8977-11-14.PMC3994290.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-02899990v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02899990","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Particle and Fibre Toxicology, 2014, 11 (1), pp.14. &#x27E8;10.1186/1743-8977-11-14&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:oskar-bordeaux.fr:20.500.12278/119885","doi":null,"is_oa":true,"landing_page_url":"https://oskar-bordeaux.fr/handle/20.500.12278/119885","pdf_url":null,"source":{"id":"https://openalex.org/S4306402569","display_name":"Oskar-Bordeaux (Universite de Bordeaux)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I15057530","host_organization_name":"Universit\u00e9 de Bordeaux","host_organization_lineage":["https://openalex.org/I15057530"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article de revue"},{"id":"pmh:oai:oskar-bordeaux.fr:20.500.12278/136959","doi":null,"is_oa":true,"landing_page_url":"https://oskar-bordeaux.fr/handle/20.500.12278/136959","pdf_url":null,"source":{"id":"https://openalex.org/S4306402569","display_name":"Oskar-Bordeaux (Universite de Bordeaux)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I15057530","host_organization_name":"Universit\u00e9 de Bordeaux","host_organization_lineage":["https://openalex.org/I15057530"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article de revue"}],"best_oa_location":{"id":"doi:10.1186/1743-8977-11-14","doi":"https://doi.org/10.1186/1743-8977-11-14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1743-8977-11-14","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/1743-8977-11-14","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329301","display_name":"Electricit\u00e9 de France","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2098417372.pdf","grobid_xml":"https://content.openalex.org/works/W2098417372.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1038316353","https://openalex.org/W1529834306","https://openalex.org/W1568601713","https://openalex.org/W1885102277","https://openalex.org/W1970953580","https://openalex.org/W1971823313","https://openalex.org/W1973744109","https://openalex.org/W1977412307","https://openalex.org/W1995478063","https://openalex.org/W1996157249","https://openalex.org/W1999206173","https://openalex.org/W1999357005","https://openalex.org/W2004850409","https://openalex.org/W2005229434","https://openalex.org/W2005427648","https://openalex.org/W2007633298","https://openalex.org/W2013547127","https://openalex.org/W2016886664","https://openalex.org/W2033310399","https://openalex.org/W2048240981","https://openalex.org/W2050734291","https://openalex.org/W2055549663","https://openalex.org/W2061662801","https://openalex.org/W2067559470","https://openalex.org/W2068945609","https://openalex.org/W2072227702","https://openalex.org/W2076224172","https://openalex.org/W2078603419","https://openalex.org/W2082778735","https://openalex.org/W2083511611","https://openalex.org/W2087468617","https://openalex.org/W2095661934","https://openalex.org/W2096553032","https://openalex.org/W2103326429","https://openalex.org/W2104808062","https://openalex.org/W2107511096","https://openalex.org/W2109126550","https://openalex.org/W2109515464","https://openalex.org/W2110135252","https://openalex.org/W2112896946","https://openalex.org/W2116933025","https://openalex.org/W2117630026","https://openalex.org/W2117665793","https://openalex.org/W2127563174","https://openalex.org/W2129921637","https://openalex.org/W2132834292","https://openalex.org/W2133820552","https://openalex.org/W2137746475","https://openalex.org/W2137849505","https://openalex.org/W2138617441","https://openalex.org/W2143007353","https://openalex.org/W2146139025","https://openalex.org/W2150521140","https://openalex.org/W2154613843","https://openalex.org/W2155052626","https://openalex.org/W2161695089","https://openalex.org/W2167806590","https://openalex.org/W2168037377","https://openalex.org/W2168854889","https://openalex.org/W2171259561","https://openalex.org/W2172105870","https://openalex.org/W2328984514","https://openalex.org/W2395618081","https://openalex.org/W2594613549","https://openalex.org/W3021519186","https://openalex.org/W4231885856","https://openalex.org/W4252019951"],"related_works":["https://openalex.org/W7098631204","https://openalex.org/W2083327209","https://openalex.org/W2944297613","https://openalex.org/W1989073805","https://openalex.org/W6940842201","https://openalex.org/W2260472920","https://openalex.org/W4413914396","https://openalex.org/W7209276711","https://openalex.org/W2337019643","https://openalex.org/W6977169639"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"mechanisms":[2],"of":[3,5,22,72,86,168,202,209],"toxicity":[4],"metal":[6,204],"oxide":[7,45,84,180],"particles":[8,41,181],"towards":[9],"lung":[10,100],"cells":[11,101,187],"are":[12,94,109,182],"far":[13],"from":[14,134],"being":[15],"understood.":[16],"In":[17],"particular,":[18],"the":[19,91,105,127,130,138,147,153,175,189],"relative":[20],"contribution":[21],"intracellular":[23,139,148,169,200],"particulate":[24,149],"versus":[25],"solubilized":[26,111,140,170],"fractions":[27],"is":[28,33,143,172],"rarely":[29],"considered":[30],"as":[31,43],"it":[32],"very":[34,87],"challenging":[35],"to":[36,53,118,162,199],"assess,":[37],"especially":[38],"for":[39,174],"low-solubility":[40,136],"such":[42],"cobalt":[44,83,119,123,141,150,171],"(Co3O4).":[46],"METHODS:":[47],"This":[48],"study":[49,80],"was":[50,124],"possible":[51],"owing":[52],"two":[54],"highly":[55],"sensitive,":[56],"independent,":[57],"analytical":[58],"techniques,":[59],"based":[60],"on":[61,69],"single-cell":[62],"analysis,":[63],"using":[64,75],"ion":[65],"beam":[66],"microanalysis,":[67],"and":[68,129,192],"bulk":[70],"analysis":[71],"cell":[73],"lysates,":[74],"mass":[76],"spectrometry.":[77],"RESULTS:":[78],"Our":[79],"shows":[81],"that":[82,164],"particles,":[85,137],"low":[88,113],"solubility":[89],"in":[90,152],"culture":[92],"medium,":[93],"readily":[95,183],"incorporated":[96],"by":[97,185],"BEAS-2B":[98],"human":[99],"through":[102,195],"endocytosis":[103],"via":[104,188],"clathrin-dependent":[106],"pathway.":[107],"They":[108],"partially":[110],"at":[112],"pH":[114],"within":[115,126],"lysosomes,":[116],"leading":[117],"ions":[120,205],"release.":[121],"Solubilized":[122],"detected":[125],"cytoplasm":[128],"nucleus.":[131],"As":[132],"expected":[133],"these":[135],"content":[142],"small":[144],"compared":[145],"with":[146],"content,":[151],"parts-per-thousand":[154],"range":[155],"or":[156],"below.":[157],"However,":[158],"we":[159],"were":[160],"able":[161],"demonstrate":[163],"this":[165],"minute":[166],"fraction":[167],"responsible":[173],"overall":[176],"toxicity.":[177,213],"CONCLUSIONS:":[178],"Cobalt":[179],"internalized":[184],"pulmonary":[186],"endo-lysosomal":[190],"pathway":[191],"can":[193],"lead,":[194],"a":[196],"Trojan-horse":[197],"mechanism,":[198],"release":[201],"toxic":[203],"over":[206],"long":[207],"periods":[208],"time,":[210],"involving":[211],"specific":[212]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
