{"id":"https://openalex.org/W2098411129","doi":"https://doi.org/10.1002/hep.27045","title":"Gene Expression Signature for Biliary Atresia and a Role for Interleukin-8 in Pathogenesis of Experimental Disease","display_name":"Gene Expression Signature for Biliary Atresia and a Role for Interleukin-8 in Pathogenesis of Experimental Disease","publication_year":2014,"publication_date":"2014-02-03","ids":{"openalex":"https://openalex.org/W2098411129","doi":"https://doi.org/10.1002/hep.27045","mag":"2098411129","pmid":"https://pubmed.ncbi.nlm.nih.gov/24493287","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4077977"},"language":"en","primary_location":{"id":"doi:10.1002/hep.27045","doi":"https://doi.org/10.1002/hep.27045","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.27045","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.27045","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.27045","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088049387","display_name":"Kazuhiko Bessho","orcid":"https://orcid.org/0000-0003-1684-2213","observed_orcids":["https://orcid.org/0000-0003-1684-2213"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuhiko Bessho","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059820410","display_name":"Reena Mourya","orcid":"https://orcid.org/0000-0003-4525-0196","observed_orcids":["https://orcid.org/0000-0003-4525-0196"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reena Mourya","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075932024","display_name":"Pranavkumar Shivakumar","orcid":"https://orcid.org/0000-0002-2095-0623","observed_orcids":["https://orcid.org/0000-0002-2095-0623"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pranavkumar Shivakumar","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027297723","display_name":"Stephanie Walters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Walters","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058001581","display_name":"John C. Magee","orcid":"https://orcid.org/0000-0001-8416-7905","observed_orcids":["https://orcid.org/0000-0001-8416-7905"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Magee","raw_affiliation_strings":["Department of Surgery of the University of Michigan Medical School, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery of the University of Michigan Medical School, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006550550","display_name":"Marepalli Bhaskara Rao","orcid":"https://orcid.org/0000-0001-5822-1576","observed_orcids":["https://orcid.org/0000-0001-5822-1576"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marepalli Rao","raw_affiliation_strings":["Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061689835","display_name":"Anil Goud Jegga","orcid":"https://orcid.org/0000-0002-4881-7752","observed_orcids":["https://orcid.org/0000-0002-4881-7752"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil G. Jegga","raw_affiliation_strings":["Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060481702","display_name":"Jorge A. Bezerra","orcid":"https://orcid.org/0000-0001-9667-7742","observed_orcids":["https://orcid.org/0000-0001-9667-7742"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jorge A. Bezerra","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5060481702"],"corresponding_institution_ids":["https://openalex.org/I1285204247"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":8.5809,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.98229326,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"60","issue":"1","first_page":"211","last_page":"223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biliary-atresia","display_name":"biliary atresia","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.9319999814033508},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lamc2","display_name":"LAMC2","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cxcr2","display_name":"CXCR2","score":0.800000011920929},{"id":"https://openalex.org/keywords/cholestasis","display_name":"cholestasis","score":0.7049999833106995},{"id":"https://openalex.org/keywords/neonatal-cholestasis","display_name":"neonatal cholestasis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.4970000088214874},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.5450000166893005},{"id":"https://openalex.org/keywords/biliary-obstruction","display_name":"biliary obstruction","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.8050625920295715},{"id":"https://openalex.org/C2779243279","wikidata":"https://www.wikidata.org/wiki/Q659033","display_name":"Biliary atresia","level":4,"score":0.7991153597831726},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.5997717976570129},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47969409823417664},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4449208676815033},{"id":"https://openalex.org/C3020625565","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin 1\u03b2","level":4,"score":0.44489070773124695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43960145115852356},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.41228681802749634},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3908783495426178},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.388838529586792},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.37476545572280884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.363961398601532},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2876793146133423},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2503208518028259},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24569904804229736},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.14667770266532898},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.048336535692214966},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.0},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001656","descriptor_name":"Biliary Atresia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001656","descriptor_name":"Biliary Atresia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001656","descriptor_name":"Biliary Atresia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/hep.27045","doi":"https://doi.org/10.1002/hep.27045","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.27045","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.27045","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:24493287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24493287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:4077977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4077977","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hepatology","raw_type":"Text"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/107580","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/107580","pdf_url":"https://hdl.handle.net/2027.42/107580","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1002/hep.27045","doi":"https://doi.org/10.1002/hep.27045","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.27045","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.27045","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1570668212","display_name":null,"funder_award_id":"DK 83781","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2705871926","display_name":null,"funder_award_id":"R01-DK083781","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2829477506","display_name":null,"funder_award_id":"DK78392","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2928735922","display_name":"Continuation of ChiLDReN, the Childhood Liver Disease Research Network: Indiana University","funder_award_id":"U01DK084536","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2956510801","display_name":"Biological Basis of Phenotypes and Clinical Outcomes in Biliary Atresia","funder_award_id":"7r01dk083781-14","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3685060599","display_name":null,"funder_award_id":"DK62497","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5233387994","display_name":null,"funder_award_id":"R01 DK83781","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G702594554","display_name":"The role of intestinal flora in the pathogenesis of biliary atresia","funder_award_id":"26461609","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7071474220","display_name":"Understanding Cholestatic Disorders in a Collaborative Network: The Role of SickK","funder_award_id":"U01DK103135","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G748054159","display_name":"Immunologic Dysfunction in Biliary Atresia","funder_award_id":"R01DK064008","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7901210138","display_name":null,"funder_award_id":"DK 62456","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8701320340","display_name":"Cincinnati Center for Clinical and Translational Sciences and Training","funder_award_id":"UL1TR000077","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G876825417","display_name":"Childhood Liver Disease Research Network Data Coordinating Center","funder_award_id":"U01DK062456","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000881299","display_name":"Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease","funder_award_id":"P30DK078392","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000920095","display_name":"Clinical Center for Cholestatic Liver Disease in Children","funder_award_id":"U01DK062497","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2098411129.pdf"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W150663644","https://openalex.org/W1483610036","https://openalex.org/W1979972626","https://openalex.org/W1985613990","https://openalex.org/W1991562400","https://openalex.org/W1994271325","https://openalex.org/W1994467099","https://openalex.org/W1997226378","https://openalex.org/W2000819449","https://openalex.org/W2001356286","https://openalex.org/W2003127893","https://openalex.org/W2028896410","https://openalex.org/W2030863773","https://openalex.org/W2047128529","https://openalex.org/W2048990275","https://openalex.org/W2053106065","https://openalex.org/W2058347425","https://openalex.org/W2067354220","https://openalex.org/W2070523026","https://openalex.org/W2070898960","https://openalex.org/W2071618738","https://openalex.org/W2083811181","https://openalex.org/W2089981790","https://openalex.org/W2093820566","https://openalex.org/W2096006325","https://openalex.org/W2098349456","https://openalex.org/W2122863289","https://openalex.org/W2123538811","https://openalex.org/W2124649657","https://openalex.org/W2149680759","https://openalex.org/W2156756875","https://openalex.org/W2162358868","https://openalex.org/W2911964244","https://openalex.org/W4234203583","https://openalex.org/W6629016854","https://openalex.org/W6673326213"],"related_works":["https://openalex.org/W1961761375","https://openalex.org/W2400482391","https://openalex.org/W2223988148","https://openalex.org/W3174607197","https://openalex.org/W3018741851","https://openalex.org/W1520541011","https://openalex.org/W2089981790","https://openalex.org/W2630767481","https://openalex.org/W4311663753","https://openalex.org/W4242441549"],"abstract_inverted_index":{"UNLABELLED:":[0],"Biliary":[1],"atresia":[2],"(BA)":[3],"is":[4],"a":[5,46,58,187,234],"progressive":[6],"fibroinflammatory":[7],"obstruction":[8],"of":[9,31,63,71,97,122,130,134,144,176,182,190,194,199,204,219,236],"extrahepatic":[10],"bile":[11,205],"ducts":[12],"that":[13],"presents":[14],"as":[15,79,233],"neonatal":[16,213],"cholestasis.":[17],"Due":[18],"to":[19,51,57,107,169],"the":[20,33,69,120,149,156,162,174,183,197,202,243],"overlap":[21],"in":[22,92,148,165,186,246],"clinical,":[23],"biochemical,":[24],"and":[25,82,103,132,208,221,230],"histological":[26],"features":[27],"with":[28,66,76,94,110,116,238],"other":[29],"causes":[30],"cholestasis,":[32,200],"diagnosis":[34,229],"requires":[35],"an":[36,95,117,239],"intraoperative":[37],"cholangiogram.":[38],"Thus,":[39],"we":[40,86,172],"determined":[41],"whether":[42,161],"diseased":[43,80,114],"livers":[44],"express":[45],"gene":[47],"expression":[48,61,218],"signature":[49],"unique":[50],"BA.":[52,192,248],"Applying":[53],"stringent":[54],"statistical":[55],"analysis":[56],"genome-wide":[59],"liver":[60],"platform":[62],"64":[64],"infants":[65],"BA":[67,93,111,227],"at":[68,228],"time":[70],"diagnosis,":[72],"14":[73],"age-appropriate":[74],"subjects":[75,109],"intrahepatic":[77],"cholestasis":[78],"controls":[81,115],"seven":[83],"normal":[84],"controls,":[85],"identified":[87],"15":[88],"genes":[89],"uniquely":[90],"expressed":[91],"accuracy":[96],"92.3%.":[98],"Among":[99],"these":[100],"genes,":[101],"IL8":[102,166,177,220,244],"LAMC2":[104,222],"were":[105],"sufficient":[106],"classify":[108],"distinctly":[112],"from":[113],"area":[118],"under":[119],"curve":[121],"0.934":[123],"(95%":[124],"confidence":[125],"interval":[126],"[CI]:":[127],"0.84-1.03),":[128],"sensitivity":[129,225],"96.9%,":[131],"specificity":[133],"85.7%":[135],"using":[136],"their":[137],"combined":[138],"first":[139],"principal":[140],"component.":[141],"Direct":[142],"measurement":[143],"interleukin":[145],"(IL)8":[146],"protein":[147],"serum,":[150],"however,":[151],"was":[152,167],"not":[153],"different":[154],"between":[155],"two":[157],"groups.":[158],"To":[159],"investigate":[160],"liver-restricted":[163],"increase":[164],"relevant":[168],"disease":[170],"pathogenesis,":[171],"inactivated":[173],"signaling":[175,245],"homologs":[178],"by":[179],"genetic":[180],"targeting":[181],"Cxcr2":[184,195],"receptor":[185],"murine":[188],"model":[189],"experimental":[191,247],"Disruption":[193],"shortened":[196],"duration":[198],"decreased":[201],"incidence":[203],"duct":[206],"obstruction,":[207],"improved":[209],"survival":[210],"above":[211],"wild-type":[212],"mice.":[214],"CONCLUSION:":[215],"The":[216],"hepatic":[217],"has":[223],"high":[224],"for":[226,242],"may":[231],"serve":[232],"biomarker":[235],"disease,":[237],"important":[240],"role":[241]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
