{"id":"https://openalex.org/W2098370708","doi":"https://doi.org/10.2337/diab.30.3.267","title":"The Insulin Gene Is Located on the Short Arm of Chromosome 11 in Humans","display_name":"The Insulin Gene Is Located on the Short Arm of Chromosome 11 in Humans","publication_year":1981,"publication_date":"1981-03-01","ids":{"openalex":"https://openalex.org/W2098370708","doi":"https://doi.org/10.2337/diab.30.3.267","mag":"2098370708","pmid":"https://pubmed.ncbi.nlm.nih.gov/7009275"},"language":"en","primary_location":{"id":"doi:10.2337/diab.30.3.267","doi":"https://doi.org/10.2337/diab.30.3.267","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.30.3.267","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023117834","display_name":"David Owerbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Owerbach","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of California\u2008San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California\u2008San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103544018","display_name":"Graeme I. Bell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Graeme I Bell","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of California\u2008San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California\u2008San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036382303","display_name":"William J. Rutter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J Rutter","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of California\u2008San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California\u2008San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011516377","display_name":"Judith A Brown","orcid":"https://orcid.org/0000-0002-8628-191X","observed_orcids":["https://orcid.org/0000-0002-8628-191X"]},"institutions":[{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith A Brown","raw_affiliation_strings":["Department of Human Genetics, Medical College of Virginia\u2008Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Medical College of Virginia\u2008Richmond, Virginia","institution_ids":["https://openalex.org/I72019824"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113582122","display_name":"Thomas B. Shows","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas B Shows","raw_affiliation_strings":["Department of Genetics, Roswell Park Memorial Institute, New York State Department of Health\u2008Buffalo, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Roswell Park Memorial Institute, New York State Department of Health\u2008Buffalo, New York","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I1298060332"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.391,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.99088695,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"30","issue":"3","first_page":"267","last_page":"270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.2946999967098236,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.2946999967098236,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.20559999346733093,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.1704999953508377,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-gene","display_name":"insulin gene","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chromosome-11","display_name":"chromosome 11","score":0.8579999804496765},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.7200000286102295},{"id":"https://openalex.org/keywords/human-mouse-somatic-cell-hybrids","display_name":"human-mouse somatic cell hybrids","score":0.8220000267028809},{"id":"https://openalex.org/keywords/chromosomal-translocation","display_name":"chromosomal translocation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/gene-localization","display_name":"gene localization","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C3020253223","wikidata":"https://www.wikidata.org/wiki/Q7748172","display_name":"Long arm","level":4,"score":0.6981449723243713},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5337703227996826},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5311896800994873},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5287708044052124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4964039921760559},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.45639508962631226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32136476039886475},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26057592034339905}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002906","descriptor_name":"Chromosomes, Human, 6-12 and X","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006822","descriptor_name":"Hybrid Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diab.30.3.267","doi":"https://doi.org/10.2337/diab.30.3.267","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.30.3.267","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"doi:10.2337/diabetes.30.3.267","doi":"https://doi.org/10.2337/diabetes.30.3.267","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.30.3.267","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:7009275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7009275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1518439906","https://openalex.org/W1974251109","https://openalex.org/W1977526480","https://openalex.org/W1979254778","https://openalex.org/W1982927929","https://openalex.org/W1988218731","https://openalex.org/W2001337273","https://openalex.org/W2006604884","https://openalex.org/W2022747960","https://openalex.org/W2028835583","https://openalex.org/W2030953510","https://openalex.org/W2050035145","https://openalex.org/W2059184636","https://openalex.org/W2060955582","https://openalex.org/W2063450941","https://openalex.org/W2067679818","https://openalex.org/W2084209513","https://openalex.org/W2087737282","https://openalex.org/W2090815691","https://openalex.org/W2093919695","https://openalex.org/W2411285136"],"related_works":["https://openalex.org/W2050035145","https://openalex.org/W2008361300","https://openalex.org/W2077908619","https://openalex.org/W2144755533","https://openalex.org/W2085772196","https://openalex.org/W2089573057","https://openalex.org/W1966369545","https://openalex.org/W2120457857","https://openalex.org/W2402958353","https://openalex.org/W2056833824"],"abstract_inverted_index":{"The":[0],"human":[1,15,30,40],"insulin":[2,41],"gene":[3,42],"has":[4],"been":[5],"previously":[6],"localized":[7],"to":[8,57],"chromosome":[9,50],"11.":[10],"We":[11],"have":[12],"analyzed":[13],"the":[14,39,46,53],"DNA":[16],"sequences":[17],"present":[18],"in":[19,52],"a":[20,27],"human-mouse":[21],"somatic":[22],"cell":[23],"hybrid":[24],"line":[25],"possessing":[26],"translocation":[28],"involving":[29],"chromosomes":[31],"11":[32,51],"and":[33],"X.":[34],"These":[35],"data":[36],"indicate":[37],"that":[38],"is":[43],"located":[44],"on":[45],"short":[47],"arm":[48],"of":[49],"region":[54],"p13":[55],"leads":[56],"pter.":[58]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}