{"id":"https://openalex.org/W2098360608","doi":"https://doi.org/10.1158/2159-8290.cd-13-0900","title":"Development of siRNA Payloads to Target KRAS -Mutant Cancer","display_name":"Development of siRNA Payloads to Target KRAS -Mutant Cancer","publication_year":2014,"publication_date":"2014-08-07","ids":{"openalex":"https://openalex.org/W2098360608","doi":"https://doi.org/10.1158/2159-8290.cd-13-0900","mag":"2098360608","pmid":"https://pubmed.ncbi.nlm.nih.gov/25100204","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4184972"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.cd-13-0900","doi":"https://doi.org/10.1158/2159-8290.cd-13-0900","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-13-0900","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4184972","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044069125","display_name":"Tina L. Yuan","orcid":"https://orcid.org/0000-0002-8844-2852","observed_orcids":["https://orcid.org/0000-0002-8844-2852"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina L. Yuan","raw_affiliation_strings":["1Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083055546","display_name":"Christof Fellmann","orcid":"https://orcid.org/0000-0002-9545-5723","observed_orcids":["https://orcid.org/0000-0002-9545-5723"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christof Fellmann","raw_affiliation_strings":["2Cold Spring Harbor Laboratory, Cold Spring Harbor, New York","Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY, 11724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cold Spring Harbor Laboratory, Cold Spring Harbor, New York","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY, 11724, USA","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047998667","display_name":"Chih-Shia Lee","orcid":"https://orcid.org/0009-0007-1473-4047","observed_orcids":["https://orcid.org/0009-0007-1473-4047"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chih-Shia Lee","raw_affiliation_strings":["3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland","Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015240122","display_name":"Cayde D. Ritchie","orcid":"https://orcid.org/0000-0003-0656-7940","observed_orcids":["https://orcid.org/0000-0003-0656-7940"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cayde D. Ritchie","raw_affiliation_strings":["1Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037868641","display_name":"Vishal Thapar","orcid":"https://orcid.org/0000-0002-8397-8279","observed_orcids":["https://orcid.org/0000-0002-8397-8279"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vishal Thapar","raw_affiliation_strings":["2Cold Spring Harbor Laboratory, Cold Spring Harbor, New York","4Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cold Spring Harbor Laboratory, Cold Spring Harbor, New York","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"4Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010540932","display_name":"Liam C. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liam C. Lee","raw_affiliation_strings":["3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland","Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060970071","display_name":"Dennis J. Hsu","orcid":"https://orcid.org/0000-0003-4200-1098","observed_orcids":["https://orcid.org/0000-0003-4200-1098"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis J. Hsu","raw_affiliation_strings":["3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland","Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048703259","display_name":"Danielle Grace","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle Grace","raw_affiliation_strings":["2Cold Spring Harbor Laboratory, Cold Spring Harbor, New York","4Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cold Spring Harbor Laboratory, Cold Spring Harbor, New York","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"4Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005641432","display_name":"Joseph O. Carver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph O. Carver","raw_affiliation_strings":["3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland","Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091324982","display_name":"Johannes A. Zuber","orcid":"https://orcid.org/0000-0001-8810-6835","observed_orcids":["https://orcid.org/0000-0001-8810-6835"]},"institutions":[{"id":"https://openalex.org/I195525897","display_name":"Research Institute of Molecular Pathology","ror":"https://ror.org/02c5jsm26","country_code":"AT","type":"facility","lineage":["https://openalex.org/I195525897"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["AT","US"],"is_corresponding":false,"raw_author_name":"Johannes Zuber","raw_affiliation_strings":["2Cold Spring Harbor Laboratory, Cold Spring Harbor, New York","5Research Institute of Molecular Pathology, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cold Spring Harbor Laboratory, Cold Spring Harbor, New York","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"5Research Institute of Molecular Pathology, Vienna, Austria","institution_ids":["https://openalex.org/I195525897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044758224","display_name":"Ji Luo","orcid":"https://orcid.org/0000-0001-5063-1626","observed_orcids":["https://orcid.org/0000-0001-5063-1626"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ji Luo","raw_affiliation_strings":["3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland","Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082685256","display_name":"Frank P. McCormick","orcid":"https://orcid.org/0000-0002-6619-7120","observed_orcids":["https://orcid.org/0000-0002-6619-7120"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frank McCormick","raw_affiliation_strings":["1Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025451142","display_name":"Scott W. Lowe","orcid":"https://orcid.org/0000-0002-5284-9650","observed_orcids":["https://orcid.org/0000-0002-5284-9650"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott W. Lowe","raw_affiliation_strings":["2Cold Spring Harbor Laboratory, Cold Spring Harbor, New York","4Memorial Sloan Kettering Cancer Center, New York, New York","6Howard Hughes Medical Institute, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cold Spring Harbor Laboratory, Cold Spring Harbor, New York","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"4Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"6Howard Hughes Medical Institute, New York, New York","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5025451142","https://openalex.org/A5044758224","https://openalex.org/A5082685256"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1344073410","https://openalex.org/I180670191","https://openalex.org/I2750212522","https://openalex.org/I4210140884","https://openalex.org/I4210149717","https://openalex.org/I4210167126"],"apc_list":null,"apc_paid":null,"fwci":3.8554,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.95263468,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":"10","first_page":"1182","last_page":"1197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.597000002861023},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.753000020980835},{"id":"https://openalex.org/keywords/rnai-therapeutics","display_name":"RNAi therapeutics","score":0.8240000009536743},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.5640000104904175},{"id":"https://openalex.org/keywords/sirna-library","display_name":"siRNA library","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.6930000185966492},{"id":"https://openalex.org/keywords/raf-1","display_name":"Raf-1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pik3cb","display_name":"PIK3CB","score":0.8080000281333923},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8410000205039978},{"id":"https://openalex.org/keywords/off-target-effects","display_name":"off-target effects","score":0.8510000109672546},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.7894139885902405},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.7634519338607788},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.7513779997825623},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.7005351781845093},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6727355718612671},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4336240291595459},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4328547716140747},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4235427975654602},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41970252990722656},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.3853665292263031},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37486737966537476},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22657400369644165},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.16532421112060547},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08020204305648804}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1158/2159-8290.cd-13-0900","doi":"https://doi.org/10.1158/2159-8290.cd-13-0900","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-13-0900","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},{"id":"pmid:25100204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25100204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer discovery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4184972","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4184972","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Discov","raw_type":"Text"},{"id":"pmh:oai:repository.cshl.edu:30687","doi":null,"is_oa":false,"landing_page_url":"https://repository.cshl.edu/id/eprint/30687/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402288","display_name":"Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Paper"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.893.9889","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.893.9889","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerdiscovery.aacrjournals.org/content/4/10/1182.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.901.9499","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.901.9499","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerdiscovery.aacrjournals.org/content/early/2014/08/06/2159-8290.CD-13-0900.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.906.1465","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.906.1465","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerdiscovery.aacrjournals.org/content/early/2014/09/12/2159-8290.CD-13-0900.full.pdf","raw_type":"text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt9jj3m1hg","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9jj3m1hg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Discovery, vol 4, iss 10","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4184972","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4184972","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Discov","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3291173584","display_name":null,"funder_award_id":"1ZIABC011437","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G4843635520","display_name":"Combinatorial genetic analysis using validated siRNA libraries","funder_award_id":"ZIABC011437","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5787525420","display_name":"COMPUTATIONAL AND FUNCTIONAL APPROACHES TO VALIDATING CANCER GENOME TARGETS","funder_award_id":"U01CA168409","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8376593020","display_name":"Bay Area Cancer Target Discovery and Development Network","funder_award_id":"U01CA168370","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8600057287","display_name":"Molecular and Cellular Mechanisms in Cancer","funder_award_id":"T32CA108462","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000856157","display_name":"Targeting Transcription and Splicing in Cancer","funder_award_id":"P01CA013106","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1520518044","https://openalex.org/W1994634031","https://openalex.org/W1999287489","https://openalex.org/W2004295816","https://openalex.org/W2004774286","https://openalex.org/W2014509855","https://openalex.org/W2015511149","https://openalex.org/W2017642141","https://openalex.org/W2020469175","https://openalex.org/W2041649971","https://openalex.org/W2043828851","https://openalex.org/W2051165598","https://openalex.org/W2062983115","https://openalex.org/W2065909963","https://openalex.org/W2066393891","https://openalex.org/W2068845555","https://openalex.org/W2074370114","https://openalex.org/W2085736853","https://openalex.org/W2095509700","https://openalex.org/W2101091611","https://openalex.org/W2106641840","https://openalex.org/W2108172661","https://openalex.org/W2108882170","https://openalex.org/W2109031404","https://openalex.org/W2113609800","https://openalex.org/W2120203403","https://openalex.org/W2120344603","https://openalex.org/W2126851107","https://openalex.org/W2129429534","https://openalex.org/W2133177414","https://openalex.org/W2135131549","https://openalex.org/W2135398049","https://openalex.org/W2140093304","https://openalex.org/W2144708319","https://openalex.org/W2149662085","https://openalex.org/W2167197258","https://openalex.org/W4211039187","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2315624601","https://openalex.org/W7214263746","https://openalex.org/W2898337648","https://openalex.org/W2164296283","https://openalex.org/W7222461299","https://openalex.org/W2335996374","https://openalex.org/W2333855314","https://openalex.org/W3022202322","https://openalex.org/W6962737300","https://openalex.org/W2597843606"],"abstract_inverted_index":{"UNLABELLED:":[0],"RNAi":[1,22,153,158],"is":[2,117],"a":[3,40,46,142,165],"powerful":[4],"tool":[5],"for":[6,15,34,145,160,183],"target":[7,36,148],"identification":[8,149],"and":[9,55,71,82,85,93,128,150],"can":[10,202],"lead":[11],"to":[12,44,56,105],"novel":[13],"therapies":[14],"pharmacologically":[16],"intractable":[17],"targets":[18,63],"such":[19],"as":[20,102,195,197],"KRAS.":[21],"therapy":[23,159],"must":[24],"combine":[25,124],"potent":[26,49],"siRNA":[27,91,94,121,127,139,167,185],"payloads":[28,122,140],"with":[29],"reliable":[30],"in":[31,80,83,180,207],"vivo":[32,84,181],"delivery":[33,88,186],"efficient":[35],"inhibition.":[37],"We":[38,76,110],"used":[39],"functional":[41],"\"Sensor\"":[42],"assay":[43],"establish":[45],"library":[47,168],"of":[48,89,137,152,193],"siRNAs":[50,79,130],"against":[51,169],"RAS":[52,170],"pathway":[53,171],"genes":[54,172],"show":[57,189],"that":[58,113,123,173,190],"they":[59],"efficiently":[60],"suppress":[61],"their":[62],"at":[64],"low":[65],"dose.":[66],"This":[67],"reduces":[68],"off-target":[69],"effects":[70],"enables":[72,174],"combination":[73,147,175],"gene":[74,176],"knockdown.":[75],"administered":[77],"Sensor":[78,138],"vitro":[81],"validated":[86,166],"the":[87,96,146],"KRAS":[90,194],"alone":[92],"targeting":[95],"complete":[97],"RAF":[98,198],"effector":[99],"node":[100],"(A/B/CRAF)":[101],"promising":[103],"strategies":[104],"treat":[106],"KRAS-mutant":[107,161,204],"colorectal":[108,205],"cancer.":[109],"further":[111],"demonstrate":[112],"improved":[114],"therapeutic":[115],"efficacy":[116],"achieved":[118],"by":[119],"formulating":[120],"both":[125],"single-gene":[126],"node-targeted":[129],"(KRAS":[131],"+":[132],"PIK3CA/B).":[133],"The":[134],"customizable":[135],"nature":[136],"offers":[141],"universal":[143],"platform":[144],"development":[151],"therapeutics.":[154],"SIGNIFICANCE:":[155],"To":[156],"advance":[157],"cancer,":[162],"we":[163,188],"developed":[164],"silencing.":[177],"Using":[178],"an":[179],"model":[182],"real-time":[184],"tracking,":[187],"siRNA-mediated":[191],"inhibition":[192],"well":[196],"or":[199],"PI3K":[200],"combinations":[201],"impair":[203],"cancer":[206],"xenograft":[208],"models.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
