{"id":"https://openalex.org/W2098219136","doi":"https://doi.org/10.1002/cbdv.201300364","title":"Inhibitory Effects of Constituents of an Endophytic Fungus Hypoxylon investiens on Nitric Oxide and Interleukin\u20106 Production in RAW264.7 Macrophages","display_name":"Inhibitory Effects of Constituents of an Endophytic Fungus Hypoxylon investiens on Nitric Oxide and Interleukin\u20106 Production in RAW264.7 Macrophages","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W2098219136","doi":"https://doi.org/10.1002/cbdv.201300364","mag":"2098219136","pmid":"https://pubmed.ncbi.nlm.nih.gov/24934680"},"language":"en","primary_location":{"id":"doi:10.1002/cbdv.201300364","doi":"https://doi.org/10.1002/cbdv.201300364","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.201300364","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005036381","display_name":"Chun\u2010Wei Chang","orcid":"https://orcid.org/0000-0002-5265-1978","observed_orcids":["https://orcid.org/0000-0002-5265-1978","https://orcid.org/0000-0003-3384-0199"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chun\u2010Wei Chang","raw_affiliation_strings":["Graduate Institute of Natural Products (GINP), College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan, ROC, (phone: +886-7-3121101 (ext\u20052191))"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Natural Products (GINP), College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan, ROC, (phone: +886-7-3121101 (ext\u20052191))","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103088487","display_name":"Hsun\u2010Shuo Chang","orcid":"https://orcid.org/0000-0003-2745-139X","observed_orcids":["https://orcid.org/0000-0003-2745-139X"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsun\u2010Shuo Chang","raw_affiliation_strings":["School of Pharmacy, College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan, ROC","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047084746","display_name":"Ming\u2010Jen Cheng","orcid":"https://orcid.org/0000-0001-9263-7620","observed_orcids":["https://orcid.org/0000-0001-9263-7620"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I4210157834","display_name":"Food Industry Research and Development Institute","ror":"https://ror.org/05yhj6j64","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210157834"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Ming\u2010Jen Cheng","raw_affiliation_strings":["Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, ROC, (phone: +886-3-5223191 (ext 585))","First co-author","Ih-Sheng Chen, School of Pharmacy, College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan, ROC===","Ming-Jen Cheng, Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, ROC, (phone: +886-3-5223191 (ext 585))==="],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, ROC, (phone: +886-3-5223191 (ext 585))","institution_ids":["https://openalex.org/I4210157834"]},{"raw_affiliation_string":"First co-author","institution_ids":[]},{"raw_affiliation_string":"Ih-Sheng Chen, School of Pharmacy, College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan, ROC===","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Ming-Jen Cheng, Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, ROC, (phone: +886-3-5223191 (ext 585))===","institution_ids":["https://openalex.org/I4210157834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101895208","display_name":"Ta-Wei Liu","orcid":"https://orcid.org/0000-0002-6978-9922","observed_orcids":["https://orcid.org/0000-0002-6978-9922","https://orcid.org/0000-0002-4286-2210"]},"institutions":[{"id":"https://openalex.org/I4210157834","display_name":"Food Industry Research and Development Institute","ror":"https://ror.org/05yhj6j64","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210157834"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ta\u2010Wei Liu","raw_affiliation_strings":["Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, ROC, (phone: +886-3-5223191 (ext 585))"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, ROC, (phone: +886-3-5223191 (ext 585))","institution_ids":["https://openalex.org/I4210157834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020145932","display_name":"Sung\u2010Yuan Hsieh","orcid":"https://orcid.org/0000-0002-5670-1426","observed_orcids":["https://orcid.org/0000-0002-5670-1426"]},"institutions":[{"id":"https://openalex.org/I4210157834","display_name":"Food Industry Research and Development Institute","ror":"https://ror.org/05yhj6j64","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210157834"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Sung\u2010Yuan Hsieh","raw_affiliation_strings":["Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, ROC, (phone: +886-3-5223191 (ext 585))"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, ROC, (phone: +886-3-5223191 (ext 585))","institution_ids":["https://openalex.org/I4210157834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103507466","display_name":"Gwo\u2010Fang Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157834","display_name":"Food Industry Research and Development Institute","ror":"https://ror.org/05yhj6j64","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210157834"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Gwo\u2010Fang Yuan","raw_affiliation_strings":["Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, ROC, (phone: +886-3-5223191 (ext 585))"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, ROC, (phone: +886-3-5223191 (ext 585))","institution_ids":["https://openalex.org/I4210157834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065659619","display_name":"Ih\u2010Sheng Chen","orcid":"https://orcid.org/0000-0002-9191-6529","observed_orcids":["https://orcid.org/0000-0002-9191-6529"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I4210157834","display_name":"Food Industry Research and Development Institute","ror":"https://ror.org/05yhj6j64","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210157834"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Ih\u2010Sheng Chen","raw_affiliation_strings":["Graduate Institute of Natural Products (GINP), College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan, ROC, (phone: +886-7-3121101 (ext 2191))","Ih-Sheng Chen, School of Pharmacy, College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan, ROC===","Ming-Jen Cheng, Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, ROC, (phone: +886-3-5223191 (ext 585))===","School of Pharmacy, College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Natural Products (GINP), College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan, ROC, (phone: +886-7-3121101 (ext 2191))","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Ih-Sheng Chen, School of Pharmacy, College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan, ROC===","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Ming-Jen Cheng, Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, ROC, (phone: +886-3-5223191 (ext 585))===","institution_ids":["https://openalex.org/I4210157834"]},{"raw_affiliation_string":"School of Pharmacy, College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan, ROC","institution_ids":["https://openalex.org/I152743029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047084746","https://openalex.org/A5065659619"],"corresponding_institution_ids":["https://openalex.org/I152743029","https://openalex.org/I4210157834"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.5291,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.54965089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"6","first_page":"949","last_page":"961"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12934","display_name":"Plant and fungal interactions","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endophytic-fungi","display_name":"endophytic fungi","score":0.8889999985694885},{"id":"https://openalex.org/keywords/fungal-secondary-metabolites","display_name":"fungal secondary metabolites","score":0.7070000171661377},{"id":"https://openalex.org/keywords/guaiane-sesquiterpenes","display_name":"guaiane sesquiterpenes","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nitric-oxide-inhibition","display_name":"nitric oxide inhibition","score":0.8180000185966492},{"id":"https://openalex.org/keywords/il-6-inhibition","display_name":"IL-6 inhibition","score":0.9909999966621399},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9629999995231628},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.7760000228881836},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7291181683540344},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7258420586585999},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.6481434106826782},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5676873326301575},{"id":"https://openalex.org/C3018223157","wikidata":"https://www.wikidata.org/wiki/Q7233257","display_name":"Positive control","level":2,"score":0.5572888851165771},{"id":"https://openalex.org/C2779678110","wikidata":"https://www.wikidata.org/wiki/Q764","display_name":"Fungus","level":2,"score":0.4431697130203247},{"id":"https://openalex.org/C2777525088","wikidata":"https://www.wikidata.org/wiki/Q260335","display_name":"Endophyte","level":2,"score":0.41673383116722107},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28859496116638184},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.2790490686893463},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.24878987669944763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16284647583961487},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1501704454421997},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013098","descriptor_name":"Xylariales","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018547","descriptor_name":"Plant Stems","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D032862","descriptor_name":"Litsea","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D045789","descriptor_name":"Sesquiterpenes, Guaiane","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D045789","descriptor_name":"Sesquiterpenes, Guaiane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045789","descriptor_name":"Sesquiterpenes, Guaiane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060026","descriptor_name":"Endophytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/cbdv.201300364","doi":"https://doi.org/10.1002/cbdv.201300364","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.201300364","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},{"id":"pmid:24934680","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24934680","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biodiversity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1978948934","https://openalex.org/W1992199779","https://openalex.org/W1999862212","https://openalex.org/W2011043165","https://openalex.org/W2013492677","https://openalex.org/W2018769950","https://openalex.org/W2021182975","https://openalex.org/W2021218641","https://openalex.org/W2031476746","https://openalex.org/W2033764552","https://openalex.org/W2040324815","https://openalex.org/W2041634592","https://openalex.org/W2044754467","https://openalex.org/W2054533326","https://openalex.org/W2063203556","https://openalex.org/W2063353959","https://openalex.org/W2070489781","https://openalex.org/W2072385173","https://openalex.org/W2074647516","https://openalex.org/W2104944437","https://openalex.org/W2120763351","https://openalex.org/W2130017704","https://openalex.org/W2136249549","https://openalex.org/W2143811153","https://openalex.org/W2150669502","https://openalex.org/W2154440307","https://openalex.org/W2163336230","https://openalex.org/W2460765472","https://openalex.org/W2463728574","https://openalex.org/W2950755667","https://openalex.org/W2952797861"],"related_works":["https://openalex.org/W2313453318","https://openalex.org/W2120075919","https://openalex.org/W2314681300","https://openalex.org/W2159467010","https://openalex.org/W4200551111","https://openalex.org/W2757204682","https://openalex.org/W4385587061","https://openalex.org/W4293095742","https://openalex.org/W2130349713","https://openalex.org/W2028034299"],"abstract_inverted_index":{"Three":[0],"new":[1,73],"compounds,":[2,40],"hypoxyloamide":[3],"(1),":[4],"8-methoxynaphthalene-1,7-diol":[5],"(2),":[6],"and":[7,84,87,96,111,127,141,170],"hypoxylonol":[8,25],"(3),":[9],"together":[10],"with":[11,37,105,135],"seven":[12],"compounds":[13,74],"isolated":[14,43],"from":[15,44,172],"nature":[16],"for":[17],"the":[18,45,58,72,117,146,154,161,173],"first":[19,162],"time,":[20],"investiamide":[21],"(4),":[22],"hypoxypropanamide":[23],"(5),":[24],"A":[26],"(6),":[27],"investienol":[28],"(7),":[29],"2-heptylfuran":[30],"(8),":[31],"(3S)-5-methyl-8-O-methylmellein":[32],"(9),":[33],"(4R)-O-methylsclerone":[34],"(10),":[35],"along":[36],"19":[38],"known":[39],"11-29,":[41],"were":[42,75],"culture":[46],"broth":[47],"of":[48,60,71,108,138,156],"Hypoxylon":[49],"investiens":[50],"BCRC":[51],"10F0115,":[52],"a":[53],"fungal":[54],"endophyte":[55],"residing":[56],"in":[57],"stems":[59],"an":[61],"endemic":[62],"Formosan":[63],"plant":[64],"Litsea":[65],"akoensis":[66],"var.":[67],"chitouchiaoensis.":[68],"The":[69],"structures":[70],"established":[76],"by":[77],"spectroscopic":[78],"methods,":[79],"including":[80],"UV,":[81],"IR,":[82],"HR-ESI-MS,":[83],"extensive":[85],"1D-":[86],"2D-NMR":[88],"techniques.":[89],"Of":[90],"these":[91],"isolates,":[92],"2,":[93,125],"8-methoxynaphthalen-1-ol":[94],"(15),":[95],"1,8-dimethoxynaphthalene":[97],"(16)":[98],"showed":[99,130],"nitric":[100],"oxide":[101],"(NO)":[102],"inhibitory":[103,133],"activity":[104,134],"IC50":[106,136],"values":[107,137],"11.8\u00b10.9,":[109],"17.8\u00b11.1,":[110],"13.3\u00b10.5":[112],"\u03bcM,":[113,143],"respectively,":[114],"stronger":[115,144],"than":[116,145],"positive":[118,147],"control":[119,148],"quercetin":[120,149],"(IC50":[121,150],"36.8\u00b11.3":[122],"\u03bcM).":[123,152],"Compounds":[124],"15,":[126],"16":[128],"also":[129],"interleukin-6":[131],"(IL-6)":[132],"9.2\u00b11.7,":[139],"18.0\u00b10.6,":[140],"2.0\u00b10.1":[142],"31.3\u00b11.6":[151],"To":[153],"best":[155],"our":[157],"knowledge,":[158],"this":[159],"is":[160],"report":[163],"on":[164],"guaiane":[165],"sesquiterpene":[166],"metabolites,":[167],"3,":[168],"6,":[169],"7,":[171],"genus":[174],"Hypoxylon.":[175]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}