{"id":"https://openalex.org/W2098217536","doi":"https://doi.org/10.1111/j.1460-9568.2012.08190.x","title":"Functional characterization of ether\u2010\u00e0\u2010go\u2010go\u2010related gene potassium channels in midbrain dopamine neurons \u2013 implications for a role in depolarization block","display_name":"Functional characterization of ether\u2010\u00e0\u2010go\u2010go\u2010related gene potassium channels in midbrain dopamine neurons \u2013 implications for a role in depolarization block","publication_year":2012,"publication_date":"2012-07-11","ids":{"openalex":"https://openalex.org/W2098217536","doi":"https://doi.org/10.1111/j.1460-9568.2012.08190.x","mag":"2098217536","pmid":"https://pubmed.ncbi.nlm.nih.gov/22780096"},"language":"en","primary_location":{"id":"doi:10.1111/j.1460-9568.2012.08190.x","doi":"https://doi.org/10.1111/j.1460-9568.2012.08190.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.2012.08190.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4042402","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064236724","display_name":"Huifang Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huifang Ji","raw_affiliation_strings":["Department of Psychiatry and the Maryland Psychiatry Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA","Deceased"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and the Maryland Psychiatry Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Deceased","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006649651","display_name":"Kristal R. Tucker","orcid":"https://orcid.org/0000-0002-5358-9088","observed_orcids":["https://orcid.org/0000-0002-5358-9088"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristal R. Tucker","raw_affiliation_strings":["Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008863323","display_name":"Ilva Putzier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilva Putzier","raw_affiliation_strings":["Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086577634","display_name":"Marco A. Huertas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marco A. Huertas","raw_affiliation_strings":["Department of Cell Biology and Anatomy and the Neuroscience Center of Excellence, LSU Health Sciences Center, Suite D, New Orleans, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy and the Neuroscience Center of Excellence, LSU Health Sciences Center, Suite D, New Orleans, LA, USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018487768","display_name":"John P. Horn","orcid":"https://orcid.org/0000-0001-5516-0210","observed_orcids":["https://orcid.org/0000-0001-5516-0210"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Horn","raw_affiliation_strings":["Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056283225","display_name":"Carmen C. Canavier","orcid":"https://orcid.org/0000-0003-4368-6906","observed_orcids":["https://orcid.org/0000-0003-4368-6906"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmen C. Canavier","raw_affiliation_strings":["Department of Cell Biology and Anatomy and the Neuroscience Center of Excellence, LSU Health Sciences Center, Suite D, New Orleans, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy and the Neuroscience Center of Excellence, LSU Health Sciences Center, Suite D, New Orleans, LA, USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052801321","display_name":"Edwin S. Levitan","orcid":"https://orcid.org/0000-0003-3319-1344","observed_orcids":["https://orcid.org/0000-0003-3319-1344"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin S. Levitan","raw_affiliation_strings":["Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103559210","display_name":"Paul D. Shepard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul D. Shepard","raw_affiliation_strings":["Department of Psychiatry and the Maryland Psychiatry Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and the Maryland Psychiatry Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5103559210"],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":{"value":3560,"currency":"USD","value_usd":3560},"apc_paid":null,"fwci":1.2772,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.78486171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"36","issue":"7","first_page":"2906","last_page":"2916"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/midbrain-dopaminergic-neurons","display_name":"midbrain dopaminergic neurons","score":0.9020000100135803},{"id":"https://openalex.org/keywords/depolarization-block","display_name":"depolarization block","score":0.8370000123977661},{"id":"https://openalex.org/keywords/burst-firing","display_name":"burst firing","score":0.8090000152587891},{"id":"https://openalex.org/keywords/spontaneous-firing","display_name":"spontaneous firing","score":0.625},{"id":"https://openalex.org/keywords/e-4031","display_name":"E-4031","score":0.8840000033378601},{"id":"https://openalex.org/keywords/antipsychotic-side-effects","display_name":"antipsychotic adverse effects","score":0.7239999771118164},{"id":"https://openalex.org/keywords/antipsychotic-drug-development","display_name":"antipsychotic drug development","score":0.7720000147819519},{"id":"https://openalex.org/keywords/ion-channel-blockers","display_name":"ion channel blockers","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.8595379590988159},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.8300663232803345},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7235382199287415},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7210218906402588},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5410207509994507},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5146880745887756},{"id":"https://openalex.org/C103796816","wikidata":"https://www.wikidata.org/wiki/Q185153","display_name":"Erg","level":3,"score":0.4901212155818939},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.4646788239479065},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.42074185609817505},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38432255387306213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36225706338882446},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.26532113552093506},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.21628639101982117}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012604","descriptor_name":"Scorpion Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012604","descriptor_name":"Scorpion Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012604","descriptor_name":"Scorpion Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012604","descriptor_name":"Scorpion Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1460-9568.2012.08190.x","doi":"https://doi.org/10.1111/j.1460-9568.2012.08190.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.2012.08190.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:22780096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22780096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European journal of neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3019720","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4042402","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4042402","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4042402","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eur J Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4042402","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4042402","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eur J Neurosci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7511430027","display_name":"Dynamic Clamp Study of Calcium Channels in Nigral Dopamine Neurons","funder_award_id":"F32NS078994","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7733249936","display_name":"Intrinsic currents modulate synaptic integration in dopamine neurons","funder_award_id":"R01NS061097","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1553156850","https://openalex.org/W1590345531","https://openalex.org/W1633847368","https://openalex.org/W1652173018","https://openalex.org/W1810663112","https://openalex.org/W1934871911","https://openalex.org/W1940417817","https://openalex.org/W1949404224","https://openalex.org/W1964023154","https://openalex.org/W1973184545","https://openalex.org/W1973229581","https://openalex.org/W1976088739","https://openalex.org/W1986330969","https://openalex.org/W1988760320","https://openalex.org/W1990514853","https://openalex.org/W1991672721","https://openalex.org/W1993369233","https://openalex.org/W2000587167","https://openalex.org/W2006427735","https://openalex.org/W2009809272","https://openalex.org/W2014006573","https://openalex.org/W2014488192","https://openalex.org/W2016126860","https://openalex.org/W2017240902","https://openalex.org/W2018543905","https://openalex.org/W2020455022","https://openalex.org/W2022675045","https://openalex.org/W2022917563","https://openalex.org/W2025921981","https://openalex.org/W2029409685","https://openalex.org/W2029474372","https://openalex.org/W2029866235","https://openalex.org/W2033863429","https://openalex.org/W2040418090","https://openalex.org/W2042335457","https://openalex.org/W2048752288","https://openalex.org/W2055915652","https://openalex.org/W2057179329","https://openalex.org/W2060915664","https://openalex.org/W2073036965","https://openalex.org/W2074858155","https://openalex.org/W2078785409","https://openalex.org/W2079286959","https://openalex.org/W2082763706","https://openalex.org/W2083195430","https://openalex.org/W2083994989","https://openalex.org/W2085750638","https://openalex.org/W2085926691","https://openalex.org/W2090020119","https://openalex.org/W2092692883","https://openalex.org/W2093024075","https://openalex.org/W2095427325","https://openalex.org/W2096118295","https://openalex.org/W2098013119","https://openalex.org/W2098771536","https://openalex.org/W2106189090","https://openalex.org/W2110747461","https://openalex.org/W2112810336","https://openalex.org/W2117120818","https://openalex.org/W2126688997","https://openalex.org/W2128253867","https://openalex.org/W2129114637","https://openalex.org/W2130566541","https://openalex.org/W2133592132","https://openalex.org/W2148979794","https://openalex.org/W2163259581","https://openalex.org/W2164975184","https://openalex.org/W2246907349"],"related_works":["https://openalex.org/W2080788537","https://openalex.org/W3181055709","https://openalex.org/W2002830460","https://openalex.org/W2064213689","https://openalex.org/W2036451364","https://openalex.org/W3195397619","https://openalex.org/W4243975172","https://openalex.org/W2130293530","https://openalex.org/W2090649048","https://openalex.org/W2006022629"],"abstract_inverted_index":{"Bursting":[0],"activity":[1,14,109,172],"by":[2,84,136],"midbrain":[3,92],"dopamine":[4,93,186,216],"neurons":[5,94,217],"reflects":[6],"the":[7,19,24,44,81,88,105,113,142,148,151,204,235],"complex":[8],"interplay":[9],"between":[10],"their":[11],"intrinsic":[12],"pacemaker":[13],"and":[15,26,66,72,74,97,145,198,218],"synaptic":[16],"inputs.":[17],"Although":[18],"precise":[20],"mechanism":[21],"responsible":[22],"for":[23,244],"generation":[25],"modulation":[27],"of":[28,91,107,150,207,215,220,229],"bursting":[29,171],"in":[30,43,95,98,170,177,195,199,234],"vivo":[31,96],"has":[32],"yet":[33],"to":[34,79,87,115,174],"be":[35],"established,":[36],"several":[37],"ion":[38],"channels":[39,57,86,190,223,233],"have":[40],"been":[41],"implicated":[42],"process.":[45],"Previous":[46],"studies":[47],"with":[48,63,141,167,212],"nonselective":[49],"blockers":[50,70],"suggested":[51],"that":[52,155,185],"ether-\u00e0-go-go-related":[53],"gene":[54],"(ERG)":[55],"K(+)":[56,189],"are":[58,210],"functionally":[59],"significant.":[60],"Here,":[61],"electrophysiology":[62],"selective":[64],"chemical":[65],"peptide":[67],"ERG":[68,85,101,124,163,188,222,232],"channel":[69,102,125],"(E-4031":[71],"rBeKm-1)":[73],"computational":[75],"methods":[76],"were":[77],"used":[78],"define":[80],"contribution":[82],"made":[83],"firing":[89],"properties":[90],"vitro.":[99],"Selective":[100],"blockade":[103,164,219],"increased":[104],"frequency":[106,122],"spontaneous":[108],"as":[110,112],"well":[111],"response":[114],"depolarizing":[116],"current":[117],"pulses":[118],"without":[119],"altering":[120],"spike":[121],"adaptation.":[123],"block":[126],"also":[127],"accelerated":[128],"entry":[129],"into":[130],"depolarization":[131,153,201,213],"inactivation":[132,154,214],"during":[133],"bursts":[134],"elicited":[135],"virtual":[137],"NMDA":[138],"receptors":[139],"generated":[140],"dynamic":[143],"clamp,":[144],"significantly":[146],"prolonged":[147],"duration":[149],"sustained":[152],"followed":[156],"pharmacologically":[157],"evoked":[158],"bursts.":[159],"In":[160],"vivo,":[161],"somatic":[162],"was":[165],"associated":[166,211],"an":[168],"increase":[169],"attributed":[173],"a":[175,192,225,241],"reduction":[176],"doublet":[178],"firing.":[179],"Taken":[180],"together,":[181],"these":[182,230],"results":[183],"show":[184],"neuron":[187],"play":[191],"prominent":[193,226],"role":[194],"limiting":[196],"excitability":[197],"minimizing":[200],"inactivation.":[202],"As":[203],"therapeutic":[205],"actions":[206],"antipsychotic":[208,245],"drugs":[209],"cardiac":[221],"is":[224],"side":[227],"effect":[228],"drugs,":[231],"central":[236],"nervous":[237],"system":[238],"may":[239],"represent":[240],"novel":[242],"target":[243],"drug":[246],"development.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
