{"id":"https://openalex.org/W2098129398","doi":null,"title":"Modeling and Simulation Approach to Characterize the Magnitude and Consistency of Drug Exposure using Sparse Concentration Sampling","display_name":"Modeling and Simulation Approach to Characterize the Magnitude and Consistency of Drug Exposure using Sparse Concentration Sampling","publication_year":2006,"publication_date":"2006-05-26","ids":{"openalex":"https://openalex.org/W2098129398","mag":"2098129398"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:6649","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/6649/1/FengYanMar2006.pdf","pdf_url":"http://d-scholarship.pitt.edu/6649/1/FengYanMar2006.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/6649/1/FengYanMar2006.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Feng Yan","orcid":"https://orcid.org/0000-0001-8663-6859","observed_orcids":["https://orcid.org/0000-0001-8663-6859"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Feng Yan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8663-6859","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.7821999788284302,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.7821999788284302,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.10920000076293945,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.09000000357627869,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.8199999928474426},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.8799999952316284},{"id":"https://openalex.org/keywords/citalopram","display_name":"citalopram","score":0.8360000252723694},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.7689999938011169},{"id":"https://openalex.org/keywords/geriatric-depression","display_name":"geriatric depression","score":0.9490000009536743},{"id":"https://openalex.org/keywords/paroxetine","display_name":"paroxetine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cyp2d6-polymorphism","display_name":"CYP2D6 polymorphism","score":0.9819999933242798},{"id":"https://openalex.org/keywords/enoxaparin","display_name":"enoxaparin","score":0.8880000114440918},{"id":"https://openalex.org/keywords/continuous-intravenous-infusion","display_name":"continuous intravenous infusion","score":0.8479999899864197},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.8669999837875366},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.7289999723434448},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7009999752044678},{"id":"https://openalex.org/keywords/individualized-dosing","display_name":"individualized dosing","score":0.6470000147819519},{"id":"https://openalex.org/keywords/dose-optimization","display_name":"dose optimization","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6500334739685059},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.644976019859314},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.612889289855957},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5341296195983887},{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.5187047123908997},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.5078528523445129},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3423525094985962},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27722984552383423},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.20377638936042786},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10394856333732605},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.0},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:6649","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/6649/1/FengYanMar2006.pdf","pdf_url":"http://d-scholarship.pitt.edu/6649/1/FengYanMar2006.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:2098129398","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/6649/1/FengYanMar2006.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:6649","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/6649/1/FengYanMar2006.pdf","pdf_url":"http://d-scholarship.pitt.edu/6649/1/FengYanMar2006.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9628999829292297}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2098129398.pdf","grobid_xml":"https://content.openalex.org/works/W2098129398.grobid-xml"},"referenced_works_count":153,"referenced_works":["https://openalex.org/W49125497","https://openalex.org/W111868135","https://openalex.org/W182370232","https://openalex.org/W296851412","https://openalex.org/W569667299","https://openalex.org/W1220174878","https://openalex.org/W1482570783","https://openalex.org/W1483497279","https://openalex.org/W1509399724","https://openalex.org/W1517281160","https://openalex.org/W1523124091","https://openalex.org/W1541002222","https://openalex.org/W1550111394","https://openalex.org/W1554083152","https://openalex.org/W1576919957","https://openalex.org/W1604241486","https://openalex.org/W1665059474","https://openalex.org/W1810018036","https://openalex.org/W1964506112","https://openalex.org/W1964688493","https://openalex.org/W1967389155","https://openalex.org/W1970473426","https://openalex.org/W1970846917","https://openalex.org/W1973235995","https://openalex.org/W1975300925","https://openalex.org/W1975655881","https://openalex.org/W1976325341","https://openalex.org/W1981282043","https://openalex.org/W1981684805","https://openalex.org/W1984204093","https://openalex.org/W1984949156","https://openalex.org/W1985156363","https://openalex.org/W1985863706","https://openalex.org/W1992536915","https://openalex.org/W1993098478","https://openalex.org/W1994311873","https://openalex.org/W1995116261","https://openalex.org/W1995945562","https://openalex.org/W1996049598","https://openalex.org/W1996719664","https://openalex.org/W1997692902","https://openalex.org/W1998978356","https://openalex.org/W1999382311","https://openalex.org/W2000902397","https://openalex.org/W2004252914","https://openalex.org/W2008617085","https://openalex.org/W2012436282","https://openalex.org/W2012961958","https://openalex.org/W2013014707","https://openalex.org/W2014756391","https://openalex.org/W2015488487","https://openalex.org/W2016110627","https://openalex.org/W2016658800","https://openalex.org/W2016999205","https://openalex.org/W2017132043","https://openalex.org/W2021243296","https://openalex.org/W2021542491","https://openalex.org/W2021854043","https://openalex.org/W2024408744","https://openalex.org/W2033537172","https://openalex.org/W2035975036","https://openalex.org/W2036207302","https://openalex.org/W2036263484","https://openalex.org/W2037911192","https://openalex.org/W2040114578","https://openalex.org/W2040655619","https://openalex.org/W2041702736","https://openalex.org/W2042405813","https://openalex.org/W2042648503","https://openalex.org/W2043376048","https://openalex.org/W2043772350","https://openalex.org/W2043935608","https://openalex.org/W2045051003","https://openalex.org/W2047533426","https://openalex.org/W2049244891","https://openalex.org/W2049749773","https://openalex.org/W2051626799","https://openalex.org/W2059586252","https://openalex.org/W2061815699","https://openalex.org/W2062685800","https://openalex.org/W2063979841","https://openalex.org/W2064718292","https://openalex.org/W2064829081","https://openalex.org/W2065054645","https://openalex.org/W2065846767","https://openalex.org/W2066464642","https://openalex.org/W2066996342","https://openalex.org/W2067223107","https://openalex.org/W2068072370","https://openalex.org/W2069146933","https://openalex.org/W2070013574","https://openalex.org/W2074792668","https://openalex.org/W2076677620","https://openalex.org/W2076871009","https://openalex.org/W2078501925","https://openalex.org/W2079925496","https://openalex.org/W2080843536","https://openalex.org/W2083402915","https://openalex.org/W2084172638","https://openalex.org/W2085089477","https://openalex.org/W2090041931","https://openalex.org/W2091883526","https://openalex.org/W2092629624","https://openalex.org/W2094019929","https://openalex.org/W2096866962","https://openalex.org/W2098867544","https://openalex.org/W2099319131","https://openalex.org/W2100522640","https://openalex.org/W2100897234","https://openalex.org/W2104994489","https://openalex.org/W2110802188","https://openalex.org/W2111199247","https://openalex.org/W2111424618","https://openalex.org/W2118502261","https://openalex.org/W2120066687","https://openalex.org/W2120713508","https://openalex.org/W2131662866","https://openalex.org/W2137785805","https://openalex.org/W2142635246","https://openalex.org/W2147690605","https://openalex.org/W2147828132","https://openalex.org/W2149599987","https://openalex.org/W2150924432","https://openalex.org/W2153187399","https://openalex.org/W2154321941","https://openalex.org/W2156890176","https://openalex.org/W2158392145","https://openalex.org/W2161446377","https://openalex.org/W2161918041","https://openalex.org/W2162583913","https://openalex.org/W2164099498","https://openalex.org/W2164733897","https://openalex.org/W2165405120","https://openalex.org/W2166531669","https://openalex.org/W2168934042","https://openalex.org/W2169845753","https://openalex.org/W2170802381","https://openalex.org/W2184940291","https://openalex.org/W2193204877","https://openalex.org/W2230049830","https://openalex.org/W2235469857","https://openalex.org/W2291231306","https://openalex.org/W2316210661","https://openalex.org/W2316460201","https://openalex.org/W2324977356","https://openalex.org/W2327002016","https://openalex.org/W2338618131","https://openalex.org/W2408244786","https://openalex.org/W2414467904","https://openalex.org/W3000563840","https://openalex.org/W4211101039","https://openalex.org/W4251091881","https://openalex.org/W4255294763"],"related_works":["https://openalex.org/W1604846925","https://openalex.org/W2104994489","https://openalex.org/W2002294776","https://openalex.org/W643930444","https://openalex.org/W2334422089","https://openalex.org/W2185949746","https://openalex.org/W4244996955","https://openalex.org/W2157062572","https://openalex.org/W2781396711","https://openalex.org/W2035387023"],"abstract_inverted_index":{"Population":[0],"pharmacokinetic":[1],"(PK)":[2],"and":[3,37,59,87,107,115,155,169,194,219,258,263,267,297,325,341],"pharmacodynamic":[4],"(PD)":[5],"modeling":[6,11],"using":[7,98,253,270],"a":[8,28,42,188,336,357],"mixed":[9],"effect":[10,121],"(MEM)":[12],"approach":[13,26,63],"has":[14],"been":[15],"widely":[16],"used":[17,285],"for":[18,191,294],"various":[19,78],"drug":[20],"classes":[21],"during":[22],"development.":[23],"The":[24,49,119,147,206,278,301],"MEM":[25,62],"provides":[27,335],"significant":[29,110],"advantage":[30],"when":[31],"analyzing":[32],"large":[33],"scale":[34],"clinical":[35],"trials":[36],"special":[38],"population":[39],"where":[40],"only":[41],"few":[43],"samples":[44],"are":[45,54,109],"available":[46],"per":[47],"subject.":[48],"aims":[50],"of":[51,61,67,85,91,117,141,164,251,269,289,314,329,343,354],"this":[52],"thesis":[53,306],"to":[55,129,137,231,309],"explore":[56],"the":[57,65,83,89,124,228,243,249,254,265,271,287,290,305,310,312,339,351],"applications":[58],"advantages":[60],"in":[64,227,242,273,304,316,348,356],"analysis":[66],"target":[68,317],"populations":[69],"(e.g.,":[70],"late-life":[71,149],"depression,":[72],"intensive":[73,195],"care":[74,196],"unit":[75,197],"patients)":[76],"from":[77],"aspects.":[79],"1):":[80],"To":[81,186,247],"characterize":[82],"sources":[84,313],"variability":[86,315],"evaluate":[88,248],"impact":[90,159],"patients\u00a1\u00af":[92,216],"specific":[93,321],"characteristics":[94],"on":[95,112,144,160,181,215],"SSRIs":[96],"disposition":[97],"hyper-sparse":[99],"concentration":[100,332],"data.":[101],"This":[102,334],"study":[103,151,207,359],"demonstrated":[104],"that":[105,153,209,225,281],"age":[106,120,126],"weight":[108,154],"covariates":[111],"citalopram":[113,142],"clearance":[114],"volume":[116],"distribution.":[118],"persists":[122],"across":[123],"entire":[125],"range":[127],"(22":[128],"93":[130],"years).":[131],"Thus":[132],"elderly":[133],"subjects":[134,171,320,355],"may":[135,176],"need":[136],"receive":[138,177,237],"different":[139,173,178],"dose":[140,179,210,239],"based":[143,180,214],"their":[145,182],"age.":[146],"other":[148],"depression":[150],"shows":[152],"CYP2D6":[156,174],"polymorphisms":[157],"significantly":[158],"maximal":[161],"velocity":[162],"(Vm)":[163],"paroxetine":[165],"elimination.":[166],"Thus,":[167],"female":[168],"male":[170],"with":[172,350],"genotypes":[175],"metabolizer":[183],"genotype.":[184],"2):":[185],"optimize":[187],"dosing":[189],"strategy":[190],"general":[192,244],"medical":[193,245],"(ICU)":[198],"patients":[199,226],"receiving":[200],"enoxaparin":[201],"by":[202],"continuous":[203],"intravenous":[204],"infusion.":[205],"suggests":[208],"should":[211,236],"be":[212,284,346],"individualized":[213],"renal":[217],"function":[218],"weight.":[220],"It":[221],"is":[222],"also":[223],"found":[224],"ICU":[229],"tend":[230],"have":[232],"higher":[233],"exposure,":[234],"thus":[235],"lower":[238],"than":[240],"those":[241],"unit.3):":[246],"consistency":[250,342],"exposure":[252,344],"deviation":[255],"between":[256],"model-predicted":[257],"observed":[259],"concentrations":[260],"(Cpred/Cobs":[261],"ratio)":[262],"assess":[264],"stability":[266],"robustness":[268],"ratio":[272,282],"reflecting":[274],"erratic":[275],"adherence":[276,292],"patterns.":[277],"simulations":[279],"demonstrate":[280],"could":[283],"as":[286,360],"indicator":[288],"extreme":[291],"conditions":[293,328],"both":[295],"long":[296],"short-half":[298],"life":[299],"drug.":[300],"knowledge":[302],"gained":[303],"will":[307],"contribute":[308],"understanding":[311],"population,":[318],"including":[319],"characteristics,":[322],"enzyme":[323],"genetics":[324],"adherence,":[326],"under":[327],"highly":[330],"sparse":[331],"sampling.":[333],"basis":[337],"whereby":[338],"magnitude":[340],"can":[345],"examined":[347],"conjunction":[349],"maintenance":[352],"response":[353,361],"future":[358],"data":[362],"become":[363],"available.":[364]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}