{"id":"https://openalex.org/W2098101378","doi":null,"title":"Two-locus linkage analysis of cutaneous malignant melanoma/dysplastic nevi.","display_name":"Two-locus linkage analysis of cutaneous malignant melanoma/dysplastic nevi.","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2098101378","mag":"2098101378","pmid":"https://pubmed.ncbi.nlm.nih.gov/8651266","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1914626"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1914626","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1914626","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1914626","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063007431","display_name":"Alisa M. Goldstein","orcid":"https://orcid.org/0000-0002-7538-3582","observed_orcids":["https://orcid.org/0000-0002-7538-3582"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A M Goldstein","raw_affiliation_strings":["Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892-7372, USA. goldstein@helix.nih.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892-7372, USA. goldstein@helix.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076029384","display_name":"Lynn R. Goldin","orcid":"https://orcid.org/0000-0001-7350-446X","observed_orcids":["https://orcid.org/0000-0001-7350-446X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L R Goldin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057068297","display_name":"Nicholas C. Dracopoli","orcid":"https://orcid.org/0000-0003-3962-4059","observed_orcids":["https://orcid.org/0000-0003-3962-4059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N C Dracopoli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109109734","display_name":"W. H. Clark","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W H Clark","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5057142749","display_name":"Margaret Anne Tucker","orcid":"https://orcid.org/0000-0003-0274-6773","observed_orcids":["https://orcid.org/0000-0003-0274-6773"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Tucker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2432,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.89082969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"58","issue":"5","first_page":"1050","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.08609999716281891,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-melanoma","display_name":"cutaneous melanoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dysplastic-nevi","display_name":"dysplastic nevi","score":0.9940000176429749},{"id":"https://openalex.org/keywords/familial-melanoma","display_name":"familial melanoma","score":0.8539999723434448},{"id":"https://openalex.org/keywords/epistasis","display_name":"epistasis","score":0.765999972820282},{"id":"https://openalex.org/keywords/heterogeneity-models","display_name":"heterogeneity models","score":0.6639999747276306},{"id":"https://openalex.org/keywords/chromosome-1p","display_name":"chromosome 1p","score":0.9049999713897705},{"id":"https://openalex.org/keywords/chromosome-9p","display_name":"chromosome 9p","score":1.0},{"id":"https://openalex.org/keywords/autosomal-dominant-inheritance","display_name":"autosomal dominant inheritance","score":0.7229999899864197},{"id":"https://openalex.org/keywords/kindred","display_name":"kindred","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.8139800429344177},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6242725253105164},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5658650994300842},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.5603365302085876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5068143010139465},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22149506211280823}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002878","descriptor_name":"Chromosomes, Human, Pair 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002899","descriptor_name":"Chromosomes, Human, Pair 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004416","descriptor_name":"Dysplastic Nevus Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1914626","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1914626","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},{"id":"pmid:8651266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8651266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},{"id":"mag:2098101378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8651266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1914626","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1914626","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W308323492","https://openalex.org/W1496249739","https://openalex.org/W1513181079","https://openalex.org/W1514535641","https://openalex.org/W1527972786","https://openalex.org/W1536056190","https://openalex.org/W1549470101","https://openalex.org/W1573179356","https://openalex.org/W1745222097","https://openalex.org/W1869177431","https://openalex.org/W1967370147","https://openalex.org/W1971512164","https://openalex.org/W1976967850","https://openalex.org/W1983348452","https://openalex.org/W1984988721","https://openalex.org/W1997073961","https://openalex.org/W2007255413","https://openalex.org/W2008444349","https://openalex.org/W2027558915","https://openalex.org/W2040687166","https://openalex.org/W2051506850","https://openalex.org/W2052912081","https://openalex.org/W2066848701","https://openalex.org/W2081656845","https://openalex.org/W2088831705","https://openalex.org/W2090644138","https://openalex.org/W2093641195","https://openalex.org/W2123444949","https://openalex.org/W2167686879","https://openalex.org/W2416250148"],"related_works":["https://openalex.org/W1869177431","https://openalex.org/W1514535641","https://openalex.org/W2056560598","https://openalex.org/W1984988721","https://openalex.org/W2905074894","https://openalex.org/W2416250148","https://openalex.org/W2159012859","https://openalex.org/W2088831705","https://openalex.org/W2080258393","https://openalex.org/W2090644138"],"abstract_inverted_index":{"Previous":[0],"linkage":[1,15,30,44,123,236,250],"analyses":[2],"of":[3,14,29,122,154,257,268],"19":[4],"cutaneous":[5],"malignant":[6],"melanoma/dysplastic":[7],"nevi":[8],"(CMM/DN)":[9],"kindreds":[10,25],"showed":[11,27,246],"significant":[12,247],"evidence":[13,28,121,248],"and":[16,22,50,56,58,76,171],"heterogeneity":[17,52,78],"to":[18,32,124,128,157,168,179,237,251,263],"both":[19,33,169,183],"chromosomes":[20],"1p":[21,129,163,190],"9p.":[23],"Five":[24],"also":[26],"(Z>0.7)":[31],"regions.":[34],"To":[35],"further":[36],"examine":[37],"these":[38],"findings,":[39],"we":[40],"conducted":[41],"two-trait-locus,":[42],"two-marker-locus":[43],"analysis.":[45],"We":[46],"examined":[47],"one":[48,51],"homogeneity":[49],"single-locus":[53],"model":[54,64,79,110],"(SL-Hom":[55],"SL-Het),":[57],"two-locus":[59],"(2L)":[60],"models:":[61],"an":[62,152],"epistatic":[63],"(Ep),":[65],"in":[66,81,148],"which":[67,82],"CMM":[68,83,103,131,155,170,180,197,222,252],"was":[69,118],"treated":[70],"as":[71,96],"a":[72,77,161,174],"genuine":[73],"2L":[74,184,258],"disease,":[75],"(Het),":[80],"could":[84],"result":[85],"from":[86,151,189],"disease":[87],"alleles":[88],"at":[89],"either":[90],"locus.":[91],"Both":[92],"loci":[93],"were":[94,105,136,191,215],"modeled":[95],"autosomal":[97],"dominant.":[98],"The":[99,146],"LOD":[100,134,149,187,213],"scores":[101,135,150,188,214],"for":[102,130,193,196,210,249],"alone":[104,156,198,223],"highest":[106],"using":[107],"the":[108,133,186,212,238,242,255,266],"SL-Het":[109],"(Z":[111],"=":[112,115],"8.48,":[113],"theta":[114],".0).":[116],"There":[117],"much":[119],"stronger":[120],"chromosome":[125,162],"9p":[126,142,175,243],"than":[127,143,195,220],"alone;":[132],"approximately":[137],"two":[138],"times":[139],"greater":[140,192],"on":[141,144,235],"1p.":[145],"change":[147],"evaluation":[153],"CMM/DN":[158,194,219],"suggested":[159],"that":[160],"locus":[164,176,244],"(or":[165],"loci)":[166],"contributed":[167,177],"CMM/DN,":[172],"whereas":[173],"more":[178],"alone.":[181,253],"For":[182],"models,":[185],"(Ep:":[199,224],"Z=4.63":[200],"vs.":[201,205,226,230],"3.83;":[202],"Het:":[203,228],"4.94":[204],"3.80,":[206],"respectively).":[207,232],"In":[208],"contrast,":[209],"9p,":[211],"substantially":[216],"lower":[217],"with":[218,221],"4.64":[225],"7.06;":[227],"5.38":[229],"7.99,":[231],"After":[233],"conditioning":[234],"other":[239],"locus,":[240],"only":[241],"consistently":[245],"Thus,":[254],"application":[256],"models":[259],"may":[260],"be":[261],"useful":[262],"help":[264],"unravel":[265],"complexities":[267],"familial":[269],"melanoma.":[270]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}