{"id":"https://openalex.org/W2097975792","doi":"https://doi.org/10.1159/000282102","title":"Surgical Treatment of Non-Alcoholic Steatohepatitis and Non-Alcoholic Fatty Liver Disease","display_name":"Surgical Treatment of Non-Alcoholic Steatohepatitis and Non-Alcoholic Fatty Liver Disease","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2097975792","doi":"https://doi.org/10.1159/000282102","mag":"2097975792","pmid":"https://pubmed.ncbi.nlm.nih.gov/20460923"},"language":"en","primary_location":{"id":"doi:10.1159/000282102","doi":"https://doi.org/10.1159/000282102","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000282102","pdf_url":null,"source":{"id":"https://openalex.org/S61881601","display_name":"Digestive Diseases","issn_l":"0257-2753","issn":["0257-2753","1421-9875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114017146","display_name":"Rudolf Alfred Weiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107566","display_name":"Krankenhaus Sachsenhausen","ror":"https://ror.org/01dfmc653","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210107566"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"R.A. Weiner","raw_affiliation_strings":["Department of Surgery, Krankenhaus Sachsenhausen, Frankfurt am Main, Germany. rweiner@khs-ffm.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Krankenhaus Sachsenhausen, Frankfurt am Main, Germany. rweiner@khs-ffm.de","institution_ids":["https://openalex.org/I4210107566"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5114017146"],"corresponding_institution_ids":["https://openalex.org/I4210107566"],"apc_list":null,"apc_paid":null,"fwci":11.2462,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.98867438,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"28","issue":"1","first_page":"274","last_page":"279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.23819999396800995,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.996999979019165},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":1.0},{"id":"https://openalex.org/keywords/bariatric-surgery","display_name":"bariatric surgery","score":0.949999988079071},{"id":"https://openalex.org/keywords/roux-en-y-gastric-bypass","display_name":"Roux-en-Y gastric bypass","score":0.8880000114440918},{"id":"https://openalex.org/keywords/adjustable-gastric-banding","display_name":"gastric banding","score":0.996999979019165},{"id":"https://openalex.org/keywords/biliopancreatic-diversion-with-duodenal-switch","display_name":"biliopancreatic diversion with duodenal switch","score":0.9860000014305115},{"id":"https://openalex.org/keywords/morbid-obesity","display_name":"morbid obesity","score":0.7400000095367432},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/liver-biopsy-histopathology","display_name":"liver biopsy histology","score":0.6079999804496765},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6439999938011169},{"id":"https://openalex.org/keywords/hepatic-necroinflammation","display_name":"hepatic necroinflammation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9332926273345947},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.83863365650177},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.8125749826431274},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.6994010210037231},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6286338567733765},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.6153673529624939},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.5872754454612732},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5835936665534973},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5770447850227356},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5614674687385559},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.44697651267051697},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4366377592086792},{"id":"https://openalex.org/C2780732942","wikidata":"https://www.wikidata.org/wiki/Q3144986","display_name":"Alcoholic hepatitis","level":4,"score":0.41705235838890076},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3422431945800781},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.23195064067840576},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10585644841194153}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009767","descriptor_name":"Obesity, Morbid","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009767","descriptor_name":"Obesity, Morbid","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050110","descriptor_name":"Bariatric Surgery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000282102","doi":"https://doi.org/10.1159/000282102","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000282102","pdf_url":null,"source":{"id":"https://openalex.org/S61881601","display_name":"Digestive Diseases","issn_l":"0257-2753","issn":["0257-2753","1421-9875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases","raw_type":"journal-article"},{"id":"pmid:20460923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20460923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive diseases (Basel, Switzerland)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1981423956","https://openalex.org/W1993405313","https://openalex.org/W1995563200","https://openalex.org/W1995930646","https://openalex.org/W2010260293","https://openalex.org/W2016522692","https://openalex.org/W2038159864","https://openalex.org/W2043610882","https://openalex.org/W2067021370","https://openalex.org/W2067490191","https://openalex.org/W2079146981","https://openalex.org/W2091424052","https://openalex.org/W2092461508","https://openalex.org/W2119049152","https://openalex.org/W2166137611"],"related_works":["https://openalex.org/W2079146981","https://openalex.org/W1587122948","https://openalex.org/W2067021370","https://openalex.org/W2466141210","https://openalex.org/W2004622453","https://openalex.org/W2045256747","https://openalex.org/W2021000378","https://openalex.org/W2104844585","https://openalex.org/W2027845972","https://openalex.org/W2020019691"],"abstract_inverted_index":{"BACKGROUND:":[0],"Overweight":[1],"and":[2,19,27,40,111,127,132,138,184,210,228,287,332,344,352],"obesity":[3,60,351],"are":[4],"the":[5,11,35,57,63,160,163,194,272,278,307,330],"most":[6],"significant":[7],"risk":[8],"factors":[9],"for":[10,129],"development":[12],"of":[13,37,59,66,222,262,310,314,319,329,356],"hepatic":[14,38,345],"steatosis,":[15,320,341],"non-alcoholic":[16,20,197],"steatohepatitis":[17],"(NASH)":[18],"fatty":[21,198],"liver":[22,76,199],"disease":[23,200,315],"(NAFLD)":[24,201],"in":[25,34,69,94,206,213,224,258,267,277,285,289,327,347],"children":[26],"adults.":[28],"Both":[29],"have":[30],"been":[31],"increasingly":[32],"implicated":[33],"genesis":[36],"fibrosis":[39,276,311,324,346],"cirrhosis.":[41,336],"However,":[42],"no":[43],"consensus":[44],"exists":[45],"about":[46],"whether":[47],"weight":[48,254],"reduction":[49],"may":[50],"reverse":[51],"this":[52],"process.":[53],"METHODS:":[54],"To":[55],"assess":[56],"effect":[58],"surgery":[61,339],"on":[62],"histological":[64],"evolution":[65],"NASH,":[67],"diagnosed":[68],"284":[70],"morbidly":[71],"obese":[72],"patients":[73,96,102,208,226,243,269,274,292,348],"by":[74],"routine":[75],"biopsy":[77,88,121,218],"('first'":[78],"biopsy)":[79],"performed":[80,85],"during":[81,124,295],"bariatric":[82],"surgery,":[83],"we":[84],"a":[86],"'second'":[87],"after":[89],"18.6":[90],"+/-":[91,170,174],"8.3":[92,171],"months":[93],"116":[95],"(109":[97],"female,":[98],"7":[99],"male).":[100],"68":[101],"underwent":[103],"Roux-en-Y":[104],"gastric":[105,109,250],"bypass,":[106],"38":[107],"adjustable":[108,249],"banding":[110,251],"16":[112,230],"biliopancreatic":[113],"diversion":[114],"with":[115,244,252,293,349],"duodenal":[116],"switch":[117],"(BPD-DS).":[118],"The":[119,216,354],"second":[120,164,217],"was":[122,204,265,283,325],"taken":[123],"CHE":[125],"(102)":[126],"relaparoscopy":[128],"suspected":[130],"complications":[131],"revisional":[133],"surgeries":[134],"(12).":[135],"All":[136,151],"primary":[137],"secondary":[139],"surgical":[140],"procedures":[141],"were":[142,153],"done":[143],"laparoscopically":[144],"without":[145,239,312],"intraoperative":[146],"or":[147,323],"postoperative":[148],"major":[149],"complications.":[150],"comorbidities":[152,359],"recorded":[154],"pre-":[155],"und":[156],"postoperatively.":[157],"RESULTS:":[158],"From":[159],"first":[161,195,279],"to":[162,172,182,191,305,335],"biopsy,":[165,196,280],"BMI":[166],"decreased":[167,179,188],"from":[168,180,189],"55.2":[169],"30.5":[173],"6.6":[175],"kg/m(2),":[176],"arterial":[177],"hypertension":[178],"65":[181],"43%,":[183],"type":[185,202,211,235,246],"2":[186],"diabetes":[187],"42":[190],"2%.":[192],"On":[193],"3":[203,247],"observed":[205,266,284,326],"186":[207],"(65.5%)":[209],"4":[212],"82":[214],"(28.9%).":[215],"revealed":[219],"complete":[220,281,298],"regression":[221,261],"NAFLD":[223,234,245],"89":[225],"(82.8%)":[227],"only":[229],"(13.8%)":[231],"still":[232],"had":[233,248],"1":[236],"(mild":[237],"steatosis":[238],"inflammation).":[240],"These":[241],"two":[242],"insufficient":[253],"loss":[255],"(EWL":[256],"<50%)":[257],"history.":[259],"Complete":[260],"necroinflammatory":[263,321,342],"activity":[264,322,343],"108":[268],"(93.1%).":[270],"Among":[271],"12":[273],"presenting":[275],"remission":[282,299],"10":[286],"improvement":[288,355],"2.":[290],"Two":[291,303],"ascites":[294],"BPD-DS":[296],"showed":[297],"within":[300],"9-15":[301],"months.":[302],"continued":[304],"show":[306],"same":[308],"degree":[309],"evidence":[313],"activity.":[316],"No":[317],"worsening":[318],"any":[328],"patients,":[331],"none":[333],"progressed":[334],"CONCLUSION:":[337],"Obesity":[338],"improves":[340],"morbid":[350],"NASH.":[353],"all":[357],"obesity-related":[358],"can":[360],"be":[361],"confirmed.":[362]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}