{"id":"https://openalex.org/W2097949385","doi":"https://doi.org/10.1182/blood.v89.3.965","title":"Detection of Cyclin D1 (bcl-1, PRAD1) Overexpression by a Simple Competitive Reverse Transcription-Polymerase Chain Reaction Assay in t(11; 14)(q13; q32)-Bearing B-Cell Malignancies and/or Mantle Cell Lymphoma","display_name":"Detection of Cyclin D1 (bcl-1, PRAD1) Overexpression by a Simple Competitive Reverse Transcription-Polymerase Chain Reaction Assay in t(11; 14)(q13; q32)-Bearing B-Cell Malignancies and/or Mantle Cell Lymphoma","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W2097949385","doi":"https://doi.org/10.1182/blood.v89.3.965","mag":"2097949385","pmid":"https://pubmed.ncbi.nlm.nih.gov/9028328"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v89.3.965","doi":"https://doi.org/10.1182/blood.v89.3.965","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v89.3.965","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066646106","display_name":"Kaoru Uchimaru","orcid":"https://orcid.org/0000-0002-1665-9606","observed_orcids":["https://orcid.org/0000-0002-1665-9606"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Kaoru Uchimaru","raw_affiliation_strings":["From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036540850","display_name":"Toshiyasu Taniguchi","orcid":"https://orcid.org/0000-0002-7746-3658","observed_orcids":["https://orcid.org/0000-0002-7746-3658"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Toshiyasu Taniguchi","raw_affiliation_strings":["From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111847049","display_name":"Miwa Yoshikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Miwa Yoshikawa","raw_affiliation_strings":["From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101101017","display_name":"Shigetaka Asano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Shigetaka Asano","raw_affiliation_strings":["From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049232174","display_name":"Andrew Arnold","orcid":"https://orcid.org/0000-0002-8821-8527","observed_orcids":["https://orcid.org/0000-0002-8821-8527"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Andrew Arnold","raw_affiliation_strings":["From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080266991","display_name":"Toshiro Fujita","orcid":"https://orcid.org/0000-0001-9141-7060","observed_orcids":["https://orcid.org/0000-0001-9141-7060"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Toshiro Fujita","raw_affiliation_strings":["From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111547689","display_name":"Toru Motokura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Toru Motokura","raw_affiliation_strings":["From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Fourth Department of Internal Medicine, School of Medicine and Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"the Laboratory of Endocrine Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":7.2836,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.97432496,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"89","issue":"3","first_page":"965","last_page":"974"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bcl-1","display_name":"BCL1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/prad1","display_name":"PRAD1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/14-q13","display_name":"14)(q13","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mantle-cell-lymphoma","display_name":"mantle cell lymphoma","score":0.949999988079071},{"id":"https://openalex.org/keywords/b-cell-malignancies","display_name":"B-cell malignancies","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cyclin-d2","display_name":"cyclin D2","score":0.7519999742507935},{"id":"https://openalex.org/keywords/cyclin-d3","display_name":"cyclin D3","score":1.0},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/myeloid-cell-lines","display_name":"myeloid cell lines","score":0.6800000071525574},{"id":"https://openalex.org/keywords/lymphoid-cell-lines","display_name":"lymphoid cell lines","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.8557553291320801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7312853932380676},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.6757909059524536},{"id":"https://openalex.org/C2777525834","wikidata":"https://www.wikidata.org/wiki/Q268713","display_name":"Mantle cell lymphoma","level":3,"score":0.6591013669967651},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.6126426458358765},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5558635592460632},{"id":"https://openalex.org/C2781403221","wikidata":"https://www.wikidata.org/wiki/Q5198273","display_name":"Cyclin D3","level":5,"score":0.5268034934997559},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4846847355365753},{"id":"https://openalex.org/C9743823","wikidata":"https://www.wikidata.org/wiki/Q5198264","display_name":"Cyclin B","level":5,"score":0.48261579871177673},{"id":"https://openalex.org/C2780733254","wikidata":"https://www.wikidata.org/wiki/Q5198271","display_name":"Cyclin D2","level":5,"score":0.4651336073875427},{"id":"https://openalex.org/C28179978","wikidata":"https://www.wikidata.org/wiki/Q5198263","display_name":"Cyclin A2","level":5,"score":0.4607219994068146},{"id":"https://openalex.org/C16438837","wikidata":"https://www.wikidata.org/wiki/Q5198260","display_name":"Cyclin A","level":5,"score":0.4495851993560791},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35442543029785156},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25616633892059326},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.21169281005859375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16902458667755127},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11489656567573547}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002880","descriptor_name":"Chromosomes, Human, Pair 11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002883","descriptor_name":"Chromosomes, Human, Pair 14","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v89.3.965","doi":"https://doi.org/10.1182/blood.v89.3.965","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v89.3.965","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:9028328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9028328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4190138553","display_name":"Cyclin D1-PRAD1 in Mammary Neoplasia","funder_award_id":"R01CA055909","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G698356294","display_name":null,"funder_award_id":"CA 55909","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1371350","https://openalex.org/W13984822","https://openalex.org/W82189645","https://openalex.org/W118980994","https://openalex.org/W139568188","https://openalex.org/W153423281","https://openalex.org/W186460312","https://openalex.org/W1412788771","https://openalex.org/W1486753210","https://openalex.org/W1507988772","https://openalex.org/W1529372075","https://openalex.org/W1546302220","https://openalex.org/W1547849202","https://openalex.org/W1640455274","https://openalex.org/W1676311359","https://openalex.org/W1923636344","https://openalex.org/W1965822374","https://openalex.org/W1983789135","https://openalex.org/W1985969919","https://openalex.org/W1994082723","https://openalex.org/W2008448206","https://openalex.org/W2009967055","https://openalex.org/W2027558915","https://openalex.org/W2035182417","https://openalex.org/W2036873964","https://openalex.org/W2037036138","https://openalex.org/W2042179893","https://openalex.org/W2054359804","https://openalex.org/W2058879820","https://openalex.org/W2061950448","https://openalex.org/W2065252273","https://openalex.org/W2078502999","https://openalex.org/W2080002820","https://openalex.org/W2081884376","https://openalex.org/W2082030057","https://openalex.org/W2083820102","https://openalex.org/W2095113053","https://openalex.org/W2115481327","https://openalex.org/W2134812217","https://openalex.org/W2140425991","https://openalex.org/W2143353301","https://openalex.org/W2153626082","https://openalex.org/W2223539243","https://openalex.org/W2237970695","https://openalex.org/W2241314352","https://openalex.org/W2289992760","https://openalex.org/W2295078395","https://openalex.org/W2303535349","https://openalex.org/W2344986401","https://openalex.org/W2346339016","https://openalex.org/W2407128474","https://openalex.org/W2413855263","https://openalex.org/W2414585151","https://openalex.org/W2419578145","https://openalex.org/W2468385423","https://openalex.org/W2471897546","https://openalex.org/W4242869024","https://openalex.org/W4294216491","https://openalex.org/W6600058844","https://openalex.org/W6603333350","https://openalex.org/W6604715805","https://openalex.org/W6606173561","https://openalex.org/W6637556124","https://openalex.org/W6704605252","https://openalex.org/W6705120085","https://openalex.org/W6715959912"],"related_works":["https://openalex.org/W7100709645","https://openalex.org/W2043366139","https://openalex.org/W1966494373","https://openalex.org/W7222789224","https://openalex.org/W1998574350","https://openalex.org/W2396758608","https://openalex.org/W2006938099","https://openalex.org/W2032187394","https://openalex.org/W1982386982","https://openalex.org/W2128957975"],"abstract_inverted_index":{"In":[0,24,153],"mantle":[1,145],"cell":[2,124,137,146,155],"lymphoma,":[3,147],"the":[4,61,81,90,101,104,111,114,157,167,265],"t(11;14)(q13;q32)":[5],"and":[6,15,60,67,100,126,164,172,183,202,206,252,267],"its":[7],"molecular":[8],"counterpart,":[9],"bcl-1":[10],"rearrangement,":[11],"are":[12],"consistent":[13],"features":[14],"lead":[16],"to":[17,26,75,231],"cyclin":[18,28,58,150,160,170,193,233,256],"D1":[19,29,59,131,151,161,182,205,234,257],"(bcl-1,":[20],"PRAD1)":[21],"proto-oncogene":[22],"overexpression.":[23],"order":[25],"detect":[27,232],"overexpression,":[30],"we":[31,120],"developed":[32],"a":[33,37,54,98,197,237],"simple":[34],"assay":[35,119],"involving":[36],"reverse":[38],"transcription":[39],"followed":[40],"by":[41,108],"competitive":[42],"polymerase":[43],"chain":[44],"reaction":[45],"(PCR).":[46],"A":[47],"single":[48],"upstream":[49,82],"primer":[50,83],"was":[51,84,106,132,177,242],"derived":[52],"from":[53],"homologous":[55],"region":[56],"between":[57],"other":[62],"D-type":[63,78],"cyclins,":[64],"cyclins":[65,181,204],"D2":[66,171,184,207],"D3,":[68],"while":[69,180],"three":[70,91,115],"downstream":[71],"primers":[72],"were":[73,185,229],"specific":[74],"their":[76],"respective":[77],"cyclins.":[79],"Because":[80],"shared":[85],"in":[86,135,140,200,264],"PCR":[87,94],"amplification":[88],"of":[89,103,110,113,159,169,220,255,269],"sequences,":[92],"each":[93],"product":[95],"served":[96],"as":[97,224,244],"competitor":[99],"quantification":[102],"target":[105],"made":[107],"comparison":[109],"intensity":[112],"products.":[116],"With":[117,215],"this":[118,216],"analyzed":[121],"45":[122],"hematopoietic":[123],"lines":[125,138],"40":[127],"clinical":[128,221,262],"specimens.":[129],"Cyclin":[130,175],"rarely":[133],"expressed":[134,149,179],"lymphoid":[136],"except":[139],"t(11;14)(q13;q32)-bearing":[141],"B-cell":[142,270],"malignancies":[143],"and/or":[144],"which":[148],"predominantly.":[152],"myeloid":[154],"lines,":[156],"levels":[158],"expression":[162],"varied":[163],"never":[165],"exceeded":[166],"sum":[168],"D3":[173,176,194],"levels.":[174],"ubiquitously":[178],"differentially":[186],"used.":[187],"The":[188,240],"observations":[189],"suggest":[190],"that":[191,203],"human":[192],"may":[195,208,259],"play":[196],"fundamental":[198],"role":[199],"hematopoiesis":[201],"have":[209,260],"different":[210],"lineage-":[211],"or":[212],"differentiation-dependent":[213],"functions.":[214],"assay,":[217],"small":[218],"aliquots":[219],"specimens":[222],"such":[223],"100":[225],"microL":[226],"peripheral":[227],"blood":[228],"enough":[230],"overexpression":[235,258],"without":[236],"well-controlled":[238],"standard.":[239],"technique":[241],"validated":[243],"highly":[245],"comparable":[246],"with":[247],"Northern":[248],"analysis.":[249],"This":[250],"rapid":[251],"reliable":[253],"detection":[254],"practical":[261],"utility":[263],"analysis":[266],"management":[268],"malignancies.":[271]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
