{"id":"https://openalex.org/W2097905655","doi":"https://doi.org/10.1080/095530097144454","title":"A new immunobiological view of radiation-promoted lymphomagenesis","display_name":"A new immunobiological view of radiation-promoted lymphomagenesis","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2097905655","doi":"https://doi.org/10.1080/095530097144454","mag":"2097905655","pmid":"https://pubmed.ncbi.nlm.nih.gov/9020967"},"language":"en","primary_location":{"id":"doi:10.1080/095530097144454","doi":"https://doi.org/10.1080/095530097144454","is_oa":false,"landing_page_url":"https://doi.org/10.1080/095530097144454","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109932952","display_name":"Joseph H. Coggin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. H. COGGIN","raw_affiliation_strings":["University of South Alabama, College of Medicine, Department of Microbiology and Immunology, Mobile 36688, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Alabama, College of Medicine, Department of Microbiology and Immunology, Mobile 36688, USA","institution_ids":["https://openalex.org/I83809506"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109932952"],"corresponding_institution_ids":["https://openalex.org/I83809506"],"apc_list":null,"apc_paid":null,"fwci":0.5628,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.66540898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"1","first_page":"81","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7188000082969666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7188000082969666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0828000009059906,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.06639999896287918,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-lymphoma","display_name":"T-cell lymphoma","score":0.8809999823570251},{"id":"https://openalex.org/keywords/x-ray-induced-dna-damage","display_name":"X-ray-induced DNA damage","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/whole-body-irradiation","display_name":"whole-body irradiation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/inbred-mouse-strains","display_name":"inbred mouse strains","score":0.6259999871253967},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.7179743051528931},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6740996837615967},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5220822691917419},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49052852392196655},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.48527976870536804},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4736296534538269},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46602416038513184},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4648536443710327},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.43611469864845276},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4293510913848877},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3443172574043274},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2342987060546875},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16355785727500916},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007953","descriptor_name":"Leukemia, Radiation-Induced","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007953","descriptor_name":"Leukemia, Radiation-Induced","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007953","descriptor_name":"Leukemia, Radiation-Induced","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009052","descriptor_name":"Leukemia Virus, Murine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D011289","descriptor_name":"Preleukemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011289","descriptor_name":"Preleukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013945","descriptor_name":"Thymoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015458","descriptor_name":"Leukemia, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015458","descriptor_name":"Leukemia, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015458","descriptor_name":"Leukemia, T-Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016385","descriptor_name":"TATA Box","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/095530097144454","doi":"https://doi.org/10.1080/095530097144454","is_oa":false,"landing_page_url":"https://doi.org/10.1080/095530097144454","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},{"id":"pmid:9020967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9020967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2471479632","display_name":"ROLE OF ONCOFETAL ANTIGENS IN RADIATION CARCINOGENESIS","funder_award_id":"5r01ca039698-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G341653323","display_name":null,"funder_award_id":"CA-39698","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W128002965","https://openalex.org/W631364738","https://openalex.org/W1444381303","https://openalex.org/W1494674466","https://openalex.org/W1542326280","https://openalex.org/W1570077934","https://openalex.org/W1581330411","https://openalex.org/W1591370835","https://openalex.org/W1851102607","https://openalex.org/W1915412223","https://openalex.org/W1978836809","https://openalex.org/W1987585085","https://openalex.org/W1992816048","https://openalex.org/W1993920739","https://openalex.org/W2003285916","https://openalex.org/W2012353269","https://openalex.org/W2016127786","https://openalex.org/W2023612597","https://openalex.org/W2024136935","https://openalex.org/W2029021906","https://openalex.org/W2046425163","https://openalex.org/W2050679786","https://openalex.org/W2062211175","https://openalex.org/W2071525800","https://openalex.org/W2077852089","https://openalex.org/W2083864203","https://openalex.org/W2105985432","https://openalex.org/W2113479141","https://openalex.org/W2120371099","https://openalex.org/W2124486286","https://openalex.org/W2141139387","https://openalex.org/W2159075468","https://openalex.org/W2164702236","https://openalex.org/W2224292681","https://openalex.org/W2278887442","https://openalex.org/W2412866659","https://openalex.org/W2423611863","https://openalex.org/W3162543865","https://openalex.org/W3184679929","https://openalex.org/W4206336485","https://openalex.org/W4236566341","https://openalex.org/W4244972941","https://openalex.org/W4313339173"],"related_works":["https://openalex.org/W1851102607","https://openalex.org/W2024136935","https://openalex.org/W2023612597","https://openalex.org/W2035206265","https://openalex.org/W1444381303","https://openalex.org/W1581330411","https://openalex.org/W1986952091","https://openalex.org/W2016127786","https://openalex.org/W2241894131","https://openalex.org/W2142968190"],"abstract_inverted_index":{"Whole-body":[0],"irradiation":[1,91],"produces":[2],"T-cell":[3,99,213,246],"leukaemias/":[4],"lymphomas":[5],"(TCL)":[6],"in":[7,13,31,50,56,92,190,216,228],"some":[8],"strains":[9,94],"of":[10,28,59,75,95,113,131,223,234],"inbred":[11],"mice":[12,33,96,115,192,199,244],"an":[14,173],"X-ray":[15],"dose-related":[16],"manner.":[17],"Radiation":[18],"biologists":[19],"have":[20,162],"related":[21],"the":[22,102,114,132,220],"rapid":[23],"\"initiation'":[24],"and":[25,52,168,185],"early":[26],"appearance":[27],"preleukaemic":[29],"cells":[30,62,167,189],"these":[32],"to":[34,66,87,107,139,141,152,237],"unrepaired":[35],"DNA":[36],"damage":[37],"inflicted":[38],"by":[39,118],"radiation.":[40],"Following":[41],"initiation,":[42],"radiation-altered":[43],"thymic":[44],"differentiation":[45],"fosters":[46],"multi-step":[47],"transformation":[48],"changes":[49],"proto-oncogenes":[51],"suppressor":[53],"gene":[54],"expression":[55],"individual":[57],"clones":[58,70,227,236],"non-invasive":[60],"preleukaemia":[61,77,125,166,201],"as":[63],"they":[64],"progress":[65],"malignancy.":[67],"The":[68,127],"malignant":[69,142,170],"arising":[71],"from":[72],"small":[73],"numbers":[74],"initiated":[76],"thymocytes":[78,202],"become":[79],"fully":[80,169],"transformed":[81],"only":[82,111,204],"after":[83,90],"several":[84,160],"more":[85],"months":[86],"a":[88],"year":[89],"those":[93],"which":[97,231,243],"develop":[98,206,245],"lymphomas.":[100,247],"When":[101],"RFM":[103,198],"mouse":[104],"was":[105],"subjected":[106],"sublethal":[108],"whole-body":[109],"X-ray,":[110],"50%":[112],"developed":[116,124],"TCL":[117,143,148,171],"6":[119],"months,":[120],"yet":[121,203],"nearly":[122],"all":[123],"thymocytes.":[126],"T-cell-mediated":[128],"immune":[129],"response":[130],"irradiated":[133,191,197,229],"host":[134,212],"has":[135],"never":[136],"been":[137],"substantiated":[138],"contribute":[140],"development.":[144],"Until":[145],"recently,":[146],"X-ray-induced":[147],"were":[149],"not":[150],"known":[151],"carry":[153],"common":[154,175],"tumour":[155],"rejection":[156],"antigens":[157],"TATA.":[158],"However,":[159],"studies":[161],"revealed":[163],"that":[164],"both":[165],"express":[172],"immunogenic,":[174],"oncofoetal":[176],"glycoprotein,":[177],"termed":[178],"44kD":[179],"OFA.":[180,194],"OFA-activated":[181],"memory":[182],"CD4":[183],"Tm":[184],"CD8":[186,225,235],"Ten.":[187],"T-effector":[188],"expressing":[193],"As":[195],"most":[196],"exhibit":[200],"half":[205],"tumours,":[207],"this":[208],"finding":[209],"implicates":[210],"active":[211],"effector":[214],"responses":[215],"X-ray-initiated":[217],"tumorigenesis.":[218],"Further,":[219],"recent":[221],"discovery":[222],"OFA-specific":[224],"Ts":[226],"mice,":[230],"inhibited":[232],"cytotoxicity":[233],"OFA":[238],"or":[239],"TSTA,":[240],"may":[241],"explain":[242]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
