{"id":"https://openalex.org/W2097798503","doi":"https://doi.org/10.1006/bbrc.1997.6919","title":"Down-Regulation of the Defective Transcripts of the Werner's Syndrome Gene in the Cells of Patients","display_name":"Down-Regulation of the Defective Transcripts of the Werner's Syndrome Gene in the Cells of Patients","publication_year":1997,"publication_date":"1997-07-01","ids":{"openalex":"https://openalex.org/W2097798503","doi":"https://doi.org/10.1006/bbrc.1997.6919","mag":"2097798503","pmid":"https://pubmed.ncbi.nlm.nih.gov/9223443"},"language":"en","primary_location":{"id":"doi:10.1006/bbrc.1997.6919","doi":"https://doi.org/10.1006/bbrc.1997.6919","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1997.6919","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111640077","display_name":"Yukako Yamabe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukako Yamabe","raw_affiliation_strings":["AGENE Research Institute, Kamakura, Kanagawa, Japan","AGENE Research Institute, 200 Kajiwara, Kamakura, Kanagawa, 247, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGENE Research Institute, Kamakura, Kanagawa, Japan","institution_ids":[]},{"raw_affiliation_string":"AGENE Research Institute, 200 Kajiwara, Kamakura, Kanagawa, 247, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103436227","display_name":"Masanobu Sugimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masanobu Sugimoto","raw_affiliation_strings":["AGENE Research Institute, 200 Kajiwara, Kamakura, Kanagawa, 247, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGENE Research Institute, 200 Kajiwara, Kamakura, Kanagawa, 247, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008516511","display_name":"Misako Satoh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Misako Satoh","raw_affiliation_strings":["AGENE Research Institute, 200 Kajiwara, Kamakura, Kanagawa, 247, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGENE Research Institute, 200 Kajiwara, Kamakura, Kanagawa, 247, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000501841","display_name":"Noriyuki Suzuki","orcid":"https://orcid.org/0000-0002-9345-6335","observed_orcids":["https://orcid.org/0000-0002-9345-6335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noriyuki Suzuki","raw_affiliation_strings":["AGENE Research Institute, 200 Kajiwara, Kamakura, Kanagawa, 247, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGENE Research Institute, 200 Kajiwara, Kamakura, Kanagawa, 247, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Minoru Sugawara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minoru Sugawara","raw_affiliation_strings":["AGENE Research Institute, 200 Kajiwara, Kamakura, Kanagawa, 247, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGENE Research Institute, 200 Kajiwara, Kamakura, Kanagawa, 247, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091648023","display_name":"Makoto Goto","orcid":"https://orcid.org/0000-0002-9473-7673","observed_orcids":["https://orcid.org/0000-0002-9473-7673"]},"institutions":[{"id":"https://openalex.org/I4210086277","display_name":"Tokyo Metropolitan Ohtsuka Hospital","ror":"https://ror.org/0015hye09","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210086277"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Goto","raw_affiliation_strings":["Department of Rheumatology, Tokyo Metropolitan Otsuka Hospital, 2-8-1 Minami-Otsuka, Toshima-ku, Tokyo, 170, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Tokyo Metropolitan Otsuka Hospital, 2-8-1 Minami-Otsuka, Toshima-ku, Tokyo, 170, Japan","institution_ids":["https://openalex.org/I4210086277"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000544104","display_name":"Yasuhiro Furuichi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yasuhiro Furuichi","raw_affiliation_strings":["AGENE Research Institute, 200 Kajiwara, Kamakura, Kanagawa, 247, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGENE Research Institute, 200 Kajiwara, Kamakura, Kanagawa, 247, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000544104"],"corresponding_institution_ids":[],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":1.9845,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.8729151,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"236","issue":"1","first_page":"151","last_page":"154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.2506999969482422,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/werner-syndrome","display_name":"Werner syndrome","score":0.9800000190734863},{"id":"https://openalex.org/keywords/wrn-gene","display_name":"WRN gene","score":0.968999981880188},{"id":"https://openalex.org/keywords/dna-helicase","display_name":"DNA helicase","score":0.9670000076293945},{"id":"https://openalex.org/keywords/mrna-levels","display_name":"mRNA levels","score":0.6570000052452087},{"id":"https://openalex.org/keywords/hutchinson-gilford-progeria-syndrome","display_name":"Hutchinson-Gilford progeria syndrome","score":0.800000011920929},{"id":"https://openalex.org/keywords/recessive-disorders","display_name":"recessive disorders","score":0.7580000162124634},{"id":"https://openalex.org/keywords/heterozygous-carriers","display_name":"heterozygous carriers","score":0.7889999747276306},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.921999990940094},{"id":"https://openalex.org/keywords/b-lymphoblastoid-cells","display_name":"B lymphoblastoid cells","score":0.9639999866485596}],"concepts":[{"id":"https://openalex.org/C2778090637","wikidata":"https://www.wikidata.org/wiki/Q1154619","display_name":"Werner syndrome","level":5,"score":0.9387765526771545},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.8260594010353088},{"id":"https://openalex.org/C2778465436","wikidata":"https://www.wikidata.org/wiki/Q213098","display_name":"Progeria","level":3,"score":0.734839677810669},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6888270378112793},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6012872457504272},{"id":"https://openalex.org/C68592252","wikidata":"https://www.wikidata.org/wiki/Q17913854","display_name":"RNA Helicase A","level":5,"score":0.5938710570335388},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5875292420387268},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5844314694404602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5506463050842285},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5358482599258423},{"id":"https://openalex.org/C113842279","wikidata":"https://www.wikidata.org/wiki/Q1873857","display_name":"Lymphoblast","level":3,"score":0.5321715474128723},{"id":"https://openalex.org/C133307689","wikidata":"https://www.wikidata.org/wiki/Q48749","display_name":"Southern blot","level":3,"score":0.5307374596595764},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4925716519355774},{"id":"https://openalex.org/C177707886","wikidata":"https://www.wikidata.org/wiki/Q48520","display_name":"Northern blot","level":4,"score":0.48889580368995667},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.30583295226097107},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.18306690454483032}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014898","descriptor_name":"Werner Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/bbrc.1997.6919","doi":"https://doi.org/10.1006/bbrc.1997.6919","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1997.6919","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:9223443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9223443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W11549471","https://openalex.org/W159681246","https://openalex.org/W1499022545","https://openalex.org/W1907299583","https://openalex.org/W1981169569","https://openalex.org/W1984653142","https://openalex.org/W2011037268","https://openalex.org/W2025425542","https://openalex.org/W2046741504","https://openalex.org/W2064310741","https://openalex.org/W2065784864","https://openalex.org/W2095919671","https://openalex.org/W2134812217","https://openalex.org/W2155835896","https://openalex.org/W2245671961","https://openalex.org/W2975803268","https://openalex.org/W4248084843"],"related_works":["https://openalex.org/W2139640067","https://openalex.org/W2033364696","https://openalex.org/W2039996950","https://openalex.org/W1499022545","https://openalex.org/W2417637700","https://openalex.org/W2095919671","https://openalex.org/W1971438029","https://openalex.org/W2149768685","https://openalex.org/W1989925857","https://openalex.org/W1987516656"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}