{"id":"https://openalex.org/W2097778960","doi":"https://doi.org/10.1186/1750-1326-3-14","title":"Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice","display_name":"Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2097778960","doi":"https://doi.org/10.1186/1750-1326-3-14","mag":"2097778960","pmid":"https://pubmed.ncbi.nlm.nih.gov/18834536","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2569036"},"language":"en","primary_location":{"id":"doi:10.1186/1750-1326-3-14","doi":"https://doi.org/10.1186/1750-1326-3-14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1750-1326-3-14","pdf_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-3-14","source":{"id":"https://openalex.org/S40861184","display_name":"Molecular Neurodegeneration","issn_l":"1750-1326","issn":["1750-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-3-14","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072879540","display_name":"K\u00e1roly Mirnics","orcid":"https://orcid.org/0000-0002-5521-0254","observed_orcids":["https://orcid.org/0000-0002-5521-0254"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K\u00e1roly Mirnics","raw_affiliation_strings":["Department of Psychiatry, Vanderbilt University, Nashville, TN37232, USA. karoly.mirnics@vanderbilt.edu","Department of Psychiatry, Vanderbilt University, Nashville, TN37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vanderbilt University, Nashville, TN37232, USA. karoly.mirnics@vanderbilt.edu","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Psychiatry, Vanderbilt University, Nashville, TN37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024978593","display_name":"Eric M. Norstrom","orcid":"https://orcid.org/0000-0001-5375-1658","observed_orcids":["https://orcid.org/0000-0001-5375-1658"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M Norstrom","raw_affiliation_strings":["Department of Neurobiology, University of Chicago, Chicago, IL60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, University of Chicago, Chicago, IL60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082517335","display_name":"Krassimira A. Garbett","orcid":"https://orcid.org/0000-0003-3969-3919","observed_orcids":["https://orcid.org/0000-0003-3969-3919"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krassimira Garbett","raw_affiliation_strings":["Department of Psychiatry, Vanderbilt University, Nashville, TN37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vanderbilt University, Nashville, TN37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059046547","display_name":"Se Hoon Choi","orcid":"https://orcid.org/0000-0002-7905-4380","observed_orcids":["https://orcid.org/0000-0002-7905-4380"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Se Choi","raw_affiliation_strings":["Department of Neurobiology, University of Chicago, Chicago, IL60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, University of Chicago, Chicago, IL60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003111302","display_name":"Xiaoqiong Zhang","orcid":"https://orcid.org/0009-0007-2849-497X","observed_orcids":["https://orcid.org/0009-0007-2849-497X","https://orcid.org/0000-0003-2081-1751"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoqiong Zhang","raw_affiliation_strings":["Department of Neurobiology, University of Chicago, Chicago, IL60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, University of Chicago, Chicago, IL60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024725508","display_name":"Philip J. Ebert","orcid":"https://orcid.org/0000-0002-8945-2948","observed_orcids":["https://orcid.org/0000-0002-8945-2948"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Ebert","raw_affiliation_strings":["Department of Psychiatry, Vanderbilt University, Nashville, TN37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vanderbilt University, Nashville, TN37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010416927","display_name":"Sangram S. Sisodia","orcid":"https://orcid.org/0000-0002-4039-8864","observed_orcids":["https://orcid.org/0000-0002-4039-8864"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sangram S Sisodia","raw_affiliation_strings":["Department of Neurobiology, University of Chicago, Chicago, IL60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, University of Chicago, Chicago, IL60637, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010416927","https://openalex.org/A5072879540"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I40347166"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.7499,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.65975358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"3","issue":"1","first_page":"14","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.8180000185966492},{"id":"https://openalex.org/keywords/psen2","display_name":"presenilin 2","score":1.0},{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9639999866485596},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9160000085830688},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":1.0},{"id":"https://openalex.org/keywords/cathepsins","display_name":"cathepsins","score":0.925000011920929},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gamma-secretase-inhibitors","display_name":"gamma-secretase inhibitors","score":0.9240000247955322},{"id":"https://openalex.org/keywords/age-related-gene-expression","display_name":"age-related gene expression","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C2776485563","wikidata":"https://www.wikidata.org/wiki/Q18253272","display_name":"PSEN1","level":5,"score":0.870445728302002},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7564924955368042},{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.6755945086479187},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.590991735458374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5681532621383667},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5141261219978333},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.47024694085121155},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.46817177534103394},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3901876211166382},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2669120728969574},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2585844397544861},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24891555309295654},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1802857220172882},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15626361966133118},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.15490859746932983},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10639849305152893},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/1750-1326-3-14","doi":"https://doi.org/10.1186/1750-1326-3-14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1750-1326-3-14","pdf_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-3-14","source":{"id":"https://openalex.org/S40861184","display_name":"Molecular Neurodegeneration","issn_l":"1750-1326","issn":["1750-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2569036","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2569036","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Neurodegener","raw_type":"Text"},{"id":"pmid:18834536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18834536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular neurodegeneration","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7e14c86b65574d3a929670f0823fba80","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7e14c86b65574d3a929670f0823fba80","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Neurodegeneration, Vol 3, Iss 1, p 14 (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1750-1326-3-14","doi":"https://doi.org/10.1186/1750-1326-3-14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1750-1326-3-14","pdf_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-3-14","source":{"id":"https://openalex.org/S40861184","display_name":"Molecular Neurodegeneration","issn_l":"1750-1326","issn":["1750-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5661851590","display_name":"Modulation of ABeta Deposition by Environmental Enrichment","funder_award_id":"R01AG027854","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7114148396","display_name":"Uncovering complex expression patterns in schizophrenia","funder_award_id":"K02MH070786","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306135","display_name":"Ellison Medical Foundation","ror":"https://ror.org/01pqy3846"},{"id":"https://openalex.org/F4320322148","display_name":"Eisai","ror":"https://ror.org/04vvh7p27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332688","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2097778960.pdf","grobid_xml":"https://content.openalex.org/works/W2097778960.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W62275226","https://openalex.org/W1966880627","https://openalex.org/W1967566501","https://openalex.org/W1967794631","https://openalex.org/W1987831563","https://openalex.org/W1987888225","https://openalex.org/W1988022242","https://openalex.org/W1989518993","https://openalex.org/W1996545500","https://openalex.org/W2002093986","https://openalex.org/W2002184303","https://openalex.org/W2005681172","https://openalex.org/W2010778459","https://openalex.org/W2023526653","https://openalex.org/W2030182984","https://openalex.org/W2030492864","https://openalex.org/W2033102468","https://openalex.org/W2035355245","https://openalex.org/W2038820492","https://openalex.org/W2041601288","https://openalex.org/W2045153164","https://openalex.org/W2046209489","https://openalex.org/W2055897605","https://openalex.org/W2062214806","https://openalex.org/W2064952846","https://openalex.org/W2072237144","https://openalex.org/W2076199082","https://openalex.org/W2078775160","https://openalex.org/W2079291061","https://openalex.org/W2089912569","https://openalex.org/W2100100832","https://openalex.org/W2101077392","https://openalex.org/W2104636742","https://openalex.org/W2108289152","https://openalex.org/W2122230892","https://openalex.org/W2122857482","https://openalex.org/W2123722683","https://openalex.org/W2133659563","https://openalex.org/W2133669258","https://openalex.org/W2134582937","https://openalex.org/W2134613265","https://openalex.org/W2157944371","https://openalex.org/W2158920723","https://openalex.org/W2168539712","https://openalex.org/W4241421879"],"related_works":["https://openalex.org/W7052519980","https://openalex.org/W2123722683","https://openalex.org/W1977199821","https://openalex.org/W2011625110","https://openalex.org/W2135561526","https://openalex.org/W4401540448","https://openalex.org/W2108289152","https://openalex.org/W3204935358","https://openalex.org/W3089214137","https://openalex.org/W7099141723"],"abstract_inverted_index":{"BACKGROUND:":[0],"Familial":[1],"Alzheimer's":[2,191],"disease-linked":[3],"variants":[4],"of":[5,14,23,69,76,99,144,172,183,185,190,199],"presenilin":[6],"(PSEN1":[7],"and":[8,19,25,35,45,59,72,82,101,113,124,139,146,174],"PSEN2)":[9],"contribute":[10],"to":[11,111,158,162],"the":[12,28,52,70,73,77,122,127,135,163,181],"pathophysiology":[13],"disease":[15],"by":[16,42],"both":[17,43],"gain-of-function":[18],"loss-of-function":[20],"mechanisms.":[21],"Deletions":[22],"PSEN1":[24,100,173],"PSEN2":[26,102],"in":[27,32,104,121,167],"mouse":[29],"forebrain":[30],"result":[31],"a":[33,64,105,141],"strong":[34,142],"progressive":[36],"neurodegenerative":[37,164],"phenotype":[38,165],"which":[39],"is":[40],"characterized":[41],"anatomical":[44],"behavioral":[46,60],"changes.":[47],"RESULTS:":[48],"To":[49],"better":[50],"understand":[51],"molecular":[53],"changes":[54,155],"associated":[55],"with":[56,169],"these":[57,116],"morphological":[58],"phenotypes,":[61],"we":[62],"performed":[63],"DNA":[65],"microarray":[66],"transcriptome":[67,108],"profiling":[68],"hippocampus":[71,123],"frontal":[74,125],"cortex":[75],"PSEN1/PSEN2":[78],"double":[79],"knock-out":[80],"mice":[81,168],"littermate":[83],"controls":[84],"at":[85],"five":[86],"different":[87],"ages":[88],"ranging":[89],"from":[90],"2-8":[91],"months.":[92],"Our":[93],"data":[94],"suggest":[95,179],"that":[96,180],"combined":[97],"deficiencies":[98],"results":[103,178],"progressive,":[106],"age-dependent":[107],"signature":[109],"related":[110],"neurodegeneration":[112],"neuroinflammation.":[114],"While":[115],"events":[117],"may":[118],"progress":[119],"differently":[120],"cortex,":[126],"most":[128],"critical":[129],"expression":[130,154],"signatures":[131],"are":[132,156],"common":[133],"across":[134],"two":[136],"brain":[137],"regions,":[138],"involve":[140],"upregulation":[143],"cathepsin":[145],"complement":[147],"system":[148,201],"transcripts.":[149],"CONCLUSION:":[150],"The":[151],"observed":[152,166],"neuroinflammatory":[153],"likely":[157],"be":[159],"causally":[160],"linked":[161],"compound":[170],"deletions":[171],"PSEN2.":[175],"Furthermore,":[176],"our":[177],"evaluation":[182],"inhibitors":[184],"PS/gamma-secretase":[186],"activity":[187],"for":[188,197],"treatment":[189],"Disease":[192],"must":[193],"include":[194],"close":[195],"monitoring":[196],"signs":[198],"calpain-cathepsin":[200],"activation.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}