{"id":"https://openalex.org/W2097724407","doi":"https://doi.org/10.1038/emboj.2010.300","title":"c\u2010IAP1 and UbcH5 promote K11\u2010linked polyubiquitination of RIP1 in TNF signalling","display_name":"c\u2010IAP1 and UbcH5 promote K11\u2010linked polyubiquitination of RIP1 in TNF signalling","publication_year":2010,"publication_date":"2010-11-26","ids":{"openalex":"https://openalex.org/W2097724407","doi":"https://doi.org/10.1038/emboj.2010.300","mag":"2097724407","pmid":"https://pubmed.ncbi.nlm.nih.gov/21113135"},"language":"en","primary_location":{"id":"doi:10.1038/emboj.2010.300","doi":"https://doi.org/10.1038/emboj.2010.300","is_oa":true,"landing_page_url":"https://doi.org/10.1038/emboj.2010.300","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/emboj.2010.300","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/emboj.2010.300","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067563618","display_name":"Jasmin N. Dynek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasmin N Dynek","raw_affiliation_strings":["Department of Protein Engineering, Genentech, Inc., South San Francisco, CA 94080, USA","Department of Protein Engineering, Genentech Inc. South San Francisco, CA, 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Engineering, Genentech, Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Department of Protein Engineering, Genentech Inc. South San Francisco, CA, 94080, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052200283","display_name":"Tatiana Goncharov","orcid":"https://orcid.org/0009-0007-5284-4319","observed_orcids":["https://orcid.org/0009-0007-5284-4319"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatiana Goncharov","raw_affiliation_strings":["Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017301570","display_name":"Erin C. Dueber","orcid":"https://orcid.org/0000-0001-6165-1083","observed_orcids":["https://orcid.org/0000-0001-6165-1083"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin C Dueber","raw_affiliation_strings":["Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anna V Fedorova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna V Fedorova","raw_affiliation_strings":["Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069926618","display_name":"Anita Izrael-Tomasevic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita Izrael\u2010Tomasevic","raw_affiliation_strings":["Department of Protein Chemistry, Genentech, Inc. South San Francisco CA USA","Department of Protein Chemistry, Genentech Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Chemistry, Genentech, Inc. South San Francisco CA USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Department of Protein Chemistry, Genentech Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112510498","display_name":"Lilian Phu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lilian Phu","raw_affiliation_strings":["Department of Protein Chemistry, Genentech, Inc. South San Francisco CA USA","Department of Protein Chemistry, Genentech Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Chemistry, Genentech, Inc. South San Francisco CA USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Department of Protein Chemistry, Genentech Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087417028","display_name":"Elizabeth Helgason","orcid":"https://orcid.org/0000-0002-0397-9125","observed_orcids":["https://orcid.org/0000-0002-0397-9125"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Helgason","raw_affiliation_strings":["Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044566453","display_name":"Wayne J. Fairbrother","orcid":"https://orcid.org/0000-0003-0480-5124","observed_orcids":["https://orcid.org/0000-0003-0480-5124"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne J Fairbrother","raw_affiliation_strings":["Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014450520","display_name":"Kurt Deshayes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kurt Deshayes","raw_affiliation_strings":["Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003718829","display_name":"Donald S. Kirkpatrick","orcid":"https://orcid.org/0000-0003-3091-2804","observed_orcids":["https://orcid.org/0000-0003-3091-2804"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald S Kirkpatrick","raw_affiliation_strings":["Department of Protein Chemistry, Genentech, Inc. South San Francisco CA USA","Department of Protein Chemistry, Genentech Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Chemistry, Genentech, Inc. South San Francisco CA USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Department of Protein Chemistry, Genentech Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048067233","display_name":"Domagoj Vucic","orcid":"https://orcid.org/0000-0003-3614-8093","observed_orcids":["https://orcid.org/0000-0003-3614-8093"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Domagoj Vucic","raw_affiliation_strings":["Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Engineering, Genentech, Inc. South San Francisco CA USA","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"\u2002Department of Protein Engineering, Genentech, Inc., South San Francisco, CA, USA","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048067233"],"corresponding_institution_ids":["https://openalex.org/I183934855"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":9.2094,"has_fulltext":true,"cited_by_count":352,"citation_normalized_percentile":{"value":0.98601864,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"29","issue":"24","first_page":"4198","last_page":"4209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.1995999962091446,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ciap1","display_name":"cIAP1","score":0.996999979019165},{"id":"https://openalex.org/keywords/ripk1","display_name":"RIPK1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.9679999947547913},{"id":"https://openalex.org/keywords/ubiquitin-conjugating-enzyme","display_name":"E2 ubiquitin-conjugating enzyme","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.953000009059906},{"id":"https://openalex.org/keywords/nemo","display_name":"NEMO","score":0.7210000157356262},{"id":"https://openalex.org/keywords/inhibitor-of-apoptosis-proteins","display_name":"inhibitor of apoptosis proteins","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.8722970485687256},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.7843605279922485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7791295051574707},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6203031539916992},{"id":"https://openalex.org/C182561583","wikidata":"https://www.wikidata.org/wiki/Q7876535","display_name":"Ubiquitin-conjugating enzyme","level":5,"score":0.6199661493301392},{"id":"https://openalex.org/C2908868211","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin-Protein Ligases","level":5,"score":0.5544567704200745},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.4481819272041321},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4236561954021454},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38492411375045776},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13689899444580078}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028861","descriptor_name":"Nuclear Pore Complex Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044763","descriptor_name":"Ubiquitin-Conjugating Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044763","descriptor_name":"Ubiquitin-Conjugating Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044763","descriptor_name":"Ubiquitin-Conjugating Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/emboj.2010.300","doi":"https://doi.org/10.1038/emboj.2010.300","is_oa":true,"landing_page_url":"https://doi.org/10.1038/emboj.2010.300","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/emboj.2010.300","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmid:21113135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21113135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3018797","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3018797","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EMBO J","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.896.9790","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.896.9790","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://emboj.embopress.org/content/embojnl/29/24/4198.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1038/emboj.2010.300","doi":"https://doi.org/10.1038/emboj.2010.300","is_oa":true,"landing_page_url":"https://doi.org/10.1038/emboj.2010.300","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/emboj.2010.300","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2097724407.pdf","grobid_xml":"https://content.openalex.org/works/W2097724407.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1492587973","https://openalex.org/W1881072801","https://openalex.org/W1969796729","https://openalex.org/W1973462203","https://openalex.org/W1976169230","https://openalex.org/W1983398917","https://openalex.org/W1991258715","https://openalex.org/W1991841644","https://openalex.org/W2002154440","https://openalex.org/W2005572311","https://openalex.org/W2007071412","https://openalex.org/W2007731525","https://openalex.org/W2013098933","https://openalex.org/W2013770400","https://openalex.org/W2029287748","https://openalex.org/W2033562377","https://openalex.org/W2033703058","https://openalex.org/W2033914606","https://openalex.org/W2036599699","https://openalex.org/W2039931633","https://openalex.org/W2041517382","https://openalex.org/W2045991166","https://openalex.org/W2054559365","https://openalex.org/W2059680729","https://openalex.org/W2060945380","https://openalex.org/W2061552846","https://openalex.org/W2064299413","https://openalex.org/W2069407758","https://openalex.org/W2069800916","https://openalex.org/W2073669171","https://openalex.org/W2075110858","https://openalex.org/W2081933521","https://openalex.org/W2099464495","https://openalex.org/W2101090646","https://openalex.org/W2115416706","https://openalex.org/W2119415370","https://openalex.org/W2123872048","https://openalex.org/W2124249714","https://openalex.org/W2125548716","https://openalex.org/W2128108747","https://openalex.org/W2144114582","https://openalex.org/W2147005308","https://openalex.org/W2150123812","https://openalex.org/W2154740729","https://openalex.org/W2166987747","https://openalex.org/W2345196156"],"related_works":["https://openalex.org/W1987982805","https://openalex.org/W4214895574","https://openalex.org/W295190513","https://openalex.org/W2054919679","https://openalex.org/W2348681936","https://openalex.org/W2169532909","https://openalex.org/W2263320115","https://openalex.org/W2040788846","https://openalex.org/W3162394609","https://openalex.org/W4287181432"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":34},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":34},{"year":2012,"cited_by_count":38}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}