{"id":"https://openalex.org/W2097709686","doi":"https://doi.org/10.1002/jlcr.2580331006","title":"Synthesis of [11C] platelet\u2010activating factor (PAF) analogs for in vivo imaging of PAF receptors","display_name":"Synthesis of [11C] platelet\u2010activating factor (PAF) analogs for in vivo imaging of PAF receptors","publication_year":1993,"publication_date":"1993-10-01","ids":{"openalex":"https://openalex.org/W2097709686","doi":"https://doi.org/10.1002/jlcr.2580331006","mag":"2097709686"},"language":"en","primary_location":{"id":"doi:10.1002/jlcr.2580331006","doi":"https://doi.org/10.1002/jlcr.2580331006","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlcr.2580331006","pdf_url":null,"source":{"id":"https://openalex.org/S90602895","display_name":"Journal of Labelled Compounds and Radiopharmaceuticals","issn_l":"0362-4803","issn":["0362-4803","1099-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Labelled Compounds and Radiopharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039367858","display_name":"T. SASAKI","orcid":"https://orcid.org/0000-0001-8833-0175","observed_orcids":["https://orcid.org/0000-0001-8833-0175"]},"institutions":[{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Sasaki","raw_affiliation_strings":["Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi, Tokyo","institution_ids":["https://openalex.org/I4210140609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110875081","display_name":"Ken Karasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Karasawa","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa 199-01"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa 199-01","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059414275","display_name":"Kiichi Ishiwata","orcid":"https://orcid.org/0000-0001-5773-7992","observed_orcids":["https://orcid.org/0000-0001-5773-7992"]},"institutions":[{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Ishiwata","raw_affiliation_strings":["Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi, Tokyo","institution_ids":["https://openalex.org/I4210140609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050656419","display_name":"Noriko Satoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Satoh","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa 199-01"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa 199-01","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078683191","display_name":"Shin\u2010ichi Ishii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Ishii","raw_affiliation_strings":["Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi, Tokyo","institution_ids":["https://openalex.org/I4210140609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075045544","display_name":"Koji Ogawa","orcid":"https://orcid.org/0000-0002-9221-6815","observed_orcids":["https://orcid.org/0000-0002-9221-6815"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Ogawa","raw_affiliation_strings":["Faculty of Hygienic Sciences, Kitasato University, Kanagawa 228 (Japan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Hygienic Sciences, Kitasato University, Kanagawa 228 (Japan)","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011452126","display_name":"T. Nozaki","orcid":"https://orcid.org/0000-0003-3102-5764","observed_orcids":["https://orcid.org/0000-0003-3102-5764"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Nozaki","raw_affiliation_strings":["Faculty of Hygienic Sciences, Kitasato University, Kanagawa 228 (Japan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Hygienic Sciences, Kitasato University, Kanagawa 228 (Japan)","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111634673","display_name":"Morio Setaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Setaka","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa 199-01"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa 199-01","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108529944","display_name":"S Nojima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Nojima","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa 199-01"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa 199-01","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060839417","display_name":"Michio Senda","orcid":"https://orcid.org/0000-0002-7520-0942","observed_orcids":["https://orcid.org/0000-0002-7520-0942"]},"institutions":[{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Senda","raw_affiliation_strings":["Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi, Tokyo","institution_ids":["https://openalex.org/I4210140609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.4132,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.68910372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"10","first_page":"921","last_page":"931"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":0.8709999918937683},{"id":"https://openalex.org/keywords/radioligand-synthesis","display_name":"radioligand synthesis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/plasma-stability","display_name":"plasma stability","score":0.578000009059906},{"id":"https://openalex.org/keywords/radiopharmaceuticals","display_name":"radiopharmaceuticals","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8965297937393188},{"id":"https://openalex.org/C2779020240","wikidata":"https://www.wikidata.org/wiki/Q420577","display_name":"Platelet-activating factor","level":2,"score":0.6834208965301514},{"id":"https://openalex.org/C2776970183","wikidata":"https://www.wikidata.org/wiki/Q20155580","display_name":"Radiosynthesis","level":3,"score":0.5175301432609558},{"id":"https://openalex.org/C2776923060","wikidata":"https://www.wikidata.org/wiki/Q576895","display_name":"Phosphocholine","level":5,"score":0.5109545588493347},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.49747350811958313},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.4925456941127777},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.47232574224472046},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4447173774242401},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3854313790798187},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3549903631210327},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20605170726776123},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14932698011398315},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.1302815079689026},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.08513054251670837},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.08091986179351807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/jlcr.2580331006","doi":"https://doi.org/10.1002/jlcr.2580331006","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlcr.2580331006","pdf_url":null,"source":{"id":"https://openalex.org/S90602895","display_name":"Journal of Labelled Compounds and Radiopharmaceuticals","issn_l":"0362-4803","issn":["0362-4803","1099-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Labelled Compounds and Radiopharmaceuticals","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1030813074","https://openalex.org/W1547302919","https://openalex.org/W1554688619","https://openalex.org/W1982134056","https://openalex.org/W1989844886","https://openalex.org/W2023943992","https://openalex.org/W2072463812","https://openalex.org/W2101091152","https://openalex.org/W2102155443","https://openalex.org/W2324334315"],"related_works":["https://openalex.org/W1991717506","https://openalex.org/W2123641406","https://openalex.org/W2015680727","https://openalex.org/W2042165945","https://openalex.org/W2000755900","https://openalex.org/W6996792383","https://openalex.org/W2005979657","https://openalex.org/W2065289037","https://openalex.org/W2078966118","https://openalex.org/W3121892774"],"abstract_inverted_index":{"Abstract":[0],"1\u2010O\u2010Hexadecyl\u20102\u2010O\u2010N,":[1],"N\u2010dimethylcarbamoyl\u2010sn\u2010glycero\u20103\u2010phosphocholine[choline":[2],"methyl\u201011C]":[3,7],"([11C]dimethylcarbamoyl\u2010PAF)":[4],"and":[5,17,36,55,60],"1\u2010O\u2010Hexadecyl\u20102\u2010O\u2010acetyl\u2010sn\u2010glycero\u20103\u2010phosphocholine[choline":[6],"([11C]C16\u2010PAF)":[8],"were":[9,38],"synthesized":[10,39],"as":[11],"follows;":[12],"Each":[13],"of":[14,42,51,68,73,79,83],"non\u2010labeled":[15],"dimethylcarbamoyl\u2010PAF":[16,35],"C16\u2010PAF":[18,37],"was":[19,57,75,97],"treated":[20],"with":[21,71,99],"sodium":[22],"benzene":[23],"thiolate":[24],"to":[25,77,91],"derive":[26],"their":[27],"desmethyl\u2010precursors":[28,45],"containing":[29],"a":[30],"dimethylphosphoethanolamine":[31],"at":[32,102],"sn\u20103.":[33],"11C\u2010Labeled":[34],"by":[40],"methylation":[41,52],"the":[43,80,89],"respective":[44],"using":[46],"[11C]CH3I.":[47],"The":[48,65],"radiochemical":[49],"yield":[50,67],"in":[53],"[11C]dimethylcarbamoyl\u2010PAF":[54,74,94],"[11C]C16\u2010PAF":[56,69,84,96],"about":[58],"15":[59],"10%":[61],"(decay":[62],"corrected),":[63],"respectively.":[64],"lower":[66],"compared":[70],"that":[72],"attributed":[76],"hydrolysis":[78],"2\u2010acetyl":[81],"group":[82],"during":[85],"methylation.":[86],"To":[87],"study":[88],"stability":[90],"enzymatic":[92],"hydrolysis,":[93],"or":[95],"incubated":[98],"mouse":[100],"plasma":[101],"37":[103],"\u00b0C.":[104]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
