{"id":"https://openalex.org/W2097680449","doi":null,"title":"Size Determination of Hyaluronan and Multivariate Analysis of Amyloid Prone Proteins","display_name":"Size Determination of Hyaluronan and Multivariate Analysis of Amyloid Prone Proteins","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2097680449","mag":"2097680449"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-46601","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46601","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46601","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025416118","display_name":"Linus Malm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Linus Malm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025416118"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9829999804496765},{"id":"https://openalex.org/keywords/gemma","display_name":"Gemma","score":0.7480000257492065},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/acylphosphatase","display_name":"acylphosphatase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8209999799728394},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pdgf-bb","display_name":"PDGF-BB","score":0.7760000228881836},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7910000085830688},{"id":"https://openalex.org/keywords/multivariate-regression","display_name":"multivariate regression","score":0.722000002861023},{"id":"https://openalex.org/keywords/hydrophobicity","display_name":"hydrophobicity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/protein-charge","display_name":"protein charge","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.538054883480072},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.502657413482666},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.4948579668998718},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.47435152530670166},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3773387670516968},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3416650891304016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24792179465293884},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.10805964469909668},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-46601","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46601","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2097680449","doi":null,"is_oa":false,"landing_page_url":"https://diva-portal.org/smash/get/diva2:439314/fulltext01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-46601","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46601","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W113688923","https://openalex.org/W163068442","https://openalex.org/W657942172","https://openalex.org/W1502415301","https://openalex.org/W1834622832","https://openalex.org/W1856532105","https://openalex.org/W1966985858","https://openalex.org/W1968280815","https://openalex.org/W1970405176","https://openalex.org/W1973680007","https://openalex.org/W1973897761","https://openalex.org/W1974949986","https://openalex.org/W1993216883","https://openalex.org/W1994446230","https://openalex.org/W2000655121","https://openalex.org/W2003380614","https://openalex.org/W2004673962","https://openalex.org/W2008678914","https://openalex.org/W2008835126","https://openalex.org/W2009275174","https://openalex.org/W2011606718","https://openalex.org/W2013279633","https://openalex.org/W2014875724","https://openalex.org/W2017005094","https://openalex.org/W2019861313","https://openalex.org/W2023306209","https://openalex.org/W2024895112","https://openalex.org/W2029858430","https://openalex.org/W2050549161","https://openalex.org/W2054060446","https://openalex.org/W2055378374","https://openalex.org/W2057694188","https://openalex.org/W2063795678","https://openalex.org/W2064611836","https://openalex.org/W2066521817","https://openalex.org/W2067014191","https://openalex.org/W2067692987","https://openalex.org/W2073503722","https://openalex.org/W2075026003","https://openalex.org/W2075635075","https://openalex.org/W2080908359","https://openalex.org/W2089210920","https://openalex.org/W2089468765","https://openalex.org/W2089753996","https://openalex.org/W2094164955","https://openalex.org/W2096601751","https://openalex.org/W2101579398","https://openalex.org/W2107853929","https://openalex.org/W2108488321","https://openalex.org/W2114790022","https://openalex.org/W2117899071","https://openalex.org/W2121753059","https://openalex.org/W2128947036","https://openalex.org/W2134661315","https://openalex.org/W2139966914","https://openalex.org/W2145533255","https://openalex.org/W2153004318","https://openalex.org/W2160171025","https://openalex.org/W2165186407","https://openalex.org/W2165531707","https://openalex.org/W2165902194","https://openalex.org/W2167704983","https://openalex.org/W2169413646","https://openalex.org/W2171989115","https://openalex.org/W2908626090","https://openalex.org/W3099514962","https://openalex.org/W3146199030"],"related_works":["https://openalex.org/W2946765176","https://openalex.org/W4317567631","https://openalex.org/W1837268776","https://openalex.org/W2105222737","https://openalex.org/W2019290387","https://openalex.org/W370582171","https://openalex.org/W79063749","https://openalex.org/W1968050351","https://openalex.org/W7100732047","https://openalex.org/W1987893498"],"abstract_inverted_index":{"Background.The":[0],"extracellular":[1,18,143],"matrix":[2],"surrounds":[3],"all":[4],"cells":[5],"within":[6],"our":[7],"bodies.":[8],"The":[9,104,150,235,270],"glycosaminoglycan":[10],"hyaluronan":[11,83,161,171,221,232,263,334,347],"is":[12,36,109,155],"a":[13,37,99,283,301],"major":[14],"component":[15],"in":[16,31,48,65,85,128,162,336],"the":[17,80,112,118,129,139,158,306,312,361],"matrix.":[19],"Despite":[20],"its":[21,55,61,204,262],"structural":[22,309],"simplicity":[23],"it":[24],"has":[25],"been":[26,124],"shown":[27,319],"to":[28,60,77,126,141,156,173,177,260,326],"be":[29,298],"involved":[30],"several":[32],"important":[33,46,363],"functions.":[34,103],"It":[35,317],"lubricant":[38],"and":[39,50,63,93,96,107,172,180,190,194,203,206,213,217,308,358],"shock":[40],"absorber,":[41],"as":[42,44,282],"well":[43],"an":[45,266,332],"player":[47],"inflammation":[49],"tumor":[51],"invasion.":[52],"Many":[53],"of":[54,74,102,114,133,145,152,160,183,220,231,239,242,289,293,305,311,346,368],"functions":[56],"are":[57,73,89,322],"closely":[58],"related":[59],"size":[62,169,205,229,287,344],"concentration":[64,207],"tissues.":[66],"Therefore":[67],"methods":[68,167,176],"for":[69,168,228,286,343,365],"measuring":[70],"these":[71],"properties":[72,113,310],"great":[75],"importance":[76],"properly":[78],"understand":[79],"role":[81],"that":[82,320,355],"play":[84],"different":[86,197,240,294],"events.":[87],"Proteins":[88],"found":[90],"both":[91],"inside":[92],"outside":[94],"cells,":[95],"they":[97],"have":[98,123],"wide":[100],"variety":[101],"protein":[105,186],"structure":[106],"function":[108,159],"determined":[110],"by":[111,136,196,246,252,277],"their":[115],"building":[116],"blocks,":[117],"amino":[119,130,313],"acids.":[120],"Several":[121],"diseases":[122],"linked":[125],"changes":[127],"acid":[131,314],"sequence":[132],"certain":[134],"proteins":[135,140],"mutations,":[137],"causing":[138],"form":[142],"deposits":[144],"structures":[146],"called":[147],"amyloid":[148,187,236,366],"aggregates.":[149],"aim":[151],"this":[153],"thesis":[154],"investigate":[157],"cell":[163],"cultures,":[164],"develop":[165],"new":[166,226,284],"determination":[170,288,345],"use":[174],"multivariate":[175,247,302],"provide":[178],"prediction":[179],"better":[181],"understanding":[182],"factors":[184,364],"driving":[185],"aggregation.":[188],"Methods.Cardiomyocytes":[189],"fibroblast":[191,214,259],"were":[192,208,215],"cultured":[193],"stimulated":[195,251,276],"growth":[198],"factors.":[199],"Hyaluronan":[200],"was":[201,223,233,244,280,318,340],"purified":[202],"measured.":[209],"Crosstalk":[210],"between":[211],"cardiomyocytes":[212,321],"investigated":[216],"gene":[218,272],"expression":[219,273],"synthases":[222],"determined.":[224],"A":[225],"method":[227,285],"measurement":[230],"developed.":[234],"aggregation":[237,292,367],"rate":[238],"mutants":[241,296],"acylphosphatase":[243,295],"predicted":[245,299],"analysis.":[248],"Results.":[249],"Cardiomyocytes":[250,256],"PDGF-BB":[253],"produced":[254],"hyaluronan.":[255,278,290],"could":[257,297],"induce":[258,331],"increase":[261],"production,":[264],"through":[265],"unknown":[267],"soluble":[268],"factor.":[269],"cardiomyocyte":[271],"changed":[274],"when":[275],"GEMMA":[279,339],"presented":[281],"Amyloid":[291],"using":[300],"regression":[303],"model":[304],"physicochemical":[307],"sequence.":[315],"Conclusion.":[316],"not":[323],"only":[324],"able":[325],"produce":[327],"hyaluronan,":[328],"but":[329],"also":[330],"increased":[333],"production":[335],"other":[337],"cells.":[338],"proven":[341],"suitable":[342],"at":[348],"very":[349],"low":[350],"concentrations.":[351],"Multivariate":[352],"analysis":[353],"showed":[354],"hydrophobic":[356],"patterns":[357],"charge":[359],"where":[360],"most":[362],"acylphosphatase.":[369]},"counts_by_year":[],"updated_date":"2026-08-13T07:04:57.449891","created_date":"2016-06-24T00:00:00"}