{"id":"https://openalex.org/W2097679135","doi":"https://doi.org/10.1128/iai.70.4.1874-1880.2002","title":"Safety and Immunogenicity of a Prototype EnterotoxigenicEscherichia coliVaccine Administered Transcutaneously","display_name":"Safety and Immunogenicity of a Prototype EnterotoxigenicEscherichia coliVaccine Administered Transcutaneously","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2097679135","doi":"https://doi.org/10.1128/iai.70.4.1874-1880.2002","mag":"2097679135","pmid":"https://pubmed.ncbi.nlm.nih.gov/11895950","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/127863"},"language":"en","primary_location":{"id":"doi:10.1128/iai.70.4.1874-1880.2002","doi":"https://doi.org/10.1128/iai.70.4.1874-1880.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.70.4.1874-1880.2002","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/127863","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078578689","display_name":"Fernando G\u00fcere\u00f1a-Burgue\u00f1o","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando Gu\u0308eren\u0303a-Burguen\u0303o","raw_affiliation_strings":["Department of Enteric Infections"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Enteric Infections","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eric R. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312537475","display_name":"Naval Medical Research Command","ror":"https://ror.org/05f421b09","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312537475","https://openalex.org/I1330347796","https://openalex.org/I3130687028","https://openalex.org/I4391768141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric R. Hall","raw_affiliation_strings":["Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910-7500"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910-7500","institution_ids":["https://openalex.org/I1312537475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109949114","display_name":"David N. Taylor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David N. Taylor","raw_affiliation_strings":["Department of Enteric Infections"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Enteric Infections","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015560869","display_name":"Frederick J. Cassels","orcid":"https://orcid.org/0000-0003-0502-6077","observed_orcids":["https://orcid.org/0000-0003-0502-6077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederick J. Cassels","raw_affiliation_strings":["Department of Enteric Infections"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Enteric Infections","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089678920","display_name":"Daniel A. Scott","orcid":"https://orcid.org/0000-0002-4916-145X","observed_orcids":["https://orcid.org/0000-0002-4916-145X"]},"institutions":[{"id":"https://openalex.org/I1312537475","display_name":"Naval Medical Research Command","ror":"https://ror.org/05f421b09","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312537475","https://openalex.org/I1330347796","https://openalex.org/I3130687028","https://openalex.org/I4391768141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Scott","raw_affiliation_strings":["Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910-7500"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910-7500","institution_ids":["https://openalex.org/I1312537475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108450646","display_name":"Marcia K. Wolf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcia K. Wolf","raw_affiliation_strings":["Department of Enteric Infections"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Enteric Infections","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111960949","display_name":"Zachary J. Roberts","orcid":"https://orcid.org/0009-0005-4981-1562","observed_orcids":["https://orcid.org/0009-0005-4981-1562"]},"institutions":[{"id":"https://openalex.org/I1312537475","display_name":"Naval Medical Research Command","ror":"https://ror.org/05f421b09","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312537475","https://openalex.org/I1330347796","https://openalex.org/I3130687028","https://openalex.org/I4391768141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary J. Roberts","raw_affiliation_strings":["Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910-7500"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910-7500","institution_ids":["https://openalex.org/I1312537475"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Galina V. Nesterova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Galina V. Nesterova","raw_affiliation_strings":["Department of Clinical Trials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Trials","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007536314","display_name":"Carl R. Alving","orcid":"https://orcid.org/0000-0002-1913-3909","observed_orcids":["https://orcid.org/0000-0002-1913-3909"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl R. Alving","raw_affiliation_strings":["Department of Membrane Biochemistry, Walter Reed Army Institute of Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Membrane Biochemistry, Walter Reed Army Institute of Research","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032295889","display_name":"Gregory M. Glenn","orcid":"https://orcid.org/0000-0002-2030-8665","observed_orcids":["https://orcid.org/0000-0002-2030-8665"]},"institutions":[{"id":"https://openalex.org/I4210165951","display_name":"Iomai (United States)","ror":"https://ror.org/0144z1077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory M. Glenn","raw_affiliation_strings":["IOMAI Corporation, Gaithersburg, Maryland 20878"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOMAI Corporation, Gaithersburg, Maryland 20878","institution_ids":["https://openalex.org/I4210165951"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.0058,"has_fulltext":false,"cited_by_count":153,"citation_normalized_percentile":{"value":0.99334898,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"70","issue":"4","first_page":"1874","last_page":"1880"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterotoxigenic-escherichia-coli","display_name":"enterotoxigenic Escherichia coli","score":0.9269999861717224},{"id":"https://openalex.org/keywords/etec-vaccine","display_name":"ETEC vaccine","score":0.8119999766349792},{"id":"https://openalex.org/keywords/transcutaneous-immunization","display_name":"transcutaneous immunization","score":0.9919999837875366},{"id":"https://openalex.org/keywords/heat-labile-enterotoxin","display_name":"heat-labile enterotoxin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/recombinant-subunit-vaccine","display_name":"recombinant subunit vaccine","score":0.8759999871253967},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.7689999938011169},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/iga","display_name":"IgA","score":0.4659999907016754},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.8579999804496765},{"id":"https://openalex.org/keywords/antibody-secreting-cells","display_name":"antibody-secreting cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.972000002861023},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.7459999918937683},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.9070000052452087},{"id":"https://openalex.org/keywords/traveler-s-diarrhea","display_name":"traveler's diarrhea","score":0.5870000123977661},{"id":"https://openalex.org/keywords/vaccine-delivery","display_name":"vaccine delivery","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C2777871010","wikidata":"https://www.wikidata.org/wiki/Q265214","display_name":"Enterotoxigenic Escherichia coli","level":5,"score":0.8853855729103088},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.8239588737487793},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6131865382194519},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5866414904594421},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.574469804763794},{"id":"https://openalex.org/C66999527","wikidata":"https://www.wikidata.org/wiki/Q421978","display_name":"Enterotoxin","level":4,"score":0.537519097328186},{"id":"https://openalex.org/C2779102806","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Immunoglobulin A","level":4,"score":0.5046504735946655},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.5035962462425232},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4908050000667572},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4703122675418854},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.46629709005355835},{"id":"https://openalex.org/C2778353597","wikidata":"https://www.wikidata.org/wiki/Q5693152","display_name":"Heat-labile enterotoxin","level":5,"score":0.4447418749332428},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4447267949581146},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4245336055755615},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3776843547821045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3508087694644928},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.18631979823112488},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000921","descriptor_name":"Antibody-Producing Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022361","descriptor_name":"Escherichia coli Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D022361","descriptor_name":"Escherichia coli Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D022361","descriptor_name":"Escherichia coli Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/iai.70.4.1874-1880.2002","doi":"https://doi.org/10.1128/iai.70.4.1874-1880.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.70.4.1874-1880.2002","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:127863","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/127863","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:11895950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11895950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:127863","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/127863","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320338325","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W4762125","https://openalex.org/W104357048","https://openalex.org/W1519536790","https://openalex.org/W1545317975","https://openalex.org/W1586182515","https://openalex.org/W1608119507","https://openalex.org/W1625990430","https://openalex.org/W1658205610","https://openalex.org/W1724733146","https://openalex.org/W1892178818","https://openalex.org/W1909582201","https://openalex.org/W1958826688","https://openalex.org/W1969393357","https://openalex.org/W1976274312","https://openalex.org/W1976713659","https://openalex.org/W1977321009","https://openalex.org/W1984889260","https://openalex.org/W1987362620","https://openalex.org/W2020043195","https://openalex.org/W2023522834","https://openalex.org/W2029927387","https://openalex.org/W2036064144","https://openalex.org/W2051605262","https://openalex.org/W2052113610","https://openalex.org/W2069530267","https://openalex.org/W2080104086","https://openalex.org/W2084899327","https://openalex.org/W2088176949","https://openalex.org/W2092275637","https://openalex.org/W2093735848","https://openalex.org/W2093857368","https://openalex.org/W2096123261","https://openalex.org/W2113095328","https://openalex.org/W2123413342","https://openalex.org/W2129322668","https://openalex.org/W2129397980","https://openalex.org/W2130957436","https://openalex.org/W2131245805","https://openalex.org/W2133109089","https://openalex.org/W2138115922","https://openalex.org/W2138875570","https://openalex.org/W2144935982","https://openalex.org/W2149597770","https://openalex.org/W2157035238","https://openalex.org/W2157739202","https://openalex.org/W2160439264","https://openalex.org/W2162946939","https://openalex.org/W2170398658","https://openalex.org/W2171460434","https://openalex.org/W2172209357","https://openalex.org/W2317619492","https://openalex.org/W2323680375","https://openalex.org/W2327463745","https://openalex.org/W2339502380","https://openalex.org/W2410531569","https://openalex.org/W2416765311","https://openalex.org/W3147589402","https://openalex.org/W4313309972","https://openalex.org/W4313316606"],"related_works":["https://openalex.org/W2036064144","https://openalex.org/W3195353462","https://openalex.org/W2150056219","https://openalex.org/W2971761352","https://openalex.org/W3089175320","https://openalex.org/W1608119507","https://openalex.org/W2085889988","https://openalex.org/W2100869121","https://openalex.org/W1994584692","https://openalex.org/W2171184029"],"abstract_inverted_index":{"Transcutaneous":[0],"immunization":[1],"(TCI)":[2],"is":[3],"a":[4,30,191,222,226],"new":[5],"method":[6],"for":[7,218],"vaccine":[8,33,64,217],"delivery":[9],"that":[10,86,186,214],"has":[11],"been":[12],"shown":[13],"to":[14,18,94,114],"induce":[15,195],"immunity":[16],"relevant":[17],"enteric":[19],"disease":[20],"vaccines.":[21],"We":[22],"evaluated":[23],"the":[24,47,83,88,97,102,135,203],"clinical":[25],"safety":[26],"and":[27,70,73,76,107,110,121,125,129,142,149,154,172],"immunogenicity":[28],"of":[29,99,134,167,205,230],"recombinant":[31,48],"subunit":[32],"against":[34],"enterotoxigenic":[35],"Escherichia":[36],"coli":[37],"(ETEC)":[38],"delivered":[39,189,220],"by":[40,190,221],"TCI.":[41],"Adult":[42],"volunteers":[43,85,136,169],"received":[44],"patches":[45,59],"containing":[46,60],"ETEC":[49,216],"colonization":[50],"factor":[51],"CS6,":[52],"either":[53],"with":[54],"heat-labile":[55],"enterotoxin":[56],"(LT)":[57],"or":[58],"CS6":[61,95,106,181],"alone.":[62,182],"The":[63,211],"was":[65,163,176],"administered":[66],"at":[67],"0,":[68],"1,":[69],"3":[71],"months,":[72],"serum":[74,116,145],"antibodies":[75],"antibody-secreting":[77],"cells":[78],"(ASCs)":[79],"were":[80,91,112],"assessed.":[81],"Among":[82],"26":[84],"completed":[87],"trial,":[89],"there":[90],"no":[92,174],"responses":[93,199],"in":[96,165,178,202],"absence":[98],"LT.":[100,210],"In":[101],"groups":[103],"receiving":[104,137,170,180],"both":[105],"LT,":[108],"68":[109],"53%":[111],"found":[113],"have":[115],"anti-CS6":[117,131],"immunoglobulin":[118],"G":[119],"(IgG)":[120],"IgA,":[122],"respectively;":[123],"37":[124],"42%":[126],"had":[127,139,144,151],"IgG":[128,153],"IgA":[130,155],"ASCs.":[132,156],"All":[133],"LT":[138,171],"anti-LT":[140,146,152],"IgG,":[141],"90%":[143],"IgA;":[147],"79":[148],"37%":[150],"Delayed-type":[157],"hypersensitivity":[158],"(DTH),":[159],"suggesting":[160],"T-cell":[161],"responses,":[162],"seen":[164,177],"14":[166],"19":[168],"CS6;":[173],"DTH":[175],"subjects":[179],"This":[183],"study":[184],"demonstrated":[185],"protein":[187],"antigens":[188],"simple":[192],"patch":[193,223],"could":[194],"significant":[196],"systemic":[197],"immune":[198],"but":[200],"only":[201],"presence":[204],"an":[206,215],"adjuvant":[207],"such":[208],"as":[209],"data":[212],"suggest":[213],"travelers":[219],"may":[224],"be":[225],"viable":[227],"approach":[228],"worthy":[229],"further":[231],"evaluation.":[232]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}