{"id":"https://openalex.org/W2097656264","doi":"https://doi.org/10.1161/01.atv.20.2.410","title":"Expression of Tumor Necrosis Factor-\u03b1 in Cultured Human Endothelial Cells Stimulated With Lipopolysaccharide or Interleukin-1\u03b1","display_name":"Expression of Tumor Necrosis Factor-\u03b1 in Cultured Human Endothelial Cells Stimulated With Lipopolysaccharide or Interleukin-1\u03b1","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W2097656264","doi":"https://doi.org/10.1161/01.atv.20.2.410","mag":"2097656264","pmid":"https://pubmed.ncbi.nlm.nih.gov/10669637"},"language":"en","primary_location":{"id":"doi:10.1161/01.atv.20.2.410","doi":"https://doi.org/10.1161/01.atv.20.2.410","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.20.2.410","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076525096","display_name":"Tadaatsu Imaizumi","orcid":"https://orcid.org/0000-0002-1560-9359","observed_orcids":["https://orcid.org/0000-0002-1560-9359"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadaatsu Imaizumi","raw_affiliation_strings":["From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024104247","display_name":"Hiroyuki Itaya","orcid":"https://orcid.org/0009-0000-9047-4100","observed_orcids":["https://orcid.org/0009-0000-9047-4100"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Itaya","raw_affiliation_strings":["From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kazumi Fujita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazumi Fujita","raw_affiliation_strings":["From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055659746","display_name":"Daisuke Kudoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Kudoh","raw_affiliation_strings":["From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109923015","display_name":"Seiji Kudoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiji Kudoh","raw_affiliation_strings":["From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103074800","display_name":"Kazuyuki Mori","orcid":"https://orcid.org/0000-0002-7682-9793","observed_orcids":["https://orcid.org/0000-0002-7682-9793"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyuki Mori","raw_affiliation_strings":["From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060264972","display_name":"Koji Fujimoto","orcid":"https://orcid.org/0000-0003-1209-7949","observed_orcids":["https://orcid.org/0000-0003-1209-7949"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Fujimoto","raw_affiliation_strings":["From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071131126","display_name":"Tomoh Matsumiya","orcid":"https://orcid.org/0000-0002-5157-3277","observed_orcids":["https://orcid.org/0000-0002-5157-3277"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoh Matsumiya","raw_affiliation_strings":["From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013262223","display_name":"Hidemi Yoshida","orcid":"https://orcid.org/0000-0002-0655-8051","observed_orcids":["https://orcid.org/0000-0002-0655-8051"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidemi Yoshida","raw_affiliation_strings":["From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112090932","display_name":"Kei Satoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Satoh","raw_affiliation_strings":["From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pathological Physiology, Institute of Neurological Diseases (T.I., H.I., K.Fujita, K.Fujimoto, H.Y., K.S.), Department of Urology (D.K., S.K., K.M.), and Department of Dentistry and Oral Surgery (T.M.), Hirosaki University School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I146516829"],"apc_list":null,"apc_paid":null,"fwci":3.4509,"has_fulltext":false,"cited_by_count":115,"citation_normalized_percentile":{"value":0.92145289,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"20","issue":"2","first_page":"410","last_page":"415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.21130000054836273,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.21130000054836273,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.19290000200271606,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.10180000215768814,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9950000047683716},{"id":"https://openalex.org/keywords/interleukin-1-alpha","display_name":"interleukin-1 alpha","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tnf-alpha-converting-enzyme","display_name":"TNF-alpha converting enzyme","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tnf-alpha-secretion","display_name":"TNF-alpha secretion","score":0.7839999794960022},{"id":"https://openalex.org/keywords/autocrine-activation","display_name":"autocrine activation","score":0.781000018119812},{"id":"https://openalex.org/keywords/juxtacrine-signaling","display_name":"juxtacrine signaling","score":0.968999981880188},{"id":"https://openalex.org/keywords/membrane-bound-tnf-alpha","display_name":"membrane-bound TNF-alpha","score":0.8610000014305115},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.7894612550735474},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6596550345420837},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.6394832730293274},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5573081970214844},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5481097102165222},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5115724205970764},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5019791126251221},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48574119806289673},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.44770318269729614},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43160688877105713},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40164610743522644},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.30215275287628174},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28859496116638184},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27368035912513733},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.24289172887802124},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15844106674194336},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09557241201400757},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072198","descriptor_name":"ADAM17 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072198","descriptor_name":"ADAM17 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072198","descriptor_name":"ADAM17 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.atv.20.2.410","doi":"https://doi.org/10.1161/01.atv.20.2.410","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.20.2.410","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"pmid:10669637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10669637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, thrombosis, and vascular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.47999998927116394}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1025991121","display_name":"SCOR ON ACUTE LUNG INJURY","funder_award_id":"5p50hl050153-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1742597533","display_name":null,"funder_award_id":"P50 HL50153","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W247569319","https://openalex.org/W1472860026","https://openalex.org/W1973443459","https://openalex.org/W1985412600","https://openalex.org/W1989783048","https://openalex.org/W2006691286","https://openalex.org/W2008619553","https://openalex.org/W2036842448","https://openalex.org/W2057943924","https://openalex.org/W2062925771","https://openalex.org/W2074881372","https://openalex.org/W2076036286","https://openalex.org/W2086255604","https://openalex.org/W2089172549","https://openalex.org/W2101060955","https://openalex.org/W2138088880","https://openalex.org/W2400907554","https://openalex.org/W2409421277","https://openalex.org/W2415274192","https://openalex.org/W2468119228"],"related_works":["https://openalex.org/W2417912960","https://openalex.org/W2095959177","https://openalex.org/W4379052364","https://openalex.org/W2416795054","https://openalex.org/W3123033141","https://openalex.org/W2392126385","https://openalex.org/W1969354036","https://openalex.org/W2799458925","https://openalex.org/W2390339137","https://openalex.org/W2393860336"],"abstract_inverted_index":{"Tumor-necrosis":[0],"factor-alpha":[1],"(TNF-alpha)":[2],"is":[3,21,24,46,59],"a":[4,8,25,42,167,204],"proinflammatory":[5],"cytokine":[6,20],"with":[7,70,139,146,166],"wide":[9],"variety":[10],"of":[11,18,31,38,44,84,94,103,107,144,155,163,192],"biological":[12],"effects.":[13],"The":[14,120],"most":[15],"important":[16],"source":[17,43],"this":[19],"monocytes/macrophages.":[22],"It":[23],"potent":[26],"agonist":[27],"in":[28,87,111,116,128,189,198],"the":[29,35,50,55,108,117,150,164,171,212],"activation":[30,191],"endothelial":[32,39,66,193,213],"cells;":[33],"however,":[34],"precise":[36],"role":[37],"cells":[40,67,165,210],"as":[41,73,203],"TNF-alpha":[45,58,85,95,104,109,152,156,179,185,196],"not":[47,100,135],"known.":[48],"In":[49],"present":[51],"study,":[52],"we":[53],"addressed":[54],"possibility":[56],"that":[57,176],"produced":[60],"by":[61,137,158],"cultured":[62],"human":[63],"umbilical":[64],"vein":[65],"(HUVEC)":[68],"stimulated":[69],"factors":[71],"such":[72],"lipopolysaccharide":[74],"(LPS)":[75],"or":[76,141],"interleukin-1alpha":[77],"(IL-1alpha).":[78],"LPS":[79,98,140],"and":[80,92,131,161,180,195],"IL-1alpha":[81,89],"induced":[82,90],"expression":[83,91],"mRNA":[86,121],"HUVEC.":[88],"secretion":[93,154],"protein,":[96],"but":[97],"did":[99],"induce":[101],"production":[102],"protein.":[105],"Most":[106],"protein":[110,157],"cell":[112,199],"lysate":[113],"was":[114,126,134],"found":[115],"membrane":[118,200],"fraction.":[119],"for":[122],"TNF-alpha-converting":[123],"enzyme":[124],"(TACE)":[125],"expressed":[127],"unstimulated":[129],"HUVEC,":[130],"its":[132],"level":[133],"altered":[136],"treatment":[138,162],"IL-1alpha.":[142],"Transfection":[143],"HUVEC":[145,177],"full-length":[147],"cDNA":[148],"encoding":[149],"precursor":[151],"enhanced":[153],"these":[159],"cells,":[160,194],"TACE":[168,182],"inhibitor":[169],"reduced":[170],"secretion.":[172],"These":[173],"results":[174],"suggest":[175],"produce":[178],"have":[181],"activity.":[183],"Secreted":[184],"may":[186,201],"be":[187],"involved":[188],"autocrine":[190],"retained":[197],"serve":[202],"juxtacrine":[205],"system":[206],"to":[207],"activate":[208],"target":[209],"on":[211],"surface.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
