{"id":"https://openalex.org/W2097608115","doi":null,"title":"Improvement and enhancement of clavulanic acid production in Streptomyces clavuligerus using vegetable oils","display_name":"Improvement and enhancement of clavulanic acid production in Streptomyces clavuligerus using vegetable oils","publication_year":2010,"publication_date":"2010-10-04","ids":{"openalex":"https://openalex.org/W2097608115","mag":"2097608115"},"language":"en","primary_location":{"id":"mag:2097608115","doi":null,"is_oa":true,"landing_page_url":"https://www.academicjournals.org/article/article1380630428_Salem-Bekhit et al.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S118568332","display_name":"AFRICAN JOURNAL OF BIOTECHNOLOGY","issn_l":"1684-5315","issn":["1684-5315"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310321074","host_organization_name":"Academic Journals","host_organization_lineage":["https://openalex.org/P4310321074"],"host_organization_lineage_names":["Academic Journals"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"AFRICAN JOURNAL OF BIOTECHNOLOGY","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.academicjournals.org/article/article1380630428_Salem-Bekhit et al.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027090023","display_name":"Mounir Mohamed Salem-Bekhit","orcid":"https://orcid.org/0000-0002-8263-137X","observed_orcids":["https://orcid.org/0000-0002-8263-137X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mounir M. Salem\u2010Bekhit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111599533","display_name":"Fars Kaed Alanazi","orcid":"https://orcid.org/0009-0006-3104-2096","observed_orcids":["https://orcid.org/0009-0006-3104-2096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fars K. Alanazi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042734923","display_name":"Ibrahim A. Alsarra","orcid":"https://orcid.org/0000-0001-5288-5953","observed_orcids":["https://orcid.org/0000-0001-5288-5953"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ibrahim A. Alsarra","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5288-5953","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1933,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.51198466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"40","first_page":"6806","last_page":"6812"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clavulanic-acid","display_name":"clavulanic acid","score":0.9739999771118164},{"id":"https://openalex.org/keywords/streptomyces-clavuligerus","display_name":"Streptomyces clavuligerus","score":1.0},{"id":"https://openalex.org/keywords/vegetable-oils","display_name":"vegetable oils","score":0.8180000185966492},{"id":"https://openalex.org/keywords/olive-oil","display_name":"olive oil","score":0.9919999837875366},{"id":"https://openalex.org/keywords/carbon-source","display_name":"carbon source","score":0.8230000138282776},{"id":"https://openalex.org/keywords/fermentation-medium-optimization","display_name":"fermentation medium optimization","score":0.8050000071525574},{"id":"https://openalex.org/keywords/ph-optimization","display_name":"pH optimization","score":0.7459999918937683},{"id":"https://openalex.org/keywords/beta-lactamase-inhibitors","display_name":"beta-lactamase inhibitors","score":0.8690000176429749},{"id":"https://openalex.org/keywords/antibiotic-production","display_name":"antibiotic production","score":0.8479999899864197},{"id":"https://openalex.org/keywords/glycerol","display_name":"glycerol","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C2777211131","wikidata":"https://www.wikidata.org/wiki/Q7623381","display_name":"Streptomyces clavuligerus","level":5,"score":0.9923174381256104},{"id":"https://openalex.org/C2779454058","wikidata":"https://www.wikidata.org/wiki/Q415709","display_name":"Clavulanic acid","level":4,"score":0.7012999057769775},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.6798540949821472},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6239442825317383},{"id":"https://openalex.org/C2780881558","wikidata":"https://www.wikidata.org/wiki/Q132501","display_name":"Glycerol","level":2,"score":0.6209161877632141},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5867716670036316},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.5531052947044373},{"id":"https://openalex.org/C2982740256","wikidata":"https://www.wikidata.org/wiki/Q56064425","display_name":"Carbon source","level":2,"score":0.4232531487941742},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.4171249270439148},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3730209469795227},{"id":"https://openalex.org/C528095902","wikidata":"https://www.wikidata.org/wiki/Q2283886","display_name":"Pulp and paper industry","level":1,"score":0.3279942572116852},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.31275421380996704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23123395442962646},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2097608115","doi":null,"is_oa":true,"landing_page_url":"https://www.academicjournals.org/article/article1380630428_Salem-Bekhit et al.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S118568332","display_name":"AFRICAN JOURNAL OF BIOTECHNOLOGY","issn_l":"1684-5315","issn":["1684-5315"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310321074","host_organization_name":"Academic Journals","host_organization_lineage":["https://openalex.org/P4310321074"],"host_organization_lineage_names":["Academic Journals"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"AFRICAN JOURNAL OF BIOTECHNOLOGY","raw_type":null}],"best_oa_location":{"id":"mag:2097608115","doi":null,"is_oa":true,"landing_page_url":"https://www.academicjournals.org/article/article1380630428_Salem-Bekhit et al.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S118568332","display_name":"AFRICAN JOURNAL OF BIOTECHNOLOGY","issn_l":"1684-5315","issn":["1684-5315"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310321074","host_organization_name":"Academic Journals","host_organization_lineage":["https://openalex.org/P4310321074"],"host_organization_lineage_names":["Academic Journals"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"AFRICAN JOURNAL OF BIOTECHNOLOGY","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W229491483","https://openalex.org/W1982048387","https://openalex.org/W1987738300","https://openalex.org/W1990658315","https://openalex.org/W1996682025","https://openalex.org/W2002701186","https://openalex.org/W2005840384","https://openalex.org/W2011886013","https://openalex.org/W2023428631","https://openalex.org/W2026585923","https://openalex.org/W2036195439","https://openalex.org/W2047633733","https://openalex.org/W2079826981","https://openalex.org/W2089325764","https://openalex.org/W2101852959","https://openalex.org/W2105055720","https://openalex.org/W2105984809","https://openalex.org/W2116649852","https://openalex.org/W2132806846","https://openalex.org/W2155809353","https://openalex.org/W2167645863","https://openalex.org/W2253845724","https://openalex.org/W2691262581"],"related_works":["https://openalex.org/W2036195439","https://openalex.org/W1974341459","https://openalex.org/W2079826981","https://openalex.org/W2948930218","https://openalex.org/W2338595164","https://openalex.org/W3124763651","https://openalex.org/W2039459390","https://openalex.org/W1990658315","https://openalex.org/W2793762940","https://openalex.org/W967315681"],"abstract_inverted_index":{"Clavulanic":[0],"acid":[1],"(CA)":[2],"is":[3,129],"a":[4,14,25,35,117,130,155],"potent":[5],"inhibitor":[6],"of":[7,16,30,34,53,69,81,120,126,163,173],"\u03b2-lactamases.":[8],"Oil":[9],"can":[10,151,166],"be":[11,152,167],"used":[12],"as":[13,45,116,154],"source":[15,47,119],"carbon":[17,46,121],"and":[18,38,62,122,141,150],"energy":[19,123],"in":[20],"CA":[21,63,86,95,134],"production.":[22,87,135],"To":[23],"develop":[24],"policy":[26],"for":[27,124,133,169],"enhanced":[28],"production":[29,36,65,172],"CA,":[31],"the":[32,67,170],"selection":[33],"medium":[37,55],"an":[39],"optimum":[40],"pH,":[41],"different":[42,54],"vegetable":[43,57],"oils":[44,84],"have":[48],"been":[49],"used.":[50],"The":[51,101,161],"effects":[52],"containing":[56,89,99],"oil":[58,91,115],"on":[59],"cell":[60],"growth":[61],"yield":[64,96],"during":[66],"fermentation":[68],"Streptomyces":[70],"clavuligerus":[71,128],"ATCC":[72],"27064":[73],"were":[74],"demonstrated.":[75],"In":[76],"this":[77,164],"study,":[78],"three":[79],"out":[80],"eight":[82],"tested":[83],"supported":[85],"Medium":[88],"olive":[90,114],"showed":[92],"two-fold":[93],"higher":[94],"than":[97],"glycerol":[98],"medium.":[100],"highest":[102],"productivity":[103],"was":[104],"obtained":[105],"at":[106],"initial":[107],"pH":[108],"7.":[109],"We":[110],"concluded":[111],"that":[112,144],"using":[113],"sole":[118],"cultivation":[125],"S.":[127],"promising":[131],"strategy":[132],"It":[136],"has":[137],"several":[138],"scientific":[139],"advantages":[140],"economic":[142],"benefits":[143],"lead":[145],"to":[146,159],"increased":[147],"antibiotic":[148],"titre":[149],"considered":[153],"cheaper":[156],"alternative":[157],"compared":[158],"carbohydrates.":[160],"results":[162],"study":[165],"applied":[168],"efficient":[171],"\u03b2-lactamase":[174],"inhibitory":[175],"antibiotics.":[176]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}