{"id":"https://openalex.org/W2097550105","doi":"https://doi.org/10.1136/gutjnl-2012-302142","title":"Role of Helicobacter pylori CagL in modulating gastrin expression","display_name":"Role of Helicobacter pylori CagL in modulating gastrin expression","publication_year":2012,"publication_date":"2012-03-09","ids":{"openalex":"https://openalex.org/W2097550105","doi":"https://doi.org/10.1136/gutjnl-2012-302142","mag":"2097550105","pmid":"https://pubmed.ncbi.nlm.nih.gov/22406936","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3919019"},"language":"en","primary_location":{"id":"doi:10.1136/gutjnl-2012-302142","doi":"https://doi.org/10.1136/gutjnl-2012-302142","is_oa":false,"landing_page_url":"https://doi.org/10.1136/gutjnl-2012-302142","pdf_url":null,"source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3919019","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017198868","display_name":"Timothy L. Cover","orcid":"https://orcid.org/0000-0001-8503-002X","observed_orcids":["https://orcid.org/0000-0001-8503-002X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy L Cover","raw_affiliation_strings":["Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. timothy.l.cover@vanderbilt.edu","Dept. of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. timothy.l.cover@vanderbilt.edu","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Dept. of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017198868"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":1.3815,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.8271301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"61","issue":"7","first_page":"965","last_page":"966"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":1.0},{"id":"https://openalex.org/keywords/cagl","display_name":"CagL","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cag-pathogenicity-island","display_name":"cag pathogenicity island","score":0.9850000143051147},{"id":"https://openalex.org/keywords/caga","display_name":"CagA","score":0.9290000200271606},{"id":"https://openalex.org/keywords/type-iv-secretion-system","display_name":"type IV secretion system","score":0.8930000066757202},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.6449999809265137},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.6449999809265137},{"id":"https://openalex.org/keywords/gastric-epithelial-cells","display_name":"gastric epithelial cells","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2778204961","wikidata":"https://www.wikidata.org/wiki/Q83146136","display_name":"CagA","level":4,"score":0.9721214771270752},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.8476477861404419},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7565404176712036},{"id":"https://openalex.org/C62130838","wikidata":"https://www.wikidata.org/wiki/Q5196163","display_name":"Pathogenicity island","level":4,"score":0.6468762159347534},{"id":"https://openalex.org/C2780941775","wikidata":"https://www.wikidata.org/wiki/Q2897350","display_name":"Gastric lymphoma","level":3,"score":0.5088434219360352},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.485718309879303},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4589378237724304},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4566974937915802},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.44600313901901245},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3416818380355835},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3285486102104187},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3144952952861786},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.22336050868034363},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099200","descriptor_name":"Scaffold Protein ILK","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005755","descriptor_name":"Gastrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1136/gutjnl-2012-302142","doi":"https://doi.org/10.1136/gutjnl-2012-302142","is_oa":false,"landing_page_url":"https://doi.org/10.1136/gutjnl-2012-302142","pdf_url":null,"source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},{"id":"pmid:22406936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22406936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2903513","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3919019","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3919019","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3919019","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Gut","raw_type":"Text"},{"id":"pmh:oai:open-archive.highwire.org:gutjnl:61/7/965","doi":null,"is_oa":false,"landing_page_url":"http://gut.bmj.com/cgi/content/short/61/7/965","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2903513","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3919019","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1210968838","display_name":"Structure and function of Helicobacter pylori VacA","funder_award_id":"R01AI039657","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G283333078","display_name":"Analysis of the H. Pylori cag pathogenicity island","funder_award_id":"R01AI068009","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000895449","display_name":"H. pylori-induced Inflammation and Gastric Cancer","funder_award_id":"P01CA116087","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1834110578","https://openalex.org/W1965323568","https://openalex.org/W1988532871","https://openalex.org/W2003035812","https://openalex.org/W2038471507","https://openalex.org/W2065945819","https://openalex.org/W2121216309","https://openalex.org/W2125809870","https://openalex.org/W2157442946","https://openalex.org/W2166628251"],"related_works":["https://openalex.org/W2528695625","https://openalex.org/W2248134792","https://openalex.org/W2543747444","https://openalex.org/W4392125218","https://openalex.org/W1848007514","https://openalex.org/W3146736758","https://openalex.org/W2751275569","https://openalex.org/W2442397882","https://openalex.org/W2151826056","https://openalex.org/W2469043157"],"abstract_inverted_index":{"Helicobacter":[0],"pylori":[1,20,53,70,89,115],"is":[2,7,30,44,61,76,91,127,133,201],"a":[3,31,45,74,128,197,207],"Gram-negative":[4,235],"bacterium":[5],"that":[6,132,179,209],"highly":[8,129],"adapted":[9],"for":[10,34],"persistent":[11],"colonisation":[12],"of":[13,27,48,58,67,79,86,100,162,188,219,227],"the":[14,25,56,68,80,92,117,186,215],"human":[15],"stomach.":[16],"Although":[17],"most":[18,81],"H":[19,52,69,88,114],"-infected":[21],"people":[22],"remain":[23],"asymptomatic,":[24],"presence":[26],"this":[28],"organism":[29],"risk":[32,57],"factor":[33],"gastric":[35,41,59,136,140,189],"adenocarcinoma,":[36],"peptic":[37],"ulcer":[38],"disease":[39,60],"and":[40,55,151,168,170,191],"lymphoma.":[42],"There":[43],"high":[46],"level":[47],"genetic":[49,84],"heterogeneity":[50],"among":[51],"strains":[54,90],"determined,":[62],"in":[63,113,125,175,185,233],"part,":[64],"by":[65,146,206],"characteristics":[66],"strain(s)":[71],"with":[72,153],"which":[73,220],"person":[75],"infected.1":[77],"One":[78],"extensively":[82],"studied":[83,124],"features":[85],"disease-associated":[87],"cag":[93,119,216],"pathogenicity":[94],"island":[95],"(PAI).":[96],"This":[97],"40\u2005kb":[98],"region":[99],"chromosomal":[101],"DNA,":[102],"comprising":[103],"about":[104,211],"27":[105],"genes,":[106],"may":[107],"be":[108,123],"present,":[109],"incomplete":[110],"or":[111],"absent":[112],"strains.\n\nCagA,":[116],"first":[118],"PAI-encoded":[120],"protein":[121,131],"to":[122,158,223],"detail,":[126],"antigenic":[130],"translocated":[134,202],"into":[135,203],"epithelial":[137,141],"cells.":[138],"Within":[139],"cells,":[142],"CagA":[143,180,193,200],"undergoes":[144],"phosphorylation":[145],"host":[147,155,204],"cell":[148,172],"tyrosine":[149],"kinases":[150],"interacts":[152],"multiple":[154],"proteins,":[156],"leading":[157],"cytoskeletal":[159],"rearrangements,":[160],"disruption":[161],"cellular":[163,166],"junctions,":[164],"altered":[165],"adhesion":[167],"polarity":[169],"increased":[171],"proliferation.":[173],"Experiments":[174],"animal":[176],"models":[177],"indicate":[178],"has":[181,194],"an":[182],"important":[183],"role":[184],"pathogenesis":[187],"cancer":[190],"therefore,":[192],"been":[195],"termed":[196],"bacterial":[198,236],"oncoprotein.2":[199],"cells":[205],"process":[208],"requires":[210],"17":[212],"genes":[213,224],"within":[214],"PAI,":[217],"several":[218],"are":[221],"homologous":[222],"encoding":[225],"components":[226],"type":[228],"IV":[229],"secretion":[230],"systems":[231],"(T4SS)":[232],"other":[234],"species.":[237],"\u2026":[238]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}