{"id":"https://openalex.org/W2097547549","doi":"https://doi.org/10.1002/ajmg.a.20132","title":"Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps","display_name":"Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps","publication_year":2003,"publication_date":"2003-04-09","ids":{"openalex":"https://openalex.org/W2097547549","doi":"https://doi.org/10.1002/ajmg.a.20132","mag":"2097547549","pmid":"https://pubmed.ncbi.nlm.nih.gov/12910485"},"language":"en","primary_location":{"id":"doi:10.1002/ajmg.a.20132","doi":"https://doi.org/10.1002/ajmg.a.20132","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajmg.a.20132","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.a.20132","source":{"id":"https://openalex.org/S180901878","display_name":"American Journal of Medical Genetics Part A","issn_l":"1552-4825","issn":["1552-4825","1552-4833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics Part A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.a.20132","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043230326","display_name":"Lorenzo D. Botto","orcid":"https://orcid.org/0000-0002-5322-7116","observed_orcids":["https://orcid.org/0000-0002-5322-7116"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210109585","display_name":"National Center on Birth Defects and Developmental Disabilities","ror":"https://ror.org/021asz590","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lorenzo D. Botto","raw_affiliation_strings":["National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA. LBotto@cdc.gov","National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA. LBotto@cdc.gov","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210109585"]},{"raw_affiliation_string":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210109585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033912023","display_name":"Joseph Mulinare","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210109585","display_name":"National Center on Birth Defects and Developmental Disabilities","ror":"https://ror.org/021asz590","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Mulinare","raw_affiliation_strings":["National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210109585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089338889","display_name":"Jon D. Erickson","orcid":"https://orcid.org/0000-0002-2235-7428","observed_orcids":["https://orcid.org/0000-0002-2235-7428"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210109585","display_name":"National Center on Birth Defects and Developmental Disabilities","ror":"https://ror.org/021asz590","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. David Erickson","raw_affiliation_strings":["National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210109585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043230326"],"corresponding_institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210109585"],"apc_list":{"value":4710,"currency":"USD","value_usd":4710},"apc_paid":{"value":4710,"currency":"USD","value_usd":4710},"fwci":2.7112,"has_fulltext":false,"cited_by_count":134,"citation_normalized_percentile":{"value":0.89373337,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"121A","issue":"2","first_page":"95","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.49070000648498535,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.49070000648498535,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.2070000022649765,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.12049999833106995,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.9549999833106995},{"id":"https://openalex.org/keywords/multivitamins","display_name":"multivitamins","score":0.9629999995231628},{"id":"https://openalex.org/keywords/folic-acid-supplementation","display_name":"folic acid supplementation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/prenatal-supplementation","display_name":"prenatal supplementation","score":0.75},{"id":"https://openalex.org/keywords/primary-prevention","display_name":"primary prevention","score":0.7009999752044678},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.5550000071525574},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.5720000267028809},{"id":"https://openalex.org/keywords/infant-mortality","display_name":"infant mortality","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C2776551950","wikidata":"https://www.wikidata.org/wiki/Q172395","display_name":"Multivitamin","level":3,"score":0.9585816860198975},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.6783546209335327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6713529229164124},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6613904237747192},{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.6110669374465942},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.5446438789367676},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4915641248226166},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2851979434490204},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27356207370758057},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.12662643194198608},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09460288286209106},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05963131785392761}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005493","descriptor_name":"Folic Acid Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008431","descriptor_name":"Maternal-Fetal Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011295","descriptor_name":"Prenatal Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014131","descriptor_name":"Trace Elements","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014815","descriptor_name":"Vitamins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014815","descriptor_name":"Vitamins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016742","descriptor_name":"Preconception Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ajmg.a.20132","doi":"https://doi.org/10.1002/ajmg.a.20132","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajmg.a.20132","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.a.20132","source":{"id":"https://openalex.org/S180901878","display_name":"American Journal of Medical Genetics Part A","issn_l":"1552-4825","issn":["1552-4825","1552-4833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics Part A","raw_type":"journal-article"},{"id":"pmid:12910485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12910485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of medical genetics. Part A","raw_type":"Evaluation Study"}],"best_oa_location":{"id":"doi:10.1002/ajmg.a.20132","doi":"https://doi.org/10.1002/ajmg.a.20132","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajmg.a.20132","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.a.20132","source":{"id":"https://openalex.org/S180901878","display_name":"American Journal of Medical Genetics Part A","issn_l":"1552-4825","issn":["1552-4825","1552-4833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics Part A","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2097547549.pdf"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1481448793","https://openalex.org/W1567287877","https://openalex.org/W1596469699","https://openalex.org/W1971281151","https://openalex.org/W1974921279","https://openalex.org/W1981841305","https://openalex.org/W1989065382","https://openalex.org/W2023998987","https://openalex.org/W2026669806","https://openalex.org/W2030771384","https://openalex.org/W2088723297","https://openalex.org/W2095927193","https://openalex.org/W2107621321","https://openalex.org/W2116527490","https://openalex.org/W2120975932","https://openalex.org/W2128463395","https://openalex.org/W2130826341","https://openalex.org/W2144523443","https://openalex.org/W2156555817","https://openalex.org/W2159294852","https://openalex.org/W2167358139","https://openalex.org/W2321900972","https://openalex.org/W2325417132","https://openalex.org/W2325954328","https://openalex.org/W2326564641","https://openalex.org/W2616967758","https://openalex.org/W3024999629","https://openalex.org/W4206832593","https://openalex.org/W4237533794","https://openalex.org/W4290775929","https://openalex.org/W4323874430"],"related_works":["https://openalex.org/W2394950184","https://openalex.org/W7096723687","https://openalex.org/W2156555817","https://openalex.org/W1915374051","https://openalex.org/W2058778432","https://openalex.org/W1981841305","https://openalex.org/W2107057426","https://openalex.org/W4295136120","https://openalex.org/W2085974079","https://openalex.org/W2921546537"],"abstract_inverted_index":{"Congenital":[0],"heart":[1,37,62],"defects":[2,63],"are":[3,11],"among":[4],"the":[5,12,43,49,65,71],"most":[6,36],"common":[7],"congenital":[8,20],"anomalies":[9],"and":[10,53,69,73],"leading":[13],"cause":[14],"of":[15,45,51],"infant":[16],"death":[17],"due":[18],"to":[19],"anomalies.":[21,38],"Except":[22],"for":[23,35,61,77],"a":[24,58,75],"few":[25],"known":[26],"measures,":[27],"effective":[28],"primary":[29],"prevention":[30],"is":[31],"not":[32],"yet":[33],"feasible":[34],"Recent":[39],"reports":[40],"have":[41],"associated":[42],"use":[44],"multivitamin":[46],"supplements":[47],"around":[48],"time":[50],"conception":[52],"during":[54],"early":[55],"pregnancy":[56],"with":[57],"reduced":[59],"risk":[60],"in":[64,80],"offspring.":[66],"We":[67],"review":[68],"discuss":[70],"evidence":[72],"suggest":[74],"framework":[76],"further":[78],"investigation":[79],"this":[81],"area.":[82]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}