{"id":"https://openalex.org/W2097546933","doi":"https://doi.org/10.1128/iai.00410-07","title":"Functional Role of the PE Domain and Immunogenicity of the Mycobacterium tuberculosis Triacylglycerol Hydrolase LipY","display_name":"Functional Role of the PE Domain and Immunogenicity of the Mycobacterium tuberculosis Triacylglycerol Hydrolase LipY","publication_year":2007,"publication_date":"2007-10-16","ids":{"openalex":"https://openalex.org/W2097546933","doi":"https://doi.org/10.1128/iai.00410-07","mag":"2097546933","pmid":"https://pubmed.ncbi.nlm.nih.gov/17938218","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2223678"},"language":"en","primary_location":{"id":"doi:10.1128/iai.00410-07","doi":"https://doi.org/10.1128/iai.00410-07","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.00410-07","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2223678/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108357193","display_name":"Kanhu Charan Mishra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387154756","display_name":"Universit\u00e9 Montpellier 2","ror":"https://ror.org/00wh4bp03","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387154756"]},{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["FR","IN"],"is_corresponding":false,"raw_author_name":"Kanhu C. Mishra","raw_affiliation_strings":["Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India","Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Universite\u0301 de Montpellier II et I, CNRS, UMR 5235, case 107, Place Euge\u0300ne Bataillon, 34095 Montpellier Cedex 05, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Universite\u0301 de Montpellier II et I, CNRS, UMR 5235, case 107, Place Euge\u0300ne Bataillon, 34095 Montpellier Cedex 05, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387154756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082652389","display_name":"Chantal de Chastellier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chantal de Chastellier","raw_affiliation_strings":["Aix Marseille Universite\u0301, Faculte\u0301 des Sciences de Luminy, Centre d'Immunologie de Marseille-Luminy (CIML), Marseille F-13288, France","CNRS, UMR6102, Marseille F-13288, France","Inserm, U631, Marseille, F-13288, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Universite\u0301, Faculte\u0301 des Sciences de Luminy, Centre d'Immunologie de Marseille-Luminy (CIML), Marseille F-13288, France","institution_ids":["https://openalex.org/I21491767","https://openalex.org/I4210144005"]},{"raw_affiliation_string":"CNRS, UMR6102, Marseille F-13288, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210144005"]},{"raw_affiliation_string":"Inserm, U631, Marseille, F-13288, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113656109","display_name":"Narayana Yeddula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yeddula Narayana","raw_affiliation_strings":["Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067288236","display_name":"Pablo Juan Bifani","orcid":"https://orcid.org/0000-0001-9651-6439","observed_orcids":["https://orcid.org/0000-0001-9651-6439"]},"institutions":[{"id":"https://openalex.org/I4405271293","display_name":"Les Amis des Instituts Pasteur \u00e0 Bruxelles","ror":"https://ror.org/026wyqd33","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4405271293"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Pablo Bifani","raw_affiliation_strings":["Department of Molecular Pathology of Tuberculosis, Pasteur Institute, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology of Tuberculosis, Pasteur Institute, Brussels, Belgium","institution_ids":["https://openalex.org/I4405271293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024127672","display_name":"Alistair K. Brown","orcid":"https://orcid.org/0000-0003-0479-8294","observed_orcids":["https://orcid.org/0000-0003-0479-8294"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alistair K. Brown","raw_affiliation_strings":["School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016293777","display_name":"Gurdyal Singh Besra","orcid":"https://orcid.org/0000-0002-5605-0395","observed_orcids":["https://orcid.org/0000-0002-5605-0395"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gurdyal S. Besra","raw_affiliation_strings":["School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019627093","display_name":"Vishwa Mohan Katoch","orcid":"https://orcid.org/0000-0002-7892-2764","observed_orcids":["https://orcid.org/0000-0002-7892-2764"]},"institutions":[{"id":"https://openalex.org/I4210132386","display_name":"National JALMA Institute for Leprosy & Other Mycobacterial Diseases","ror":"https://ror.org/03a8gee76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210132386"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vishwa M. Katoch","raw_affiliation_strings":["National JALMA Institute for Leprosy and Other Mycobacterial Diseases (ICMR), Taj Ganj, Agra 282001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National JALMA Institute for Leprosy and Other Mycobacterial Diseases (ICMR), Taj Ganj, Agra 282001, India","institution_ids":["https://openalex.org/I4210132386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017536627","display_name":"Beenu Joshi","orcid":"https://orcid.org/0000-0002-5487-1798","observed_orcids":["https://orcid.org/0000-0002-5487-1798"]},"institutions":[{"id":"https://openalex.org/I4210132386","display_name":"National JALMA Institute for Leprosy & Other Mycobacterial Diseases","ror":"https://ror.org/03a8gee76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210132386"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Beenu Joshi","raw_affiliation_strings":["National JALMA Institute for Leprosy and Other Mycobacterial Diseases (ICMR), Taj Ganj, Agra 282001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National JALMA Institute for Leprosy and Other Mycobacterial Diseases (ICMR), Taj Ganj, Agra 282001, India","institution_ids":["https://openalex.org/I4210132386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068809657","display_name":"Kithiganahalli Narayanaswamy Balaji","orcid":"https://orcid.org/0000-0002-0006-5707","observed_orcids":["https://orcid.org/0000-0002-0006-5707"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kithiganahalli N. Balaji","raw_affiliation_strings":["Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056305582","display_name":"Laurent Kremer","orcid":"https://orcid.org/0000-0002-6604-4458","observed_orcids":["https://orcid.org/0000-0002-6604-4458"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154756","display_name":"Universit\u00e9 Montpellier 2","ror":"https://ror.org/00wh4bp03","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387154756"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Laurent Kremer","raw_affiliation_strings":["INSERM, DIMNP, Place Euge\u0300ne Bataillon, 34095 Montpellier Cedex 05, France","Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Universite\u0301 de Montpellier II et I, CNRS, UMR 5235, case 107, Place Euge\u0300ne Bataillon, 34095 Montpellier Cedex 05, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, DIMNP, Place Euge\u0300ne Bataillon, 34095 Montpellier Cedex 05, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Universite\u0301 de Montpellier II et I, CNRS, UMR 5235, case 107, Place Euge\u0300ne Bataillon, 34095 Montpellier Cedex 05, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387154756"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5056305582"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4387154756"],"apc_list":null,"apc_paid":null,"fwci":3.4435,"has_fulltext":false,"cited_by_count":145,"citation_normalized_percentile":{"value":0.92303975,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"76","issue":"1","first_page":"127","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/triacylglycerol-hydrolase","display_name":"triacylglycerol hydrolase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/pe-ppe-proteins","display_name":"PE/PPE proteins","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mycobacterium-marinum","display_name":"Mycobacterium marinum","score":0.843999981880188},{"id":"https://openalex.org/keywords/mycobacterium-smegmatis","display_name":"Mycobacterium smegmatis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cell-wall-localization","display_name":"cell wall localization","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cell-surface-localization","display_name":"cell surface localization","score":0.8640000224113464},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.8849999904632568},{"id":"https://openalex.org/keywords/immunodominant-antigens","display_name":"immunodominant antigens","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tuberculosis-immunology","display_name":"tuberculosis immunology","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.790265679359436},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6857634782791138},{"id":"https://openalex.org/C2777204207","wikidata":"https://www.wikidata.org/wiki/Q606230","display_name":"Mycobacterium smegmatis","level":4,"score":0.5809446573257446},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.570344865322113},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4974839985370636},{"id":"https://openalex.org/C2781119180","wikidata":"https://www.wikidata.org/wiki/Q508803","display_name":"Mycobacterium marinum","level":4,"score":0.4795081913471222},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.472587913274765},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.44532671570777893},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.41329169273376465},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32120564579963684},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2775163948535919},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.23433628678321838},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1269156038761139},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09263691306114197},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08003684878349304},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009163","descriptor_name":"Mycobacterium bovis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1128/iai.00410-07","doi":"https://doi.org/10.1128/iai.00410-07","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.00410-07","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmid:17938218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17938218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2223678","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2223678/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.334.5328","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.5328","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://iai.asm.org/content/76/1/127.full.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-00202869v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00202869","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Infection and Immunity, 2008, 76 (1), pp.127-40. ⟨10.1128/IAI.00410-07⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.iisc.ac.in:13050","doi":null,"is_oa":false,"landing_page_url":"http://eprints.iisc.ac.in/13050/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:nrl.northumbria.ac.uk:2133","doi":null,"is_oa":false,"landing_page_url":"http://nrl.northumbria.ac.uk/2133/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401884","display_name":"Northumbria Research Link (Northumbria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32394136","host_organization_name":"Northumbria University","host_organization_lineage":["https://openalex.org/I32394136"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/f35132ac-3289-4136-9174-942a85561864","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/f35132ac-3289-4136-9174-942a85561864","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mishra, KC, de Chastellier, C, Narayana, Y, Bifani, P, Brown, A, Besra, G, Katoch, VM, Joshi, B, Balaji, KN & Kremer, L 2008, 'Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY', Infection and Immunity, vol. 76, no. 1, pp. 127-40. https://doi.org/10.1128/IAI.00410-07","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2223678","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2223678/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W220877146","https://openalex.org/W1476520622","https://openalex.org/W1537333064","https://openalex.org/W1551684330","https://openalex.org/W1583996382","https://openalex.org/W1684260872","https://openalex.org/W1804428368","https://openalex.org/W1906780201","https://openalex.org/W1952695080","https://openalex.org/W1958432512","https://openalex.org/W1967981179","https://openalex.org/W1972851920","https://openalex.org/W1982648171","https://openalex.org/W1991988259","https://openalex.org/W1996873880","https://openalex.org/W2009010596","https://openalex.org/W2011409189","https://openalex.org/W2025187029","https://openalex.org/W2030298643","https://openalex.org/W2032610888","https://openalex.org/W2036218860","https://openalex.org/W2040558306","https://openalex.org/W2044293736","https://openalex.org/W2053867514","https://openalex.org/W2057480992","https://openalex.org/W2078290231","https://openalex.org/W2089777523","https://openalex.org/W2091859563","https://openalex.org/W2096249816","https://openalex.org/W2099932462","https://openalex.org/W2106703974","https://openalex.org/W2107650019","https://openalex.org/W2108950717","https://openalex.org/W2113111972","https://openalex.org/W2114685191","https://openalex.org/W2117936351","https://openalex.org/W2122947253","https://openalex.org/W2125173637","https://openalex.org/W2127224528","https://openalex.org/W2131705975","https://openalex.org/W2132521111","https://openalex.org/W2137614072","https://openalex.org/W2158023121","https://openalex.org/W2164848899","https://openalex.org/W2165511339","https://openalex.org/W2394596436"],"related_works":["https://openalex.org/W6981989305","https://openalex.org/W2943097986","https://openalex.org/W2102271070","https://openalex.org/W7096187185","https://openalex.org/W2954246838","https://openalex.org/W7095391840","https://openalex.org/W2148157651","https://openalex.org/W2175294007","https://openalex.org/W7097003990","https://openalex.org/W2065036180"],"abstract_inverted_index":{"PE":[0,47,89,95,118,175,233],"and":[1,10,140,155,163,216,234,242],"PPE":[2,124,147,235],"proteins":[3],"appear":[4],"to":[5,111,182],"be":[6],"important":[7],"for":[8,127,180,227],"virulence":[9],"immunopathogenicity":[11],"in":[12,57,60,64,83,98,115,132,168,220],"mycobacteria,":[13],"yet":[14],"the":[15,18,26,34,44,65,71,88,94,99,117,137,146,169,174,200,205,228],"functions":[16],"of":[17,28,55,67,74,101,130,149,189],"PE/PPE":[19],"domains":[20,236],"remain":[21],"an":[22,50],"enigma.":[23],"To":[24],"decipher":[25],"role":[27],"these":[29],"domains,":[30],"we":[31],"have":[32],"characterized":[33],"triacylglycerol":[35],"(TAG)":[36],"hydrolase":[37],"LipY":[38,56,86,102,162,215,244],"from":[39],"Mycobacterium":[40,105,133],"tuberculosis,":[41],"which":[42,116],"is":[43,120],"only":[45],"known":[46],"protein":[48,109],"expressing":[49],"enzymatic":[51],"activity.":[52,103],"The":[53],"overproduction":[54],"mycobacteria":[58,84],"resulted":[59],"a":[61,108,123,193,210,246],"significant":[62],"reduction":[63,79],"pool":[66],"TAGs,":[68],"consistent":[69],"with":[70,204],"lipase":[72,201],"activity":[73],"this":[75,78,141,183],"enzyme.":[76],"Unexpectedly,":[77],"was":[80,142,151,177,218],"more":[81],"pronounced":[82,144],"overexpressing":[85],"lacking":[87],"domain":[90,96,119,148,176],"[LipY(deltaPE)],":[91],"suggesting":[92,198],"that":[93,160,173,199,231,243],"participates":[97],"modulation":[100],"Interestingly,":[104],"marinum":[106],"contains":[107],"homologous":[110],"LipY,":[112,128],"termed":[113],"LipY(mar),":[114],"substituted":[121],"by":[122],"domain.":[125],"As":[126],"overexpression":[129],"LipY(mar)":[131,150],"smegmatis":[134],"significantly":[135],"reduced":[136],"TAG":[138],"pool,":[139],"further":[143],"when":[145],"removed.":[152],"Fractionation":[153],"studies":[154],"Western":[156],"blot":[157],"analysis":[158],"demonstrated":[159],"both":[161,232],"LipY(deltaPE)":[164,190,217],"were":[165],"mainly":[166],"present":[167],"cell":[170,194],"wall,":[171],"indicating":[172],"not":[178],"required":[179],"translocation":[181],"site.":[184],"Furthermore,":[185],"electron":[186],"microscopy":[187],"immunolabeling":[188],"clearly":[191],"showed":[192],"surface":[195],"localization,":[196],"thereby":[197],"may":[202],"interact":[203],"host":[206],"immune":[207],"system.":[208],"Accordingly,":[209],"strong":[211],"humoral":[212],"response":[213],"against":[214],"observed":[219],"tuberculosis":[221],"patients.":[222],"Together,":[223],"our":[224],"results":[225],"suggest":[226],"first":[229],"time":[230],"can":[237],"share":[238],"similar":[239],"functional":[240],"roles":[241],"represents":[245],"novel":[247],"immunodominant":[248],"antigen.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}