{"id":"https://openalex.org/W2097511413","doi":null,"title":"Effect of sodium chloride concentration on adriamycin and N-trifluoroacetyladriamycin-14-valerate (AD32)-induced cell killing and DNA damage in Chinese hamster V79 cells.","display_name":"Effect of sodium chloride concentration on adriamycin and N-trifluoroacetyladriamycin-14-valerate (AD32)-induced cell killing and DNA damage in Chinese hamster V79 cells.","publication_year":1987,"publication_date":"1987-04-01","ids":{"openalex":"https://openalex.org/W2097511413","mag":"2097511413","pmid":"https://pubmed.ncbi.nlm.nih.gov/3815376"},"language":"en","primary_location":{"id":"pmid:3815376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3815376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076541190","display_name":"George E. Iliakis","orcid":"https://orcid.org/0000-0002-1152-5342","observed_orcids":["https://orcid.org/0000-0002-1152-5342"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Iliakis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008456926","display_name":"Wendy Lazar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Lazar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.348,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.49197536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"7","first_page":"1853","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.28439998626708984,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8519999980926514},{"id":"https://openalex.org/keywords/sodium-chloride","display_name":"sodium chloride","score":0.6179999709129333},{"id":"https://openalex.org/keywords/osmotic-stress","display_name":"osmotic stress","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hypotonic-stress","display_name":"hypotonic stress","score":0.6389999985694885},{"id":"https://openalex.org/keywords/hyperosmotic-stress","display_name":"hyperosmotic stress","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cell-killing","display_name":"cell killing","score":0.5960000157356262},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9259999990463257},{"id":"https://openalex.org/keywords/drug-accumulation","display_name":"drug accumulation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/v79-cells","display_name":"V79 cells","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.550000011920929},{"id":"https://openalex.org/keywords/survivorship-curves","display_name":"survival curves","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C51296783","wikidata":"https://www.wikidata.org/wiki/Q1645498","display_name":"Microgram","level":3,"score":0.9646047353744507},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5886921882629395},{"id":"https://openalex.org/C117277713","wikidata":"https://www.wikidata.org/wiki/Q925744","display_name":"Tonicity","level":2,"score":0.5357280373573303},{"id":"https://openalex.org/C2777755551","wikidata":"https://www.wikidata.org/wiki/Q2539773","display_name":"Chinese hamster","level":3,"score":0.44493240118026733},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.42577242851257324},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.40557634830474854},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40127599239349365},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33854639530181885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2702704668045044},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2238050103187561},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1972474455833435}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:3815376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3815376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2097511413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3815376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3847940783","display_name":"ENZYMATIC MECHANISMS OF DNA DOUBLE STRAND BREAK REPAIR","funder_award_id":"R01CA042026","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W281745366","https://openalex.org/W1514525963","https://openalex.org/W1520124386","https://openalex.org/W1549176003","https://openalex.org/W1613283346","https://openalex.org/W1966827166","https://openalex.org/W1973494839","https://openalex.org/W1984864591","https://openalex.org/W2001537957","https://openalex.org/W2010511880","https://openalex.org/W2012888776","https://openalex.org/W2013733971","https://openalex.org/W2021206009","https://openalex.org/W2035215935","https://openalex.org/W2050347622","https://openalex.org/W2056168855","https://openalex.org/W2065480253","https://openalex.org/W2070707667","https://openalex.org/W2080343398","https://openalex.org/W2085729093","https://openalex.org/W2093479257","https://openalex.org/W2104016903","https://openalex.org/W2109600992","https://openalex.org/W2334435047","https://openalex.org/W2407309141"],"related_works":["https://openalex.org/W2280996027","https://openalex.org/W1799031652","https://openalex.org/W1980188577","https://openalex.org/W3199602715","https://openalex.org/W2119551409","https://openalex.org/W2122815075","https://openalex.org/W4244643037","https://openalex.org/W2095115046","https://openalex.org/W190756422","https://openalex.org/W2171219384"],"abstract_inverted_index":{"Exponentially":[0],"growing":[1],"Chinese":[2],"hamster":[3],"V79":[4],"cells":[5,50,130,170,209,225,242,341],"were":[6,116,200],"exposed":[7,111,131,194,210],"to":[8,43,51,112,119,132,181,195,203,211,218,234,241,283,291,318,342],"Adriamycin":[9,113,120,133,166,196,212,216,236,343,381],"either":[10],"in":[11,27,67,74,91,96,114,134,168,175,197,213,224,227,243,252,262,287,295,300,312,321,334,344,356,373],"phosphate":[12],"buffered":[13],"saline":[14],"(PBS)":[15],"or":[16],"fresh":[17],"growth":[18],"medium":[19,143,189],"(F-med)":[20],"supplemented":[21],"with":[22,273,376],"various":[23],"amounts":[24],"of":[25,49,150,165,186,326,340,352,359,369,379],"NaCl":[26,151,191],"the":[28,38,44,142,148,169,187,235,274,301,319,331,357],"range":[29],"between":[30],"50-1000":[31],"mM":[32,54,77,99,153,230,266],"and":[33,88,178,190,279,290,305],"survival":[34,45,302],"was":[35,70,139,144,173,179,221,248,271,281,315,354,371],"measured":[36,174],"by":[37,147,349,366],"colony":[39],"forming":[40],"assay.":[41],"Compared":[42,233],"obtained":[46,333],"after":[47,72,94,239,250,260,285,293,310,338],"exposure":[48,240,251,261,311,339],"isotonic":[52,244,335],"(140":[53],"NaCl)":[55,78,100,154,231],"PBS":[56,79,101,198,254,264,289,314],"(D0":[57,80,102,121,155],"=":[58,62,81,85,103,107,122,126,156,160],"0.16":[59],"microgram/ml,":[60,83,105,124,158],"Dq":[61,84,106,125,159],"0.49":[63],"microgram/ml)":[64,87,128],"a":[65,89,176,184,347,350,363,367],"potentiation":[66],"cell":[68,92,137,374],"killing":[69,93,138,375],"observed":[71,238,249,309,355,372],"treatment":[73,95,172,188,286,294],"hypotonic":[75,253,288,313],"(50":[76],"0.08":[82],"0.19":[86],"reduction":[90,348,364],"hypertonic":[97,146,228,263,296,345],"(500":[98,152,229,265],"0.36":[104],"0.55":[108],"microgram/ml).":[109,162],"Cells":[110,193],"F-med":[115],"more":[117],"sensitive":[118],"0.1":[123],"0.27":[127],"than":[129,208],"PBS,":[135,245,346],"but":[136,257,362],"reduced":[140],"when":[141],"made":[145],"addition":[149],"0.23":[157],"0.45":[161],"The":[163,298],"amount":[164],"accumulated":[167,223],"during":[171],"spectrophotofluorometer":[177],"found":[180,282],"vary":[182],"as":[183],"function":[185],"concentration.":[192],"(isotonic)":[199],"accumulating":[201],"three":[202,219],"four":[204],"times":[205],"less":[206],"drug":[207,323],"F-med.":[214,232],"Less":[215],"(two":[217],"times)":[220,256],"also":[222],"treated":[226],"accumulation":[237],"an":[246],"increase":[247,284],"(2.3":[255],"no":[258,377],"change":[259],"NaCl).":[267],"Adriamycin-induced":[268],"DNA":[269,306,360],"damage":[270,307,361],"assayed":[272],"alkaline":[275],"filter":[276],"elution":[277],"technique":[278],"it":[280],"decrease":[292],"PBS.":[297],"modification":[299,320,378],"curve":[303],"slope":[304],"induction":[308,358],"quantitatively":[316],"similar":[317],"intracellular":[322,380],"concentration":[324],"(factor":[325],"2.3,":[327],"comparison":[328],"based":[329],"on":[330],"results":[332],"PBS).":[336],"However,":[337],"factor":[351,368],"20":[353],"only":[365],"2.3":[370],"concentration.(ABSTRACT":[382],"TRUNCATED":[383],"AT":[384],"400":[385],"WORDS)":[386]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}