{"id":"https://openalex.org/W2097363073","doi":null,"title":"Immunization against spontaneous and autografted mouse mammary carcinomas in the autochthonous C3H-Crgl mouse.","display_name":"Immunization against spontaneous and autografted mouse mammary carcinomas in the autochthonous C3H-Crgl mouse.","publication_year":1969,"publication_date":"1969-11-01","ids":{"openalex":"https://openalex.org/W2097363073","mag":"2097363073","pmid":"https://pubmed.ncbi.nlm.nih.gov/5358209"},"language":"en","primary_location":{"id":"pmid:5358209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5358209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019457485","display_name":"Jan Vaage","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Vaage","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005085659","display_name":"David Walter Weiss","orcid":"https://orcid.org/0000-0002-3253-8441","observed_orcids":["https://orcid.org/0000-0002-3253-8441"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D W Weiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0528,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.74631896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"11","first_page":"1920","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mammary-tumor-virus","display_name":"mammary tumor virus","score":0.6200000047683716},{"id":"https://openalex.org/keywords/cancer-vaccination","display_name":"cancer vaccination","score":0.6940000057220459},{"id":"https://openalex.org/keywords/liver-preparations","display_name":"liver preparations","score":0.3540000021457672},{"id":"https://openalex.org/keywords/tumor-antigens","display_name":"tumor antigens","score":0.7120000123977661},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7129999995231628},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.3799999952316284},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.3199999928474426}],"concepts":[{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.5975745916366577},{"id":"https://openalex.org/C2994001847","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Mammary carcinoma","level":3,"score":0.5909475088119507},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4782901406288147},{"id":"https://openalex.org/C2780635560","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Neoplasm","level":2,"score":0.45621055364608765},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42120349407196045},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3761942386627197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28681159019470215},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2587718963623047},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.13465729355812073}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014020","descriptor_name":"Tissue Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014181","descriptor_name":"Transplantation Immunology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:5358209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5358209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1969-2421","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1969/1422","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1969","raw_type":"text"},{"id":"mag:2097363073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5358209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W252815649","https://openalex.org/W1508332747","https://openalex.org/W1508370257","https://openalex.org/W1512491817","https://openalex.org/W1542318439","https://openalex.org/W1555296713","https://openalex.org/W1573968193","https://openalex.org/W1592224632","https://openalex.org/W1595512435","https://openalex.org/W1966548797","https://openalex.org/W1989837810","https://openalex.org/W2019855795","https://openalex.org/W2020590572","https://openalex.org/W2024344753","https://openalex.org/W2114451595","https://openalex.org/W2121466275","https://openalex.org/W2124795073","https://openalex.org/W2128142072","https://openalex.org/W2273705231","https://openalex.org/W2292493336","https://openalex.org/W2428939892","https://openalex.org/W2464113033","https://openalex.org/W2992708729"],"related_works":["https://openalex.org/W1751152825","https://openalex.org/W1898163120","https://openalex.org/W2992708729","https://openalex.org/W2128142072","https://openalex.org/W1539437156","https://openalex.org/W2116191663","https://openalex.org/W2165866041","https://openalex.org/W1557731407","https://openalex.org/W1947921571","https://openalex.org/W7098262821"],"abstract_inverted_index":{"JanVaageandDavidW.Weiss2CancerResearchGeneticsLaboratoryandDepartmentofBacteriologyandImmunology,UniversityofCalifornia,Berkeley,California94720SUMMARYIntwoseparateexperimentswithC3H/Crglmicebearingautochthonous,mammarytumorvirus-inducedtumorsinsitu,orasheterotopicautografts,itwasfoundthatinjectionofanirradiatedorfree/e-thawedpreparationofabiopsysampleoftheliverofthetumorhostinterferedwiththegrowthoftheautochthonous":[0],"tumor.ImmunizationofnormalC3H/Crglmicewithliverpreparationsfromanimalsbearingisograftsofimmunogenicmammarytumorswasaseffectiveasimmunizationwithlivingtumorimplantsinpreventingthedevelopmentoftumorisograftsuponsubsequentchallenge.Liversfromnormalmiceorfrommicebearingisograftsofnonimmuno-genicmammarytumorswerenoteffective.It":[1],"issuggestedthatthislivereffectisofimmunologienatureandthattheliversoftumor-bearingmicemaycontainactivatedtumorantigens.INTRODUCTIONThefirstdirectevidenceforautochthonous":[2],"antitumoiimmunityinanexperimentalsystemwasreportedbyGeorgeKleinetal.(11).Resistancewasdemonstratedagainstmethyl-cholanthrene-inducedsarcomasinmicewhoseautochthonoustumorswerereimplantedfollowingsurgicalremovalofthetumorandaperiodofvaccinationwithirradiatedsarcomacells.Yoshida(28)reportedtheinvitroimmuneadherencebetweenspleencellsandautochthonousmethylcholanthrene-inducedsarcomacellsfromthesametumorhost.Mikulskaetal.(13)foundevidenceforimmunologieresistanceagainstautochthonousbenzopyrene-inducedsarcomasinrats,whenautograftsoftumorcellsfailedtogrowandspleencellsfromtheoriginaltumorhostinhibitedthegrowthoftumorisografts.Takedaetal.(19)reportedevidenceofimmunityinrats":[3],"against":[4],"autografts":[5],"ofmethylcholanthrene-inducedsarcomasafterexcisionoftheprimarytumor.Feferetal.(6)reportedthatregressionofvirus-inducedMoloneysarcomasin'ThisworkwassupportedbyGrantsCA-05388,CA-08357,andCA-05045fromtheNationalCancerInstitute,NIH,andbyGrantE344fromtheAmericanCancerSociety.Presentaddress:DepartmentofImmunology,HadassahMedicalSchool,HebrewUniversity,Jerusalem,Israel.ReceivedJanuary15,1969;acceptedFebruary21,1969.micewasaccompaniedbytheproductionofneutralizingantibodiesagainsttheinducingvirusandwasfollowedbyahighlevelofresistancetochallengewithsyngeneicMoloneysarcomacells.HellstrA\u00b6metal.(8)demonstrated,withthesensitivecolonyinhibitiontechnic,thegrowth-inhibitingabilityofmouselymphnodecellsagainstautochthonousmethylcholanthrene-induced":[6],"sarcomasinvitro.Withthesamemethod(9)theyalsodetectedcellularandhumoralimmunityinmiceagainsttheirownprimarytumorsinducedbytheinoculationoftheMoloneysarcomavirus.However,theinvestigations":[7],"ofautochthonous":[8],"tumorimmunogenicityinexperimentalanimalshavebeenveryfewcomparedtotheworkdoneinsyngeneicsystems.Themainreasonforthisdisparity":[9],"thatit":[10],"usuallybothmoreexpedientandappropriatetoexperimentinasyngeneicsystemwheremultiplefactorscanbetestedsimultaneouslyinlargegroupsofanimals,Despitethegreatusefulnessofsyngeneicsystems,theultimatequestioniswhetherthehostcanmakeanimmuneresponseagainstitsownspontaneoustumor.Theanswerstothisquestionareofdirectrelevancetothehumancancerproblem.Themousemammarytumorsystemisofspecialinterestasaclinicaltestmodelbecauseithasthegeneralcharacteristicsofspontaneousneoplasms.Itisthusdifferentiatedfrommostotherexperimentaltumorsystemsandisclosertohumanformsofcancer.Themaindifferenceisthattheroleofavirusintheetiologyofthespontaneousmammarycarcinomainmiceisknown,whileaviraletiologyforsomeformsofcancerinhumanshassofaronlybeenindicated(5,7,16,17).Theantigenicityofmammarycarcinomasinducedbythemammarytumorvirus(MTV)hasalreadybeendemonstratedinsyngeneicMTV-freemice(2,4,12,14,15,23,25),aswellasinsyngeneicMTV-infectedmice(1,21,22).Thepurposeofthepresentworkwastoinvestigatetheimmunogenicityofspontaneous,MTV-inducedmammarycarcinomasinthoseMTV-infectedmiceinwhichthetumorsdeveloped,withspecialreferencetoanimmunotherapeuticapproach.MATERIALSANDMETHODSMice.AllanimalsusedintheseexperimentscamefromthebreedingcolonymaintainedbytheCancerResearchGeneticsLaboratoryoftheUniversityofCaliforniainBerkeley.The1920":[11],"CANCERRESEARCHVOL.29":[12]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
