{"id":"https://openalex.org/W2097352128","doi":"https://doi.org/10.1186/1478-811x-12-30","title":"Good guy or bad guy: the opposing roles of microRNA 125b in cancer","display_name":"Good guy or bad guy: the opposing roles of microRNA 125b in cancer","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2097352128","doi":"https://doi.org/10.1186/1478-811x-12-30","mag":"2097352128","pmid":"https://pubmed.ncbi.nlm.nih.gov/24774301","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4011766"},"language":"en","primary_location":{"id":"doi:10.1186/1478-811x-12-30","doi":"https://doi.org/10.1186/1478-811x-12-30","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1478-811x-12-30","pdf_url":"https://biosignaling.biomedcentral.com/counter/pdf/10.1186/1478-811X-12-30","source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biosignaling.biomedcentral.com/counter/pdf/10.1186/1478-811X-12-30","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024666752","display_name":"Julia Banzhaf\u2010Strathmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Julia Banzhaf-Strathmann","raw_affiliation_strings":["German Center for Neurodegenerative Diseases, Site Munich, Schillerstr, 44, 80336 Munich, Germany. julia.banzhaf@dzne.lmu.de","German Center for Neurodegenerative Diseases, Site Munich, Schillerstr. 44, Munich, 80336, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases, Site Munich, Schillerstr, 44, 80336 Munich, Germany. julia.banzhaf@dzne.lmu.de","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases, Site Munich, Schillerstr. 44, Munich, 80336, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014535603","display_name":"Dieter Edbauer","orcid":"https://orcid.org/0000-0002-7186-4653","observed_orcids":["https://orcid.org/0000-0002-7186-4653"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210113080","display_name":"Munich Cluster for Systems Neurology","ror":"https://ror.org/025z3z560","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210113080","https://openalex.org/I62916508","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4405260761","display_name":"Adolf-Butenandt-Institut f\u00fcr Physiologische Chemie, Physikalische Biochemie und Zellbiologie","ror":"https://ror.org/0480tmh03","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405260761","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dieter Edbauer","raw_affiliation_strings":["Adolf Butenandt Institute, Biochemistry, Ludwig-Maximilians University Munich, Schillerstr. 44, Munich, 80336, Germany","German Center for Neurodegenerative Diseases, Site Munich, Schillerstr. 44, Munich, 80336, Germany","Munich Cluster of Systems Neurology (SyNergy), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adolf Butenandt Institute, Biochemistry, Ludwig-Maximilians University Munich, Schillerstr. 44, Munich, 80336, Germany","institution_ids":["https://openalex.org/I4405260761","https://openalex.org/I8204097"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases, Site Munich, Schillerstr. 44, Munich, 80336, Germany","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Munich Cluster of Systems Neurology (SyNergy), Munich, Germany","institution_ids":["https://openalex.org/I4210113080"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024666752"],"corresponding_institution_ids":["https://openalex.org/I2801533059"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":2.1321,"has_fulltext":true,"cited_by_count":172,"citation_normalized_percentile":{"value":0.90670391,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"30","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-125b","display_name":"miR-125b","score":0.9070000052452087},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6890000104904175},{"id":"https://openalex.org/keywords/oncogenic-microrna","display_name":"oncogenic microRNA","score":0.8420000076293945},{"id":"https://openalex.org/keywords/tumor-suppressor-microrna","display_name":"tumor suppressor microRNA","score":0.9520000219345093},{"id":"https://openalex.org/keywords/microrna-target-genes","display_name":"miRNA target genes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.6639999747276306},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hematopoietic-cancers","display_name":"hematopoietic tumors","score":0.984000027179718},{"id":"https://openalex.org/keywords/mammary-tumors","display_name":"mammary tumors","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8462163209915161},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.824093222618103},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6753873229026794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6364558935165405},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6027027368545532},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5703158974647522},{"id":"https://openalex.org/C39845236","wikidata":"https://www.wikidata.org/wiki/Q7092103","display_name":"Oncomir","level":4,"score":0.5221136808395386},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32241183519363403},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17458641529083252},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17345738410949707}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/1478-811x-12-30","doi":"https://doi.org/10.1186/1478-811x-12-30","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1478-811x-12-30","pdf_url":"https://biosignaling.biomedcentral.com/counter/pdf/10.1186/1478-811X-12-30","source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2990264","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4011766","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24774301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24774301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell communication and signaling : CCS","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4011766","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4011766/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Commun Signal","raw_type":"Text"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:22889","doi":null,"is_oa":false,"landing_page_url":"https://epub.ub.uni-muenchen.de/22889/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Communication and Signaling","raw_type":"doc-type:article"},{"id":"pmh:oai:pub.dzne.de:137381","doi":null,"is_oa":true,"landing_page_url":"https://pub.dzne.de/search?p=id:%22DZNE-2020-03703%22","pdf_url":null,"source":{"id":"https://openalex.org/S7407051172","display_name":"DZNE Pub","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801533059","host_organization_name":"German Center for Neurodegenerative Diseases","host_organization_lineage":["https://openalex.org/I2801533059"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell communication and signaling 12(1), 30 (2014). doi:10.1186/1478-811X-12-30","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1478-811x-12-30","doi":"https://doi.org/10.1186/1478-811x-12-30","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1478-811x-12-30","pdf_url":"https://biosignaling.biomedcentral.com/counter/pdf/10.1186/1478-811X-12-30","source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2097352128.pdf","grobid_xml":"https://content.openalex.org/works/W2097352128.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W84886273","https://openalex.org/W1533076763","https://openalex.org/W1558175729","https://openalex.org/W1663251599","https://openalex.org/W1963953467","https://openalex.org/W1971806005","https://openalex.org/W1972434476","https://openalex.org/W1972989638","https://openalex.org/W1975167804","https://openalex.org/W1977588066","https://openalex.org/W1977808594","https://openalex.org/W1988389975","https://openalex.org/W1990958957","https://openalex.org/W1991663093","https://openalex.org/W1992497308","https://openalex.org/W1996956937","https://openalex.org/W1997421768","https://openalex.org/W2002995168","https://openalex.org/W2004462371","https://openalex.org/W2004503198","https://openalex.org/W2006920657","https://openalex.org/W2008095421","https://openalex.org/W2008326956","https://openalex.org/W2014177368","https://openalex.org/W2015088673","https://openalex.org/W2018532884","https://openalex.org/W2020206637","https://openalex.org/W2028747625","https://openalex.org/W2030166934","https://openalex.org/W2030888171","https://openalex.org/W2033969079","https://openalex.org/W2034269086","https://openalex.org/W2036752075","https://openalex.org/W2037876982","https://openalex.org/W2037902495","https://openalex.org/W2038940805","https://openalex.org/W2040204759","https://openalex.org/W2040534118","https://openalex.org/W2041630873","https://openalex.org/W2042316019","https://openalex.org/W2042673698","https://openalex.org/W2045228008","https://openalex.org/W2046959378","https://openalex.org/W2048603557","https://openalex.org/W2054336427","https://openalex.org/W2055313665","https://openalex.org/W2062378348","https://openalex.org/W2063217394","https://openalex.org/W2065552057","https://openalex.org/W2069540657","https://openalex.org/W2070328448","https://openalex.org/W2079251691","https://openalex.org/W2085784456","https://openalex.org/W2090196938","https://openalex.org/W2090453278","https://openalex.org/W2092113020","https://openalex.org/W2101314927","https://openalex.org/W2103151642","https://openalex.org/W2108966286","https://openalex.org/W2109377963","https://openalex.org/W2117391818","https://openalex.org/W2117692326","https://openalex.org/W2128520557","https://openalex.org/W2130423812","https://openalex.org/W2131441612","https://openalex.org/W2133763262","https://openalex.org/W2134055438","https://openalex.org/W2135613885","https://openalex.org/W2138664009","https://openalex.org/W2143377286","https://openalex.org/W2143939772","https://openalex.org/W2147346646","https://openalex.org/W2148340578","https://openalex.org/W2150536104","https://openalex.org/W2152122421","https://openalex.org/W2158207797","https://openalex.org/W2158556487","https://openalex.org/W2160322468","https://openalex.org/W2160467221","https://openalex.org/W2161693225","https://openalex.org/W2166430233","https://openalex.org/W2168314151","https://openalex.org/W2168859271","https://openalex.org/W2330357251","https://openalex.org/W3023299375","https://openalex.org/W3145571634","https://openalex.org/W4210582839"],"related_works":["https://openalex.org/W2384078320","https://openalex.org/W3111032171","https://openalex.org/W4399059266","https://openalex.org/W2002746037","https://openalex.org/W2113988296","https://openalex.org/W7099842917","https://openalex.org/W3180366563","https://openalex.org/W1781739971","https://openalex.org/W7097127832","https://openalex.org/W3149933729"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"are":[2,124,166],"a":[3,17,43,52],"class":[4],"of":[5,14,35,55,108,132,150,181,198,204],"non-coding":[6],"RNAs":[7],"that":[8,27,47,173,190],"post-transcriptionally":[9],"silence":[10],"target":[11,164,182],"mRNAs.":[12],"Dysregulation":[13],"miRNAs":[15],"is":[16,38,42,48,68,99,104],"frequent":[18],"event":[19],"in":[20,32,51,88,138,160,209],"several":[21,144,188],"diseases,":[22],"including":[23],"cancer.":[24],"One":[25],"miRNA":[26,46],"has":[28],"gained":[29],"special":[30],"interest":[31],"the":[33,83,129,147,179,202],"field":[34],"cancer":[36,63],"research":[37],"miRNA-125b":[39],"(miR-125b).":[40],"MiR-125b":[41],"ubiquitously":[44],"expressed":[45,50],"aberrantly":[49],"great":[53],"variety":[54],"tumors.":[56],"In":[57,86],"some":[58],"tumor":[59,90,140,169,205,211],"types,":[60],"e.g.":[61,92],"colon":[62],"and":[64,70,79,95,111,134,142,168],"hematopoietic":[65],"tumors,":[66],"miR-125b":[67,98,133,152,176,191,199,216],"upregulated":[69],"displays":[71],"oncogenic":[72,194],"potential,":[73],"as":[74],"it":[75],"induces":[76],"cell":[77],"growth":[78],"proliferation,":[80],"while":[81,196],"blocking":[82],"apoptotic":[84],"machinery.":[85],"contrast,":[87],"other":[89],"entities,":[91],"mammary":[93],"tumors":[94],"hepatocellular":[96],"carcinoma,":[97],"heavily":[100],"downregulated.":[101],"This":[102],"downregulation":[103,197],"accompanied":[105],"by":[106,175],"de-repression":[107],"cellular":[109],"proliferation":[110],"anti-apoptotic":[112],"programs,":[113],"contributing":[114],"to":[115,201,220],"malignant":[116],"transformation.":[117],"The":[118],"reasons":[119],"for":[120,146],"these":[121],"opposing":[122,148],"roles":[123,149],"poorly":[125],"understood.":[126],"We":[127],"summarize":[128],"current":[130],"knowledge":[131],"its":[135],"relevant":[136],"targets":[137,153],"different":[139,210],"types":[141],"offer":[143],"hypotheses":[145],"miR-125b:":[151],"multiple":[154],"mRNAs,":[155],"which":[156],"have":[157],"diverse":[158],"functions":[159],"individual":[161],"tissues.":[162],"These":[163],"mRNAs":[165],"tissue":[167],"specifically":[170],"expressed,":[171],"suggesting":[172],"misregulation":[174],"depends":[177],"on":[178],"levels":[180],"gene":[183],"expression.":[184],"Moreover,":[185],"we":[186],"provide":[187],"examples":[189],"upregulation":[192],"dictates":[193],"characteristics,":[195],"corresponds":[200],"loss":[203],"suppressive":[206],"functions.":[207],"Thus,":[208],"entities":[212],"increased":[213],"or":[214],"decreased":[215],"expression":[217],"may":[218],"contribute":[219],"carcinogenesis.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}