{"id":"https://openalex.org/W2097345834","doi":"https://doi.org/10.1086/587900","title":"Long\u2010Term Effects of Highly Active Antiretroviral Therapy on CD4+Cell Evolution among Children and Adolescents Infected with HIV: 5 Years and Counting","display_name":"Long\u2010Term Effects of Highly Active Antiretroviral Therapy on CD4+Cell Evolution among Children and Adolescents Infected with HIV: 5 Years and Counting","publication_year":2008,"publication_date":"2008-04-22","ids":{"openalex":"https://openalex.org/W2097345834","doi":"https://doi.org/10.1086/587900","mag":"2097345834","pmid":"https://pubmed.ncbi.nlm.nih.gov/18426371","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3154876"},"language":"en","primary_location":{"id":"doi:10.1086/587900","doi":"https://doi.org/10.1086/587900","is_oa":true,"landing_page_url":"https://doi.org/10.1086/587900","pdf_url":"https://academic.oup.com/cid/article-pdf/46/11/1751/1069627/46-11-1751.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/cid/article-pdf/46/11/1751/1069627/46-11-1751.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108114376","display_name":"Kunjal Patel","orcid":"https://orcid.org/0000-0003-0002-681X","observed_orcids":["https://orcid.org/0000-0003-0002-681X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kunjal Patel","raw_affiliation_strings":["Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kpatel@hsph.harvard.edu","Center for Biostatistics in AIDS Research, Boston","Department of Epidemiology, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kpatel@hsph.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Center for Biostatistics in AIDS Research, Boston","institution_ids":[]},{"raw_affiliation_string":"Department of Epidemiology, Boston","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084268825","display_name":"Miguel \u00c1ngel Hern\u00e1n","orcid":"https://orcid.org/0000-0003-1619-8456","observed_orcids":["https://orcid.org/0000-0003-1619-8456"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel\u00a0A. Hern\u00e1n","raw_affiliation_strings":["Department of Epidemiology, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Boston","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030452461","display_name":"Paige L. Williams","orcid":"https://orcid.org/0000-0002-7160-574X","observed_orcids":["https://orcid.org/0000-0002-7160-574X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paige\u00a0L. Williams","raw_affiliation_strings":["Center for Biostatistics in AIDS Research, Boston","Department of Biostatistics, Harvard School of Public Health, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biostatistics in AIDS Research, Boston","institution_ids":[]},{"raw_affiliation_string":"Department of Biostatistics, Harvard School of Public Health, Boston","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002078534","display_name":"John D. Seeger","orcid":"https://orcid.org/0000-0002-8020-3144","observed_orcids":["https://orcid.org/0000-0002-8020-3144"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John\u00a0D. Seeger","raw_affiliation_strings":["i3 Drug Safety, Auburndale, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3 Drug Safety, Auburndale, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018848119","display_name":"Kenneth McIntosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth McIntosh","raw_affiliation_strings":["Harvard Medical School, Children's Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Children's Hospital, Boston","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110208645","display_name":"Russell B. Van Dyke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell\u00a0B.\u00a0Van Dyke","raw_affiliation_strings":["Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002712707","display_name":"George R. Seage","orcid":"https://orcid.org/0000-0001-5657-2970","observed_orcids":["https://orcid.org/0000-0001-5657-2970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George\u00a0R. Seage III","raw_affiliation_strings":["Center for Biostatistics in AIDS Research, Boston","Department of Epidemiology, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biostatistics in AIDS Research, Boston","institution_ids":[]},{"raw_affiliation_string":"Department of Epidemiology, Boston","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108114376"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":6.0115,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.96443182,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"46","issue":"11","first_page":"1751","last_page":"1760"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.35010001063346863,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.10000000149011612,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.9620000123977661},{"id":"https://openalex.org/keywords/pediatric-hiv","display_name":"pediatric HIV","score":0.75},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.8080000281333923},{"id":"https://openalex.org/keywords/perinatal-hiv-infection","display_name":"perinatal HIV infection","score":0.7789999842643738},{"id":"https://openalex.org/keywords/severe-immunosuppression","display_name":"severe immunosuppression","score":0.8019999861717224},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/non-nucleoside-reverse-transcriptase-inhibitors","display_name":"non-nucleoside reverse transcriptase inhibitors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/treatment-initiation-timing","display_name":"treatment initiation timing","score":0.5509999990463257},{"id":"https://openalex.org/keywords/marginal-structural-models","display_name":"marginal structural models","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8394083976745605},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.7817071080207825},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.6390906572341919},{"id":"https://openalex.org/C2776452011","wikidata":"https://www.wikidata.org/wiki/Q311463","display_name":"Sida","level":4,"score":0.6104958653450012},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5194272994995117},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5125164985656738},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5109278559684753},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.4995555877685547},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.49092963337898254},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.4590955376625061},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.43549472093582153},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.4285764694213867},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.40568968653678894},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.3813619911670685},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30463552474975586},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.11233788728713989}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013995","descriptor_name":"Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D018445","descriptor_name":"Infectious Disease Transmission, Vertical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1086/587900","doi":"https://doi.org/10.1086/587900","is_oa":true,"landing_page_url":"https://doi.org/10.1086/587900","pdf_url":"https://academic.oup.com/cid/article-pdf/46/11/1751/1069627/46-11-1751.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:18426371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18426371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2161188","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3154876","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3154876","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3154876","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1086/587900","doi":"https://doi.org/10.1086/587900","is_oa":true,"landing_page_url":"https://doi.org/10.1086/587900","pdf_url":"https://academic.oup.com/cid/article-pdf/46/11/1751/1069627/46-11-1751.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2309195745","display_name":"Statistical and Data Management Center-Pediatric,Adolescent, and Maternal CTG","funder_award_id":"U01AI068616","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2655221040","display_name":"General Clinical Research Center","funder_award_id":"M01RR006192","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3527324634","display_name":"Miami Treatment and Prevention Clinical Trials Unit (CTU)","funder_award_id":"UM1AI069477","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5252127659","display_name":"Integrated University of Puerto Rico Clinical Trials Unit","funder_award_id":"UM1AI069415","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6086077386","display_name":"International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group","funder_award_id":"U01AI068632","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7437516314","display_name":"Statistical/Data Management Center-Pediatric AIDS CTG","funder_award_id":"U01AI041110","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000898900","display_name":"Biostatistics/Epidemiology Training Grants in AIDS","funder_award_id":"T32AI007358","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2097345834.pdf","grobid_xml":"https://content.openalex.org/works/W2097345834.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1484620035","https://openalex.org/W1494122660","https://openalex.org/W1965152590","https://openalex.org/W1965153851","https://openalex.org/W1971771720","https://openalex.org/W1978209044","https://openalex.org/W1984834713","https://openalex.org/W1989307265","https://openalex.org/W1991351220","https://openalex.org/W2009187570","https://openalex.org/W2012377587","https://openalex.org/W2018122569","https://openalex.org/W2020178995","https://openalex.org/W2023841615","https://openalex.org/W2025937041","https://openalex.org/W2034385594","https://openalex.org/W2039293710","https://openalex.org/W2043122232","https://openalex.org/W2045322466","https://openalex.org/W2050363797","https://openalex.org/W2053286376","https://openalex.org/W2060513447","https://openalex.org/W2060621425","https://openalex.org/W2064154402","https://openalex.org/W2093979189","https://openalex.org/W2102155948","https://openalex.org/W2102323094","https://openalex.org/W2116258000","https://openalex.org/W2117740478","https://openalex.org/W2120110886","https://openalex.org/W2127300645","https://openalex.org/W2132845988","https://openalex.org/W2134482312","https://openalex.org/W2146676275","https://openalex.org/W2159943759","https://openalex.org/W2166061477","https://openalex.org/W2170988154","https://openalex.org/W2174240998","https://openalex.org/W2253217407","https://openalex.org/W2318180004","https://openalex.org/W2416652115","https://openalex.org/W4247917425"],"related_works":["https://openalex.org/W2126952925","https://openalex.org/W7099008947","https://openalex.org/W1991061977","https://openalex.org/W2064154402","https://openalex.org/W1758596381","https://openalex.org/W2102323094","https://openalex.org/W2060523822","https://openalex.org/W1987876529","https://openalex.org/W2285896198","https://openalex.org/W1991841269"],"abstract_inverted_index":{"BACKGROUND:":[0],"Lower":[1],"percentages":[2,60],"of":[3,30,108,136,139,158,172,206,218,231,242,256,265],"CD4(+)":[4,23,47,58,121,142,164,195,212,244],"T":[5],"lymphocytes":[6],"are":[7,50],"associated":[8,260],"with":[9,18,28,63,77,111,116,174,202,261],"adverse":[10,258],"clinical":[11],"outcomes":[12],"among":[13,200],"children":[14,62,72,201,234],"and":[15,52,73,95,114],"adolescents":[16,74],"infected":[17,76],"human":[19],"immunodeficiency":[20],"virus":[21],"(HIV).":[22],"lymphocyte":[24],"percentage":[25,49,144,166,197,214],"generally":[26],"increases":[27,45,162,183,193],"receipt":[29],"highly":[31],"active":[32],"antiretroviral":[33],"therapy":[34],"(HAART),":[35],"but":[36],"long-term":[37,240],"follow-up":[38],"is":[39],"required":[40],"to":[41,56,128,156],"assess":[42],"whether":[43,53],"these":[44,175],"in":[46,61,82,151,163,194,233],"cell":[48,59,122,143,165,196,213,245],"maintained":[51],"they":[54],"lead":[55],"normal":[57,223,243],"severe":[64,236],"immunosuppression.":[65],"METHODS:":[66],"The":[67,160],"study":[68,88,102,227],"population":[69],"included":[70],"1236":[71],"perinatally":[75],"HIV":[78],"who":[79,96],"were":[80,97,178,198],"enrolled":[81],"a":[83,203],"US-based":[84],"multicenter":[85],"prospective":[86],"cohort":[87],"(Pediatric":[89],"AIDS":[90],"Clinical":[91],"Trials":[92],"Group":[93],"219/219C)":[94],"not":[98,221],"receiving":[99],"HAART":[100,110,115,140,219,232],"at":[101,208],"initiation.":[103,190],"We":[104],"estimated":[105],"the":[106,152,169,210,229,254,262],"effects":[107],"HAART,":[109],"protease":[112],"inhibitors,":[113],"nonnucleoside":[117],"reverse-transcriptase":[118],"inhibitors":[119],"on":[120],"percentage,":[123],"using":[124],"marginal":[125],"structural":[126],"models":[127],"account":[129],"for":[130,186,239],"confounding":[131],"by":[132,145,180],"severity.":[133],"RESULTS:":[134],"Initiation":[135],"any":[137],"type":[138],"increased":[141],"2.34%":[146],"(95%":[147],"confidence":[148],"interval,":[149],"1.35%-3.33%)":[150],"first":[153,170],"year,":[154],"relative":[155],"noninitiation":[157],"HAART.":[159],"substantial":[161],"observed":[167,199],"after":[168,189,215],"year":[171],"experience":[173],"combination":[176],"therapies":[177],"followed":[179],"relatively":[181],"smaller":[182],"that":[184],"continued":[185],"5":[187,216],"years":[188,217],"Although":[191],"larger":[192],"greater":[204],"degree":[205],"immunosuppression":[207,237],"baseline,":[209],"mean":[211],"did":[220],"reach":[222],"levels.":[224],"CONCLUSIONS:":[225],"Our":[226],"supports":[228],"initiation":[230],"before":[235],"occurs":[238],"maintenance":[241],"percentages.":[246],"This":[247],"beneficial":[248],"result":[249],"must":[250],"be":[251],"weighed":[252],"against":[253],"evidence":[255],"potential":[257],"events":[259],"prolonged":[263],"use":[264],"such":[266],"therapy.":[267]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
