{"id":"https://openalex.org/W2097312477","doi":"https://doi.org/10.1097/01.asn.0000138233.78329.4e","title":"Increased Endothelin Activity Mediates Augmented Distal Nephron Acidification Induced by Dietary Protein","display_name":"Increased Endothelin Activity Mediates Augmented Distal Nephron Acidification Induced by Dietary Protein","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W2097312477","doi":"https://doi.org/10.1097/01.asn.0000138233.78329.4e","mag":"2097312477","pmid":"https://pubmed.ncbi.nlm.nih.gov/15339976"},"language":"en","primary_location":{"id":"doi:10.1097/01.asn.0000138233.78329.4e","doi":"https://doi.org/10.1097/01.asn.0000138233.78329.4e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.asn.0000138233.78329.4e","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1473158","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108205782","display_name":"Apurv Khanna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Apurv Khanna","raw_affiliation_strings":["Texas Tech University Health Sciences Center, Renal Section, 3601 Fourth Street, Lubbock, TX 79430, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Tech University Health Sciences Center, Renal Section, 3601 Fourth Street, Lubbock, TX 79430, USA","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029844807","display_name":"Jane M. Simoni","orcid":"https://orcid.org/0000-0002-8711-1576","observed_orcids":["https://orcid.org/0000-0002-8711-1576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Simoni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009465061","display_name":"Callenda Hacker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Callenda Hacker","raw_affiliation_strings":["Texas Tech University Health Sciences Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Tech University Health Sciences Center","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marie-Jose[Combining Acute Accent]e Duran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie-Jose[Combining Acute Accent]e Duran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019935894","display_name":"Donald E. Wesson","orcid":"https://orcid.org/0009-0007-7952-7401","observed_orcids":["https://orcid.org/0009-0007-7952-7401"]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald E. Wesson","raw_affiliation_strings":["Texas Tech University Health Sciences Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Tech University Health Sciences Center","institution_ids":["https://openalex.org/I926076166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8749,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.86428748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"9","first_page":"2266","last_page":"2275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dietary-protein","display_name":"dietary protein","score":0.7689999938011169},{"id":"https://openalex.org/keywords/renal-bicarbonate-reabsorption","display_name":"renal bicarbonate reabsorption","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hydrogen-ion-secretion","display_name":"hydrogen ion secretion","score":0.7940000295639038},{"id":"https://openalex.org/keywords/na-h-exchange","display_name":"Na+/H+ exchange","score":0.9319999814033508},{"id":"https://openalex.org/keywords/h-atpase","display_name":"H+-ATPase","score":0.972000002861023},{"id":"https://openalex.org/keywords/h-k-atpase","display_name":"H+/K+-ATPase","score":0.8960000276565552},{"id":"https://openalex.org/keywords/bosentan","display_name":"bosentan","score":0.8240000009536743},{"id":"https://openalex.org/keywords/high-protein-diet","display_name":"high-protein diet","score":0.6629999876022339},{"id":"https://openalex.org/keywords/renal-acid-base-balance","display_name":"renal acid-base balance","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.7436920404434204},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7289371490478516},{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.7255812287330627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6965875625610352},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6790375709533691},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.5334684252738953},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5149227380752563},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4854036271572113},{"id":"https://openalex.org/C2778577996","wikidata":"https://www.wikidata.org/wiki/Q2307492","display_name":"Renal cortex","level":3,"score":0.45628035068511963},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4517100751399994},{"id":"https://openalex.org/C161457703","wikidata":"https://www.wikidata.org/wiki/Q3317402","display_name":"Renal physiology","level":3,"score":0.435600221157074},{"id":"https://openalex.org/C2779539245","wikidata":"https://www.wikidata.org/wiki/Q1428362","display_name":"Metabolic alkalosis","level":2,"score":0.4306837022304535},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27391111850738525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19856572151184082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16716846823692322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11181211471557617},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004044","descriptor_name":"Dietary Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009399","descriptor_name":"Nephrons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/01.asn.0000138233.78329.4e","doi":"https://doi.org/10.1097/01.asn.0000138233.78329.4e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.asn.0000138233.78329.4e","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:297316","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1473158","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:15339976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15339976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology : JASN","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:297316","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1473158","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1825874823","https://openalex.org/W1910386836","https://openalex.org/W1978772278","https://openalex.org/W1982187499","https://openalex.org/W2005356697","https://openalex.org/W2012497346","https://openalex.org/W2016739244","https://openalex.org/W2017689959","https://openalex.org/W2026567508","https://openalex.org/W2039420647","https://openalex.org/W2043667186","https://openalex.org/W2063570717","https://openalex.org/W2076644187","https://openalex.org/W2086726580","https://openalex.org/W2134812217","https://openalex.org/W2148532557","https://openalex.org/W2150908752","https://openalex.org/W2172140066","https://openalex.org/W2266182493","https://openalex.org/W2285733453","https://openalex.org/W2398132370","https://openalex.org/W2409887329","https://openalex.org/W2412121734","https://openalex.org/W2414304497","https://openalex.org/W2427244273","https://openalex.org/W2467325257","https://openalex.org/W2467927451"],"related_works":["https://openalex.org/W2141438558","https://openalex.org/W2106947836","https://openalex.org/W2428037793","https://openalex.org/W2346012389","https://openalex.org/W2017689959","https://openalex.org/W2172140066","https://openalex.org/W2030530251","https://openalex.org/W2369910057","https://openalex.org/W2078671471","https://openalex.org/W102131595"],"abstract_inverted_index":{"The":[0,221],"hypothesis":[1],"that":[2,22,112,233,254],"increased":[3,113,154,237],"dietary":[4,248],"protein":[5,249],"augments":[6,250],"distal":[7,48,166,238,251],"nephron":[8,49,167,239,252],"acidification":[9,253],"and":[10,30,90,122,147,204,242,264],"does":[11],"so":[12],"through":[13,257],"an":[14,160,258],"endothelin":[15],"(ET-1)-dependent":[16],"mechanism":[17],"was":[18,116],"tested.":[19],"Munich-Wistar":[20],"rats":[21],"ate":[23],"minimum":[24],"electrolyte":[25],"diets":[26],"of":[27,73,135,187],"50%":[28],"(HiPro)":[29],"20%":[31],"(CON)":[32],"casein-provided":[33],"protein,":[34],"the":[35,236],"latter":[36],"comparable":[37],"to":[38,143],"standard":[39],"diet,":[40],"were":[41],"compared.":[42],"HiPro":[43,129,229],"versus":[44,60,80,97,130,174,194,211],"CON":[45,131],"had":[46,132,224],"higher":[47,74,133,205],"net":[50,168],"HCO(3)":[51,92,169,206],"reabsorption":[52,170],"by":[53,118],"in":[54,145,228,245,261],"vivo":[55],"microperfusion":[56],"(37.8":[57],"+/-":[58,62,78,82,95,99,172,176,192,196,209,213],"3.2":[59,177],"16.6":[61],"1.5":[63],"pmol/mm":[64,84,101,178,198,215],"per":[65,85,102,179,199,216],"min;":[66,86,103,180,200,217],"P":[67,87,104,181,201,218],"<":[68,88,105,182,202,219],"0.001)":[69,183],"as":[70,184],"a":[71,185],"result":[72,186],"H(+)":[75,109,114,189,222],"secretion":[76,93,115,190,207],"(41.3":[77],"4.0":[79,197],"23.0":[81],"2.1":[83],"0.002)":[89],"lower":[91,188],"(-3.5":[94],"0.4":[96,214],"-6.4":[98],"0.8":[100],"0.001).":[106],"Perfusion":[107],"with":[108,153],"inhibitors":[110,223],"support":[111],"mediated":[117,235,256],"augmented":[119,126],"Na(+)/H(+)":[120,240,262],"exchange":[121,241,263],"H(+)-ATPase":[123,243,265],"activity":[124,244],"without":[125],"H(+),K(+)-ATPase":[127],"activity.":[128,266],"levels":[134],"urine":[136],"ET-1":[137,141,150,156],"excretion,":[138],"renal":[139,148,155],"cortical":[140,149],"addition":[142],"microdialysate":[144],"vivo,":[146],"mRNA,":[151],"consistent":[152],"production.":[157],"Oral":[158],"bosentan,":[159,231],"ET":[161,234],"A/B":[162],"receptor":[163],"antagonist,":[164],"decreased":[165],"(22.4":[171],"1.9":[173],"37.8":[175],"(28.4":[191],"2.4":[193],"41.3":[195],"0.016)":[203],"(-6.0":[208],"0.7":[210],"-3.5":[212],"0.006).":[220],"no":[225],"additional":[226],"effect":[227],"ingesting":[230],"supporting":[232],"HiPro.":[246],"Increased":[247],"is":[255],"ET-sensitive":[259],"increase":[260]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
