{"id":"https://openalex.org/W2097271293","doi":"https://doi.org/10.1177/2045125314560740","title":"Characteristics of bipolar disorder patients treated with immediate- and extended-release quetiapine in a real clinical setting: a longitudinal, cohort study of 1761 patients","display_name":"Characteristics of bipolar disorder patients treated with immediate- and extended-release quetiapine in a real clinical setting: a longitudinal, cohort study of 1761 patients","publication_year":2014,"publication_date":"2014-11-24","ids":{"openalex":"https://openalex.org/W2097271293","doi":"https://doi.org/10.1177/2045125314560740","mag":"2097271293","pmid":"https://pubmed.ncbi.nlm.nih.gov/25653826","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4315674"},"language":"en","primary_location":{"id":"doi:10.1177/2045125314560740","doi":"https://doi.org/10.1177/2045125314560740","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2045125314560740","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/2045125314560740","source":{"id":"https://openalex.org/S2765027927","display_name":"Therapeutic Advances in Psychopharmacology","issn_l":"2045-1253","issn":["2045-1253","2045-1261"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/2045125314560740","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054184978","display_name":"Andreas Carlborg","orcid":"https://orcid.org/0000-0001-9719-3045","observed_orcids":["https://orcid.org/0000-0001-9719-3045"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210099778","display_name":"Saint G\u00f6ran Hospital","ror":"https://ror.org/00x6s3a91","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210099778"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Andreas Carlborg","raw_affiliation_strings":["Department of Emergency Psychiatry, St G\u00f6rans Hospital, SE-112 81, Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Psychiatry, St G\u00f6rans Hospital, SE-112 81, Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907","https://openalex.org/I4210099778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091007028","display_name":"Marcus Thuresson","orcid":"https://orcid.org/0000-0001-5431-9365","observed_orcids":["https://orcid.org/0000-0001-5431-9365"]},"institutions":[{"id":"https://openalex.org/I4210161621","display_name":"Statisticon (Sweden)","ror":"https://ror.org/05a781r26","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210161621"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marcus Thuresson","raw_affiliation_strings":["Statisticon AB, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statisticon AB, Uppsala, Sweden","institution_ids":["https://openalex.org/I4210161621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044617128","display_name":"Lena Ferntoft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lena Ferntoft","raw_affiliation_strings":["AstraZeneca NordicBaltic, S\u00f6dert\u00e4lje, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca NordicBaltic, S\u00f6dert\u00e4lje, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015552621","display_name":"Johan Bodeg\u00e5rd","orcid":"https://orcid.org/0000-0001-5423-3967","observed_orcids":["https://orcid.org/0000-0001-5423-3967"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Johan Bodegard","raw_affiliation_strings":["AstraZeneca NordicBaltic, S\u00f6dert\u00e4lje, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca NordicBaltic, S\u00f6dert\u00e4lje, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":0.2375,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.60537272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"5","issue":"1","first_page":"13","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":1.0},{"id":"https://openalex.org/keywords/quetiapine","display_name":"quetiapine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/extended-release-formulation","display_name":"sustained-release formulation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/immediate-release-formulation","display_name":"immediate-release formulation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/formulation-switching","display_name":"formulation switching","score":0.7200000286102295},{"id":"https://openalex.org/keywords/antipsychotic-dose","display_name":"antipsychotic dosing","score":0.6970000267028809},{"id":"https://openalex.org/keywords/psychiatric-comorbidity","display_name":"psychiatric comorbidity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/employment","display_name":"employment","score":0.31200000643730164},{"id":"https://openalex.org/keywords/disease-burden","display_name":"disease burden","score":0.5910000205039978},{"id":"https://openalex.org/keywords/real-world-treatment-patterns","display_name":"real-world treatment patterns","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2780634440","wikidata":"https://www.wikidata.org/wiki/Q408535","display_name":"Quetiapine","level":3,"score":0.839409589767456},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.6875339150428772},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5813678503036499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.546431839466095},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5391775369644165},{"id":"https://openalex.org/C2911140283","wikidata":"https://www.wikidata.org/wiki/Q408535","display_name":"Quetiapine Fumarate","level":5,"score":0.4864466190338135},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.4104580879211426},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3957816958427429},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.37623071670532227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36120104789733887},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.35284721851348877},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.34213846921920776},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.28072962164878845},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.20898985862731934},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.1884339153766632},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1423088014125824}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1177/2045125314560740","doi":"https://doi.org/10.1177/2045125314560740","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2045125314560740","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/2045125314560740","source":{"id":"https://openalex.org/S2765027927","display_name":"Therapeutic Advances in Psychopharmacology","issn_l":"2045-1253","issn":["2045-1253","2045-1261"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Psychopharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3284145","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4315674","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4315674","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4315674","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Adv Psychopharmacol","raw_type":"Text"},{"id":"pmid:25653826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25653826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic advances in psychopharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1177/2045125314560740","doi":"https://doi.org/10.1177/2045125314560740","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2045125314560740","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/2045125314560740","source":{"id":"https://openalex.org/S2765027927","display_name":"Therapeutic Advances in Psychopharmacology","issn_l":"2045-1253","issn":["2045-1253","2045-1261"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Psychopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2097271293.pdf"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W12515863","https://openalex.org/W42852372","https://openalex.org/W1736583785","https://openalex.org/W1966865495","https://openalex.org/W1969114959","https://openalex.org/W1972982805","https://openalex.org/W1978587895","https://openalex.org/W1984344128","https://openalex.org/W1995358122","https://openalex.org/W2003490971","https://openalex.org/W2006100396","https://openalex.org/W2007513773","https://openalex.org/W2008099992","https://openalex.org/W2009915820","https://openalex.org/W2012398376","https://openalex.org/W2025326800","https://openalex.org/W2037583123","https://openalex.org/W2045018265","https://openalex.org/W2059519261","https://openalex.org/W2063598898","https://openalex.org/W2072722131","https://openalex.org/W2072728766","https://openalex.org/W2080350725","https://openalex.org/W2093305066","https://openalex.org/W2098161537","https://openalex.org/W2104870705","https://openalex.org/W2105984674","https://openalex.org/W2113635808","https://openalex.org/W2115748046","https://openalex.org/W2116693941","https://openalex.org/W2122672550","https://openalex.org/W2122710476","https://openalex.org/W2124715574","https://openalex.org/W2126230575","https://openalex.org/W2141761576","https://openalex.org/W2144476887","https://openalex.org/W2145141773","https://openalex.org/W2145491085","https://openalex.org/W2145980711","https://openalex.org/W2157430893","https://openalex.org/W2158704403","https://openalex.org/W2163241875","https://openalex.org/W2164398896","https://openalex.org/W2323680035","https://openalex.org/W4211192060","https://openalex.org/W4238215801","https://openalex.org/W4414130865"],"related_works":["https://openalex.org/W2101206650","https://openalex.org/W1972982805","https://openalex.org/W2145980711","https://openalex.org/W2067893463","https://openalex.org/W2318148631","https://openalex.org/W1978042883","https://openalex.org/W2015737546","https://openalex.org/W2323778701","https://openalex.org/W2022024713","https://openalex.org/W2073976465"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,59],"objective":[2],"of":[3,14,69,88,120,151,184,208,215,251],"this":[4],"work":[5],"was":[6,62,74,83,155,173,229],"to":[7,20,36,67,93,235,272],"study":[8,60],"characteristics":[9,228],"and":[10,22,38,52,97,125,135,162,198,218,226,246,262,279],"clinical":[11,267],"treatment":[12,271],"patterns":[13],"bipolar":[15,221,259],"disorder":[16,222,260],"(BD)":[17],"patients":[18,34,87,108,160,167,223,261],"admitted":[19,35],"hospital":[21,37],"treated":[23],"with":[24,224],"quetiapine":[25,40,171,186,216,236],"(immediate-release":[26],"[IR]":[27],"or":[28],"extended-release":[29],"[XR]":[30],"formulations).":[31],"METHODS:":[32],"BD":[33],"prescribed":[39],"IR":[41,82,101,132,144,166,181,199,219],"were":[42,109,202,233,244],"followed":[43],"by":[44],"linking":[45],"two":[46],"Swedish":[47],"nationwide":[48],"registries;":[49],"the":[50,149,195,209,256,264,274],"hospitalization":[51],"drug":[53],"dispense":[54],"registries":[55],"[ClinicalTrials.gov":[56],"identifier:":[57],"NCT01455961].":[58],"period":[61],"from":[63],"1":[64],"January":[65],"2008,":[66],"end":[68],"31":[70],"December":[71],"2011.":[72],"Data":[73],"primarily":[75],"analysed":[76],"using":[77],"descriptive":[78],"methods.":[79],"RESULTS:":[80],"Quetiapine":[81],"used":[84],"in":[85,157,164,176,194,204,220,266],"1761":[86],"whom":[89],"1303":[90],"subsequently":[91],"switched":[92,234],"XR":[94,107,159,178,196,217,237],"(switch":[95],"XR)":[96],"458":[98],"remained":[99],"on":[100],"(continuous":[102],"IR).":[103],"At":[104],"baseline,":[105],"Switch":[106],"younger":[110,245],"(-3.3":[111],"years),":[112],"more":[113],"frequently":[114],"employed":[115],"(+7.1%),":[116],"had":[117,238,247],"higher":[118,163,175,240,249],"prevalence":[119],"single":[121],"depressive":[122],"episodes":[123],"(+6.7%)":[124],"anxiety":[126],"disorders":[127,140],"(+5.8%),":[128],"lower":[129,156,185],"mean":[130],"daily":[131,170],"dose":[133,172],"(-19.3%)":[134],"fewer":[136],"medications":[137,154],"for":[138,269,276],"somatic":[139],"(-7.5%)":[141],"than":[142],"continuous":[143,165,180,200],"patients.":[145,182],"During":[146],"follow":[147],"up,":[148],"number":[150],"concomitant":[152],"psychiatric":[153,241],"switch":[158,177,197],"(-6%)":[161],"(+6%).":[168],"Mean":[169],"21%":[174],"versus":[179,206],"Prescriptions":[183],"dosages":[187],"calculated":[188],"below":[189],"50":[190],"mg":[191],"per":[192],"day":[193],"groups":[201],"seen":[203],"8%":[205],"10%":[207],"patients,":[210],"respectively.":[211],"CONCLUSIONS:":[212],"Differential":[213],"use":[214],"different":[225],"important":[227],"demonstrated.":[230],"Patients":[231],"who":[232],"a":[239,248],"disease":[242],"burden,":[243],"degree":[250],"employment.":[252],"These":[253],"differences":[254],"demonstrate":[255],"heterogeneity":[257],"among":[258],"indicate":[263],"need":[265],"practice":[268],"individualized":[270],"reduce":[273],"risk":[275],"both":[277],"patient":[278],"society":[280],"related":[281],"losses.":[282]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
