{"id":"https://openalex.org/W2097201002","doi":"https://doi.org/10.1586/14779072.2013.849572","title":"Dabigatran etexilate for thromboembolic prophylaxis in non-valvular atrial fibrillation: the RE-LY study and substudies with commentary","display_name":"Dabigatran etexilate for thromboembolic prophylaxis in non-valvular atrial fibrillation: the RE-LY study and substudies with commentary","publication_year":2013,"publication_date":"2013-10-23","ids":{"openalex":"https://openalex.org/W2097201002","doi":"https://doi.org/10.1586/14779072.2013.849572","mag":"2097201002","pmid":"https://pubmed.ncbi.nlm.nih.gov/24147516"},"language":"en","primary_location":{"id":"doi:10.1586/14779072.2013.849572","doi":"https://doi.org/10.1586/14779072.2013.849572","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14779072.2013.849572","pdf_url":null,"source":{"id":"https://openalex.org/S108504264","display_name":"Expert Review of Cardiovascular Therapy","issn_l":"1477-9072","issn":["1477-9072","1744-8344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Cardiovascular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077968800","display_name":"Jonathan W. Waks","orcid":"https://orcid.org/0000-0001-5560-5638","observed_orcids":["https://orcid.org/0000-0001-5560-5638"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan W Waks","raw_affiliation_strings":["Department of Cardiovascular Diseases, Beth Israel Deaconess Medical Center, 185 Pilgrim Avenue, Baker 4, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Diseases, Beth Israel Deaconess Medical Center, 185 Pilgrim Avenue, Baker 4, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012332896","display_name":"PETER J. ZIMETBAUM","orcid":"https://orcid.org/0000-0002-7958-7558","observed_orcids":["https://orcid.org/0000-0002-7958-7558"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter J Zimetbaum","raw_affiliation_strings":["Department of Cardiovascular Diseases, Beth Israel Deaconess Medical Center, 185 Pilgrim Avenue, Baker 4, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Diseases, Beth Israel Deaconess Medical Center, 185 Pilgrim Avenue, Baker 4, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012332896"],"corresponding_institution_ids":["https://openalex.org/I1316535847"],"apc_list":null,"apc_paid":null,"fwci":0.2267,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66922315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"11","issue":"11","first_page":"1461","last_page":"1471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dabigatran-etexilate","display_name":"dabigatran etexilate","score":0.9959999918937683},{"id":"https://openalex.org/keywords/non-valvular-atrial-fibrillation","display_name":"non-valvular atrial fibrillation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/direct-thrombin-inhibitors","display_name":"direct thrombin inhibitors","score":0.7919999957084656},{"id":"https://openalex.org/keywords/direct-oral-anticoagulants","display_name":"direct oral anticoagulants","score":0.8980000019073486},{"id":"https://openalex.org/keywords/re-ly-trial","display_name":"RE-LY trial","score":0.9359999895095825},{"id":"https://openalex.org/keywords/warfarin-comparison","display_name":"warfarin comparison","score":0.8989999890327454},{"id":"https://openalex.org/keywords/stroke-and-systemic-embolism","display_name":"stroke and systemic embolism","score":0.8730000257492065},{"id":"https://openalex.org/keywords/major-bleeding","display_name":"major bleeding","score":0.9710000157356262},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.4909999966621399},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7889999747276306},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C2778810321","wikidata":"https://www.wikidata.org/wiki/Q419345","display_name":"Dabigatran","level":4,"score":0.9819252490997314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9732990264892578},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.8618346452713013},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.8220775723457336},{"id":"https://openalex.org/C2778661090","wikidata":"https://www.wikidata.org/wiki/Q420262","display_name":"Rivaroxaban","level":4,"score":0.7657565474510193},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6441035270690918},{"id":"https://openalex.org/C2776710957","wikidata":"https://www.wikidata.org/wiki/Q5280395","display_name":"Direct thrombin inhibitor","level":5,"score":0.5996232032775879},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48284775018692017},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4820207357406616},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.468493789434433},{"id":"https://openalex.org/C2777185221","wikidata":"https://www.wikidata.org/wiki/Q275466","display_name":"Embolism","level":2,"score":0.43572238087654114},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069604","descriptor_name":"Dabigatran","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1586/14779072.2013.849572","doi":"https://doi.org/10.1586/14779072.2013.849572","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14779072.2013.849572","pdf_url":null,"source":{"id":"https://openalex.org/S108504264","display_name":"Expert Review of Cardiovascular Therapy","issn_l":"1477-9072","issn":["1477-9072","1744-8344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Cardiovascular Therapy","raw_type":"journal-article"},{"id":"pmid:24147516","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24147516","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of cardiovascular therapy","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W161992551","https://openalex.org/W1508825876","https://openalex.org/W1526262186","https://openalex.org/W1595057647","https://openalex.org/W1804375307","https://openalex.org/W1967889750","https://openalex.org/W1969667526","https://openalex.org/W1971220180","https://openalex.org/W1971941179","https://openalex.org/W1976437213","https://openalex.org/W1979251728","https://openalex.org/W1981294902","https://openalex.org/W1982179895","https://openalex.org/W1984364985","https://openalex.org/W1986637035","https://openalex.org/W1993614294","https://openalex.org/W1999468381","https://openalex.org/W2000172311","https://openalex.org/W2003081601","https://openalex.org/W2006947006","https://openalex.org/W2012154384","https://openalex.org/W2013832146","https://openalex.org/W2017922054","https://openalex.org/W2021808899","https://openalex.org/W2022219945","https://openalex.org/W2025557370","https://openalex.org/W2029758847","https://openalex.org/W2033102959","https://openalex.org/W2033104269","https://openalex.org/W2036252666","https://openalex.org/W2045093798","https://openalex.org/W2051599542","https://openalex.org/W2051910688","https://openalex.org/W2054077136","https://openalex.org/W2057308876","https://openalex.org/W2062786076","https://openalex.org/W2062946016","https://openalex.org/W2064357176","https://openalex.org/W2066777625","https://openalex.org/W2067977631","https://openalex.org/W2073015884","https://openalex.org/W2075749661","https://openalex.org/W2083035480","https://openalex.org/W2084719078","https://openalex.org/W2090513638","https://openalex.org/W2095647706","https://openalex.org/W2103053426","https://openalex.org/W2113021651","https://openalex.org/W2113446992","https://openalex.org/W2114775432","https://openalex.org/W2117712240","https://openalex.org/W2119221555","https://openalex.org/W2121394112","https://openalex.org/W2121403509","https://openalex.org/W2121519022","https://openalex.org/W2121902831","https://openalex.org/W2122667952","https://openalex.org/W2127985968","https://openalex.org/W2130909191","https://openalex.org/W2131555931","https://openalex.org/W2136489990","https://openalex.org/W2138320008","https://openalex.org/W2138482871","https://openalex.org/W2140485936","https://openalex.org/W2141889414","https://openalex.org/W2146197955","https://openalex.org/W2149989524","https://openalex.org/W2151074096","https://openalex.org/W2154658516","https://openalex.org/W2155779925","https://openalex.org/W2161876144","https://openalex.org/W2166302161","https://openalex.org/W2166603122","https://openalex.org/W2744079636","https://openalex.org/W2894541987","https://openalex.org/W4233664165","https://openalex.org/W4292280632","https://openalex.org/W4294236164"],"related_works":["https://openalex.org/W2084764579","https://openalex.org/W2587063264","https://openalex.org/W2041177841","https://openalex.org/W1521723250","https://openalex.org/W2188448900","https://openalex.org/W2127435768","https://openalex.org/W2121403509","https://openalex.org/W1979457761","https://openalex.org/W177846389","https://openalex.org/W1998231182"],"abstract_inverted_index":{"In":[0],"2010,":[1],"dabigatran":[2,61,88,115,151],"etexilate,":[3],"a":[4,31,35,108],"direct":[5],"thrombin":[6],"inhibitor,":[7],"was":[8,93,105,120,130],"the":[9,97,144,157],"first":[10],"new":[11],"oral":[12],"anticoagulant":[13,39],"to":[14],"be":[15],"approved":[16],"for":[17],"thromboembolic":[18],"prophylaxis":[19],"in":[20,23,72,95,123,152],"atrial":[21,76],"fibrillation":[22,77],"over":[24],"50":[25],"years.":[26],"Dabigatran,":[27],"unlike":[28],"warfarin,":[29,87],"has":[30],"short":[32],"half-life":[33],"with":[34,52,68,74,86,107,132,161],"rapid":[36],"onset":[37],"of":[38,60,99,111,150],"effect,":[40],"does":[41,49],"not":[42,50],"require":[43],"dose":[44,70,146],"adjustment":[45],"or":[46,101,126],"monitoring,":[47],"and":[48,63,78,104,129,147,159],"interact":[51],"food.":[53],"The":[54],"RE-LY":[55],"trial":[56],"compared":[57],"two":[58],"doses":[59],"(110":[62],"150":[64,89],"mg":[65,90,117],"twice":[66,91,118],"daily)":[67],"adjusted":[69],"warfarin":[71],"patients":[73],"non-valvular":[75],"at":[79],"least":[80],"1":[81],"stroke":[82,100,125],"risk":[83,98],"factor.":[84],"Compared":[85],"daily":[92,119],"superior":[94],"reducing":[96,124],"systemic":[102,127],"embolism":[103,128],"associated":[106,131],"similar":[109],"rate":[110],"major":[112,134],"bleeding,":[113],"while":[114],"110":[116],"equally":[121],"effective":[122],"less":[133],"bleeding.":[135],"Despite":[136],"these":[137],"favorable":[138],"results,":[139],"there":[140],"remains":[141],"disagreement":[142],"regarding":[143],"optimal":[145],"overall":[148],"safety":[149],"certain":[153],"patient":[154],"populations":[155],"including":[156],"elderly":[158],"those":[160],"renal":[162],"dysfunction.":[163]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
