{"id":"https://openalex.org/W2097010495","doi":"https://doi.org/10.1093/clinids/22.supplement_2.s161","title":"Is Antifungal Susceptibility Testing Useful in Guiding Fluconazole Therapy?","display_name":"Is Antifungal Susceptibility Testing Useful in Guiding Fluconazole Therapy?","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2097010495","doi":"https://doi.org/10.1093/clinids/22.supplement_2.s161","mag":"2097010495","pmid":"https://pubmed.ncbi.nlm.nih.gov/8722845"},"language":"en","primary_location":{"id":"doi:10.1093/clinids/22.supplement_2.s161","doi":"https://doi.org/10.1093/clinids/22.supplement_2.s161","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinids/22.supplement_2.s161","pdf_url":null,"source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089635085","display_name":"Mahmoud Afif Ghannoum","orcid":"https://orcid.org/0000-0002-8833-7323","observed_orcids":["https://orcid.org/0000-0002-8833-7323"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mahmoud A. Ghannoum","raw_affiliation_strings":["Division of Infectious Diseases, St. John's Cardiovascular Research Center, Torrance, California 90509, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, St. John's Cardiovascular Research Center, Torrance, California 90509, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5089635085"],"corresponding_institution_ids":[],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":3.1872,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.91611454,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"Supplement_2","first_page":"S161","last_page":"S165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12668","display_name":"Yeasts and Rust Fungi Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antifungal-susceptibility-testing","display_name":"antifungal susceptibility testing","score":0.9660000205039978},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":0.9710000157356262},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.890999972820282},{"id":"https://openalex.org/keywords/in-vitro-in-vivo-correlation","display_name":"in vitro-in vivo correlation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/candidemia","display_name":"candidemia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cryptococcal-meningitis","display_name":"cryptococcal meningitis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/host-factors","display_name":"host factors","score":0.7020000219345093},{"id":"https://openalex.org/keywords/treatment-outcome-prediction","display_name":"treatment outcome prediction","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.9461631774902344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7723404169082642},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.6020062565803528},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.48374247550964355},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4785352647304535},{"id":"https://openalex.org/C2780908437","wikidata":"https://www.wikidata.org/wiki/Q464067","display_name":"Mycosis","level":2,"score":0.4638192057609558},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39719265699386597},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3701397776603699},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3248050808906555},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.1471845507621765},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009894","descriptor_name":"Opportunistic Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012015","descriptor_name":"Reference Standards","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015725","descriptor_name":"Fluconazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015725","descriptor_name":"Fluconazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016867","descriptor_name":"Immunocompromised Host","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017088","descriptor_name":"AIDS-Related Opportunistic Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/clinids/22.supplement_2.s161","doi":"https://doi.org/10.1093/clinids/22.supplement_2.s161","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinids/22.supplement_2.s161","pdf_url":null,"source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:8722845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8722845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.991.5280","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.991.5280","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cid.oxfordjournals.org/content/22/Supplement_2/S161.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1504567645","https://openalex.org/W1534171183","https://openalex.org/W1770723515","https://openalex.org/W1985925706","https://openalex.org/W1994352071","https://openalex.org/W2001756812","https://openalex.org/W2010948179","https://openalex.org/W2049243163","https://openalex.org/W2054747131","https://openalex.org/W2064752727","https://openalex.org/W2074890764","https://openalex.org/W2111331431","https://openalex.org/W2113159885","https://openalex.org/W2114055030","https://openalex.org/W2115958412","https://openalex.org/W2140847782","https://openalex.org/W2154068656","https://openalex.org/W2325995795","https://openalex.org/W2339375844","https://openalex.org/W4299528091"],"related_works":["https://openalex.org/W7096437895","https://openalex.org/W2131355745","https://openalex.org/W2140847782","https://openalex.org/W2140769127","https://openalex.org/W2890206156","https://openalex.org/W2101653681","https://openalex.org/W7145959030","https://openalex.org/W2149925685","https://openalex.org/W2397830518","https://openalex.org/W2007440879"],"abstract_inverted_index":{"Recently,":[0],"the":[1,41,79,89,100,146,153,167,183,192,198],"National":[2],"Committee":[3],"for":[4,18,23,33,112,128],"Clinical":[5],"Laboratory":[6],"Standards":[7],"(NCCLS)":[8],"subcommittee":[9],"on":[10,99,156],"antifungal":[11,149,205],"susceptibility":[12,26],"testing":[13,27,206],"published":[14],"a":[15,19,36,74],"proposed":[16,81],"standard":[17],"broth":[20],"macrodilution":[21],"method":[22,37],"in":[24,59,66,69,172,197,210],"vitro":[25,60],"of":[28,47,51,53,73,76,169,194],"yeasts.":[29],"The":[30],"major":[31],"reason":[32],"developing":[34],"such":[35,177],"is":[38,97],"to":[39,57,91,148,185],"predict":[40,92,186],"likely":[42],"clinical":[43,93,110,126,175],"and":[44],"microbiological":[45],"outcome":[46,94],"treatment.":[48],"A":[49],"number":[50],"studies":[52,84],"fluconazole":[54,105,120,170],"have":[55,85,135,139],"attempted":[56],"correlate":[58,124],"minimum":[61],"inhibitory":[62],"concentrations":[63],"(MICs)":[64],"with":[65,95,109,114,125,130,158,174],"vivo":[67,200],"efficacy":[68],"humans":[70],"by":[71],"means":[72],"variety":[75],"methods,":[77],"including":[78],"NCCLS":[80],"standard.":[82],"These":[83],"clearly":[86],"demonstrated":[87,165],"that":[88,142,166],"ability":[90,184],"MICs":[96,106,121,171],"dependent":[98],"patient":[101],"population":[102],"studies.":[103],"Thus,":[104],"were":[107],"correlated":[108],"outcomes":[111,127],"patients":[113,129,138,157],"AIDS-associated":[115,159],"oropharyngeal":[116],"candidiasis.":[117],"In":[118],"contrast,":[119],"did":[122,133],"not":[123,134],"candidemia":[131],"who":[132],"AIDS;":[136],"these":[137],"numerous":[140],"factors":[141,196],"can":[143,207],"independently":[144],"influence":[145],"response":[147],"therapy":[150],"aside":[151],"from":[152,162],"MIC.":[154],"Data":[155],"cryptococcal":[160],"meningitis":[161],"my":[163],"laboratory":[164],"use":[168],"conjunction":[173],"variables,":[176],"as":[178],"blood":[179],"culture":[180],"results,":[181],"enhances":[182],"treatment":[187],"outcome.":[188],"More":[189],"investigations":[190],"addressing":[191],"role":[193],"host":[195],"vitro-in":[199],"correlation":[201],"are":[202],"necessary":[203],"before":[204],"be":[208],"useful":[209],"guiding":[211],"therapy.":[212]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
