{"id":"https://openalex.org/W2097005377","doi":"https://doi.org/10.1161/circresaha.110.218404","title":"Nitro-Oleic Acid Inhibits Angiotensin II\u2013Induced Hypertension","display_name":"Nitro-Oleic Acid Inhibits Angiotensin II\u2013Induced Hypertension","publication_year":2010,"publication_date":"2010-06-18","ids":{"openalex":"https://openalex.org/W2097005377","doi":"https://doi.org/10.1161/circresaha.110.218404","mag":"2097005377","pmid":"https://pubmed.ncbi.nlm.nih.gov/20558825","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2937264"},"language":"en","primary_location":{"id":"doi:10.1161/circresaha.110.218404","doi":"https://doi.org/10.1161/circresaha.110.218404","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.110.218404","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.110.218404","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.110.218404","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100784039","display_name":"Jifeng Zhang","orcid":"https://orcid.org/0000-0001-5161-4705","observed_orcids":["https://orcid.org/0000-0001-5161-4705"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jifeng Zhang","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Jifeng Zhang From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Jifeng Zhang From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044540974","display_name":"Luis Villacorta","orcid":"https://orcid.org/0000-0001-7824-7028","observed_orcids":["https://orcid.org/0000-0001-7824-7028"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis Villacorta","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Luis Villacorta From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Luis Villacorta From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079226908","display_name":"Lin Chang","orcid":"https://orcid.org/0000-0002-5621-8426","observed_orcids":["https://orcid.org/0000-0002-5621-8426"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Chang","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Lin Chang From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Lin Chang From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055719616","display_name":"Zhenzhen Fan","orcid":"https://orcid.org/0000-0001-6270-7552","observed_orcids":["https://orcid.org/0000-0001-6270-7552"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenzhen Fan","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Zhenzhen Fan From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Zhenzhen Fan From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Milton Hamblin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milton Hamblin","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Milton Hamblin From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Milton Hamblin From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068985187","display_name":"Tianqing Zhu","orcid":"https://orcid.org/0000-0003-3592-5276","observed_orcids":["https://orcid.org/0000-0003-3592-5276"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianqing Zhu","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Tianqing Zhu From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Tianqing Zhu From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006386441","display_name":"Chen S. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen S. Chen","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Chen S. Chen From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Chen S. Chen From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026130515","display_name":"Marsha Paulette Cole","orcid":"https://orcid.org/0000-0001-9402-4780","observed_orcids":["https://orcid.org/0000-0001-9402-4780"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marsha P. Cole","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Marsha P. Cole From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Marsha P. Cole From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052711997","display_name":"Francisco Jose Schopfer","orcid":"https://orcid.org/0000-0001-9526-695X","observed_orcids":["https://orcid.org/0000-0001-9526-695X"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco J. Schopfer","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Francisco J. Schopfer From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Francisco J. Schopfer From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073684130","display_name":"Cheri Xiaoyu Deng","orcid":"https://orcid.org/0000-0002-5445-1056","observed_orcids":["https://orcid.org/0000-0002-5445-1056"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheri X. Deng","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Cheri X. Deng From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cheri X. Deng From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040445213","display_name":"Minerva T. Garcia-Barrio","orcid":"https://orcid.org/0000-0002-3381-3847","observed_orcids":["https://orcid.org/0000-0002-3381-3847"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minerva T. Garcia-Barrio","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Minerva T. Garcia-Barrio From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Minerva T. Garcia-Barrio From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111492449","display_name":"Ying\u2010Hong Feng","orcid":"https://orcid.org/0000-0003-0995-2254","observed_orcids":["https://orcid.org/0000-0003-0995-2254"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying-Hong Feng","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Ying-Hong Feng From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Ying-Hong Feng From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013958345","display_name":"Bruce \u0391. Freeman","orcid":"https://orcid.org/0000-0002-2028-8369","observed_orcids":["https://orcid.org/0000-0002-2028-8369"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce A. Freeman","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Bruce A. Freeman From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Bruce A. Freeman From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012043518","display_name":"Yanxing Chen","orcid":"https://orcid.org/0000-0001-6346-9752","observed_orcids":["https://orcid.org/0000-0001-6346-9752"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Eugene Chen","raw_affiliation_strings":["From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","Y. Eugene Chen From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.); and Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan; Department of Pharmacology &amp; Chemical Biology (C.S.C., M.P.C., F.J.S., B.A.F.), University of Pittsburgh, Pa; Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga; and Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I27837315","https://openalex.org/I6332465"]},{"raw_affiliation_string":"Cardiovascular Research Institute (M.T.G.-B.), Morehouse School of Medicine, Atlanta, Ga","institution_ids":["https://openalex.org/I6332465"]},{"raw_affiliation_string":"Department of Biomedical Engineering (Z.F., C.X.D.), College of Engineering, University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology (Y.-H.F.), Uniformed Services University of the Health Sciences, Bethesda, Md","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Y. Eugene Chen From the Cardiovascular Center (J.Z., L.V., L.C., M.H., T.Z., Y.E.C.)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.566,"has_fulltext":true,"cited_by_count":118,"citation_normalized_percentile":{"value":0.9644373,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"107","issue":"4","first_page":"540","last_page":"548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.10580000281333923,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitro-oleic-acid","display_name":"nitro-oleic acid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9150000214576721},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9440000057220459},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.890999972820282},{"id":"https://openalex.org/keywords/g-protein-coupling","display_name":"G protein coupling","score":0.8479999899864197},{"id":"https://openalex.org/keywords/inositol-trisphosphate","display_name":"inositol trisphosphate","score":0.8199999928474426},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.9470000267028809},{"id":"https://openalex.org/keywords/vascular-protection","display_name":"vascular protection","score":0.7289999723434448},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C2781403372","wikidata":"https://www.wikidata.org/wiki/Q207688","display_name":"Oleic acid","level":2,"score":0.6728846430778503},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6172168254852295},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.5372222661972046},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5294302105903625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4986684322357178},{"id":"https://openalex.org/C2780639532","wikidata":"https://www.wikidata.org/wiki/Q7041427","display_name":"Nitro","level":3,"score":0.4866984188556671},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46152132749557495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4226512610912323},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39206039905548096},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31259703636169434},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2725321054458618},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08735406398773193},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008041","descriptor_name":"Linoleic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009574","descriptor_name":"Nitro Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009829","descriptor_name":"Oleic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019301","descriptor_name":"Oleic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1161/circresaha.110.218404","doi":"https://doi.org/10.1161/circresaha.110.218404","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.110.218404","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.110.218404","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:20558825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20558825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:2153725","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2937264","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2937264","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2937264","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Res","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.946.1531","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.946.1531","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circres.ahajournals.org/content/107/4/540.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1161/circresaha.110.218404","doi":"https://doi.org/10.1161/circresaha.110.218404","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.110.218404","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.110.218404","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1239903842","display_name":"Redox-Derived Pulmonary Anti-Inflammatory Mediators","funder_award_id":"R01HL064937","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1250753618","display_name":null,"funder_award_id":"HL 58115","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1922817664","display_name":"Mechanisms of ultrasound mediated intracellular drug and gene delivery","funder_award_id":"R01CA116592","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4007870955","display_name":"Nitroalkenes and Blood Pressure Regulation","funder_award_id":"R01HL089544","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4385136508","display_name":"Redox Transduction of Nitric Oxide Signaling","funder_award_id":"R37HL058115","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4688069298","display_name":"Nitric Oxide Regulation of Vascular Oxidant Injury","funder_award_id":"R01HL058115","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5424119448","display_name":"CRP Biology and Vascular Disease","funder_award_id":"R01HL088391","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G542547905","display_name":"Nitro-Fatty Acids and Nrf2 in Vascular Remodeling","funder_award_id":"R01HL105114","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6320493427","display_name":"PPAR-gamma and Vascular Disease","funder_award_id":"R01HL068878","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6916845380","display_name":"Metabolic Stress-Induced Fatty Acid Nitration and Cardiovascular Function","funder_award_id":"K99HL095769","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7596088089","display_name":"Advanced Ultrasound Ablation Therapy for Atrial Fibrillation","funder_award_id":"R01EB008999","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G8142044688","display_name":"PPAR-delta in obesity-related vascular remodeling","funder_award_id":"R01HL075397","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2097005377.pdf","grobid_xml":"https://content.openalex.org/works/W2097005377.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1511302815","https://openalex.org/W1622211725","https://openalex.org/W1975740938","https://openalex.org/W1977944032","https://openalex.org/W1978334998","https://openalex.org/W1979166300","https://openalex.org/W1982380290","https://openalex.org/W1990185204","https://openalex.org/W1991594689","https://openalex.org/W1993635466","https://openalex.org/W1993820363","https://openalex.org/W1995592237","https://openalex.org/W2004517091","https://openalex.org/W2008048680","https://openalex.org/W2021907601","https://openalex.org/W2023421218","https://openalex.org/W2027487087","https://openalex.org/W2031801552","https://openalex.org/W2033357754","https://openalex.org/W2040758907","https://openalex.org/W2042149164","https://openalex.org/W2042154246","https://openalex.org/W2048748448","https://openalex.org/W2051727048","https://openalex.org/W2058422032","https://openalex.org/W2064023056","https://openalex.org/W2066554947","https://openalex.org/W2070186643","https://openalex.org/W2086506907","https://openalex.org/W2095368090","https://openalex.org/W2097996389","https://openalex.org/W2104477830","https://openalex.org/W2106452970","https://openalex.org/W2109621677","https://openalex.org/W2109692501","https://openalex.org/W2117854326","https://openalex.org/W2124663880","https://openalex.org/W2127710249","https://openalex.org/W2128632568","https://openalex.org/W2129697991","https://openalex.org/W2135606776","https://openalex.org/W2135949681","https://openalex.org/W2136018315","https://openalex.org/W2153065065","https://openalex.org/W2155616119","https://openalex.org/W2155777324","https://openalex.org/W2156835140","https://openalex.org/W2164476520","https://openalex.org/W2168664410","https://openalex.org/W2170339244"],"related_works":["https://openalex.org/W7100394540","https://openalex.org/W2132785282","https://openalex.org/W7095399884","https://openalex.org/W2323760953","https://openalex.org/W1858498970","https://openalex.org/W2377389052","https://openalex.org/W2156429510","https://openalex.org/W2082921744","https://openalex.org/W2171329003","https://openalex.org/W2234970798"],"abstract_inverted_index":{"RATIONALE:":[0],"Nitro-oleic":[1],"acid":[2,10,104],"(OA-NO(2))":[3],"is":[4,112,130],"a":[5,24,68,79,203],"bioactive,":[6],"nitric-oxide":[7],"derived":[8],"fatty":[9],"with":[11],"physiologically":[12],"relevant":[13],"vasculoprotective":[14],"properties":[15],"in":[16,36,51,67,75,106,133],"vivo.":[17],"OA-NO(2)":[18,50,65,93,136,142,188,201],"exerts":[19,78],"cell":[20,34],"signaling":[21,122],"actions":[22],"as":[23,100,202],"result":[25],"of":[26,49,64,71,148,206],"its":[27],"strong":[28],"electrophilic":[29],"nature":[30],"and":[31,77,168,172,196],"mediates":[32],"pleiotropic":[33],"responses":[35],"the":[37,46,115,139,162,181,190],"vasculature.":[38],"OBJECTIVE:":[39],"The":[40,109],"present":[41],"study":[42],"sought":[43],"to":[44,102,135,161,180,193],"investigate":[45],"protective":[47],"role":[48],"angiotensin":[52],"(Ang)":[53],"II-induced":[54,73,145,208],"hypertension.":[55,209],"METHODS":[56],"AND":[57],"RESULTS:":[58],"We":[59],"show":[60],"that":[61,187],"systemic":[62],"administration":[63],"results":[66,185],"sustained":[69],"reduction":[70],"Ang":[72,90,96,116,144,177,194,207],"hypertension":[74,87,146],"mice":[76],"significant":[80],"blood":[81],"pressure":[82],"lowering":[83],"effect":[84],"on":[85],"preexisting":[86],"established":[88],"by":[89,126],"II":[91,97,117,178,195],"infusion.":[92],"significantly":[94],"inhibits":[95,169,197],"contractile":[98],"response":[99,134,192],"compared":[101],"oleic":[103],"(OA)":[105],"mesenteric":[107],"vessels.":[108],"improved":[110],"vasoconstriction":[111],"specific":[113],"for":[114],"type":[118],"1":[119],"receptor":[120,151],"(AT(1)R)-mediated":[121],"because":[123],"vascular":[124],"contraction":[125],"other":[127],"G-protein-coupled":[128],"receptors":[129],"not":[131,157],"altered":[132],"treatment.":[137],"From":[138],"mechanistic":[140],"viewpoint,":[141],"lowers":[143],"independently":[147],"peroxisome":[149],"proliferation-activated":[150],"(PPAR)gamma":[152],"activation.":[153],"Rather,":[154],"OA-NO(2),":[155],"but":[156],"OA,":[158],"specifically":[159],"binds":[160],"AT(1)R,":[163],"reduces":[164],"heterotrimeric":[165],"G-protein":[166],"coupling,":[167],"IP(3)":[170],"(inositol-1,4,5-trisphosphate)":[171],"calcium":[173],"mobilization,":[174],"without":[175],"inhibiting":[176],"binding":[179],"receptor.":[182],"CONCLUSIONS:":[183],"These":[184],"demonstrate":[186],"diminishes":[189],"pressor":[191],"AT(1)R-dependent":[198],"vasoconstriction,":[199],"revealing":[200],"novel":[204],"antagonist":[205]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
