{"id":"https://openalex.org/W2096997337","doi":"https://doi.org/10.1093/nar/23.11.1887","title":"Phosphorylation of theOxytrichatelomere protein: possible cell cycle regulation","display_name":"Phosphorylation of theOxytrichatelomere protein: possible cell cycle regulation","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W2096997337","doi":"https://doi.org/10.1093/nar/23.11.1887","mag":"2096997337","pmid":"https://pubmed.ncbi.nlm.nih.gov/7596814","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/306959"},"language":"en","primary_location":{"id":"doi:10.1093/nar/23.11.1887","doi":"https://doi.org/10.1093/nar/23.11.1887","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/23.11.1887","pdf_url":"https://academic.oup.com/nar/article-pdf/23/11/1887/7122868/23-11-1887.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/nar/article-pdf/23/11/1887/7122868/23-11-1887.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091386833","display_name":"Brian J. Hicke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Hicke","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, Howard Hughes Medical Institute, University of Colorado, Boulder 80309-0215, USA","Department of Molecular, Cellular and Developmental BiologyUSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, Howard Hughes Medical Institute, University of Colorado, Boulder 80309-0215, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I188538660"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental BiologyUSA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082083413","display_name":"Rachel E. Rempel","orcid":"https://orcid.org/0000-0002-6113-1659","observed_orcids":["https://orcid.org/0000-0002-6113-1659"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Rempel","raw_affiliation_strings":["Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado School of Medicine Denver, CO 80262, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado School of Medicine Denver, CO 80262, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044887954","display_name":"James L. Mailer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Mailer","raw_affiliation_strings":["Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado School of Medicine Denver, CO 80262, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado School of Medicine Denver, CO 80262, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089089920","display_name":"Richard A. Swank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Swank","raw_affiliation_strings":["Department of Biological Chemistry, School of Medicine, University of California Davis, CA 95016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, School of Medicine, University of California Davis, CA 95016, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040347432","display_name":"Joyce R. Hamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce R. Hamaguchi","raw_affiliation_strings":["Department of Biological Chemistry, School of Medicine, University of California Davis, CA 95016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, School of Medicine, University of California Davis, CA 95016, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009849681","display_name":"E. Morton Bradbury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Morton Bradbury","raw_affiliation_strings":["Department of Biological Chemistry, School of Medicine, University of California Davis, CA 95016, USA","Life Sciences Division, Los Alamos National Laboratory Los Alamos, NM 87545, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, School of Medicine, University of California Davis, CA 95016, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Life Sciences Division, Los Alamos National Laboratory Los Alamos, NM 87545, USA","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111750361","display_name":"David M. Prescott","orcid":"https://orcid.org/0000-0002-9798-9526","observed_orcids":["https://orcid.org/0000-0002-9798-9526"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David M. Prescott","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017573996","display_name":"Thomas R. Cech","orcid":"https://orcid.org/0000-0001-7338-3389","observed_orcids":["https://orcid.org/0000-0001-7338-3389"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas R. Cech","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Howard Hughes Medical Institute University of Colorado, Boulder, CO 80309-0215, USA","Department of Molecular, Cellular and Developmental Biology USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Howard Hughes Medical Institute University of Colorado, Boulder, CO 80309-0215, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I188538660"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5017573996"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I188538660"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":0.8583,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.75395225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"11","first_page":"1887","last_page":"1893"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxytricha-nova","display_name":"Oxytricha nova","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/threonine-phosphorylation","display_name":"threonine phosphorylation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cdc2-cyclin-b","display_name":"Cdc2/cyclin B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.6269999742507935},{"id":"https://openalex.org/keywords/macronucleus","display_name":"macronucleus","score":0.8190000057220459},{"id":"https://openalex.org/keywords/telomere-structure","display_name":"telomere structure","score":0.6340000033378601},{"id":"https://openalex.org/keywords/dephosphorylation","display_name":"dephosphorylation","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.903189480304718},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.6491328477859497},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.6455145478248596},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.6253386735916138},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.5825902819633484},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5502458214759827},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.504623532295227},{"id":"https://openalex.org/C202265312","wikidata":"https://www.wikidata.org/wiki/Q7697810","display_name":"Telomere-binding protein","level":5,"score":0.46612098813056946},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.4325312674045563},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.41414177417755127},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39984941482543945},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3794262409210205},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.30214065313339233},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.27878478169441223},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.13897940516471863},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.11469888687133789},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0809493362903595}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004277","descriptor_name":"DNA, Single-Stranded","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016813","descriptor_name":"Oxytricha","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016813","descriptor_name":"Oxytricha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/23.11.1887","doi":"https://doi.org/10.1093/nar/23.11.1887","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/23.11.1887","pdf_url":"https://academic.oup.com/nar/article-pdf/23/11/1887/7122868/23-11-1887.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:306959","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/306959","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:7596814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7596814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/23.11.1887","doi":"https://doi.org/10.1093/nar/23.11.1887","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/23.11.1887","pdf_url":"https://academic.oup.com/nar/article-pdf/23/11/1887/7122868/23-11-1887.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2222028608","display_name":null,"funder_award_id":"GM 28039","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G282505685","display_name":"PROCESSING OF DNA BY HYPOTRICHOUS CILIATES","funder_award_id":"R01GM019199","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3295891751","display_name":null,"funder_award_id":"GM 45890-03","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5923161094","display_name":"CONTROL OF THE CELL DIVISION CYCLE","funder_award_id":"R01GM045890","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G892215622","display_name":null,"funder_award_id":"GM19199","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2096997337.pdf","grobid_xml":"https://content.openalex.org/works/W2096997337.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W164751788","https://openalex.org/W935855719","https://openalex.org/W1596735906","https://openalex.org/W1624519387","https://openalex.org/W1748661035","https://openalex.org/W1882943721","https://openalex.org/W1964170914","https://openalex.org/W1966724584","https://openalex.org/W1970965142","https://openalex.org/W1972145114","https://openalex.org/W1972303536","https://openalex.org/W1980725176","https://openalex.org/W2003727007","https://openalex.org/W2004106262","https://openalex.org/W2005576986","https://openalex.org/W2008900071","https://openalex.org/W2010975156","https://openalex.org/W2021856126","https://openalex.org/W2022991912","https://openalex.org/W2023377008","https://openalex.org/W2025931491","https://openalex.org/W2027884659","https://openalex.org/W2029222292","https://openalex.org/W2034151551","https://openalex.org/W2034468934","https://openalex.org/W2038013843","https://openalex.org/W2041212841","https://openalex.org/W2045515164","https://openalex.org/W2052968074","https://openalex.org/W2059428026","https://openalex.org/W2060255686","https://openalex.org/W2062395030","https://openalex.org/W2063602878","https://openalex.org/W2070397575","https://openalex.org/W2072612208","https://openalex.org/W2073722866","https://openalex.org/W2077449437","https://openalex.org/W2090083872","https://openalex.org/W2091876286","https://openalex.org/W2096893503","https://openalex.org/W2098101908","https://openalex.org/W2123006322","https://openalex.org/W2123930515","https://openalex.org/W2128240046","https://openalex.org/W2131501858","https://openalex.org/W2164647774","https://openalex.org/W2168184899","https://openalex.org/W2169665882","https://openalex.org/W2177878554","https://openalex.org/W2192138573","https://openalex.org/W2314225431","https://openalex.org/W2322597121","https://openalex.org/W2411028245","https://openalex.org/W4206302388","https://openalex.org/W4290260729","https://openalex.org/W6600715346","https://openalex.org/W6603617765","https://openalex.org/W6603860674","https://openalex.org/W6720842974","https://openalex.org/W6733560187","https://openalex.org/W6815322837"],"related_works":["https://openalex.org/W2165455779","https://openalex.org/W1965544079","https://openalex.org/W2107505972","https://openalex.org/W1975239850","https://openalex.org/W2682996847","https://openalex.org/W2109295879","https://openalex.org/W2052530801","https://openalex.org/W568541166","https://openalex.org/W2139846936","https://openalex.org/W2051381737"],"abstract_inverted_index":{"In":[0,45,123],"the":[1,4,23,84,99,110,144,194],"macronucleus":[2],"of":[3,73,77,83,148,164,186,196],"ciliate":[5],"Oxytricha":[6],"nova,":[7],"telomeres":[8,151],"end":[9],"with":[10,109,199,203],"single-stranded":[11],"(T4G4)2":[12],"DNA":[13,63,92],"bound":[14],"to":[15,40,207],"a":[16,41,54,81],"heterodimeric":[17],"telomere":[18,85,165,197],"protein":[19,86],"(alpha":[20],"beta).":[21],"Both":[22],"alpha":[24],"and":[25,29,137,170],"beta":[26],"subunits":[27],"(alpha-TP":[28],"beta-TP)":[30],"were":[31],"phosphorylated":[32,39,51,133],"in":[33,53,68,106,134,139,152],"asynchronously":[34],"growing":[35],"Oxytricha;":[36],"beta-TP":[37,52,78,113,131,187],"was":[38,132],"much":[42],"higher":[43,69],"degree.":[44],"vitro,":[46],"mouse":[47,100],"cyclin-dependent":[48],"kinases":[49,173,190],"(Cdks)":[50],"lysine-rich":[55],"domain":[56],"that":[57,87,98,112,127,184],"is":[58,66,88,183,191],"not":[59],"required":[60,175,192],"for":[61,160,176,193],"specific":[62,91],"binding":[64],"but":[65],"implicated":[67],"order":[70],"structure":[71],"formation":[72],"telomeres.":[74],"Therefore,":[75],"phosphorylation":[76,149,185],"could":[79],"modulate":[80],"function":[82],"separate":[89],"from":[90],"binding.":[93],"Phosphoamino":[94],"acid":[95],"analysis":[96],"revealed":[97],"Cdks":[101],"modify":[102],"predominantly":[103],"threonine":[104,121],"residues":[105],"beta-TP,":[107],"consistent":[108],"observation":[111],"contains":[114],"two":[115],"consensus":[116],"Cdk":[117],"recognition":[118],"sequences":[119],"containing":[120],"residues.":[122],"Xenopus":[124],"egg":[125],"extracts":[126],"undergo":[128],"cell":[129,161],"cycling,":[130],"M":[135],"phase":[136],"dephosphorylated":[138],"interphase.":[140],"This":[141],"work":[142],"provides":[143],"first":[145],"direct":[146],"evidence":[147,159],"at":[150],"any":[153],"organism,":[154],"as":[155,157],"well":[156],"indirect":[158],"cycle":[162],"regulation":[163],"phosphorylation.":[166],"The":[167],"Cdc2/cyclin":[168,171],"A":[169],"B":[172],"are":[174],"major":[177],"mitotic":[178],"events.":[179],"An":[180],"attractive":[181],"model":[182],"by":[188],"these":[189],"breakdown":[195],"associations":[198],"each":[200],"other":[201],"and/or":[202],"nuclear":[204,208],"structures":[205],"prior":[206],"division.":[209]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}